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/* Copyright (c) 2008-2025 the MRtrix3 contributors.
*
* This Source Code Form is subject to the terms of the Mozilla Public
* License, v. 2.0. If a copy of the MPL was not distributed with this
* file, You can obtain one at http://mozilla.org/MPL/2.0/.
*
* Covered Software is provided under this License on an "as is"
* basis, without warranty of any kind, either expressed, implied, or
* statutory, including, without limitation, warranties that the
* Covered Software is free of defects, merchantable, fit for a
* particular purpose or non-infringing.
* See the Mozilla Public License v. 2.0 for more details.
*
* For more details, see http://www.mrtrix.org/.
*/
#include <sstream>
#include <string>
#include "command.h"
#include "image.h"
#include "progressbar.h"
#include "thread_queue.h"
#include "types.h"
#include "connectome/connectome.h"
#include "dwi/tractography/file.h"
#include "dwi/tractography/properties.h"
#include "dwi/tractography/weights.h"
#include "dwi/tractography/connectome/extract.h"
#include "dwi/tractography/connectome/streamline.h"
#include "dwi/tractography/mapping/loader.h"
using namespace MR;
using namespace App;
using namespace MR::Connectome;
using namespace MR::DWI;
using namespace MR::DWI::Tractography;
using namespace MR::DWI::Tractography::Connectome;
const char* file_outputs[] = { "per_edge", "per_node", "single", NULL };
const OptionGroup TrackOutputOptions = OptionGroup ("Options for determining the content / format of output files")
+ Option ("nodes", "only select tracks that involve a set of nodes of interest (provide as a comma-separated list of integers)")
+ Argument ("list").type_sequence_int()
+ Option ("exclusive", "only select tracks that exclusively connect nodes from within the list of nodes of interest")
+ Option ("files", "select how the resulting streamlines will be grouped in output files. "
"Options are: per_edge, per_node, single (default: per_edge)")
+ Argument ("option").type_choice (file_outputs)
+ Option ("exemplars", "generate a mean connection exemplar per edge, rather than keeping all streamlines "
"(the parcellation node image must be provided in order to constrain the exemplar endpoints)")
+ Argument ("image").type_image_in()
+ Option ("keep_unassigned", "by default, the program discards those streamlines that are not successfully assigned to a node. "
"Set this option to generate corresponding outputs containing these streamlines (labelled as node index 0)")
+ Option ("keep_self", "by default, the program will not output streamlines that connect to the same node at both ends. "
"Set this option to instead keep these self-connections.");
void usage ()
{
// Note: Creation of this OptionGroup depends on Tractography::TrackWeightsInOption
// already being defined; therefore, it cannot be defined statically, and
// must be constructed after the command is executed.
const OptionGroup TrackWeightsOptions = OptionGroup ("Options for importing / exporting streamline weights")
+ Tractography::TrackWeightsInOption
+ Option ("prefix_tck_weights_out", "provide a prefix for outputting a text file corresponding to each output file, "
"each containing only the streamline weights relevant for that track file")
+ Argument ("prefix").type_text();
AUTHOR = "Robert E. Smith (robert.smith@florey.edu.au)";
SYNOPSIS = "Extract streamlines from a tractogram based on their assignment to parcellated nodes";
DESCRIPTION
+ "The compulsory input file \"assignments_in\" should contain a text file where there is one row for each streamline, "
"and each row contains a list of numbers corresponding to the parcels to which that streamline was assigned "
"(most typically there will be two entries per streamline, one for each endpoint; but this is not strictly a requirement). "
"This file will most typically be generated using the tck2connectome command with the -out_assignments option.";
EXAMPLES
+ Example ("Default usage",
"connectome2tck tracks.tck assignments.txt edge-",
"The command will generate one track file for every edge in the connectome, with the name of each file "
"indicating the nodes connected via that edge; for instance, all streamlines connecting nodes "
"23 and 49 will be written to file \"edge-23-49.tck\".")
+ Example ("Extract only the streamlines between nodes 1 and 2",
"connectome2tck tracks.tck assignments.txt tracks_1_2.tck -nodes 1,2 -exclusive -files single",
"Since only a single edge is of interest, this example provides only the two nodes involved "
"in that edge to the -nodes option, adds the -exclusive option so that only streamlines for which "
"both assigned nodes are in the list of nodes of interest are extracted (i.e. only streamlines connecting "
"nodes 1 and 2 in this example), and writes the result to a single output track file.")
