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/* -*- mia-c++ -*-
*
* This file is part of MIA - a toolbox for medical image analysis
* Copyright (c) Leipzig, Madrid 1999-2014 Gert Wollny
*
* MIA is free software; you can redistribute it and/or modify
* it under the terms of the GNU General Public License as published by
* the Free Software Foundation; either version 3 of the License, or
* (at your option) any later version.
*
* This program is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with MIA; if not, see <http://www.gnu.org/licenses/>.
*
*/
#define VSTREAM_DOMAIN "2dmyoica-full"
#include <fstream>
#include <itpp/signal/fastica.h>
#include <mia/core/msgstream.hh>
#include <mia/core/threadedmsg.hh>
#include <mia/core/cmdlineparser.hh>
#include <mia/core/errormacro.hh>
#include <mia/core/minimizer.hh>
#include <mia/core/bfsv23dispatch.hh>
#include <mia/core/attribute_names.hh>
#include <mia/2d/nonrigidregister.hh>
#include <mia/2d/perfusion.hh>
#include <mia/2d/imageio.hh>
#include <mia/2d/segsetwithimages.hh>
#include <mia/2d/transformfactory.hh>
#include <tbb/parallel_for.h>
#include <tbb/parallel_reduce.h>
#include <tbb/blocked_range.h>
using namespace tbb;
using namespace std;
using namespace mia;
namespace bfs=boost::filesystem;
const SProgramDescription g_description = {
{pdi_group, "Registration of series of 2D images"},
{pdi_short, "Run a registration of a series of 2D images."},
{pdi_description, "This program implements the 2D version of the motion compensation algorithm "
"described in Wollny G, Kellman P, Santos A, Ledesma-Carbayo M-J, \"Automatic Motion "
"Compensation of Free Breathing acquired Myocardial Perfusion Data by using Independent "
"Component Analysis\", Medical Image Analysis, 2012, DOI:10.1016/j.media.2012.02.004. "
"The software may first run a linear registration and then a non-linear registration or "
"just one of the both."
"This version of the program may run all registrations in parallel."},
{pdi_example_descr, "Register the perfusion series given in 'segment.set' by using automatic "
"ICA estimation. Skip two images at the beginning and otherwiese use the default parameters. "
"Store the result in 'registered.set'."},
{pdi_example_code, " -i segment.set -o registered.set -k 2"}
};
C2DFullCostList create_costs(const string& imagecostbase, int idx)
{
stringstream cost_descr;
cost_descr << imagecostbase << ",src=src" << idx << ".@,ref=ref" << idx << ".@";
auto imagecost = C2DFullCostPluginHandler::instance().produce(cost_descr.str());
C2DFullCostList result;
result.push(imagecost);
return result;
}
P2DTransformationFactory create_spline_transform_creator(size_t c_rate, double divcurlweight)
{
stringstream transf;
transf << "spline:rate=" << c_rate << ",imgboundary=mirror,imgkernel=[bspline:d=3]"
<< ",penalty=[divcurl:weight=" << divcurlweight << "]";
return C2DTransformCreatorHandler::instance().produce(transf.str());
}
C2DBounds segment_and_crop_input(CSegSetWithImages& input_set,
const C2DPerfusionAnalysis& ica,
float box_scale,
C2DPerfusionAnalysis::EBoxSegmentation segmethod,
C2DImageSeries& references,
const string& save_crop_feature)
{
C2DBounds crop_start = C2DBounds::_0;
auto cropper = ica.get_crop_filter(box_scale, crop_start,
segmethod, save_crop_feature);
if (!cropper) {
cvwarn() << "Cropping was requested, but segmentation failed - continuing at full image size\n";
return crop_start;
}
C2DImageSeries input_images = input_set.get_images();
for(auto i = input_images.begin(); i != input_images.end(); ++i)
*i = cropper->filter(**i);
for (auto i = references.begin(); i != references.end(); ++i)
*i = cropper->filter(**i);
auto tr_creator = C2DTransformCreatorHandler::instance().produce("translate");
P2DTransformation shift = tr_creator->create(C2DBounds(1,1));
auto p = shift->get_parameters();
p[0] = crop_start.x;
