1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
|
> 1== M63632 1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
--------------------MNGTE--G-------------------DNFYVPFSNKTG-
-------------------------------LARSPYEYPQY----------------YL
AEPW---------KYSA-----LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILL
NLAMANLFMVLFG-FTVTMYTSMN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLAI
ERYIVICKPMGNF-RFGNTHAIMGVAFTWIMALACAAP-PLVG-WS-----RYIPEGMQC
SCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKEAAAAQQESA----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFT-HQGS--
DFGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTLC-----C----GKNPLGDDE
-SGA-STSK-TEVSSVS-TSPVSPA-----------------------------------
-----------------------------------------------------------
> 2== U22180 1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
--------------------MNGTE--G-------------------PNFYVPFSNITG-
-------------------------------VVRSPFEQPQY----------------YL
AEPW---------QFSM-----LAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILL
NLAVADLFMVFGG-FTTTLYTSLH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLAI
ERYVVVCKPMSNF-RFGENHAIMGVAFTWVMALACAAP-PLVG-WS-----RYIPEGMQC
SCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESA----
------------------------------------------------------------
------------------------------------------------------------
-----------------TTQKAEKEVTRMVIIMVIFFLICWLPYASVAMYIFT-HQGS--
NFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLC-----C----GKNPLGDDE
-ASA-TASK-TETSQVA-PA----------------------------------------
-----------------------------------------------------------
> 3== M92038 1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
--------------------MNGTE--G-------------------INFYVPMSNKTG-
-------------------------------VVRSPFEYPQY----------------YL
AEPW---------KYRL-----VCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILV
NLAVADLFMACFG-FTVTFYTAWN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLAI
ERYIVVCKPMGNF-RFSATHAMMGIAFTWVMAFSCAAP-PLFG-WS-----RYMPEGMQC
SCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVREAAAQQQESA----
------------------------------------------------------------
------------------------------------------------------------
-----------------TTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFT-NKGA--
DFTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTIC-----C----GKNPFGDED
VSSTVSQSK-TEVSSVS-SSQVSPA-----------------------------------
-----------------------------------------------------------
> 4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
--------------------MNGTE--G-------------------KNFYVPMSNRTG-
-------------------------------LVRSPFEYPQY----------------YL
AEPW---------QFKI-----LALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILV
NLAVAGTIMVCFG-FTVTFYTAIN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLAI
ERYIVVCKPMGSF-KFSSSHAFAGIAFTWVMALACAAP-PLFG-WS-----RYIPEGMQC
SCGPDYYTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVKAAAAQQQDSA----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEREVTKMVILMVFGFLIAWTPYATVAAWIFF-NKGA--
DFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTIF-----C----GKNPLGDDE
-SSTVSTSK-TEVSSVS-PA----------------------------------------
-----------------------------------------------------------
> 5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
--------------------MNGTE--G-------------------NNFYVPLSNRTG-
-------------------------------LVRSPFEYPQY----------------YL
AEPW---------QFKL-----LAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILV
NLAVAGAIMVCFG-FTVTFYTAIN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLAI
ERYIVVCKPMGSF-KFSSTHASAGIAFTWVMAMACAAP-PLVG-WS-----RYIPEGIQC
SCGPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKAAAAQQQDSA----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEREVTKMVILMVLGFLVAWTPYATVAAWIFF-NKGA--
AFSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTLF-----C----GKNPLGDEE
-SSTVSTSK-TEVSSVS-PA----------------------------------------
-----------------------------------------------------------
> 6== L11864 1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
--------------------MKQVPEFH-------------------EDFYIPIPLDIN-
-----------------------------NLSAYSPFLVPQD----------------HL
GNQG---------IFMA-----MSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILV
NLSIANLFVAIFG-SPLSFYSFFN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVAF
ERWLVICKPLGNF-TFKTPHAIAGCILPWISALAASLP-PLFG-WS-----RYIPEGLQC
SCGPDWYTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLKLAAKAQADSA----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEREVTKMVVVMVLGFLVCWAPYASFSLWIVS-HRGE--
EFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMM-KMV-----C----GKN-IEEDE
-AST-SSQV-TQVSSVA-PEK---------------------------------------
-----------------------------------------------------------
> 7== M13299 1 human BCP <>[Science232(4747),193-202'86]
--------------------MRKMS--E-------------------EEFYL-----FK-