+ Example ("Extract the streamlines connecting node 15 to all other nodes in the parcellation, with one track file for each edge",
"connectome2tck tracks.tck assignments.txt from_15_to_ -nodes 15 -keep_self",
"The command will generate the same number of track files as there are nodes in the parcellation: "
"one each for the streamlines connecting node 15 to every other node; i.e. "
"\"from_15_to_1.tck\", \"from_15_to_2.tck\", \"from_15_to_3.tck\", etc.. "
"Because the -keep_self option is specified, file \"from_15_to_15.tck\" will also be "
"generated, containing those streamlines that connect to node 15 at both endpoints.")
+ Example ("For every node, generate a file containing all streamlines connected to that node",
"connectome2tck tracks.tck assignments.txt node -files per_node",
"Here the command will generate one track file for every node in the connectome: "
"\"node1.tck\", \"node2.tck\", \"node3.tck\", etc.. Each of these files will contain "
"all streamlines that connect the node of that index to another node in the connectome "
"(it does not select all tracks connecting a particular node, since the -keep_self "
"option was omitted and therefore e.g. a streamline that is assigned to node 41 will "
"not be present in file \"node41.tck\"). Each streamline in the input tractogram will "
"in fact appear in two different output track files; e.g. a streamline connecting nodes "
"8 and 56 will be present both in file \"node8.tck\" and file \"node56.tck\".")
+ Example ("Get all streamlines that were not successfully assigned to a node pair",
"connectome2tck tracks.tck assignments.txt unassigned.tck -nodes 0 -keep_self -files single",
"Node index 0 corresponds to streamline endpoints that were not successfully assigned to "
"a node. As such, by selecting all streamlines that are assigned to \"node 0\" "
"(including those streamlines for which neither endpoint is assigned to a node due to "
"use of the -keep_self option), the single output track file will contain all streamlines "
"for which at least one of the two endpoints was not successfully assigned to a node.")
+ Example ("Generate a single track file containing edge exemplar trajectories",
"connectome2tck tracks.tck assignments.txt exemplars.tck -files single -exemplars nodes.mif",
"This produces the track file that is required as input when attempting to display "
"connectome edges using the streamlines or streamtubes geometries within the meview "
"connectome tool.");
ARGUMENTS
+ Argument ("tracks_in", "the input track file").type_file_in()
+ Argument ("assignments_in", "input text file containing the node assignments for each streamline").type_file_in()
+ Argument ("prefix_out", "the output file / prefix").type_text();
OPTIONS
+ TrackOutputOptions
+ TrackWeightsOptions;
}
void run ()
{
Tractography::Properties properties;
Tractography::Reader<float> reader (argument[0], properties);
vector< vector<node_t> > assignments_lists;
assignments_lists.reserve (to<size_t>(properties["count"]));
vector<NodePair> assignments_pairs;
bool nonpair_found = false;
node_t max_node_index = 0;
{
std::ifstream stream (argument[1]);
std::string line;
ProgressBar progress ("reading streamline assignments file");
while (std::getline (stream, line)) {
line = strip (line.substr (0, line.find_first_of ('#')));
if (line.empty())
continue;
std::stringstream line_stream (line);
vector<node_t> nodes;
while (1) {
node_t n;
line_stream >> n;
if (!line_stream) break;
nodes.push_back (n);
max_node_index = std::max (max_node_index, n);
}
if (nodes.size() != 2)
nonpair_found = true;
assignments_lists.push_back (std::move (nodes));
++progress;
}
}
const size_t count = to<size_t>(properties["count"]);
if (assignments_lists.size() != count)
throw Exception ("Assignments file contains " + str(assignments_lists.size()) + " entries; track file contains " + str(count) + " tracks");
// If the node assignments have been performed in such a way that each streamline is
// assigned to precisely two nodes, use the assignments_pairs class which is
// designed as such. This _should_ be the majority of cases, but the situation
// where each streamline could potentially be assigned to any number of nodes is
// now supported.
