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/* cdscan.c
* ===========================================================================
*
* PUBLIC DOMAIN NOTICE
* National Center for Biotechnology Information (NCBI)
*
* This software/database is a "United States Government Work" under the
* terms of the United States Copyright Act. It was written as part of
* the author's official duties as a United States Government employee and
* thus cannot be copyrighted. This software/database is freely available
* to the public for use. The National Library of Medicine and the U.S.
* Government do not place any restriction on its use or reproduction.
* We would, however, appreciate having the NCBI and the author cited in
* any work or product based on this material
*
* Although all reasonable efforts have been taken to ensure the accuracy
* and reliability of the software and data, the NLM and the U.S.
* Government do not and cannot warrant the performance or results that
* may be obtained by using this software or data. The NLM and the U.S.
* Government disclaim all warranties, express or implied, including
* warranties of performance, merchantability or fitness for any particular
* purpose.
*
* ===========================================================================
*
* File Name: cdscan.c
*
* Author: Kans, Schuler, Ostell
*
* Version Creation Date: 2/26/95
*
* $Revision: 6.1 $
*
* File Description:
* scans through sequence records on the Entrez discs
* This program is meant to serve as a model for programs that scan
* all the files on the Entrez CDROM disks. Basically it does some
* setup in the main routine to find the disks and get a list of files
* on them for nucleic acid or protein sequences. It then goes through
* each file and reads each Seq-entry from them. On the Entrez CDROMs
* the Seq-entries are Huffman compressed, so the Casn calls decompress
* them for you. Once you have a Seq-entry, you can do whatever you
* want with it. In this program we give the options of printing as
* FASTA file or as GenBank or GenPept file. You can modify this part
* to do whatever you want. The function that receives the SeqEntry is
* called "ProcessSeqEntry".
*
* This function is passed one SeqEntry at a time by the CDROM scanning
* Routines. Depending on the global variables it will call routines to
* make fasta, genbank format, or to call a custom routine. The default
* custom routine (CustomRoutine) just prints the SeqIds of the sequences
* to the outputfile and to the progress monitor.
*
* At the end of the file are some custom routines written for various
* purposes that could be substituted or modified for other purposes.
* To activate, call them instead of "CustomRoutine"
*
* The first locates all GenBank entries and prints out a short summary
* of their citations. It is called GenBankPubs()
*
* The second prints the sequence of all CdRegion features in the entry.
* It is called SeqEntryToFeat()
*
*
* Before trying any of this, be sure you have installed the Entrez
* application itself and ensured that it works. This program uses the
* the same configuration file and will not run if Entrez has not been
* properly installed.
*
* Modifications:
* --------------------------------------------------------------------------
* Date Name Description of modification
* ------- ---------- -----------------------------------------------------
*
*
* ==========================================================================
*/
#ifndef _NEW_CdEntrez_
#define _NEW_CdEntrez_
#endif
#include <ncbi.h>
#include <casn.h>
#include <accentr.h>
#include <cdromlib.h>
#include <seqport.h>
#include <asn2ff.h>
#include <tofasta.h>
/*****************************************************************************
*
* structs used by main routines
*
*****************************************************************************/
typedef struct filelist {
Int2 cdnum;
CharPtr fdir;
CharPtr fname;
struct filelist PNTR next;
} FileList, PNTR FileListPtr;
/*****************************************************************************
*
* Function prototypes for routines in this module
*
*****************************************************************************/
static Boolean LIBCALLBACK EnumerateFiles PROTO((int cdnum, const char *fdir,
const char *fname, long fsize,
void *opaque_data));
static FileListPtr FileListNew PROTO((FileListPtr flp, Int2 cdnum,
CharPtr fdir, CharPtr fname));
static void ProcessFileList PROTO((FileListPtr flp, CharPtr outputfile));
static void ProcessFile PROTO((FileListPtr flp, CharPtr root, CharPtr outputfile));
static void ProcessSeqEntry PROTO((SeqEntryPtr sep, FILE *fp));
static void CustomRoutine PROTO((SeqEntryPtr sep, FILE * fp));
static void PrintIdDefLine PROTO((SeqEntryPtr sep, Pointer data,
Int4 index, Int2 indent));
/*****************************************************************************
*
* Static Data used by the main routines
*
*****************************************************************************/
static Char root [PATH_MAX];
static EntrezInfoPtr eip;
static EntrezDivInfo *div_info;
static Int2 format; /* 1 = GenBank, 2 = FASTA */
static Boolean is_na, /* TRUE = nucleic acids, FALSE = proteins */
is_custom; /* call custom process instead of std ones */
static MonitorPtr pmon = NULL; /* progress monitor */
#define NUMARGS 5
Args myargs [NUMARGS] = {
{"Scan DNA (1) or Protein (2)", "1", "1", "2", FALSE, 's', ARG_INT, 0.0, 0, NULL},
{"Output format: GenBank (1) or FASTA (2)", "1", "1", "2", TRUE, 'f', ARG_INT, 0.0, 0, NULL},
{"Call custom process", "F", NULL, NULL, TRUE, 'c', ARG_BOOLEAN, 0.0, 0, NULL},
{"Show progress monitor", "F", NULL, NULL, TRUE, 'p', ARG_BOOLEAN, 0.0, 0, NULL},
{"Output File", "stdout", NULL, NULL, FALSE, 'o', ARG_FILE_OUT, 0.0, 0, NULL}
};
/*****************************************************************************
*
* This is the main program.