p[1] = crop_start.y;
shift->set_parameters(p);
input_set.transform(*shift);
input_set.set_images(input_images);
return crop_start;
}
struct SeriesRegistration {
C2DImageSeries& input_images;
CSegSetWithImages::Frames& frames;
const C2DImageSeries& references;
string minimizer;
size_t mg_levels;
P2DTransformationFactory transform_creator;
string imagecostbase;
int skip_images;
int global_reference;
SeriesRegistration(C2DImageSeries& _input_images,
CSegSetWithImages::Frames& _frames,
const C2DImageSeries& _references,
const string& _minimizer,
size_t _mg_levels,
P2DTransformationFactory _transform_creator,
string _imagecostbase,
int _skip_images,
int _global_reference):
input_images(_input_images),
frames(_frames),
references(_references),
minimizer(_minimizer),
mg_levels(_mg_levels),
transform_creator(_transform_creator),
imagecostbase(_imagecostbase),
skip_images(_skip_images),
global_reference(_global_reference)
{
}
P2DTransformation operator()( const blocked_range<int>& range, P2DTransformation init) const {
CThreadMsgStream thread_stream;
TRACE_FUNCTION;
P2DTransformation result = init;
auto m = CMinimizerPluginHandler::instance().produce(minimizer);
for( int i=range.begin(); i!=range.end(); ++i ) {
auto costs = create_costs(imagecostbase, i);
C2DNonrigidRegister nrr(costs, m, transform_creator, mg_levels, i);
if (i + skip_images != global_reference) {
cvmsg() << "image size ["<< i << "]= " << input_images[i + skip_images]->get_size() << ":" << references[i]->get_size() << "\n";
P2DTransformation transform = nrr.run(input_images[i + skip_images], references[i]);
input_images[i + skip_images] = (*transform)(*input_images[i + skip_images]);
frames[i + skip_images].inv_transform(*transform);
}else {
result = nrr.run(references[i], input_images[i + skip_images]);
}
}
return result;
}
};
void run_registration_pass(CSegSetWithImages& input_set,
const C2DImageSeries& references,
int skip_images, const string& minimizer,
size_t mg_levels, P2DTransformationFactory transform_creator,
const string& imagecost, int global_reference)
{
C2DImageSeries input_images = input_set.get_images();
CSegSetWithImages::Frames& frames = input_set.get_frames();
SeriesRegistration sreg(input_images, frames, references, minimizer,
mg_levels, transform_creator,
imagecost, skip_images, global_reference);
P2DTransformation init;
P2DTransformation inv_transf = parallel_reduce(blocked_range<int>( 0, references.size()), init, sreg,
[](P2DTransformation a, P2DTransformation b) {
if (a)
return a;
return b;
});
// apply inverse to all images
if (inv_transf) {
cvmsg() << "Apply inverse for reference correction\n";
const C2DTransformation& inv_transf_ref = * inv_transf;
parallel_for(blocked_range<int>( 0, references.size()),
[&inv_transf_ref, &frames, skip_images, global_reference, &input_images](const blocked_range<int>& range){
CThreadMsgStream thread_stream;
for( int i=range.begin(); i!=range.end(); ++i ) {
if (i != global_reference - skip_images) {
input_images[i + skip_images] = inv_transf_ref(*input_images[i + skip_images]);
frames[i + skip_images].inv_transform(inv_transf_ref);
}
}
});
}
input_set.set_images(input_images);
}
void run_nonlinear_registration_passes (CSegSetWithImages& input_set,
C2DImageSeries& references,
int components, bool normalize, bool no_meanstrip, int max_ica_iterations,
int skip_images,
const string& minimizer,
size_t mg_levels, double c_rate, double c_rate_divider,
double divcurlweight, double divcurlweight_divider,
int max_pass, const string& imagecost, int global_reference, float min_rel_frequency)
{
int current_pass = 0;
bool do_continue=true;
bool lastpass = false;
vector<C2DFImage> references_float;
do {
++current_pass;
cvmsg() << "Registration pass " << current_pass << "\n";
auto transform_creator = create_spline_transform_creator(c_rate, divcurlweight);
run_registration_pass(input_set, references,
