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#include "muscle.h"
#include "profile.h"
#include "pwpath.h"
#include <math.h>
#define TRACE 0
#define EQ(a, b) (fabs(a-b) < 0.1)
SCORE TraceBack(const ProfPos *PA, unsigned uLengthA, const ProfPos *PB,
unsigned uLengthB, const SCORE *DPM_, const SCORE *DPD_, const SCORE *DPI_,
PWPath &Path)
{
#if TRACE
Log("\n");
Log("TraceBack LengthA=%u LengthB=%u\n", uLengthA, uLengthB);
#endif
assert(uLengthB > 0 && uLengthA > 0);
const unsigned uPrefixCountA = uLengthA + 1;
const unsigned uPrefixCountB = uLengthB + 1;
Path.Clear();
unsigned uPrefixLengthA = uLengthA;
unsigned uPrefixLengthB = uLengthB;
const SCORE scoreM = DPM(uPrefixLengthA, uPrefixLengthB);
SCORE scoreD = DPD(uPrefixLengthA, uPrefixLengthB);
SCORE scoreI = DPI(uPrefixLengthA, uPrefixLengthB);
const ProfPos &LastPPA = PA[uLengthA - 1];
const ProfPos &LastPPB = PB[uLengthB - 1];
scoreD += LastPPA.m_scoreGapClose;
scoreI += LastPPB.m_scoreGapClose;
char cEdgeType = cInsane;
SCORE scoreMax;
if (scoreM >= scoreD && scoreM >= scoreI)
{
scoreMax = scoreM;
cEdgeType = 'M';
}
else if (scoreD >= scoreM && scoreD >= scoreI)
{
scoreMax = scoreD;
cEdgeType = 'D';
}
else
{
assert(scoreI >= scoreM && scoreI >= scoreD);
scoreMax = scoreI;
cEdgeType = 'I';
}
for (;;)
{
if ('S' == cEdgeType)
break;
PWEdge Edge;
Edge.cType = cEdgeType;
Edge.uPrefixLengthA = uPrefixLengthA;
Edge.uPrefixLengthB = uPrefixLengthB;
Path.PrependEdge(Edge);
char cPrevEdgeType;
unsigned uPrevPrefixLengthA = uPrefixLengthA;
unsigned uPrevPrefixLengthB = uPrefixLengthB;
switch (cEdgeType)
{
case 'M':
{
assert(uPrefixLengthA > 0);
assert(uPrefixLengthB > 0);
const ProfPos &PPA = PA[uPrefixLengthA - 1];
const ProfPos &PPB = PB[uPrefixLengthB - 1];
const SCORE Score = DPM(uPrefixLengthA, uPrefixLengthB);
const SCORE scoreMatch = ScoreProfPos2(PPA, PPB);
SCORE scoreSM;
if (1 == uPrefixLengthA && 1 == uPrefixLengthB)
scoreSM = scoreMatch;
else
scoreSM = MINUS_INFINITY;
SCORE scoreMM = MINUS_INFINITY;
SCORE scoreDM = MINUS_INFINITY;
SCORE scoreIM = MINUS_INFINITY;
if (uPrefixLengthA > 1 && uPrefixLengthB > 1)
scoreMM = DPM(uPrefixLengthA-1, uPrefixLengthB-1) + scoreMatch;
if (uPrefixLengthA > 1)
{
SCORE scoreTransDM = PA[uPrefixLengthA-2].m_scoreGapClose;
scoreDM = DPD(uPrefixLengthA-1, uPrefixLengthB-1) + scoreTransDM + scoreMatch;
}
if (uPrefixLengthB > 1)
{
SCORE scoreTransIM = PB[uPrefixLengthB-2].m_scoreGapClose;
scoreIM = DPI(uPrefixLengthA-1, uPrefixLengthB-1) + scoreTransIM + scoreMatch;
}
if (EQ(scoreMM, Score))
cPrevEdgeType = 'M';
else if (EQ(scoreDM, Score))
cPrevEdgeType = 'D';
else if (EQ(scoreIM, Score))
cPrevEdgeType = 'I';
else if (EQ(scoreSM, Score))
cPrevEdgeType = 'S';
else
Quit("TraceBack: failed to match M score=%g M=%g D=%g I=%g S=%g",
Score, scoreMM, scoreDM, scoreIM, scoreSM);
--uPrevPrefixLengthA;
--uPrevPrefixLengthB;
break;
}
case 'D':
{
assert(uPrefixLengthA > 0);
const SCORE Score = DPD(uPrefixLengthA, uPrefixLengthB);
SCORE scoreMD = MINUS_INFINITY;
SCORE scoreDD = MINUS_INFINITY;
SCORE scoreSD = MINUS_INFINITY;
if (uPrefixLengthB == 0)
{
if (uPrefixLengthA == 1)
scoreSD = PA[0].m_scoreGapOpen;
else
scoreSD = DPD(uPrefixLengthA - 1, 0);
}
if (uPrefixLengthA > 1)
{
const ProfPos &PPA = PA[uPrefixLengthA - 1];
SCORE scoreTransMD = PPA.m_scoreGapOpen;
scoreMD = DPM(uPrefixLengthA-1, uPrefixLengthB) + scoreTransMD;
scoreDD = DPD(uPrefixLengthA-1, uPrefixLengthB);
}
if (EQ(Score, scoreMD))
cPrevEdgeType = 'M';
else if (EQ(Score, scoreDD))
cPrevEdgeType = 'D';
else if (EQ(Score, scoreSD))
cPrevEdgeType = 'S';
else
Quit("TraceBack: failed to match D");
--uPrevPrefixLengthA;
break;
}
case 'I':
{
assert(uPrefixLengthB > 0);
const SCORE Score = DPI(uPrefixLengthA, uPrefixLengthB);
SCORE scoreMI = MINUS_INFINITY;
SCORE scoreII = MINUS_INFINITY;
SCORE scoreSI = MINUS_INFINITY;
if (uPrefixLengthA == 0)
{
if (uPrefixLengthB == 1)
scoreSI = PB[0].m_scoreGapOpen;
else
scoreSI = DPI(0, uPrefixLengthB - 1);
}
if (uPrefixLengthB > 1)
{
const ProfPos &PPB = PB[uPrefixLengthB - 1];
SCORE scoreTransMI = PPB.m_scoreGapOpen;
scoreMI = DPM(uPrefixLengthA, uPrefixLengthB-1) + scoreTransMI;
scoreII = DPI(uPrefixLengthA, uPrefixLengthB-1);
}
if (EQ(Score, scoreMI))
cPrevEdgeType = 'M';
else if (EQ(Score, scoreII))
cPrevEdgeType = 'I';
else if (EQ(Score, scoreSI))
cPrevEdgeType = 'S';
else
Quit("TraceBack: failed to match I");
--uPrevPrefixLengthB;
break;
}
default:
assert(false);
}
#if TRACE
Log("Edge %c%c%u.%u", cPrevEdgeType, cEdgeType, uPrefixLengthA, uPrefixLengthB);
Log("\n");
#endif
cEdgeType = cPrevEdgeType;
uPrefixLengthA = uPrevPrefixLengthA;
uPrefixLengthB = uPrevPrefixLengthB;
}
return scoreMax;
}
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