* It reads command line or initial dialogue arguments
* It initializes parse trees, entrez
* It makes a list of the relevant files to search
* It then calls ProcessFileList to open each file and process it
*
*****************************************************************************/
Int2 Main (void)
{
Char div [8];
FileListPtr flp = NULL;
FILE *fp;
Int2 i;
Boolean is_network, did_init=FALSE;
FileListPtr next;
CharPtr outputfile;
if (! GetArgs ("CdScan", NUMARGS, myargs)) /* get input args */
goto ret;
/* process input args */
if (myargs[0].intvalue == 1)
is_na = TRUE; /* scan nucleic acids */
else
is_na = FALSE; /* scan proteins */
format = (Int2)(myargs[1].intvalue);
is_custom = (Boolean)(myargs[2].intvalue);
if (myargs[3].intvalue) /* show progress */
{
pmon = MonitorStrNew("CdScan", 40);
}
outputfile = myargs[4].strvalue; /* output file name */
if (pmon != NULL)
MonitorStrValue(pmon, "Reading Parse Trees");
if (! SeqEntryLoad() || ! SubmitAsnLoad()) /* read ASN.1 parse trees */
{
Message(MSG_ERROR, "Can't open parse trees");
goto ret;
}
if (! PrintTemplateSetLoad ("asn2ff.prt"))
{
Message(MSG_ERROR, "Can't load print templates");
goto ret;
}
if (pmon != NULL)
MonitorStrValue(pmon, "Initializing Entrez");
if (! EntrezInit ("cdscan", FALSE, &is_network)) /* init Entrez */
{
Message(MSG_ERROR, "Can't initialize Entrez");
goto ret;
}
did_init = TRUE;
if (is_network)
{
Message (MSG_ERROR, "Network service does not allow scanning");
goto ret;
}
if (pmon != NULL)
MonitorStrValue(pmon, "Building File List");
eip = EntrezGetInfo (); /* set up the file lists */
if ((eip == NULL) || (eip->div_info == NULL))
{
Message(MSG_ERROR, "Can't find Entrez file info");
goto ret;
}
flp = FileListNew (NULL, INT2_MIN, NULL, NULL);
if (flp == NULL)
{
Message(MSG_ERROR, "Can't allocate file list");
goto ret;
}
div_info = eip->div_info;
for (i = 0; i < eip->div_count; i++)
{
StringNCpy (div, div_info [i].tag, sizeof (div) - 1);
if (! is_na)
{
CdEnumFiles (CdDir_rec, TYP_AA, div, EnumerateFiles, &flp);
}
else
{
CdEnumFiles (CdDir_rec, TYP_NT, div, EnumerateFiles, &flp);
}
}
fp = FileOpen (outputfile, "w"); /* test that we can open output file */
if (fp == NULL)
{
Message(MSG_ERROR, "Can't open [%s]", outputfile);
goto ret;
}
FileClose (fp); /* will be reopened for each input file */
ProcessFileList (flp, outputfile); /* process the file list */
ret: /* clean up */
if (pmon != NULL) /* close the progress monitor */
MonitorFree(pmon);
if (did_init)
EntrezFini(); /* close entrez */
while (flp != NULL) /* free file list */
{
next = flp->next;
MemFree (flp->fdir);
MemFree (flp->fname);
MemFree (flp);
flp = next;
}
return 0;
}
/*****************************************************************************
*
* ProcessSeqEntry (sep, fp)
*
*
* This function is passed one SeqEntry at a time by the CDROM scanning
* Routines. Depending on the global variables it will call routines to
* make fasta, genbank format, or to call a custom routine. The default
* custom routine (CustomRoutine) just prints the SeqIds of the sequences
* to the outputfile and to the progress monitor.
*
* At the end of the file are some custom routines written for various
* purposes that could be substituted or modified for other purposes.