-----------------------------NISSVGPWDGPQY----------------HI
APVW---------AFYL-----QAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILV
NVSFGGFLLCIFS-VFPVFVASCN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLAF
ERYIVICKPFGNF-RFSSKHALTVVLATWTIGIGVSIP-PFFG-WS-----RFIPEGLQC
SCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESA----
------------------------------------------------------------
------------------------------------------------------------
-----------------TTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVN-NRNH--
GLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIM-KMV-----C----GKA-MTDES
-DTC-SSQK-TEVSTVS-STQVGPN-----------------------------------
-----------------------------------------------------------
> 8=opsin, greensensitive human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----DLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISW
ERWLVVCKPFGNV-RFDAKLAIVGIAFSWIWAAVWTAP-PIFG-WS-----RYWPHGLKT
SCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEKEVTRMVVVMVLAFC----------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------
> 9== K03494 1 human GCP <>[Science232(4747),193-202'86]
MAQQWS-LQRLAGRHPQDSYEDSTQ--S-------------------SIFTYTNSN----
-------------------------------STRGPFEGPNY----------------HI
APRW---------VYHL-----TSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILV
NLAVADLAETVIA-STISVVNQVY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISW
ERWMVVCKPFGNV-RFDAKLAIVGIAFSWIWAAVWTAP-PIFG-WS-----RYWPHGLKT
SCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAA-NPGY--
PFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCIL-QLF----------GKK-VDDGS
-ELS-SASK-TEVSSV---SSVSPA-----------------------------------
-----------------------------------------------------------
> 10== Z68193 1 human Red Opsin <>[]
MAQQWS-LQRLAGRHPQDSYEDSTQ--S-------------------SIFTYTNSN----
-------------------------------STRGPFEGPNY----------------HI
APRW---------VYHL-----TSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILV
NLAVADLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISW
ERWLVVCKPFGNV-RFDAKLAIVGIAFSWIWSAVWTAP-PIFG-WS-----RYWPHGLKT
SCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESE----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAA-NPGY--
AFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCIL-QLF----------GKK-VDDGS
-ELS-SASK-TEVSSV---SSVSPA-----------------------------------
-----------------------------------------------------------
> 11== M92036 1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
MTEAWNVAVFAARRSRDD--DDTTR--G-------------------SVFTYTNTN----
-------------------------------NTRGPFEGPNY----------------HI
APRW---------VYNL-----VSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILV
NLAFVDLVETLVA-STISVFNQIF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIISW
ERWFVVCKPFGNI-KFDSKLAIIGIVFSWVWAWGWSAP-PIFG-WS-----RYWPHGLKT
SCGPDVFSGSVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAIRAVAAQQKESE----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEREVSRMVVVMIVAFCICWGPYASFVSFAAA-NPGY--
AFHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIM-QLF----------GKK-VDDGS
-EAS-TTSR-TEVSSVS-NSSVAPA-----------------------------------
-----------------------------------------------------------
> 12== M62903 1 chicken visual pigment <>[BBRC173,1212-1217'90]
MA-AWE-AAFAARRRHEE--EDTTR--D-------------------SVFTYTNSN----
-------------------------------NTRGPFEGPNY----------------HI
APRW---------VYNL-----TSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILV
NLAVADLGETVIA-STISVINQIS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIISW
ERWFVVCKPFGNI-KFDGKLAVAGILFSWLWSCAWTAP-PIFG-WS-----RYWPHGLKT
SCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIRAVAAQQKESE----
------------------------------------------------------------
------------------------------------------------------------
-----------------STQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAA-NPGY--
AFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIL-QLF----------GKK-VDDGS
-EVS-T-SR-TEVSSVS-NSSVSPA-----------------------------------
-----------------------------------------------------------
> 13== S75720 1 chicken P-opsin <>[Science267(5203),1502-1506'95]
------------------------M--S-------------------SNSSQAPPN----
-------------------------------GTPGPFDGPQW---------------PYQ
APQS---------TYVG-----VAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILV
NLAVADLLVTLCG-SSVSLSNNIN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILAL
ERYVVVCKPLGDF-QFQRRHAVSGCAFTWGWALLWSAP-PLLG-WS-----SYVPEGLRT
SCGPNWYTGGSN--NNSYILSLFVTCFVLPLSLILFSYTNLLLTLRAAAAQQKEAD----
------------------------------------------------------------
------------------------------------------------------------
-----------------TTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVAT-HKGI--
IIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLL-EML-----CCGYQPQR-TGKAS
-PGT-PGPH-ADVTAAGLRNKVMPAHPV--------------------------------
-----------------------------------------------------------
