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/* Copyright (c) 2008-2025 the MRtrix3 contributors.
*
* This Source Code Form is subject to the terms of the Mozilla Public
* License, v. 2.0. If a copy of the MPL was not distributed with this
* file, You can obtain one at http://mozilla.org/MPL/2.0/.
*
* Covered Software is provided under this License on an "as is"
* basis, without warranty of any kind, either expressed, implied, or
* statutory, including, without limitation, warranties that the
* Covered Software is free of defects, merchantable, fit for a
* particular purpose or non-infringing.
* See the Mozilla Public License v. 2.0 for more details.
*
* For more details, see http://www.mrtrix.org/.
*/
#include "metadata/phase_encoding.h"
#include "exception.h"
namespace MR {
namespace Metadata {
namespace PhaseEncoding {
using namespace App;
const OptionGroup ImportOptions =
OptionGroup("Options for importing phase-encode tables")
+ Option("import_pe_table", "import a phase-encoding table from file")
+ Argument("file").type_file_in()
+ Option("import_pe_topup", "import a phase-encoding table intended for FSL TOPUP from file")
+ Argument("file").type_file_in()
+ Option("import_pe_eddy", "import phase-encoding information from an EDDY-style config / index file pair")
+ Argument("config").type_file_in()
+ Argument("indices").type_file_in();
const OptionGroup SelectOptions =
OptionGroup("Options for selecting volumes based on phase-encoding")
+ Option("pe",
"select volumes with a particular phase encoding;"
" this can be three comma-separated values"
" (for i,j,k components of vector direction)"
" or four (direction & total readout time)")
+ Argument("desc").type_sequence_float();
const OptionGroup ExportOptions =
OptionGroup("Options for exporting phase-encode tables")
+ Option("export_pe_table", "export phase-encoding table to file")
+ Argument("file").type_file_out()
+ Option("export_pe_topup", "export phase-encoding table to a file intended for FSL topup")
+ Argument("file").type_file_out()
+ Option("export_pe_eddy", "export phase-encoding information to an EDDY-style config / index file pair")
+ Argument("config").type_file_out()
+ Argument("indices").type_file_out();
void check(const scheme_type& PE) {
if (PE.rows() == 0)
throw Exception("No valid phase encoding table found");
if (PE.cols() < 3)
throw Exception("Phase-encoding matrix must have at least 3 columns");
for (ssize_t row = 0; row != PE.rows(); ++row) {
for (ssize_t axis = 0; axis != 3; ++axis) {
if (std::round(PE(row, axis)) != PE(row, axis))
throw Exception("Phase-encoding matrix contains non-integral axis designation");
}
}
}
void check(const scheme_type& PE, const Header& header) {
check(PE);
const ssize_t num_volumes = (header.ndim() > 3) ? header.size(3) : 1;
if (num_volumes != PE.rows())
throw Exception("Number of volumes in image \"" + header.name() + "\" (" + str(num_volumes) + ")"
+ " does not match that in phase encoding table (" + str(PE.rows()) + ")");
}
namespace {
void erase(KeyValues& keyval, const std::string& s) {
auto it = keyval.find(s);
if (it != keyval.end())
keyval.erase(it);
};
}
void set_scheme(KeyValues& keyval, const scheme_type& PE) {
if (PE.rows() == 0) {
erase(keyval, "pe_scheme");
erase(keyval, "PhaseEncodingDirection");
erase(keyval, "TotalReadoutTime");
return;
}
std::string pe_scheme;
std::string first_line;
bool variation = false;
for (ssize_t row = 0; row < PE.rows(); ++row) {
std::string line = str(PE(row, 0));
for (ssize_t col = 1; col < PE.cols(); ++col)
line += "," + str(PE(row, col), 3);
add_line(pe_scheme, line);
if (first_line.empty())
first_line = line;
else if (line != first_line)
variation = true;
}
if (variation) {
