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#ifndef INCLUDED_SLS_ALP_SIMULATION
#define INCLUDED_SLS_ALP_SIMULATION
/* $Id: $
* ===========================================================================
*
* PUBLIC DOMAIN NOTICE
* National Center for Biotechnology Information
*
* This software/database is a "United States Government Work" under the
* terms of the United States Copyright Act. It was written as part of
* the author's offical duties as a United States Government employee and
* thus cannot be copyrighted. This software/database is freely available
* to the public for use. The National Library of Medicine and the U.S.
* Government have not placed any restriction on its use or reproduction.
*
* Although all reasonable efforts have been taken to ensure the accuracy
* and reliability of the software and data, the NLM and the U.S.
* Government do not and cannot warrant the performance or results that
* may be obtained by using this software or data. The NLM and the U.S.
* Government disclaim all warranties, express or implied, including
* warranties of performance, merchantability or fitness for any particular
* purpose.
*
* Please cite the author in any work or product based on this material.
*
* ===========================================================================*/
/*****************************************************************************
File name: sls_alp_sim.hpp
Author: Sergey Sheetlin
Contents: Simulation of Gumbel parameters
******************************************************************************/
#include <complex>
#include <iostream>
#include <map>
#include <vector>
#include <fstream>
#include <float.h>
#include <algorithm>
#include "sls_alp_data.hpp"
#include "sls_alp.hpp"
#include "sls_alp_regression.hpp"
namespace Sls {
struct struct_for_lambda_calculation
{
void **d_alp_distr;
void **d_alp_distr_errors;
long int d_nalp;
double d_f_error;
double d_last_sum;
double d_last_sum_error;
bool d_calculate_alp_number;
long int d_alp_number;
};
class alp_sim{
public:
alp_sim(//constructor
alp_data *alp_data_
);
~alp_sim();//destructor
void alp_sim_from_random_seed(//simulation from random seed
alp_data *alp_data_);
void quick_test(//runs quick tests to determine whether the scoring scheme is linear
long int trials_number_,
double max_time_);
void get_minimal_simulation(
long int ind1_,
long int ind2_,
long int &M_min_,
long int &nalp_,
long int &nalp_lambda_,
bool C_calculation_,
bool check_time_flag_);//simulation using [ind1_,ind2_] range of realizations with an estimation of parameters for accuracy, memory usage and calculation time
void memory_release_for_get_minimal_simulation(
long int nalp_,
void **&alp_distr,
void **&alp_distr_errors);
bool the_criterion(//criteria of stopping of the simulating ALP
//if the function returns true then calculates optimal M_min and ALP number
//sets the flags M_min_flag_ and nalp_flag_ checking the corresponding condition
long int upto_nalp_,
long int &nalp_for_lambda_simulation_,
long int ind1_,
long int ind2_,
void **&alp_distr,
void **&alp_distr_errors,
long int &M_min_,
bool &M_min_flag_,
bool &nalp_flag_,
bool &inside_simulation_flag_,
bool C_calculation_,
double *lambda_=NULL,
double *lambda_error_=NULL);
void calculate_lambda(
bool check_the_criteria_,
long int nalp_,
long int &nalp_thr_,
bool &inside_simulation_flag_,
void **alp_distr,
void **alp_distr_errors,
double &lambda_,
double &lambda_error_,
double &test_difference_,
double &test_difference_error_);
void calculate_C(
long int starting_point,
long int nalp_,
void **alp_distr,
void **alp_distr_errors,
double lambda_,
double lambda_error_,
double &C_,
double &C_error_,
double &Sc_,
double &Sc_error_);
void memory_release_for_calculate_FSC(
