File: 2dmyoica-nonrigid2.cc

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/* -*- mia-c++  -*-
 *
 * This file is part of MIA - a toolbox for medical image analysis 
 * Copyright (c) Leipzig, Madrid 1999-2014 Gert Wollny
 *
 * MIA is free software; you can redistribute it and/or modify
 * it under the terms of the GNU General Public License as published by
 * the Free Software Foundation; either version 3 of the License, or
 * (at your option) any later version.
 *
 * This program is distributed in the hope that it will be useful,
 * but WITHOUT ANY WARRANTY; without even the implied warranty of
 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 * GNU General Public License for more details.
 *
 * You should have received a copy of the GNU General Public License
 * along with MIA; if not, see <http://www.gnu.org/licenses/>.
 *
 */

#define VSTREAM_DOMAIN "2dmyoica"

#include <fstream>
#include <libxml++/libxml++.h>
#include <itpp/signal/fastica.h>
#include <boost/filesystem.hpp>

#include <mia/core/msgstream.hh>
#include <mia/core/cmdlineparser.hh>
#include <mia/core/errormacro.hh>
#include <mia/core/minimizer.hh>
#include <mia/core/bfsv23dispatch.hh>
#include <mia/2d/nonrigidregister.hh>
#include <mia/2d/perfusion.hh>
#include <mia/2d/segsetwithimages.hh>
#include <mia/2d/transformfactory.hh>

using namespace std;
using namespace mia;

namespace bfs=boost::filesystem; 

const SProgramDescription g_description = {
        {pdi_group, "Registration of series of 2D images"}, 
	{pdi_short, "Run a registration of a series of 2D images."}, 
	{pdi_description, "This program runs the non-rigid registration of an perfusion image series."
	 "In each pass, first an ICA analysis is run to estimate and eliminate " 
	 "the periodic movement and create reference images with intensities similar "
	 "to the corresponding original image. Then non-rigid registration is run "
	 "using the an \"ssd + divcurl\" cost model. The B-spline c-rate and the "
	 "divcurl cost weight are changed in each pass according to given parameters."
	 "In the first pass a bounding box around the LV myocardium may be extracted" 
	 "to speed up computation\n"
	 "Special note to this implemnentation: the registration is always run from the "
	 "original images to avoid the accumulation of interpolation errors."}, 
 	{pdi_example_descr, "Register the perfusion series given in 'segment.set' by "
	 "using automatic ICA estimation. Skip two images at the beginning and otherwiese "
	 "use the default parameters. Store the result in 'registered.set'."}, 
	{pdi_example_code, "  -i segment.set -o registered.set -k 2"}
}; 

C2DFullCostList create_costs(double imageweight)
{
	C2DFullCostList result; 
	stringstream image_descr; 
	image_descr << "image:weight=" << imageweight; 
	result.push(C2DFullCostPluginHandler::instance().produce(image_descr.str())); 
	return result; 
}

P2DTransformationFactory create_transform_creator(size_t c_rate, double divcurlweight)
{
	stringstream transf; 
	transf << "spline:rate=" << c_rate << ",penalty=[divcurl:weight=" << divcurlweight << "]"; 
	return C2DTransformCreatorHandler::instance().produce(transf.str()); 
}
	

void segment_and_crop_input(CSegSetWithImages&  input_set, 
			    const C2DPerfusionAnalysis& ica, 
			    float box_scale, 
			    C2DPerfusionAnalysis::EBoxSegmentation segmethod, 
			    C2DImageSeries& references, 
			    const string& save_crop_feature)
{
	C2DBounds crop_start; 
	auto cropper = ica.get_crop_filter(box_scale, crop_start, 
					   segmethod, save_crop_feature); 
	if (!cropper)
		throw create_exception<runtime_error>( "Cropping was requested, but segmentation failed"); 
	C2DImageSeries input_images = input_set.get_images(); 
	for(auto i = input_images.begin(); i != input_images.end(); ++i)
		*i = cropper->filter(**i); 
	
	for (auto i = references.begin(); i != references.end(); ++i) 
		*i = cropper->filter(**i); 
	
	auto tr_creator = C2DTransformCreatorHandler::instance().produce("translate");
	P2DTransformation shift = tr_creator->create(C2DBounds(1,1)); 
	auto p = shift->get_parameters(); 
	p[0] = crop_start.x; 
	p[1] = crop_start.y; 
	shift->set_parameters(p); 
	
	input_set.transform(*shift);
	input_set.set_images(input_images);  
}

vector<P2DTransformation> 
run_registration_pass(CSegSetWithImages&  input_set, 
		      C2DImageSeries& registered,
		      const C2DImageSeries& references, 
		      int skip_images, PMinimizer minimizer, size_t mg_levels, 
			   double c_rate, double divcurlweight, double imageweight) 
{
	vector<P2DTransformation> result; 
	C2DImageSeries input_images = input_set.get_images(); 
	registered.resize(input_images.size()); 
	auto costs  = create_costs(imageweight); 
	auto transform_creator = create_transform_creator(c_rate, divcurlweight); 
	C2DNonrigidRegister nrr(costs, minimizer,  transform_creator, mg_levels);

