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/* Copyright (c) 2008-2025 the MRtrix3 contributors.
*
* This Source Code Form is subject to the terms of the Mozilla Public
* License, v. 2.0. If a copy of the MPL was not distributed with this
* file, You can obtain one at http://mozilla.org/MPL/2.0/.
*
* Covered Software is provided under this License on an "as is"
* basis, without warranty of any kind, either expressed, implied, or
* statutory, including, without limitation, warranties that the
* Covered Software is free of defects, merchantable, fit for a
* particular purpose or non-infringing.
* See the Mozilla Public License v. 2.0 for more details.
*
* For more details, see http://www.mrtrix.org/.
*/
#include "command.h"
#include "progressbar.h"
#include "image.h"
#include "fixel/keys.h"
#include "fixel/helpers.h"
#include "fixel/types.h"
#include "math/SH.h"
#include "thread_queue.h"
#include "dwi/fmls.h"
#include "dwi/directions/set.h"
#include "file/path.h"
using namespace MR;
using namespace MR::DWI;
using namespace MR::DWI::FMLS;
using namespace App;
using Fixel::index_type;
const OptionGroup OutputOptions = OptionGroup ("Metric values for fixel-based sparse output images")
+ Option ("afd",
"output the total Apparent Fibre Density per fixel (integral of FOD lobe)")
+ Argument ("image").type_image_out()
+ Option ("peak_amp",
"output the amplitude of the FOD at the maximal peak per fixel")
+ Argument ("image").type_image_out()
+ Option ("disp",
"output a measure of dispersion per fixel as the ratio between FOD lobe integral and maximal peak amplitude")
+ Argument ("image").type_image_out();
void usage ()
{
AUTHOR = "Robert E. Smith (robert.smith@florey.edu.au)";
SYNOPSIS = "Perform segmentation of continuous Fibre Orientation Distributions (FODs) to produce discrete fixels";
REFERENCES
+ "* Reference for the FOD segmentation method:\n"
"Smith, R. E.; Tournier, J.-D.; Calamante, F. & Connelly, A. " // Internal
"SIFT: Spherical-deconvolution informed filtering of tractograms. "
"NeuroImage, 2013, 67, 298-312 (Appendix 2)"
+ "* Reference for Apparent Fibre Density (AFD):\n"
"Raffelt, D.; Tournier, J.-D.; Rose, S.; Ridgway, G.R.; Henderson, R.; Crozier, S.; Salvado, O.; Connelly, A. " // Internal
"Apparent Fibre Density: a novel measure for the analysis of diffusion-weighted magnetic resonance images."
"Neuroimage, 2012, 15;59(4), 3976-94";
ARGUMENTS
+ Argument ("fod", "the input fod image.").type_image_in ()
+ Argument ("fixel_directory", "the output fixel directory").type_directory_out();
OPTIONS
+ OutputOptions
+ FMLSSegmentOption
+ OptionGroup ("Other options for fod2fixel")
+ Option ("mask", "only perform computation within the specified binary brain mask image.")
+ Argument ("image").type_image_in()
+ Option ("maxnum", "maximum number of fixels to output for any particular voxel (default: no limit)")
+ Argument ("number").type_integer(1)
+ Option ("nii", "output the directions and index file in nii format (instead of the default mif)")
+ Option ("dirpeak", "define the fixel direction as that of the lobe's maximal peak as opposed to its weighted mean direction (the default)");
}
class Segmented_FOD_receiver { MEMALIGN(Segmented_FOD_receiver)
public:
Segmented_FOD_receiver (const Header& header, const index_type maxnum = 0, bool dir_from_peak = false) :
H (header), fixel_count (0), max_per_voxel (maxnum), dir_from_peak (dir_from_peak) { }
void commit ();
void set_fixel_directory_output (const std::string& path) { fixel_directory_path = path; }
void set_index_output (const std::string& path) { index_path = path; }
void set_directions_output (const std::string& path) { dir_path = path; }
void set_afd_output (const std::string& path) { afd_path = path; }
void set_peak_amp_output (const std::string& path) { peak_amp_path = path; }
void set_disp_output (const std::string& path) { disp_path = path; }
bool operator() (const FOD_lobes&);
private:
struct Primitive_FOD_lobe { MEMALIGN (Primitive_FOD_lobe)
Eigen::Vector3f dir;
float integral;
float max_peak_amp;
Primitive_FOD_lobe (Eigen::Vector3f dir, float integral, float max_peak_amp) :
dir (dir), integral (integral), max_peak_amp (max_peak_amp) {}
};
class Primitive_FOD_lobes : public vector<Primitive_FOD_lobe> { MEMALIGN (Primitive_FOD_lobes)
public:
Primitive_FOD_lobes (const FOD_lobes& in, const index_type maxcount, bool dir_from_peak) :
vox (in.vox)
{
const index_type N = maxcount ? std::min (index_type(in.size()), maxcount) : in.size();
for (index_type i = 0; i != N; ++i) {
const FOD_lobe& lobe (in[i]);
if (dir_from_peak)
this->emplace_back (lobe.get_peak_dir(0).cast<float>(), lobe.get_integral(), lobe.get_max_peak_value());
else
this->emplace_back (lobe.get_mean_dir().cast<float>(), lobe.get_integral(), lobe.get_max_peak_value());
}
}
Eigen::Array3i vox;
};
Header H;
std::string fixel_directory_path, index_path, dir_path, afd_path, peak_amp_path, disp_path;
vector<Primitive_FOD_lobes> lobes;
index_type fixel_count;
index_type max_per_voxel;
bool dir_from_peak;
};