skip_images, minimizer, mg_levels, transform_creator,
imagecost, global_reference);
if (lastpass)
break;
C2DPerfusionAnalysis ica2(components, normalize, !no_meanstrip);
if (max_ica_iterations)
ica2.set_max_ica_iterations(max_ica_iterations);
if (min_rel_frequency >= 0)
ica2.set_min_movement_frequency(min_rel_frequency);
vector<C2DFImage> series(input_set.get_images().size() - skip_images);
transform(input_set.get_images().begin() + skip_images,
input_set.get_images().end(), series.begin(), FCopy2DImageToFloatRepn());
if (!ica2.run(series)) {
ica2.set_approach(FICA_APPROACH_SYMM);
ica2.run(series);
}
divcurlweight /= divcurlweight_divider;
if (c_rate > 1)
c_rate /= c_rate_divider;
references_float = ica2.get_references();
cvmsg() << "references_float size:" << references_float[0].get_size() << "\n";
transform(references_float.begin(), references_float.end(),
references.begin(), FWrapStaticDataInSharedPointer<C2DImage>());
do_continue = (!max_pass || current_pass < max_pass) && ica2.has_movement();
// run one more pass if the limit is not reached and no movement identified
lastpass = (!do_continue && (!max_pass || current_pass < max_pass));
} while (do_continue || lastpass);
}
void run_linear_registration_passes (CSegSetWithImages& input_set,
C2DImageSeries& references,
int components, bool normalize, bool no_meanstrip, int max_ica_iterations,
int skip_images, const string& minimizer, const string& linear_transform,
size_t mg_levels, int max_pass, const string& imagecost, int global_reference,
float min_rel_frequency)
{
int current_pass = 0;
bool do_continue=true;
bool lastpass = false;
vector<C2DFImage> references_float;
do {
++current_pass;
cvmsg() << "Registration pass " << current_pass << "\n";
auto transform_creator = C2DTransformCreatorHandler::instance().produce(linear_transform);
cvmsg() << "references_float size:" << references[0]->get_size() << "\n";
run_registration_pass(input_set, references,
skip_images, minimizer, mg_levels, transform_creator,
imagecost, global_reference);
if (lastpass)
break;
C2DPerfusionAnalysis ica2(components, normalize, !no_meanstrip);
if (max_ica_iterations)
ica2.set_max_ica_iterations(max_ica_iterations);
if (min_rel_frequency >= 0)
ica2.set_min_movement_frequency(min_rel_frequency);
vector<C2DFImage> series(input_set.get_images().size() - skip_images);
transform(input_set.get_images().begin() + skip_images,
input_set.get_images().end(), series.begin(), FCopy2DImageToFloatRepn());
if (!ica2.run(series)) {
ica2.set_approach(FICA_APPROACH_SYMM);
ica2.run(series);
}
references_float = ica2.get_references();
transform(references_float.begin(), references_float.end(),
references.begin(), FWrapStaticDataInSharedPointer<C2DImage>());
cvmsg() << "references_float size:" << references[0]->get_size() << "\n";
do_continue = (!max_pass || current_pass < max_pass) && ica2.has_movement();
// run one more pass if the limit is not reached and no movement identified
lastpass = (!do_continue && (!max_pass || current_pass < max_pass));
} while (do_continue || lastpass);
}
class FInsertData : public TFilter< P2DImage > {
public:
FInsertData(const C2DBounds& start, const C2DBounds& end):
m_start(start), m_end(end){}
template <typename T>
void operator () ( const T2DImage<T>& a, T2DImage<T>& b) const {
auto ia = a.begin();
auto ea = a.end();
auto ib = b.begin_range(m_start,m_end);
while (ia != ea) {
*ib = *ia;
++ia;
++ib;
}
}
private:
C2DBounds m_start;
C2DBounds m_end;
};
float get_relative_min_breathing_frequency(const C2DImageSeries& images, int skip, float min_breathing_frequency)
{
if (min_breathing_frequency < 0)
return -1;
if (min_breathing_frequency == 0)
return 0;
int n_heartbeats = images.size() - skip;
auto image_begin = images[skip];
auto image_end = images[images.size() - 1];
if (image_begin->has_attribute("AcquisitionTime") && image_end->has_attribute(IDAcquisitionTime)) {