if (!nonpair_found) {
INFO ("Assignments file contains node pair for every streamline; operating accordingly");
assignments_pairs.reserve (assignments_lists.size());
for (auto i = assignments_lists.begin(); i != assignments_lists.end(); ++i)
assignments_pairs.push_back (NodePair ((*i)[0], (*i)[1]));
assignments_lists.clear();
}
const std::string prefix (argument[2]);
auto opt = get_options ("prefix_tck_weights_out");
const std::string weights_prefix = opt.size() ? std::string (opt[0][0]) : "";
INFO ("Maximum node index in assignments file is " + str(max_node_index));
const node_t first_node = get_options ("keep_unassigned").size() ? 0 : 1;
const bool keep_self = get_options ("keep_self").size();
// Get the list of nodes of interest
vector<node_t> nodes;
opt = get_options ("nodes");
bool manual_node_list = false;
if (opt.size()) {
manual_node_list = true;
const auto data = parse_ints<node_t> (opt[0][0]);
bool zero_in_list = false;
for (auto i : data) {
if (i > max_node_index) {
WARN ("Node of interest " + str(i) + " is above the maximum detected node index of " + str(max_node_index));
} else {
nodes.push_back (i);
if (!i)
zero_in_list = true;
}
}
if (!zero_in_list && !first_node)
nodes.push_back (0);
std::sort (nodes.begin(), nodes.end());
} else {
for (node_t i = first_node; i <= max_node_index; ++i)
nodes.push_back (i);
}
const bool exclusive = get_options ("exclusive").size();
if (exclusive && !manual_node_list)
WARN ("List of nodes of interest not provided; -exclusive option will have no effect");
opt = get_options ("files");
const int file_format = opt.size() ? opt[0][0] : 0;
opt = get_options ("exemplars");
if (opt.size()) {
if (keep_self)
WARN ("Exemplars cannot be calculated for node self-connections; -keep_self option ignored");
// Load the node image, get the centres of mass
// Generate exemplars - these can _only_ be done per edge, and requires a mutex per edge to multi-thread
auto image = Image<node_t>::open (opt[0][0]);
vector<Eigen::Vector3f> COMs (max_node_index+1, Eigen::Vector3f (0.0f, 0.0f, 0.0f));
vector<size_t> volumes (max_node_index+1, 0);
for (auto i = Loop() (image); i; ++i) {
const node_t index = image.value();
if (index) {
while (index >= COMs.size()) {
COMs.push_back (Eigen::Vector3f (0.0f, 0.0f, 0.0f));
volumes.push_back (0);
}
COMs[index] += Eigen::Vector3f (image.index(0), image.index(1), image.index(2));
++volumes[index];
}
}
if (COMs.size() > max_node_index + 1) {
WARN ("Parcellation image \"" + std::string (opt[0][0]) + "\" provided via -exemplars option contains more nodes (" + str(COMs.size()-1) + ") than are present in input assignments file \"" + std::string (argument[1]) + "\" (" + str(max_node_index) + ")");
max_node_index = COMs.size()-1;
}
Transform transform (image);
for (node_t index = 1; index <= max_node_index; ++index) {
if (volumes[index])
COMs[index] = (transform.voxel2scanner * (COMs[index] * (1.0f / float(volumes[index]))).cast<default_type>()).cast<float>();
else
COMs[index][0] = COMs[index][1] = COMs[index][2] = NaN;
}
// If user specifies a subset of nodes, only a subset of exemplars need to be calculated
WriterExemplars generator (properties, nodes, exclusive, first_node, COMs);
{
std::mutex mutex;
ProgressBar progress ("generating exemplars for connectome", count);
if (assignments_pairs.size()) {
auto loader = [&] (Tractography::Connectome::Streamline_nodepair& out) { if (!reader (out)) return false; out.set_nodes (assignments_pairs[out.get_index()]); return true; };
auto worker = [&] (const Tractography::Connectome::Streamline_nodepair& in) { generator (in); std::lock_guard<std::mutex> lock (mutex); ++progress; return true; };
Thread::run_queue (loader, Thread::batch (Tractography::Connectome::Streamline_nodepair()), Thread::multi (worker));
} else {
auto loader = [&] (Tractography::Connectome::Streamline_nodelist& out) { if (!reader (out)) return false; out.set_nodes (assignments_lists[out.get_index()]); return true; };