	// this loop could be parallized 
	for (size_t i = skip_images; i < input_images.size(); ++i) {
		cvmsg() << "Register frame " << i << "\n"; 
		P2DTransformation transform = nrr.run(input_images[i], 
						      references[i - skip_images]);
		registered[i] = (*transform)(*input_images[i]);
		result.push_back(transform); 
	}
	return result; 
}

int do_main( int argc, char *argv[] )
{
	// IO parameters 
	string in_filename;
	string out_filename;
	string registered_filebase("reg");

	// debug options: save some intermediate steps 
	string cropped_filename;
	string save_crop_feature; 

	// this parameter is currently not exported - reading the image data is 
	// therefore done from the path given in the segmentation set 
	bool override_src_imagepath = true;

	// registration parameters
	PMinimizer minimizer;
	double c_rate = 32; 
	double c_rate_divider = 4; 
	double divcurlweight = 20.0; 
	double divcurlweight_divider = 4.0; 
	double imageweight = 1.0; 

	PSplineKernel interpolator_kernel;
	size_t mg_levels = 3; 

	// ICA parameters 
	size_t components = 0;
	bool normalize = false; 
	bool no_meanstrip = false; 
	float box_scale = 0.0;
	size_t skip_images = 0; 
	size_t max_ica_iterations = 400; 
	C2DPerfusionAnalysis::EBoxSegmentation 
		segmethod=C2DPerfusionAnalysis::bs_features; 

	size_t current_pass = 0; 
	size_t pass = 3; 

	CCmdOptionList options(g_description);
	
	options.set_group("\nFile-IO"); 
	options.add(make_opt( in_filename, "in-file", 'i', 
			      "input perfusion data set", CCmdOptionFlags::required_input));
	options.add(make_opt( out_filename, "out-file", 'o', 
			      "output perfusion data set", CCmdOptionFlags::required_output));
	options.add(make_opt( registered_filebase, "registered", 'r', 
			      "file name base for registered fiels")); 
	
	options.add(make_opt( cropped_filename, "save-cropped", 0, 
			      "save cropped set to this file")); 
	options.add(make_opt( save_crop_feature, "save-feature", 0, 
			      "save segmentation feature images"
			      " and initial ICA mixing matrix")); 
	
	
	options.set_group("\nRegistration"); 
	options.add(make_opt( minimizer, "gsl:opt=gd,step=0.1", "optimizer", 'O', "Optimizer used for minimization"));
	options.add(make_opt( c_rate, "start-c-rate", 'a', 
				    "start coefficinet rate in spines,"
				    " gets divided by --c-rate-divider with every pass"));
	options.add(make_opt( c_rate_divider, "c-rate-divider", 0, 
				    "cofficient rate divider for each pass"));
	options.add(make_opt( divcurlweight, "start-divcurl", 'd',
				    "start divcurl weight, gets divided by"
				    " --divcurl-divider with every pass")); 
	options.add(make_opt( divcurlweight_divider, "divcurl-divider", 0,
				    "divcurl weight scaling with each new pass")); 
	options.add(make_opt( imageweight, "imageweight", 'w', 
				    "image cost weight")); 
	options.add(make_opt( interpolator_kernel, "bspline:d=3", "interpolator", 'p', "image interpolator kernel"));
	options.add(make_opt( mg_levels, "mg-levels", 'l', "multi-resolution levels"));
	options.add(make_opt( pass, "passes", 'P', "registration passes")); 

	options.set_group("\nICA"); 
	options.add(make_opt( components, "components", 'C', "ICA components 0 = automatic estimation"));
	options.add(make_opt( normalize, "normalize", 0, "don't normalized ICs"));
	options.add(make_opt( no_meanstrip, "no-meanstrip", 0, 
				    "don't strip the mean from the mixing curves"));
	options.add(make_opt( box_scale, "segscale", 's', 
				    "segment and scale the crop box around the LV (0=no segmentation)"));
	options.add(make_opt( skip_images, "skip", 'k', "skip images at the beginning of the series "
				    "e.g. because as they are of other modalities")); 
	options.add(make_opt( max_ica_iterations, "max-ica-iter", 'm', "maximum number of iterations in ICA")); 

	options.add(make_opt(segmethod , C2DPerfusionAnalysis::segmethod_dict, "segmethod", 'E', 
				   "Segmentation method")); 
				    

	if (options.parse(argc, argv) != CCmdOptionList::hr_no) 
		return EXIT_SUCCESS; 



