File: theta2.md

package info (click to toggle)
multiqc 1.21%2Bdfsg-3
  • links: PTS, VCS
  • area: main
  • in suites: forky, sid
  • size: 30,164 kB
  • sloc: python: 52,323; javascript: 7,064; sh: 76; makefile: 21
file content (15 lines) | stat: -rw-r--r-- 728 bytes parent folder | download | duplicates (2) 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
 
---
name: THeTA2
url: http://compbio.cs.brown.edu/projects/theta/
description: >
  THeTA2 estimates tumour purity and clonal / subclonal copy number.
---

[THeTA2](http://compbio.cs.brown.edu/projects/theta/) (Tumor Heterogeneity Analysis)
is an algorithm that estimates the tumour purity and clonal / subclonal copy number
aberrations directly from high-throughput DNA sequencing data.

The THeTA2 MultiQC module plots the % germline and % tumour subclone for each sample.
Note that each sample can have multiple maximum likelihood solutions - the MultiQC
module plots proportions for the first one in the results file (`*.BEST.results`).
Also note that if there are more than 5 tumour subclones, their percentages are summed.