auto worker = [&] (const Tractography::Connectome::Streamline_nodelist& in) { generator (in); std::lock_guard<std::mutex> lock (mutex); ++progress; return true; };
Thread::run_queue (loader, Thread::batch (Tractography::Connectome::Streamline_nodelist()), Thread::multi (worker));
}
}
generator.finalize();
// Get exemplars to the output file(s), depending on the requested format
if (file_format == 0) { // One file per edge
if (exclusive) {
ProgressBar progress ("writing exemplars to files", nodes.size() * (nodes.size()-1) / 2);
for (size_t i = 0; i != nodes.size(); ++i) {
const node_t one = nodes[i];
for (size_t j = i+1; j != nodes.size(); ++j) {
const node_t two = nodes[j];
generator.write (one, two, prefix + str(one) + "-" + str(two) + ".tck", weights_prefix.size() ? (weights_prefix + str(one) + "-" + str(two) + ".csv") : "");
++progress;
}
}
} else {
// For each node in the list, write one file for an exemplar to every other node
ProgressBar progress ("writing exemplars to files", nodes.size() * COMs.size());
for (vector<node_t>::const_iterator n = nodes.begin(); n != nodes.end(); ++n) {
for (size_t i = first_node; i != COMs.size(); ++i) {
generator.write (*n, i, prefix + str(*n) + "-" + str(i) + ".tck", weights_prefix.size() ? (weights_prefix + str(*n) + "-" + str(i) + ".csv") : "");
++progress;
}
}
}
} else if (file_format == 1) { // One file per node
ProgressBar progress ("writing exemplars to files", nodes.size());
for (vector<node_t>::const_iterator n = nodes.begin(); n != nodes.end(); ++n) {
generator.write (*n, prefix + str(*n) + ".tck", weights_prefix.size() ? (weights_prefix + str(*n) + ".csv") : "");
++progress;
}
} else if (file_format == 2) { // Single file
std::string path = prefix;
if (path.rfind (".tck") != path.size() - 4)
path += ".tck";
std::string weights_path = weights_prefix;
if (weights_prefix.size() && weights_path.rfind (".tck") != weights_path.size() - 4)
weights_path += ".csv";
generator.write (path, weights_path);
}
} else { // Old behaviour ie. all tracks, rather than generating exemplars
WriterExtraction writer (properties, nodes, exclusive, keep_self);
switch (file_format) {
case 0: // One file per edge
for (size_t i = 0; i != nodes.size(); ++i) {
const node_t one = nodes[i];
if (exclusive) {
for (size_t j = i; j != nodes.size(); ++j) {
const node_t two = nodes[j];
writer.add (one, two, prefix + str(one) + "-" + str(two) + ".tck", weights_prefix.size() ? (weights_prefix + str(one) + "-" + str(two) + ".csv") : "");
}
} else {
// Allow duplication of edges; want to have an exhaustive set of files for each node
for (node_t two = first_node; two <= max_node_index; ++two)
writer.add (one, two, prefix + str(one) + "-" + str(two) + ".tck", weights_prefix.size() ? (weights_prefix + str(one) + "-" + str(two) + ".csv") : "");
}
}
INFO ("A total of " + str (writer.file_count()) + " output track files will be generated (one for each edge)");
break;
case 1: // One file per node
for (vector<node_t>::const_iterator i = nodes.begin(); i != nodes.end(); ++i)
writer.add (*i, prefix + str(*i) + ".tck", weights_prefix.size() ? (weights_prefix + str(*i) + ".csv") : "");
INFO ("A total of " + str (writer.file_count()) + " output track files will be generated (one for each node)");
break;
case 2: // Single file
std::string path = prefix;
if (path.rfind (".tck") != path.size() - 4)
path += ".tck";
std::string weights_path = weights_prefix;
if (weights_prefix.size() && weights_path.rfind (".tck") != weights_path.size() - 4)
weights_path += ".csv";
writer.add (nodes, path, weights_path);
break;
}
ProgressBar progress ("Extracting tracks from connectome", count);
if (assignments_pairs.size()) {
Tractography::Connectome::Streamline_nodepair tck;
while (reader (tck)) {
tck.set_nodes (assignments_pairs[tck.get_index()]);
writer (tck);
++progress;
}
} else {
Tractography::Connectome::Streamline_nodelist tck;
while (reader (tck)) {
tck.set_nodes (assignments_lists[tck.get_index()]);
writer (tck);
++progress;
}
}
}
}
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