* To active, call them instead of "CustomRoutine"
*
*****************************************************************************/
static void ProcessSeqEntry (SeqEntryPtr sep, FILE *fp)
{
Uint1 fmt;
if ((sep == NULL) || (fp == NULL))
return;
if (is_custom)
CustomRoutine(sep, fp); /* this is the one you modify */
else if (format == 1) /* genbank format */
{
if (is_na) /* defined in asn2ff.h */
fmt = GENBANK_FMT;
else
fmt = GENPEPT_FMT;
SeqEntryToFlat(sep, fp, fmt, RELEASE_MODE); /* dump like entrez does */
}
else if (format == 2) /* fasta format */
SeqEntryToFasta(sep, fp, is_na); /* defined in tofasta.h */
return;
}
/*****************************************************************************
*
* CustomRoutine (sep, fp)
* This is just a little model of a customized routine
* Normally you would replace this with one of your own design
* Some examples follow below. In this routine, it prints the
* SeqId and definition line of each entry it finds using SeqEntryExplore.
*
*****************************************************************************/
static void CustomRoutine (SeqEntryPtr sep, FILE * fp)
{
SeqEntryExplore(sep, (Pointer)(fp), PrintIdDefLine);
}
/*****************************************************************************
*
* PrintIdDefLine
* SeqEntryExplore callback routine that prints the seqids and definition
* lines.
*
*****************************************************************************/
static void PrintIdDefLine (SeqEntryPtr sep, Pointer data,
Int4 index, Int2 indent)
{
BioseqPtr bsp;
FILE * fp;
Char buf[40];
CharPtr title = NULL;
if (IS_Bioseq (sep)) {
*buf = '\0';
bsp = (BioseqPtr) sep->data.ptrvalue;
fp = (FILE *) data;
title = BioseqGetTitle(bsp); /* this does not deal with all cases */
SeqIdPrint(bsp->id, buf, PRINTID_FASTA_LONG); /* print SeqId */
if (pmon != NULL)
MonitorStrValue(pmon, buf);
fprintf(fp, ">%s", buf);
if (title != NULL)
fprintf(fp, " %s", title);
fprintf(fp, "\n");
}
return;
}
/*****************************************************************************
*
* Other possible Custom routines follow below.
* The first locates all GenBank entries and prints out a short summary
* of their citations. It is called GenBankPubs
*
* The second prints the sequence of all CdRegion features in the entry.
* It is called SeqEntryToFeat()
*
*****************************************************************************/
/*****************************************************************************
*
* GenBankPubs(sep, fp)
* This set of routines finds GenBank entries and prints a summary of
* their citations
*
*****************************************************************************/
static void GetPubFromGenBank PROTO((SeqEntryPtr sep, Pointer data,
Int4 index, Int2 indent));
static void GenBankPubs (SeqEntryPtr sep, FILE * fp)
{
SeqEntryExplore(sep, (Pointer)(fp), GetPubFromGenBank);
}
static void PubWrite(CharPtr accession, ValNodePtr vnp, FILE * fp)
{
CitArtPtr cap = NULL;
CitJourPtr cjp;
ValNodePtr tvnp;
ImprintPtr ip;
Int2 year = 0;
CharPtr jta = NULL,
volume,
pages;
Char buf[250];
switch (vnp->choice)
{
case PUB_Equiv:
for (tvnp = (ValNodePtr)(vnp->data.ptrvalue); tvnp != NULL;
tvnp = tvnp->next)
{
PubWrite(accession, tvnp, fp);
}
break;
case PUB_Article:
cap = (CitArtPtr)(vnp->data.ptrvalue);
if (cap->from == 1) /* from a journal */
{
cjp = (CitJourPtr)(cap->fromptr);
ip = cjp->imp;
for (tvnp = cjp->title; tvnp != NULL; tvnp = tvnp->next)
{
switch (tvnp->choice)
{
case Cit_title_jta:
case Cit_title_iso_jta:
case Cit_title_ml_jta:
jta = (CharPtr)(tvnp->data.ptrvalue);
break;
default:
break;
}