> 14== M17718 1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
-MESGNVS--SS--------LFGNV--S-------------------TALR-------P-
-------------------------------EARLSA---E---TRLLGWNVPPEELRHI
PEHWLTYPEPPESMNYL-----LGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVI
NLAFCDFMMMVK--TPIFIYNSFH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIAY
DRFNVITRPMEG--KMTHGKAIAMIIFIYMYATPWVVA-CYTETWG-----RFVPEGYLT
SCTFDYLTDN--FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKMN
VE------------------SLRS------------------------------------
------------------------------------------------------------
-------------NVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAF-GDKT--
LLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQ-KRCPWL--AL---NEK-APESS
-AVA-STST-TQEPQQT------TAA----------------------------------
-----------------------------------------------------------
> 15== X65879 1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
-MEYHNVS--SV--------L-GNV--S-------------------SVLR-------P-
-------------------------------DARLSA---E---SRLLGWNVPPDELRHI
PEHWLIYPEPPESMNYL-----LGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVI
NLAFCDFMMMIK--TPIFIYNSFH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIAY
DRYNVITRPMEG--KMTHGKAIAMIIFIYLYATPWVVA-CYTESWG-----RFVPEGYLT
SCTFDYLTDN--FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKMN
VD------------------SLRS------------------------------------
------------------------------------------------------------
-------------NVDKSKEAAEIRIAKAAITICFLFFASWTPYGVMSLIGAF-GDKT--
LLTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQ-KRCPWL--AI---SEK-APESR
-AAI-STST-TQEQQQT------TAA----------------------------------
-----------------------------------------------------------
> 16== M17730 1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
-ME--------P--------LCNAS--E-------------------PPLR-------P-
-------------------------------EAR-SSGNGD---LQFLGWNVPPDQIQYI
PEHWLTQLEPPASMHYM-----LGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVL
NLAVFDLIMCLK--APIF--NSFH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIGY
DRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPWVVL-PLTQFWD-----RFVPEGYLT
SCSFDYLSDN--FDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKMN
VE------------------SLRS------------------------------------
------------------------------------------------------------
-------------NVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAF-GDKS--
LLTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQ-KRCPWL--GV---NEK-SGEIS
-SAQ-STTT-QEQQQTT------AA-----------------------------------
-----------------------------------------------------------
> 17== X65880 1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
-MD--------A--------LCNAS--E-------------------PPLR-------P-
-------------------------------EARMSSGSDE---LQFLGWNVPPDQIQYI
PEHWLTQLEPPASMHYM-----LGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVL
NLAVFDLIMCLK--APIFIYNSFH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIGY
DRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPWVVL-PLTQFWD-----RFVPEGYLT
SCSFDYLSDN--FDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKALREQAKKMN
VE------------------SLRS------------------------------------
------------------------------------------------------------
-------------NVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAF-GDKS--
LLTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQ-KRCPWL--GV---NEK-SGEAS
-SAQ-STTT-QEQTQQT------SAA----------------------------------
-----------------------------------------------------------
> 18== D50584 1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
--------------------MTNAT--G-------------------PQMAY-----YG-
-------------------------------AASMDFGYPE---GVSIVDFVRPEIKPYV
HQHWYNYPPVNPMWHYL-----LGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVV
NLALSDLIMLTTN-VPFFTYNCFSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMISF
DRYNIICNGFNGP-KLTTGKAVVFALISWVIAIGCALP-PFFG-WG-----NYILEGILD
SCSYDYLTQD--FNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQAKKMN
VS------------------TLRS------------------------------------
------------------------------------------------------------
--------------NEADAQRAEIRIAKTALVNVSLWFICWTPYALISLKGVM-GDTS--
GITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAIT-QHLPWF--CV---HET-ETKSN
-DDS-QSNS-TVAQDKA-------------------------------------------
-----------------------------------------------------------
> 19== D50583 1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
--------------------MANVT--G-------------------PQMAF-----YG-
-------------------------------SGAATFGYPE---GMTVADFVPDRVKHMV
LDHWYNYPPVNPMWHYL-----LGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIV
NLALSDLIMLTTN-FPPFCYNCFSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMISF
DRYNIICNGFNGP-KLTQGKATFMCGLAWVISVGWSLP-PFFG-WG-----SYTLEGILD
SCSYDYFTRD--MNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKKMN
VT------------------NLRS------------------------------------
