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#include "muscle.h"
#include "objscore.h"
#include "msa.h"
#include "textfile.h"
#include "pwpath.h"
const unsigned INDELS = 1;
static void GetPos(const char Str[], unsigned L, int *pi1, int *pi2)
{
int i1;
for (;;)
{
i1 = rand()%(L-2) + 1;
if (Str[i1] == 'M')
break;
}
int i2;
for (;;)
{
i2 = rand()%(L-2) + 1;
if (i1 != i2 && Str[i2] == 'M')
break;
}
*pi1 = i1;
*pi2 = i2;
}
static void MakePath(unsigned uSeqLength, unsigned uIndelCount, char Str[])
{
unsigned uPathLength = uSeqLength + uIndelCount;
for (unsigned i = 0; i < uPathLength; ++i)
Str[i] = 'M';
for (unsigned i = 0; i < uIndelCount; ++i)
{
int i1, i2;
GetPos(Str, uPathLength, &i1, &i2);
Str[i1] = 'D';
Str[i2] = 'I';
}
Str[uPathLength] = 0;
Log("MakePath=%s\n", Str);
}
void SPTest()
{
SetPPScore(PPSCORE_SV);
SetListFileName("c:\\tmp\\muscle.log", false);
TextFile file1("c:\\tmp\\msa1.afa");
TextFile file2("c:\\tmp\\msa2.afa");
MSA msa1;
MSA msa2;
msa1.FromFile(file1);
msa2.FromFile(file2);
Log("msa1=\n");
msa1.LogMe();
Log("msa2=\n");
msa2.LogMe();
const unsigned uColCount = msa1.GetColCount();
if (msa2.GetColCount() != uColCount)
Quit("Different lengths");
const unsigned uSeqCount1 = msa1.GetSeqCount();
const unsigned uSeqCount2 = msa2.GetSeqCount();
const unsigned uSeqCount = uSeqCount1 + uSeqCount2;
MSA::SetIdCount(uSeqCount);
for (unsigned uSeqIndex1 = 0; uSeqIndex1 < uSeqCount1; ++uSeqIndex1)
{
msa1.SetSeqWeight(uSeqIndex1, 1.0);
msa1.SetSeqId(uSeqIndex1, uSeqIndex1);
}
for (unsigned uSeqIndex2 = 0; uSeqIndex2 < uSeqCount2; ++uSeqIndex2)
{
msa2.SetSeqWeight(uSeqIndex2, 1.0);
msa2.SetSeqId(uSeqIndex2, uSeqCount1 + uSeqIndex2);
}
MSA alnA;
MSA alnB;
char strPathA[1024];
char strPathB[1024];
MakePath(uColCount, INDELS, strPathA);
MakePath(uColCount, INDELS, strPathB);
PWPath PathA;
PWPath PathB;
PathA.FromStr(strPathA);
PathB.FromStr(strPathB);
Log("PathA=\n");
PathA.LogMe();
Log("PathB=\n");
PathB.LogMe();
AlignTwoMSAsGivenPath(PathA, msa1, msa2, alnA);
AlignTwoMSAsGivenPath(PathB, msa1, msa2, alnB);
for (unsigned uSeqIndex = 0; uSeqIndex < uSeqCount; ++uSeqIndex)
{
alnA.SetSeqWeight(uSeqIndex, 1.0);
alnB.SetSeqWeight(uSeqIndex, 1.0);
}
unsigned Seqs1[1024];
unsigned Seqs2[1024];
for (unsigned uSeqIndex1 = 0; uSeqIndex1 < uSeqCount1; ++uSeqIndex1)
Seqs1[uSeqIndex1] = uSeqIndex1;
for (unsigned uSeqIndex2 = 0; uSeqIndex2 < uSeqCount2; ++uSeqIndex2)
Seqs2[uSeqIndex2] = uSeqCount1 + uSeqIndex2;
MSA msaA1;
MSA msaA2;
MSA msaB1;
MSA msaB2;
MSAFromSeqSubset(alnA, Seqs1, uSeqCount1, msaA1);
MSAFromSeqSubset(alnB, Seqs1, uSeqCount1, msaB1);
MSAFromSeqSubset(alnA, Seqs2, uSeqCount2, msaA2);
MSAFromSeqSubset(alnB, Seqs2, uSeqCount2, msaB2);
for (unsigned uSeqIndex1 = 0; uSeqIndex1 < uSeqCount1; ++uSeqIndex1)
{
msaA1.SetSeqWeight(uSeqIndex1, 1.0);
msaB1.SetSeqWeight(uSeqIndex1, 1.0);
}
for (unsigned uSeqIndex2 = 0; uSeqIndex2 < uSeqCount2; ++uSeqIndex2)
{
msaA2.SetSeqWeight(uSeqIndex2, 1.0);
msaB2.SetSeqWeight(uSeqIndex2, 1.0);
}
Log("msaA1=\n");
msaA1.LogMe();
Log("msaB1=\n");
msaB1.LogMe();
Log("msaA2=\n");
msaA2.LogMe();
Log("msaB2=\n");
msaB2.LogMe();
Log("alnA=\n");
alnA.LogMe();
Log("AlnB=\n");
alnB.LogMe();
Log("\nSPA\n---\n");
SCORE SPA = ObjScoreSP(alnA);
Log("\nSPB\n---\n");
SCORE SPB = ObjScoreSP(alnB);
Log("\nXPA\n---\n");
SCORE XPA = ObjScoreXP(msaA1, msaA2);
Log("\nXPB\n---\n");
SCORE XPB = ObjScoreXP(msaB1, msaB2);
Log("SPA=%.4g SPB=%.4g Diff=%.4g\n", SPA, SPB, SPA - SPB);
Log("XPA=%.4g XPB=%.4g Diff=%.4g\n", XPA, XPB, XPA - XPB);
}
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