if (jta != NULL) break;
}
if (ip->date->data[0] == 1) /* std date */
year = (Int2)ip->date->data[1] + 1900;
else
year = 0;
volume = ip->volume;
if (volume == NULL)
volume = "(no volume)";
pages = ip->pages;
if (pages == NULL)
pages = "(no pages)";
if (jta == NULL)
jta = "(no jta)";
sprintf(buf, "%s - %s (%d) %s:%s", accession, jta, (int)year,
volume, pages);
fprintf(fp, "%s\n", buf);
if (pmon != NULL)
MonitorStrValue(pmon, buf);
}
break;
default:
break;
}
return;
}
static void GetPubFromGenBank (SeqEntryPtr sep, Pointer data,
Int4 index, Int2 indent)
{
BioseqPtr bsp;
BioseqContextPtr bcp;
SeqFeatPtr sfp;
ValNodePtr vnp;
FILE * fp;
CharPtr accession = NULL;
ValNode tpub;
TextSeqIdPtr tsip;
PubdescPtr pdp;
Char buf[40];
if (! IS_Bioseq(sep))
return;
fp = (FILE *) data; /* get the output file pointer */
bsp = (BioseqPtr) sep->data.ptrvalue;
if (pmon != NULL)
{
*buf = '\0';
SeqIdPrint(bsp->id, buf, PRINTID_FASTA_LONG);
MonitorStrValue(pmon, buf);
}
for (vnp = bsp->id; ((vnp != NULL) && (accession == NULL)); vnp = vnp->next)
{
switch (vnp->choice)
{
case SEQID_GENBANK:
case SEQID_EMBL:
case SEQID_DDBJ:
tsip = (TextSeqIdPtr)(vnp->data.ptrvalue);
if (tsip->accession != NULL)
accession = tsip->accession;
break;
default:
break;
}
}
if (accession == NULL) return;
bcp = BioseqContextNew(bsp);
if (bcp == NULL)
return;
vnp = NULL;
tpub.choice = PUB_Equiv;
tpub.next = NULL;
/* get any pub descriptors */
while ((vnp = BioseqContextGetSeqDescr(bcp, (Int2)Seq_descr_pub, vnp, NULL)) != NULL)
{
pdp = (PubdescPtr)(vnp->data.ptrvalue); /* it's a Pubdesc */
tpub.data.ptrvalue = pdp->pub; /* make Pub-equiv into a Pub */
PubWrite(accession, &tpub, fp);
}
sfp = NULL;
while ((sfp = BioseqContextGetSeqFeat(bcp, 0, sfp, NULL, 0)) != NULL)
{
if (sfp->data.choice == 6) /* a pub feature */
{
pdp = (PubdescPtr)(sfp->data.value.ptrvalue);
tpub.data.ptrvalue = pdp->pub;
PubWrite(accession, &tpub, fp);
}
/* get any feature citations */
if (sfp->cit != NULL)
{
for (vnp = sfp->cit->data.ptrvalue; vnp != NULL; vnp = vnp->next)
PubWrite(accession, vnp, fp);
}
}
BioseqContextFree(bcp);
return;
}
/*****************************************************************************
*
* SeqEntryToFeat()
* This set of routines finds features (in this case CdRegion) and prints
* the part of the sequence that they cover
*
*****************************************************************************/
#define CHARSPERLINE 50
typedef struct expstruct {
FILE *fp; /* file to write sequence to */
AsnIoPtr aip;
Boolean is_na; /* target sequence nucleic acid? */
Uint1 feat; /* type of feature to find */
} ExpStruct, PNTR ExpStructPtr;
static void PrintSequence PROTO((BioseqPtr bsp, SeqFeatPtr sfp,
FILE *fp, Boolean is_na));
static void LIBCALLBACK GetSeqFeat PROTO((AsnExpOptStructPtr aeosp));
static void SeqEntryToFeat (SeqEntryPtr sep, FILE *fp)
{
AsnExpOptPtr aeop;
AsnIoPtr aip;
ExpStructPtr esp;
if (sep != NULL && fp != NULL) {
esp = MemNew (sizeof (ExpStruct));
if (esp != NULL) {
aip = AsnIoNullOpen ();
if (aip != NULL) {
esp->fp = fp;
esp->aip = AsnIoNew (ASNIO_TEXT_OUT, fp, NULL, NULL, NULL);
esp->is_na = is_na;
esp->feat = 3; /* look for CdRegion SeqFeat */
aeop = AsnExpOptNew (aip, "Seq-feat", (Pointer) esp, GetSeqFeat);
if (aeop != NULL) {
SeqEntryAsnWrite (sep, aip, NULL);
fflush (fp);
AsnExpOptFree (aip, aeop);
}
AsnIoClose (aip);
}
MemFree (esp);
}
}
}
static void PrintSequence (BioseqPtr bsp, SeqFeatPtr sfp,
FILE *fp, Boolean is_na)
{
Char buffer [255];
Uint1 code;
Int2 count;
Uint1 repr;
Uint1 residue;
SeqPortPtr spp;
CharPtr title;
CharPtr tmp;
if (bsp != NULL && fp != NULL) {