------------------------------------------------------------
--------------NEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQGLL-GNAE--
GITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAIT-QHLPWF--CV---HEK-DPNDV
-EEN-QSSN-TQTQEKS-------------------------------------------
-----------------------------------------------------------
> 20== K02320 1 D.melanogaster opsin <>[Cell40,851-858'85]
------MESFAV--------AAAQL--G-------------------PHFA---------
---------------------------------PLS--------NGSVVDKVTPDMAHLI
SPYWNQFPAMDPIWAKI-----LTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVI
NLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISL
DRYQVIVKGMAGR-PMTIPLALGKM---------------------------YVPEGNLT
SCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMN
VK------------------SLRS------------------------------------
------------------------------------------------------------
--------------SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLF-KF-E--
GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALK-EKCPCC--VF---GKV-DDGKS
-SDA-QSQA-TASEAES------KA-----------------------------------
-----------------------------------------------------------
> 21== K02315 1 D.melanogaster ninaE <>[Cell40,839-850'85]
------MESFAV--------AAAQL--G-------------------PHFA---------
---------------------------------PLS--------NGSVVDKVTPDMAHLI
SPYWNQFPAMDPIWAKI-----LTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVI
NLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISL
DRYQVIVKGMAGR-PMTIPLALGKIAYIWFMSSIW-CLAPAFG-WS-----RYVPEGNLT
SCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMN
VK------------------SLRS------------------------------------
------------------------------------------------------------
--------------SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLF-KF-E--
GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALK-EKCPCC--VF---GKV-DDGKS
-SDA-QSQA-TASEAES------KA-----------------------------------
-----------------------------------------------------------
> 22== X65877 1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
------MDSFAA--------VATQL--G-------------------PQFA---------
---------------------------------APS--------NGSVVDKVTPDMAHLI
SPYWDQFPAMDPIWAKI-----LTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVI
NLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISL
DRYQVIVKGMAGR-PMTIPLALGKIAYIWFMSTIWCCLAPVFG-WS-----RYVPEGNLT
SCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMN
VK------------------SLRS------------------------------------
------------------------------------------------------------
--------------SEDADKSAEGKLAKVALVTISLWFMAWTPYLVINCMGLF-KF-E--
GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALK-EKCPCC--VF---GKV-DDGKS
-SEA-QSQA-TTSEAES------KA-----------------------------------
-----------------------------------------------------------
> 23== M12896 1 D.melanogaster Rh2 <>[Cell44,705-710'86]
-MERSHLPETPF--------DLAHS--G-------------------PRFQ---------
---------------------------------AQSSG------NGSVLDNVLPDMAHLV
NPYWSRFAPMDPMMSKI-----LGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVL
NLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIAF
DRYNVIVKGINGT-PMTIKTSIMKILFIWMMAVFWTVM-PLIG-WS-----AYVPEGNLT
ACSIDYMTRM--WNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMN
VK------------------SLRS------------------------------------
------------------------------------------------------------
--------------SEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLF-KI-D--
GLTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLK-EKCPMC--VF---GNT-DEPKP
-DAP-ASDTETTSEADS------KA-----------------------------------
-----------------------------------------------------------
> 24== X65878 1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
-MERSLLPEPPL--------AMALL--G-------------------PRFE---------
---------------------------------AQTGG------NRSVLDNVLPDMAPLV
NPHWSRFAPMDPTMSKI-----LGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVL
NLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIAF
DRYNVIVKGINGT-PMTIKTSIMKIAFIWMMAVFWTIM-PLIG-WS-----SYVPEGNLT
ACSIDYMTRQ--WNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHEKAMRDQAKKMN
VK------------------SLRS------------------------------------
------------------------------------------------------------
--------------SEDCDKSAENKLAKVALTTISLWFMAWTPYLIICYFGLF-KI-D--
GLTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLK-EKCPMC--VC---GTT-DEPKP
-DAP-PSDTETTSEAES------KD-----------------------------------
-----------------------------------------------------------
> 25== U26026 1 Apis mellifera long-wavelength rhodopsin <>[]
--------------------MIAVS--G-------------------PSYE---------
---------------------------------AFSYGGQARFNNQTVVDKVPPDMLHLI
DANWYQYPPLNPMWHGI-----LGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVI
NLAISNFLMMFCM-SPPMVINCYY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIAF
DRYNVIVKGLSGK-PLSINGALIRIIAIWLFSLGWTIA-PMFG-WN-----RYVPEGNMT
ACGTDYFNRG--LLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKKMN
VA------------------SLRS------------------------------------
------------------------------------------------------------
--------------SENQNTSAECKLAKVALMTISLWFMAWTPYLVINFSGIF-NL-V--
KISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALF-AKFPSL--AC----AA-EPSSD
-AVS-TTSG-TTTVTDN------EKSNA--------------------------------
-----------------------------------------------------------
> 26== L03781 1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
----------------------MAN--Q-------------------LSYS---------
---------------------------------SLGWPYQP---NASVVDTMPKEMLYMI
HEHWYAFPPMNPLWYSI-----LGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVV
NLAFSDFCMMAFM-MPTMTSNCFA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMITL
DRYNVIVRGMAAA-PLTHKKATLLLLFVWIWSGGWTIL-PFFG-WS-----RYVPEGNLT
SCTVDYLTKD--WSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQLREQAKKMN
VA------------------SLRA------------------------------------
------------------------------------------------------------
-------------NADQQKQSAECRLAKVAMMTVGLWFMAWTPYLIISWAGVF-SSGT--
RLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALY-QRFPSL--AC---GSG-ESGSD
-VKS-EASA-TTTMEEK------PKIPEA-------------------------------
-----------------------------------------------------------
> 27== X07797 1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
----------------------MVE--S-------------------TTLV---------
---------------------------------NQTWWY-----NPTV----------DI
HPHWAKFDPIPDAVYYS-----VGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFII
NLAMSDLSFSAINGFPLKTISAFM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMISI
DRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSIVWSVG-PVFN-WG-----AYVPEGILT
SCSFDYLSTD--PSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKEMAAMAKRLN
AK------------------ELRK------------------------------------
------------------------------------------------------------
--------------AQ-AGASAEMKLAKISMVIITQFMLSWSPYAIIALLAQF-GPAE--
WVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQ-TTFPWLLTCC---QFD-EKECE
-DAN-DAEE-EVVASER----GGESRDAAQMKEMMAMMQKMQAQQAAYQP---PPPPQGY
PPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQGAPPQGVDNQAYQA
> 28== X70498 1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
-----------------------MG--R-------------------DLRD---------
---------------------------------NETWWY-----NPSI----------VV
HPHWREFDQVPDAVYYS-----LGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFII
NLAFSDFTFSLVNGFPLMTISCFL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMISI
DRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIG-PIFG-WG-----AYTLEGVLC
NCSFDYISRD--STTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLN
AK------------------ELRK------------------------------------
------------------------------------------------------------
--------------AQ-AGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQF-GPLE--
WVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAIS-QTFPWVLTCC---QFD-DKETE
-DDK-DAET-EIPAGES--SDAAPSADAAQMKEMMAMMQKMQQQQAAYPPQGYAPPPQGY
PPQGYPPQGY--PPQGYPPQGYPP---PPQGAPPQGAPP------AAPPQGVDNQAYQA
> 29== L21195 1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
-------------------MMDVNS-SG----RPDLYGHLRSFLLPEVGRGLPDLSPDG-
-----------GADPVAGSWAPHLLS---EVTASPA---PTW--DA------PPDNASGC
GEQ----INYGRVEKVV-----IGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIV
SLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISI
DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-PLFG-WA-----QNVNDDKVC
LISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF------
--------PGFPRVEPDSVIALNG------------------------------------
----------------IVKLQKE------------------VEECAN-------------
-----LSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS
CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYR-SLL---------QCQYRNINRK
LSAA-GMHE-ALKLAER------PERPEFVL------------QNADYCRK---------
-------------------------------------------------KGHDS-----
> 30== L15228 1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
------------------------------------------------------------
--------------------MPHLLSGFLEVTASPA---PTW--DA------PPDNVSGC
GEQ----INYGRVEKVV-----IGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIV
SLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISI
DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-PLFG-WA-----QNVNDDKVC
LISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF------
--------PGFPRVQPESVISLNG------------------------------------
----------------VVKLQKE------------------VEECAN-------------
-----LSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS
CIPLWVERTCLWLGYANSLINPFIYAFFNRDLRPTSR-SLL---------QCQYRNINRK
LSAA-GMHE-ALKLAER------PERSEFVL------------QNSDHCGK---------
-------------------------------------------------KGHDT-----
> 31=p A47425 serotonin receptor 5HT-7 - rat
------------------------------------------------------------
--------------------MPHLLSGFLEVTASPA---PTW--DA------PPDNVSGC
GEQ----INYGRVEKVV-----IGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIV
SLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISI
DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-PLFG-WA-----QNVNDDKVC
LISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF------
--------PGFPRVQPESVISLNG------------------------------------
----------------VVKLQKE------------------VEECAN-------------
-----LSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS
CIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYR-SLL---------QCQYRNINRK
LSAA-GMHE-ALKLAER------PERSEFVL------------QNSDHCGK---------
-------------------------------------------------KGHDT-----
> 32== M83181 1 human serotonin receptor <>[JBC267(11),7553-7562'92]
--------------------MDVLS-PG--------------------------------
-------------------------------QGNNT--------TSPPAPFETGGNTTGI
S-------DVTVSYQVI-----TSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIG
SLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIAL
DRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-PMLG-WRTPEDRSDPD---AC
TISKDH----------GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTG
ADTRHGASPAPQPKK-----SVNG--ESGSRNWRLGVESKAGGALCANGAVRQGDDGAAL
--EVIEVHRVGNSKEHLPLPSEAGPTPCAPAS------------------FERKNERNA-
------------EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPF-CESSC-
HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFK-KII---------KCKFCRQ---
------------------------------------------------------------
-----------------------------------------------------------
> 33=p A35181 serotonin receptor class 1A - rat
--------------------MDVFS-FG--------------------------------
-------------------------------QGNNT--------TASQEPFGTGGNVTSI
S-------DVTFSYQVI-----TSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIG
SLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIAL
DRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-PMLG-WRTPEDRSDPD---AC
TISKDH----------GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKG
AGTSLGTSSAPPPKK-----SLNG--QPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATL
--EVIEVHRVGNSKEHLPLPSESGSNSYAPAC------------------LERKNERNA-
------------EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPF-CESSC-
HMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFK-KII---------KCKFCRR---
------------------------------------------------------------
-----------------------------------------------------------
> 34== L06803 1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
------MANFTFGDL----ALDVAR-MGGLASTPS---GLRS-----TGLTTPGLSPTGL
VTSDFNDSYGLTGQFINGSHSSRSRD---NASANDT--------SATNM---TDDRYWSL
T-------VYSHEHLVL-----TSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLIL
SLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAM
DRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFISIP-PLFG-WRDPNN--DPDKTGTC
IISQDK----------GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKAR
LKTEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKL
PENANGVNSNSSSSERLKQIQIETAEAFANGCAEEASIAMLERQCNNGKKISSNDTPYS-
------------RTREKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPF-VDPE--
GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQ-KIL---------FGKYRRGHR-
------------------------------------------------------------
-----------------------------------------------------------
> 35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
------MANFTFGDL----ALDVAR-MGGLASTPS---GLRS-----TGLTTPGLSPTGL
VTSDFNDSYGLTGQFINGSHSSRSRD---NASANDT--------SATNM---TDDRYWSL
T-------VYSHEHLVL-----TSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLIL
SLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAM
DRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFISIP-PLFG-WRDPNN--DPDKTGTC
IISQDK----------GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKAR
LKTEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKL
PENANGVNSNSSSSERLKQIQIETAEAFANGCAEEASIAMLERQCNNGKKISSNDTPYS-
------------RTREKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPF-VDPE--
GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQ-KIL---------FGKYRRGHR-
------------------------------------------------------------
-----------------------------------------------------------
> 36== X95604 1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
-------MEGAEGQE----ELDWEA-LY---------------------LRLP-------
------------------------LQ---NCSWNSTGWEPNW--NVTVV---PNTTWWQA
S-------APFDTPAALVRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLIL
SLAVADLLVACLV-MPLGAVYEVV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIAL
DRYWAVTN-IDYIHASTAKRVGMMIACVWTVSFFVCIA-QLLG-WKDPDWNQRVSEDLRC
VVSQDV----------GYQIFATASSFYVPVLIILILYWRIYQTARKRIRR------RRG
ATARGGVGPPPVPAGGALV-AGGG----------------------------SGGIAAAV
---------VAVIGRPLPTISETTTTGFTNVSSNNTSPE--KQSCANGLEADPPTTGYGA
VAAAYYPSLVRRKPKEAADSKRERKAAKTLAIITGAFVACWLPFFVLAILVPT-CDCE--
-VSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQ-RLL---------CGRRVRRRRA
-----------------------PQ-----------------------------------
-----------------------------------------------------------
|