keyval["pe_scheme"] = pe_scheme;
erase(keyval, "PhaseEncodingDirection");
erase(keyval, "TotalReadoutTime");
} else {
erase(keyval, "pe_scheme");
const Metadata::BIDS::axis_vector_type dir{int(PE(0, 0)), int(PE(0, 1)), int(PE(0, 2))};
keyval["PhaseEncodingDirection"] = Metadata::BIDS::vector2axisid(dir);
if (PE.cols() >= 4)
keyval["TotalReadoutTime"] = str(PE(0, 3), 3);
else
erase(keyval, "TotalReadoutTime");
}
}
void clear_scheme(KeyValues& keyval) {
auto erase = [&](const std::string& s) {
auto it = keyval.find(s);
if (it != keyval.end())
keyval.erase(it);
};
erase("pe_scheme");
erase("PhaseEncodingDirection");
erase("TotalReadoutTime");
}
scheme_type parse_scheme(const KeyValues& keyval, const Header& header) {
scheme_type PE;
const auto it = keyval.find("pe_scheme");
if (it != keyval.end()) {
try {
PE = MR::parse_matrix(it->second);
} catch (Exception& e) {
throw Exception(e, "malformed PE scheme associated with image \"" + header.name() + "\"");
}
if (ssize_t(PE.rows()) != ((header.ndim() > 3) ? header.size(3) : 1))
throw Exception("malformed PE scheme associated with image \"" + header.name() + "\": "
+ "number of rows does not equal number of volumes");
} else {
const auto it_dir = keyval.find("PhaseEncodingDirection");
if (it_dir != keyval.end()) {
const auto it_time = keyval.find("TotalReadoutTime");
const size_t cols = it_time == keyval.end() ? 3 : 4;
Eigen::Matrix<default_type, Eigen::Dynamic, 1> row(cols);
try {
row.head(3) = BIDS::axisid2vector(it_dir->second).cast<default_type>();
} catch (Exception& e) {
throw Exception(e, "malformed phase encoding direction associated with image \"" + header.name() + "\"");
}
if (it_time != keyval.end()) {
try {
row[3] = to<default_type>(it_time->second);
} catch (Exception& e) {
throw Exception(e, "Error adding readout time to phase encoding table");
}
}
PE.resize((header.ndim() > 3) ? header.size(3) : 1, cols);
PE.rowwise() = row.transpose();
}
}
return PE;
}
scheme_type get_scheme(const Header& header) {
DEBUG("searching for suitable phase encoding data...");
using namespace App;
const auto opt_table = get_options("import_pe_table");
const auto opt_topup = get_options("import_pe_topup");
const auto opt_eddy = get_options("import_pe_eddy");
if (opt_table.size() + opt_topup.size() + opt_eddy.size() > 1)
throw Exception("Cannot specify more than one command-line option"
" for importing phase encoding information from external file(s)");
scheme_type result;
try {
if (!opt_table.empty())
result = load_table(opt_table[0][0], header);
else if (!opt_topup.empty())
result = load_topup(opt_topup[0][0], header);
else if (!opt_eddy.empty())
result = load_eddy(opt_eddy[0][0], opt_eddy[0][1], header);
else
result = parse_scheme(header.keyval(), header);
} catch (Exception &e) {
throw Exception(e, "error importing phase encoding table for image \"" + header.name() + "\"");
}
if (result.rows() == 0)
return result;
if (result.cols() < 3)
throw Exception("unexpected phase encoding table matrix dimensions");
INFO("found " + str(result.rows()) + "x" + str(result.cols()) + " phase encoding table");
return result;
}
void transform_for_image_load(KeyValues& keyval, const Header& H) {
scheme_type pe_scheme;
try {
pe_scheme = parse_scheme(keyval, H);
} catch (Exception& e) {
if ((keyval.find("PhaseEncodingDirection") != keyval.end()
&& keyval["PhaseEncodingDirection"] != "variable")
|| (keyval.find("pe_scheme") != keyval.end()
&& keyval["pe_scheme"] != "variable")) {
WARN("Unable to conform phase encoding information to image realignment"
" for image \"" + H.name() + "\"; erasing");
}
clear_scheme(keyval);
return;
}
if (pe_scheme.rows() == 0) {
DEBUG("No phase encoding information found for transformation with load of image \"" + H.name() + "\"");