double aq_time = image_end->get_attribute_as<double>(IDAcquisitionTime) -
image_begin->get_attribute_as<double>(IDAcquisitionTime);
if (aq_time < 0)
throw create_exception<runtime_error>("Got non-postive aquisition time range ", aq_time,
", can't handle this");
double heart_rate = 60 * n_heartbeats / aq_time;
cvmsg() << "Read a heartbeat rate of " << heart_rate << " beats/min\n";
return heart_rate / min_breathing_frequency;
}else
return -1;
}
int do_main( int argc, char *argv[] )
{
// IO parameters
string in_filename;
string out_filename;
string registered_filebase;
// debug options: save some intermediate steps
string cropped_filename;
string save_crop_feature;
string save_ref_filename;
string save_reg_filename;
// non-linear registration parameters
string linear_minimizer("gsl:opt=simplex,step=1.0");
string nonlinear_minimizer("gsl:opt=gd,step=0.1");
string imagecost("image:weight=1,cost=ssd");
double c_rate = 16;
double c_rate_divider = 2;
double divcurlweight = 10000.0;
double divcurlweight_divider = 2.0;
string linear_transform("affine");
size_t mg_levels = 3;
// ICA parameters
size_t components = 0;
bool normalize = false;
bool no_meanstrip = false;
float box_scale = 0.0;
size_t skip_images = 0;
size_t max_ica_iterations = 400;
C2DPerfusionAnalysis::EBoxSegmentation
segmethod=C2DPerfusionAnalysis::bs_features;
float min_breathing_frequency = -1.0f;
size_t max_linear_passes = 3;
size_t max_nonlinear_passes = 3;
int global_reference = -1;
CCmdOptionList options(g_description);
options.set_group("File-IO");
options.add(make_opt( in_filename, "in-file", 'i',
"input perfusion data set", CCmdOptionFlags::required_input));
options.add(make_opt( out_filename, "out-file", 'o',
"output perfusion data set", CCmdOptionFlags::required_output));
options.add(make_opt( registered_filebase, "registered", 'r',
"File name base for the registered images. Image type and numbering "
"scheme are taken from the input images as given in the input data set."));
options.add(make_opt( cropped_filename, "save-cropped", 0,
"save cropped set to this file, the image files will use the stem of the "
"name as file name base", CCmdOptionFlags::output));
options.add(make_opt( save_crop_feature, "save-feature", 0,
"save segmentation feature images and initial ICA mixing matrix", CCmdOptionFlags::output));
options.add(make_opt( save_ref_filename, "save-refs", 0,
"for each registration pass save the reference images to files with the given name base",
CCmdOptionFlags::output
));
options.add(make_opt( save_reg_filename, "save-regs", 0,
"for each registration pass save intermediate registered images", CCmdOptionFlags::output));
options.set_group("Registration");
options.add(make_opt(linear_minimizer, "linear-optimizer", 'L',
"Optimizer used for minimization of the linear registration",
CCmdOptionFlags::none, &CMinimizerPluginHandler::instance()));
options.add(make_opt(linear_transform, "linear-transform", 0,
"linear transform to be used",
CCmdOptionFlags::none, &C2DTransformCreatorHandler::instance()));
options.add(make_opt(nonlinear_minimizer, "non-linear-optimizer", 'O',
"Optimizer used for minimization in the non-linear registration.",
CCmdOptionFlags::none, &CMinimizerPluginHandler::instance()));
options.add(make_opt( c_rate, "start-c-rate", 'a',
"start coefficinet rate in spines,"
" gets divided by --c-rate-divider with every pass."));
options.add(make_opt( c_rate_divider, "c-rate-divider", 0,
"Cofficient rate divider for each pass."));
options.add(make_opt( divcurlweight, "start-divcurl", 'd',
"Start divcurl weight, gets divided by"
" --divcurl-divider with every pass."));
options.add(make_opt( divcurlweight_divider, "divcurl-divider", 0,
"Divcurl weight scaling with each new pass."));
options.add(make_opt( global_reference, "reference", 'R', "Global reference all image should be aligned to. If set "