double *&exp_array,
double *&delta_E,
double *&delta_E_error,
double *&delta_E_E,
double *&delta_E_E_error,
double *&delta_I,
double *&delta_I_error,
double *&delta_J,
double *&delta_J_error,
double *&delta_I_I,
double *&delta_I_I_error,
double *&delta_I_J,
double *&delta_I_J_error,
double *&delta_J_J,
double *&delta_J_J_error,
double *&cov_J_J,
double *&cov_J_J_error,
double *&cov_I_J,
double *&cov_I_J_error,
double *&cov_I_I,
double *&cov_I_I_error,
double *&cov_E_E,
double *&cov_E_E_error);
void calculate_FSC(
long int nalp_,
long int ind1_,
long int ind2_,
void **alp_distr,
double lambda_,
double Sc_,
//double Sc_error_,
double &a_I_,
double &a_I_error_,
double &a_J_,
double &a_J_error_,
double &sigma_,
double &sigma_error_,
double &alpha_I_,
double &alpha_I_error_,
double &alpha_J_,
double &alpha_J_error_);
void sigma_calculation(
double delta_I_aver_,
double delta_I_aver_error_,
double delta_J_aver_,
double delta_J_aver_error_,
double delta_E_aver_,
double delta_E_aver_error_,
double cov_E_E_aver_,
double cov_E_E_aver_error_,
double cov_I_J_aver_,
double cov_I_J_aver_error_,
double &sigma_,
double &sigma_error_);
void get_and_allocate_alp_distribution(
long int ind1_,
long int ind2_,
void **&alp_distr,
void **&alp_distr_errors,
long int nalp);
bool check_K_criterion(
long int nalp_,
long int ind1_,
long int ind2_,
double lambda_,
double eps_K_,
long int &M_min_);
void kill(
bool check_time_,
long int ind1_,
long int ind2_,
long int M_min_,
double lambda_,
double eps_K_,
double &K_C_,
double &K_C_error_,
long int &level_,
long int &diff_opt_);
bool check_K_criterion_during_killing2(
long int ind1_,
long int ind2_,
double lambda_,
double eps_K_,
long int current_level_,
long int &recommended_level_,
long int &diff_opt_,
double &K_C_,
double &K_C_error_);
bool check_K_criterion_during_killing(
long int ind1_,
long int ind2_,
double lambda_,
double eps_K_,
long int current_level_,
long int &recommended_level_,
long int &diff_opt_,
double &K_C_,
double &K_C_error_);
inline static double lambda_exp(
long int &i_,
double *&exp_array_);
void get_single_realization(
bool check_time_,
long int M_min_,
long int nalp_,
bool killing_flag_,
long int level_,
long int diff_opt_,
alp *&obj_,
bool &sucess_flag_,
double &d_eps_);
void calculate_main_parameters(
long int final_realizations_number_lambda_,
long int final_realizations_number_killing_,
long int nalp,
long int nalp_for_lambda_simulation,
long int level,
bool &inside_simulation_flag,
double &lambda,
double &lambda_error,
double &test_difference,
double &test_difference_error,
double &C,
double &C_error,
double &C2,
double &C2_error,
double &C4,
double &C4_error,
double &K_C,
double &K_C_error,
double &a_I,
double &a_I_error,
double &a_J,
double &a_J_error,
double &sigma,
double &sigma_error,
double &alpha_I,
double &alpha_I_error,
double &alpha_J,
double &alpha_J_error,
double &K,
double &K_error);
void calculate_main_parameters2(
long int final_realizations_number_lambda_,
long int final_realizations_number_killing_,
long int nalp,
long int nalp_for_lambda_simulation,
long int level,
bool &inside_simulation_flag,
double &lambda,
double &lambda_error,
double &test_difference,
double &test_difference_error,
double &C,
double &C_error,
double &C2,
double &C2_error,
double &C4,
double &C4_error,
double &K_C,
double &K_C_error,
double &a_I,
double &a_I_error,
double &a_J,
double &a_J_error,
double &sigma,
double &sigma_error,
double &alpha_I,
double &alpha_I_error,
double &alpha_J,
double &alpha_J_error,
double &K,
double &K_error);
void memory_release_for_calculate_main_parameters2m(
long int nalp_for_lambda_simulation,
long int *&d_mult_realizations,
long int *&d_mult_K_realizations,
double *&lambda_mult,
double *&lambda_mult_error,