return;
}
if (H.realignment().is_identity()) {
INFO("No transformation of phase encoding data for load of image \"" + H.name() + "\" required");
return;
}
set_scheme(keyval, transform_for_image_load(pe_scheme, H));
INFO("Phase encoding data transformed to match RAS realignment of image \"" + H.name() + "\"");
}
scheme_type transform_for_image_load(const scheme_type& pe_scheme, const Header& H) {
if (H.realignment().is_identity())
return pe_scheme;
scheme_type result(pe_scheme.rows(), pe_scheme.cols());
for (ssize_t row = 0; row != pe_scheme.rows(); ++row) {
Eigen::VectorXd new_line = pe_scheme.row(row);
new_line.head<3>() = (H.realignment().applied_transform() * new_line.head<3>().cast<int>()).cast<default_type>();
result.row(row) = new_line;
}
return result;
}
void transform_for_nifti_write(KeyValues& keyval, const Header& H) {
const scheme_type pe_scheme = parse_scheme(keyval, H);
if (pe_scheme.rows() == 0) {
DEBUG("No phase encoding information found for transformation with save of NIfTI image \"" + H.name() + "\"");
return;
}
set_scheme(keyval, transform_for_nifti_write(pe_scheme, H));
}
scheme_type transform_for_nifti_write(const scheme_type& pe_scheme, const Header& H) {
if (pe_scheme.rows() == 0)
return pe_scheme;
Axes::Shuffle shuffle = File::NIfTI::axes_on_write(H);
if (shuffle.is_identity()) {
INFO("No transformation of phase encoding data required for export to file:"
" output image will be RAS");
return pe_scheme;
}
scheme_type result(pe_scheme.rows(), pe_scheme.cols());
for (ssize_t row = 0; row != pe_scheme.rows(); ++row) {
Eigen::VectorXd new_line = pe_scheme.row(row);
for (ssize_t axis = 0; axis != 3; ++axis)
new_line[axis] =
pe_scheme(row, shuffle.permutations[axis]) != 0.0 && shuffle.flips[axis] ?
-pe_scheme(row, shuffle.permutations[axis]) :
pe_scheme(row, shuffle.permutations[axis]);
result.row(row) = new_line;
}
INFO("Phase encoding data transformed to match NIfTI / MGH image export prior to writing to file");
return result;
}
void topup2eddy(const scheme_type& PE, Eigen::MatrixXd& config, Eigen::Array<int, Eigen::Dynamic, 1>& indices) {
try {
check(PE);
} catch (Exception& e) {
throw Exception(e, "Cannot convert phase-encoding scheme to eddy format");
}
if (PE.cols() != 4)
throw Exception("Phase-encoding matrix requires 4 columns to convert to eddy format");
config.resize(0, 0);
indices = Eigen::Array<int, Eigen::Dynamic, 1>::Constant (PE.rows(), PE.rows());
for (ssize_t PE_row = 0; PE_row != PE.rows(); ++PE_row) {
for (ssize_t config_row = 0; config_row != config.rows(); ++config_row) {
const bool dir_match = PE.template block<1, 3>(PE_row, 0).isApprox(config.block<1, 3>(config_row, 0));
const bool time_match = abs(PE(PE_row, 3) - config(config_row, 3)) < 1e-3;
if (dir_match && time_match) {
// FSL-style index file indexes from 1
indices[PE_row] = config_row + 1;
break;
}
}
if (indices[PE_row] == PE.rows()) {
// No corresponding match found in config matrix; create a new entry
config.conservativeResize(config.rows() + 1, 4);
config.row(config.rows() - 1) = PE.row(PE_row);
indices[PE_row] = config.rows();
}
}
}
scheme_type eddy2topup(const Eigen::MatrixXd& config, const Eigen::Array<int, Eigen::Dynamic, 1>& indices) {
if (config.cols() != 4)
throw Exception("Expected 4 columns in EDDY-format phase-encoding config file");
scheme_type result(indices.size(), 4);
for (ssize_t row = 0; row != indices.size(); ++row) {
if (indices[row] > config.rows())
throw Exception("Malformed EDDY-style phase-encoding information:"
" index exceeds number of config entries");
result.row(row) = config.row(indices[row] - 1);
}
return result;
}
void export_commandline(const Header& header) {
auto check = [&](const scheme_type& m) -> const scheme_type & {