"to a non-negative value, the images will be aligned to this references, and the cropped "
"output image date will be injected into the original images. Leave at -1 if "
"you don't care. In this case all images with be registered to a mean position of the movement"));
// why do I allow to set this parameter, it should always be image:cost=ssd
options.add(make_opt( imagecost, "imagecost", 'w',
"image cost, do not specify the src and ref parameters, these will be set by the program.",
CCmdOptionFlags::none, &C2DFullCostPluginHandler::instance()));
options.add(make_opt( mg_levels, "mg-levels", 'l', "multi-resolution levels"));
options.add(make_opt( max_linear_passes, "linear-passes", 'p', "linear registration passes (0 to disable)"));
options.add(make_opt( max_nonlinear_passes, "nonlinear-passes", 'P', "non-linear registration passes (0 to disable)"));
options.set_group("ICA");
options.add(make_opt( components, "components", 'C', "ICA components 0 = automatic estimation"));
options.add(make_opt( normalize, "normalize", 0, "normalized ICs"));
options.add(make_opt( no_meanstrip, "no-meanstrip", 0,
"don't strip the mean from the mixing curves"));
options.add(make_opt( box_scale, "segscale", 's',
"segment and scale the crop box around the LV (0=no segmentation)"));
options.add(make_opt( skip_images, "skip", 'k', "skip images at the beginning of the series "
"e.g. because as they are of other modalities"));
options.add(make_opt( max_ica_iterations, "max-ica-iter", 'm', "maximum number of iterations in ICA"));
options.add(make_opt(segmethod , C2DPerfusionAnalysis::segmethod_dict, "segmethod", 'E',
"Segmentation method"));
options.add(make_opt(min_breathing_frequency, "min-breathing-frequency", 'b',
"minimal mean frequency a mixing curve can have to be considered to stem from brething. "
"A healthy rest breating rate is 12 per minute. A negative value disables the test. "
"A value 0.0 forces the series to be indentified as acquired with initial breath hold."));
if (options.parse(argc, argv) != CCmdOptionList::hr_no)
return EXIT_SUCCESS;
// load input data set
CSegSetWithImages input_set(in_filename, true);
C2DImageSeries input_images = input_set.get_images();
// copy the original image if the global reference it set, because in this case we
// want the original sized data as result
C2DImageSeries original_images;
if (global_reference >= 0)
original_images = input_set.get_images();
float rel_min_bf = get_relative_min_breathing_frequency(input_images, skip_images, min_breathing_frequency);
// now start the first ICA to run the segmentation etc.
cvmsg() << "skipping " << skip_images << " images\n";
vector<C2DFImage> series(input_images.size() - skip_images);
transform(input_images.begin() + skip_images, input_images.end(),
series.begin(), FCopy2DImageToFloatRepn());
// run ICA
unique_ptr<C2DPerfusionAnalysis> ica(new C2DPerfusionAnalysis(components, normalize, !no_meanstrip));
if (max_ica_iterations)
ica->set_max_ica_iterations(max_ica_iterations);
if (rel_min_bf >= 0)
ica->set_min_movement_frequency(rel_min_bf);
ica->set_approach(FICA_APPROACH_DEFL);
if (!ica->run(series)) {
ica.reset(new C2DPerfusionAnalysis(components, normalize, !no_meanstrip));
ica->set_approach(FICA_APPROACH_SYMM);
if (!ica->run(series))
box_scale = false;
}
if( input_set.get_RV_peak() < 0) {
if (ica->get_RV_peak_time() > 0)
input_set.set_RV_peak(ica->get_RV_peak_time() + skip_images);
}
if( input_set.get_LV_peak() < 0) {
if (ica->get_LV_peak_time() > 0)
input_set.set_LV_peak(ica->get_LV_peak_time() + skip_images);
}
bool segentation_possible = ica->get_RV_idx() >= 0 && ica->get_LV_idx() >= 0;
if (!save_crop_feature.empty() && segentation_possible)
ica->save_feature_images(save_crop_feature);
vector<C2DFImage> references_float = ica->get_references();