bool Segmented_FOD_receiver::operator() (const FOD_lobes& in)
{
if (in.size()) {
lobes.emplace_back (in, max_per_voxel, dir_from_peak);
fixel_count += lobes.back().size();
}
return true;
}
void Segmented_FOD_receiver::commit ()
{
if (!lobes.size() || !fixel_count)
return;
using DataImage = Image<float>;
using IndexImage = Image<index_type>;
const auto index_filepath = Path::join (fixel_directory_path, index_path);
std::unique_ptr<IndexImage> index_image;
std::unique_ptr<DataImage> dir_image;
std::unique_ptr<DataImage> afd_image;
std::unique_ptr<DataImage> peak_amp_image;
std::unique_ptr<DataImage> disp_image;
auto index_header (H);
index_header.keyval()[Fixel::n_fixels_key] = str(fixel_count);
index_header.ndim() = 4;
index_header.size(3) = 2;
index_header.datatype() = DataType::from<index_type>();
index_header.datatype().set_byte_order_native();
index_image = make_unique<IndexImage> (IndexImage::create (index_filepath, index_header));
auto fixel_data_header (H);
fixel_data_header.ndim() = 3;
fixel_data_header.size(0) = fixel_count;
fixel_data_header.size(2) = 1;
fixel_data_header.datatype() = DataType::Float32;
fixel_data_header.datatype().set_byte_order_native();
if (dir_path.size()) {
auto dir_header (fixel_data_header);
dir_header.size(1) = 3;
dir_image = make_unique<DataImage> (DataImage::create (Path::join(fixel_directory_path, dir_path), dir_header));
dir_image->index(1) = 0;
Fixel::check_fixel_size (*index_image, *dir_image);
}
if (afd_path.size()) {
auto afd_header (fixel_data_header);
afd_header.size(1) = 1;
afd_image = make_unique<DataImage> (DataImage::create (Path::join(fixel_directory_path, afd_path), afd_header));
afd_image->index(1) = 0;
Fixel::check_fixel_size (*index_image, *afd_image);
}
if (peak_amp_path.size()) {
auto peak_amp_header (fixel_data_header);
peak_amp_header.size(1) = 1;
peak_amp_image = make_unique<DataImage> (DataImage::create (Path::join(fixel_directory_path, peak_amp_path), peak_amp_header));
peak_amp_image->index(1) = 0;
Fixel::check_fixel_size (*index_image, *peak_amp_image);
}
if (disp_path.size()) {
auto disp_header (fixel_data_header);
disp_header.size(1) = 1;
disp_image = make_unique<DataImage> (DataImage::create (Path::join(fixel_directory_path, disp_path), disp_header));
disp_image->index(1) = 0;
Fixel::check_fixel_size (*index_image, *disp_image);
}
size_t offset (0);
for (const auto& vox_fixels : lobes) {
size_t n_vox_fixels = vox_fixels.size();
assign_pos_of (vox_fixels.vox).to (*index_image);
index_image->index(3) = 0;
index_image->value () = n_vox_fixels;
index_image->index(3) = 1;
index_image->value() = offset;
if (dir_image) {
for (size_t i = 0; i < n_vox_fixels; ++i) {
dir_image->index(0) = offset + i;
dir_image->row(1) = vox_fixels[i].dir;
}
}
if (afd_image) {
for (size_t i = 0; i < n_vox_fixels; ++i) {
afd_image->index(0) = offset + i;
afd_image->value() = vox_fixels[i].integral;
}
}
if (peak_amp_image) {
for (size_t i = 0; i < n_vox_fixels; ++i) {
peak_amp_image->index(0) = offset + i;
peak_amp_image->value() = vox_fixels[i].max_peak_amp;
}
}
if (disp_image) {
for (size_t i = 0; i < n_vox_fixels; ++i) {
disp_image->index(0) = offset + i;
disp_image->value() = vox_fixels[i].integral / vox_fixels[i].max_peak_amp;
}
}
offset += n_vox_fixels;
}
assert (offset == fixel_count);
}
void run ()
{
Header H = Header::open (argument[0]);
Math::SH::check (H);
auto fod_data = H.get_image<float>();
const bool dir_as_peak = get_options ("dirpeak").size();
const index_type maxnum = get_option_value ("maxnum", 0);
Segmented_FOD_receiver receiver (H, maxnum, dir_as_peak);
auto& fixel_directory_path = argument[1];
receiver.set_fixel_directory_output (fixel_directory_path);
std::string file_extension (".mif");
if (get_options ("nii").size())
file_extension = ".nii";
static const std::string default_index_filename ("index" + file_extension);
static const std::string default_directions_filename ("directions" + file_extension);
receiver.set_index_output (default_index_filename);
receiver.set_directions_output (default_directions_filename);
auto
opt = get_options ("afd"); if (opt.size()) receiver.set_afd_output (opt[0][0]);
opt = get_options ("peak_amp"); if (opt.size()) receiver.set_peak_amp_output (opt[0][0]);
opt = get_options ("disp"); if (opt.size()) receiver.set_disp_output (opt[0][0]);
opt = get_options ("mask");
Image<float> mask;
if (opt.size()) {
mask = Image<float>::open (std::string (opt[0][0]));
if (!dimensions_match (fod_data, mask, 0, 3))
throw Exception ("Cannot use image \"" + str(opt[0][0]) + "\" as mask image; dimensions do not match FOD image");
}
Fixel::check_fixel_directory (fixel_directory_path, true, true);
FMLS::FODQueueWriter writer (fod_data, mask);
const DWI::Directions::FastLookupSet dirs (1281);
Segmenter fmls (dirs, Math::SH::LforN (H.size(3)));
load_fmls_thresholds (fmls);
Thread::run_queue (writer, Thread::batch (SH_coefs()), Thread::multi (fmls), Thread::batch (FOD_lobes()), receiver);
receiver.commit ();
}
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