if (m.rows() == 0)
throw Exception("no phase-encoding information found within image \"" + header.name() + "\"");
return m;
};
auto scheme = parse_scheme(header.keyval(), header);
auto opt = get_options("export_pe_table");
if (!opt.empty())
save_table(check(scheme), header, opt[0][0]);
opt = get_options("export_pe_topup");
if (!opt.empty())
save_topup(check(scheme), header, opt[0][0]);
opt = get_options("export_pe_eddy");
if (!opt.empty())
save_eddy(check(scheme), header, opt[0][0], opt[0][1]);
}
scheme_type load_table(const std::string& path, const Header& header) {
if (Path::has_suffix(header.name(), {".nii", ".nii.gz", ".img", ".mgh", "mgz"})) {
WARN("Note use of -import_pe_table in conjunction with MGH / NIfTI image"
" interprets phase encoding directions as being strictly with respect to image axes,"
" not with respect to the FSL internal convention;"
" consider if -import_pe_topup is more appropriate for your use case"
" (see: mrtrix.readthedocs.org/en/" MRTRIX_BASE_VERSION "/concepts/pe_scheme.html#reference-axes-for-phase-encoding-directions)");
}
const scheme_type PE = load_matrix(path);
check(PE, header);
// As with JSON import, need to query the header to discover if the
// strides / transform were modified on image load to make the image
// data appear approximately axial, in which case we need to apply the
// same transforms to the phase encoding data on load
return transform_for_image_load(PE, header);
}
scheme_type load_topup(const std::string& path, const Header& header) {
if (!Path::has_suffix(header.name(), {".nii", ".nii.gz", ".img", ".mgh", "mgz"})) {
WARN("Loading FSL topup format phase encoding information"
" accompanying image \"" + header.name() + "\" that is not MGH / NIfTI format"
" may be erroneous due to possible flipping of first image axis"
" (see: mrtrix.readthedocs.org/en/" MRTRIX_BASE_VERSION "/concepts/pe_scheme.html#reference-axes-for-phase-encoding-directions)");
}
scheme_type PE = load_matrix(path);
check(PE, header);
// Flip of first image axis based on determinant of image transform
// applies to however the image was stored on disk,
// before any interpretation by MRtrix3
if (header.realignment().orig_transform().linear().determinant() > 0.0)
PE.col(0) *= -1;
return transform_for_image_load(PE, header);
}
scheme_type load_eddy(const std::string& config_path, const std::string& index_path, const Header& header) {
if (!Path::has_suffix(header.name(), {".nii", ".nii.gz", ".img", ".mgh", "mgz"})) {
WARN("Loading FSL eddy format phase encoding information"
" accompanying image \"" + header.name() + "\" that is not MGH / NIfTI format"
" may be erroneous due to possible flipping of first image axis"
" (see: mrtrix.readthedocs.org/en/" MRTRIX_BASE_VERSION "/concepts/pe_scheme.html#reference-axes-for-phase-encoding-directions)");
}
const Eigen::MatrixXd config = load_matrix(config_path);
const Eigen::Array<int, Eigen::Dynamic, 1> indices = load_vector<int>(index_path);
scheme_type PE = eddy2topup(config, indices);
check(PE, header);
if (header.realignment().orig_transform().linear().determinant() > 0.0)
PE.col(0) *= -1;
return transform_for_image_load(PE, header);
}
void save_table(const scheme_type& PE, const std::string& path, const bool write_command_history) {
File::OFStream out(path);
if (write_command_history)
out << "# " << App::command_history_string << "\n";
for (ssize_t row = 0; row != PE.rows(); ++row) {
// Write phase-encode direction as integers; other information as floating-point
out << PE.template block<1, 3>(row, 0).template cast<int>();
if (PE.cols() > 3)
out << " " << PE.block(row, 3, 1, PE.cols() - 3);
out << "\n";
}
}
}
}
}
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