double *&C_mult,
double *&C_mult_error,
double *&a_I_mult,
double *&a_I_mult_error,
double *&a_J_mult,
double *&a_J_mult_error,
double *&sigma_mult,
double *&sigma_mult_error,
double *&alpha_I_mult,
double *&alpha_I_mult_error,
double *&alpha_J_mult,
double *&alpha_J_mult_error,
double *&K_C_mult,
double *&K_C_mult_error,
double *&K_mult,
double *&K_mult_error,
double *&Sc_mult,
double *&Sc_mult_error,
void **&alp_distr,
void **&alp_distr_errors,
void ***&alp_mult_distr,
void ***&alp_mult_distr_errors);
void calculate_main_parameters2m(
long int final_realizations_number_lambda_,
long int final_realizations_number_killing_,
long int nalp_for_lambda_simulation,
long int level,
bool &inside_simulation_flag,
double &lambda,
double &lambda_error,
double &test_difference,
double &test_difference_error,
double &C,
double &C_error,
double &K_C,
double &K_C_error,
double &a_I,
double &a_I_error,
double &a_J,
double &a_J_error,
double &sigma,
double &sigma_error,
double &alpha_I,
double &alpha_I_error,
double &alpha_J,
double &alpha_J_error,
double &K,
double &K_error,
bool &flag_);
void randomize_realizations(
long int final_realizations_number_lambda_,
long int final_realizations_number_killing_);
void randomize_realizations_ind(
long int ind1_,
long int ind2_);
void generate_random_permulation(
long int *perm_,
long int dim_);
static void error_in_calculate_main_parameters2m(
double C,
double &C_error,
double C_mult2,
double C_mult2_error);
void output_main_parameters(
double time_,
long int nalp,
long int nalp_for_lambda_simulation,
long int level,
long int M_min_,
bool &inside_simulation_flag,
long int final_realizations_number_lambda_,
long int final_realizations_number_killing_);
void output_main_parameters2(
double time_,
long int nalp,
long int nalp_for_lambda_simulation,
long int level,
long int M_min_,
bool &inside_simulation_flag,
long int final_realizations_number_lambda_,
long int final_realizations_number_killing_);
void output_main_parameters2m_new(
long int nalp_for_lambda_simulation,
long int level,
bool &inside_simulation_flag,
long int final_realizations_number_lambda_,
long int final_realizations_number_killing_);
void symmetric_parameters_for_symmetric_scheme();
static double relative_error_in_percents(
double val_,
double val_error_);
static double round_double(
double val_,
long int digits_);
static long int get_number_of_subsimulations(
long int number_of_realizations_);
static double function_for_lambda_calculation(
double lambda_,
void * data_);
static double get_root(
const std::vector<double> &res_tmp_,
double point_);
public:
alp_data *d_alp_data;//initial data
array_positive<alp*> *d_alp_obj;//vector with the alp objects
long int d_n_alp_obj;//number of alp objects
array_positive<double> *d_lambda_tmp;
array_positive<double> *d_lambda_tmp_errors;
array_positive<double> *d_C_tmp;
array_positive<double> *d_C_tmp_errors;
//Subsimulations' parameters
//number of subsimulations
long int d_mult_number;
//parameters estimations
double m_Lambda;
double m_LambdaError;
double m_K;
double m_KError;
double m_C;
double m_CError;
double m_Sigma;
double m_SigmaError;
double m_GaplessAlpha;
double m_GaplessAlphaError;
double m_GaplessA;
double m_GaplessAError;
double m_AlphaI;
double m_AlphaIError;
double m_AlphaJ;
double m_AlphaJError;
double m_AI;
double m_AIError;
double m_AJ;
double m_AJError;
double m_CalcTime;
long int m_G;
long int m_G1;
long int m_G2;
std::vector<double> m_LambdaSbs;
std::vector<double> m_KSbs;
std::vector<double> m_CSbs;
std::vector<double> m_SigmaSbs;
std::vector<double> m_AlphaISbs;
std::vector<double> m_AlphaJSbs;
std::vector<double> m_AISbs;
std::vector<double> m_AJSbs;
};
}
#endif
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