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# $Id: README,v 1.31 2006-01-12 14:21:47 flux Exp $

   If you use MCL software in your research, cite it as you would cite a
   journal or a book. This includes papers published in regular or electronic
   journals, usage of MCL as a back-end to a database that is accessible via a
   web interface, or inclusion of MCL in a larger framework of software that is
   distributed for other people to use.  Include at least one of the following
   citations:

      Stijn van Dongen, Graph Clustering by Flow Simulation.
      PhD thesis, University of Utrecht, May 2000.
      ( http://www.library.uu.nl/digiarchief/dip/diss/1895620/inhoud.htm )

      Stijn van Dongen. A cluster algorithm for graphs.  Technical Report
      INS-R0010, National Research Institute for Mathematics and Computer
      Science in the Netherlands, Amsterdam, May 2000.
      ( http://www.cwi.nl/ftp/CWIreports/INS/INS-R0010.ps.Z )

   and proper attributions to mcl's home http://micans.org/mcl/ and its author,
   Stijn van Dongen.

   Do this *also* if you are using some wrapper around mcl such as the blast
   module or the tribe module.

   For biological applications, it is appropriate to cite, additionally,
   the reference article for the first application of mcl to biological data:

      Enright A.J., Van Dongen S., Ouzounis C.A.
      An efficient algorithm for large-scale detection of protein families,
      Nucleic Acids Research 30(7):1575-1584 (2002).


   For BLAST users, consider using the blast package that is very well
   integrated with the core mcl libraries and offers many options and extensive
   configurability. Use mcxdeblast to parse BLAST files, use mcxassemble to
   transform the parser's output to mcl input.
      The Genome Protein view at ensembl.org uses these programs.
      -----------------------------------------------------------
   It is also possible to use the pipeline script mclblastline that
   encapsulates mcxdeblast, mcxassemble, mcl, and clmformat (the latter
   prettyprints clustering results).
   
   MCL documentation is in doc/, in various formats. It gets installed in
   <prefix>/share/doc/mcl/. A few example input graphs are in graphs/, in the
   mcl matrix format; these are installed in <prefix>/share/doc/mcl/examples/.
   The MCL webpage is at http://micans.org/mcl/ .

   MCL development is discussed on mcl-devel@lists.micans.org, info about this
   list can be found at https://lists.micans.org:446/listinfo/mcl-devel this list
   is archived at https://lists.micans.org:446/pipermail/mcl-devel/ . You can use
   this forum also for asking any MCL-related question.

   The version tag, which is of the form dd-ddd, encodes the year and day in
   year in which the distribution was made. So 02-058 encodes the 58-th day of
   the year 2002.

Configure and compiler options

Synopsis

   configure options:
      --prefix=YOUR-PREFIX    (e.g. $HOME/local)
      --enable-blast

   By default, MCL is compiled using C ints and floats -- the ints are used to
   encode graph nodes/matrix indices, and the floats are used to encode edge
   weights / matrix entries.  These can be changed respectively to long and
   double, by adding '-DINDEX_AS_LONG', and/or '-DVALUE_AS_DOUBLE' to the
   CFLAGS environment variable.  The first enables a possibly wider range of
   indices to be used, the second increases the precision (which is presumably
   not useful in the vast majority of cases).  Using gcc under bash, you might
   for example do

      export CFLAGS='-g -O2 -Wall -ansi -pedantic -DVALUE_AS_DOUBLE'

   before doing ./configure and make. If you are rebuilding, make sure to do
   'make clean' first.  You need not use doubles though; MCL does fine with
   floats.  These features (changing the basic types) have not yet been tested
   thoroughly.

   For enabling rudimentary runtime integrity checks, add -DRUNTIME_INTEGRITY.

   MCL comes nowadays packaged with the BLAST parsing script mcxdeblast and the
   pipeline script mclblastline. It encapsulates all the stages of parsing,
   matrix creation, running mcl, and formatting the result into a single
   application. These scripts can be used in place of the tribe module. Enable
   them by adding --enable-blast to ./configure.  For the TribeMCL module issue
   --enable-tribe. Be sure to read http://micans.org/mcl/#mods first though. It
   is suggested you use the BLAST module instead.

See also

   LICENSE for copyright and licensing, THANKS for contributors, INSTALL for
   generic installation instructions.