C2DImageSeries references(references_float.size());
transform(references_float.begin(), references_float.end(), references.begin(),
FWrapStaticDataInSharedPointer<C2DImage>());
// crop if requested && possible
C2DBounds crop_start;
if (box_scale && segentation_possible) {
crop_start = segment_and_crop_input(input_set, *ica, box_scale, segmethod, references, save_crop_feature);
input_images = input_set.get_images();
}else if (!save_crop_feature.empty()) {
stringstream cfile;
cfile << save_crop_feature << ".txt";
ica->save_coefs(cfile.str());
}
// save cropped images if requested
if (!cropped_filename.empty()) {
bfs::path cf(cropped_filename);
cf.replace_extension();
input_set.rename_base(__bfs_get_filename(cf));
input_set.save_images(cropped_filename);
unique_ptr<xmlpp::Document> test_cropset(input_set.write());
ofstream outfile(cropped_filename, ios_base::out );
if (outfile.good())
outfile << test_cropset->write_to_string_formatted();
else
throw create_exception<runtime_error>("unable to save to '", cropped_filename, "'");
}
if (max_linear_passes > 0)
run_linear_registration_passes (input_set, references,
components, normalize, no_meanstrip, max_ica_iterations,
skip_images, linear_minimizer, linear_transform,
mg_levels, max_linear_passes, imagecost, global_reference, rel_min_bf);
if (max_nonlinear_passes > 0) {
// if we come from the linear registration, then the references must be re-generated
vector<C2DFImage> references_float;
if (max_linear_passes > 0) {
C2DPerfusionAnalysis ica2(components, normalize, !no_meanstrip);
if (max_ica_iterations)
ica2.set_max_ica_iterations(max_ica_iterations);
if (rel_min_bf >= 0)
ica2.set_min_movement_frequency(rel_min_bf);
vector<C2DFImage> series(input_set.get_images().size() - skip_images);
transform(input_set.get_images().begin() + skip_images,
input_set.get_images().end(), series.begin(), FCopy2DImageToFloatRepn());
if (!ica2.run(series)) {
ica2.set_approach(FICA_APPROACH_SYMM);
ica2.run(series);
}
references_float = ica2.get_references();
transform(references_float.begin(), references_float.end(),
references.begin(), FWrapStaticDataInSharedPointer<C2DImage>());
}
run_nonlinear_registration_passes (input_set, references,
components, normalize, no_meanstrip, max_ica_iterations,
skip_images, nonlinear_minimizer,
mg_levels, c_rate, c_rate_divider,
divcurlweight, divcurlweight_divider,
max_nonlinear_passes, imagecost, global_reference, rel_min_bf);
}
cvmsg() << "Registration finished\n";
// copy the data back to the original images if requested
// re-insert the registered sub-images if we have a global reference
if (global_reference >= 0 && box_scale && input_set.get_images()[0]->get_size() != original_images[0]->get_size()) {
cvmsg() << "Put cropped and aligned data back into the original images\n";
auto registered_images = input_set.get_images();
const FInsertData id(crop_start, crop_start + registered_images[0]->get_size());
transform(original_images.begin(), original_images.end(), registered_images.begin(),
original_images.begin(),
[&id](P2DImage orig, P2DImage part) {
filter_equal_inplace(id, *part, *orig);
return orig;
});
auto tr_creator = C2DTransformCreatorHandler::instance().produce("translate");
P2DTransformation shift = tr_creator->create(C2DBounds(1,1));
auto p = shift->get_parameters();
p[0] = -(float)crop_start.x;
p[1] = -(float)crop_start.y;
shift->set_parameters(p);
input_set.transform(*shift);
input_set.set_images(original_images);
}
cvmsg() << "Save registered images\n";
input_set.save_images(out_filename);
unique_ptr<xmlpp::Document> outset(input_set.write());
ofstream outfile(out_filename.c_str(), ios_base::out );
if (outfile.good())
outfile << outset->write_to_string_formatted();
return outfile.good() ? EXIT_SUCCESS : EXIT_FAILURE;
}
#include <mia/internal/main.hh>
MIA_MAIN(do_main);
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