	// this cost will always be used 

	// load input data set
	CSegSetWithImages  input_set(in_filename, override_src_imagepath);
	C2DImageSeries input_images = input_set.get_images(); 
	
	cvmsg() << "skipping " << skip_images << " images\n"; 
	vector<C2DFImage> series(input_images.size() - skip_images); 
	transform(input_images.begin() + skip_images, input_images.end(), 
		  series.begin(), FCopy2DImageToFloatRepn()); 
	

	// run ICA
	unique_ptr<C2DPerfusionAnalysis> ica(new C2DPerfusionAnalysis(components, normalize, !no_meanstrip)); 
	if (max_ica_iterations) 
		ica->set_max_ica_iterations(max_ica_iterations); 

	ica->set_approach(FICA_APPROACH_DEFL); 
	if (!ica->run(series)) {
		ica.reset(new C2DPerfusionAnalysis(components, normalize, !no_meanstrip)); 
		ica->set_approach(FICA_APPROACH_SYMM); 
		if (!ica->run(series)) 
			box_scale = false; 
	}

	vector<C2DFImage> references_float = ica->get_references(); 
	
	C2DImageSeries references(references_float.size()); 
	transform(references_float.begin(), references_float.end(), references.begin(), 
		  FWrapStaticDataInSharedPointer<C2DImage>()); 

	// crop if requested
	if (box_scale) {
		segment_and_crop_input(input_set, *ica, box_scale, segmethod, references, save_crop_feature); 
		input_images = input_set.get_images(); 
	}

	// save cropped images if requested
	if (!cropped_filename.empty()) {
		bfs::path cf(cropped_filename);
		cf.replace_extension(); 
		input_set.rename_base(__bfs_get_filename(cf)); 
		input_set.save_images(cropped_filename);

		unique_ptr<xmlpp::Document> test_cropset(input_set.write());
		ofstream outfile(cropped_filename, ios_base::out );
		if (outfile.good())
			outfile << test_cropset->write_to_string_formatted();
		else 
			throw create_exception<runtime_error>( "unable to save to '", cropped_filename, "'"); 

	}
	vector<P2DTransformation> transformations; 
	C2DImageSeries registered;

	bool do_continue=true; 
	bool lastpass = false; 

	while (do_continue || lastpass){
		++current_pass; 
		cvmsg() << "Registration pass " << current_pass << "\n"; 
		transformations = 
			run_registration_pass(input_set, registered, references,  skip_images,  minimizer, 
					      mg_levels, c_rate, divcurlweight, imageweight); 
		
		if (lastpass) 
			break; 

		C2DPerfusionAnalysis ica2(components, normalize, !no_meanstrip); 
		if (max_ica_iterations) 
			ica2.set_max_ica_iterations(max_ica_iterations); 
	
		transform(registered.begin() + skip_images, 
			  registered.end(), series.begin(), FCopy2DImageToFloatRepn()); 

		if (!ica2.run(series))
			ica2.set_approach(FICA_APPROACH_SYMM); 

		ica2.run(series); 
		divcurlweight /= divcurlweight_divider; 
		if (c_rate > 1) 
			c_rate /= c_rate_divider; 
		references_float = ica2.get_references(); 
		transform(references_float.begin(), references_float.end(), 
			  references.begin(), FWrapStaticDataInSharedPointer<C2DImage>()); 

		const bool can_one_more_pass = !pass || current_pass < pass; 
		do_continue = can_one_more_pass && ica2.has_movement(); 
		if (!do_continue && !save_crop_feature.empty()) {
			stringstream cfile; 
			cfile << save_crop_feature << "-final.txt"; 
			ica2.save_coefs(cfile.str()); 
			stringstream new_base; 
			new_base << save_crop_feature << "-p"<< pass << "-final"; 
			ica2.save_feature_images(new_base.str()); 
		}
		
		// run one more pass if the limit is not reached and no movement identified
		lastpass = (!do_continue && can_one_more_pass); 

	}

	CSegSetWithImages::Frames& frames = input_set.get_frames();
	for (size_t i = skip_images; i < input_images.size(); ++i) 
		frames[i].inv_transform(*transformations[i-skip_images]);

	C2DImageSeries iimages = input_set.get_images(); 
	copy(iimages.begin(), iimages.begin() + skip_images, registered.begin());  

	input_set.set_images(registered); 
	input_set.rename_base(registered_filebase); 
	input_set.save_images(out_filename); 
	
	unique_ptr<xmlpp::Document> outset(input_set.write());
	ofstream outfile(out_filename.c_str(), ios_base::out );
	if (outfile.good())
		outfile << outset->write_to_string_formatted();
	
	return outfile.good() ? EXIT_SUCCESS : EXIT_FAILURE;

}


#include <mia/internal/main.hh>
MIA_MAIN(do_main);