if ((Boolean) ISA_na (bsp->mol) == is_na) {
repr = Bioseq_repr (bsp);
if (repr == Seq_repr_raw || repr == Seq_repr_const) {
title = BioseqGetTitle (bsp);
tmp = StringMove (buffer, ">");
tmp = SeqIdPrint (bsp->id, tmp, PRINTID_FASTA_LONG);
tmp = StringMove (tmp, " ");
StringNCpy (tmp, title, 200);
fprintf (fp, "%s\n", buffer);
if (pmon != NULL)
MonitorStrValue(pmon, buffer);
if (is_na) {
code = Seq_code_iupacna;
} else {
code = Seq_code_iupacaa;
}
if (sfp != NULL) {
spp = SeqPortNewByLoc (sfp->location, code);
} else {
spp = SeqPortNew (bsp, 0, -1, 0, code);
}
if (spp != NULL) {
count = 0;
while ((residue = SeqPortGetResidue (spp)) != SEQPORT_EOF) {
if (! IS_residue (residue)) {
buffer [count] = '\0';
fprintf (fp, "%s\n", buffer);
count = 0;
switch (residue) {
case SEQPORT_VIRT :
fprintf (fp, "[Gap]\n");
break;
case SEQPORT_EOS :
fprintf (fp, "[EOS]\n");
break;
default :
fprintf (fp, "[Invalid Residue]\n");
break;
}
} else {
buffer [count] = residue;
count++;
if (count >= CHARSPERLINE) {
buffer [count] = '\0';
fprintf (fp, "%s\n", buffer);
count = 0;
}
}
}
if (count != 0) {
buffer [count] = '\0';
fprintf (fp, "%s\n", buffer);
}
SeqPortFree (spp);
}
}
}
}
}
static void LIBCALLBACK GetSeqFeat (AsnExpOptStructPtr aeosp)
{
BioseqPtr bsp;
ExpStructPtr esp;
SeqFeatPtr sfp;
if (aeosp->dvp->intvalue == START_STRUCT) {
esp = (ExpStructPtr) aeosp->data;
sfp = (SeqFeatPtr) aeosp->the_struct;
if (esp != NULL && esp->fp != NULL && sfp != NULL &&
sfp->data.choice == esp->feat) {
bsp = BioseqFind (SeqLocId (sfp->location));
if (bsp != NULL) {
PrintSequence (bsp, sfp, esp->fp, esp->is_na);
}
}
}
}
/*****************************************************************************
*
* These are the rest of the utility routines for reading the CDROM.
*
*****************************************************************************/
/*****************************************************************************
*
* opens a file and reads SeqEntrys
* calls ProcessSeqEntry to do the actual work on it
*
*****************************************************************************/
static void ProcessFile (FileListPtr flp, CharPtr root, CharPtr outputfile)
{
CASN_Handle casnh;
FILE *fp;
Char path [PATH_MAX];
SeqEntryPtr sep;
CASN_Type type;
Char buf[40];
Int4 ctr = 0;
if (flp != NULL) {
fp = FileOpen (outputfile, "a");
if (fp != NULL) {
if (pmon != NULL)
{
sprintf(path, "Opening [%s]", flp->fname);
MonitorStrValue(pmon, path);
}
StringCpy (path, root);
FileBuildPath (path, flp->fdir, NULL);
FileBuildPath (path, NULL, flp->fname);
if ((casnh = CASN_Open (path)) != NULL) {
if (! is_na) {
type = CASN_Type_aa;
} else {
type = CASN_Type_nt;
}
if (CASN_DocType (casnh) == type) {
while ((sep = CASN_NextSeqEntry (casnh)) != NULL) {
if (pmon != NULL)
{
ctr++;
sprintf(buf, "Processing %s Entry %ld", flp->fname,(long)ctr);
MonitorStrValue(pmon, buf);
}
ProcessSeqEntry (sep, fp);
SeqEntryFree (sep);
}
}
CASN_Close (casnh);
}
else
Message(MSG_ERROR, "Can't open [%s]", path);
FileClose (fp);
} else {
Message (MSG_FATAL, "Unable to reopen output file [%s]", outputfile);
}
}
}
/*****************************************************************************
*
* Mounts the appropriate cdrom
* Calls ProcessFile to Open and read through the file
*
*****************************************************************************/
static void ProcessFileList (FileListPtr flp, CharPtr outputfile)
{
Int2 device;
FileListPtr next;
Char root [PATH_MAX];
if (flp != NULL) {
root [0] = '\0';
device = flp->cdnum;
flp = flp->next;
while (flp != NULL) {
next = flp->next;
if (device != flp->cdnum) {
if (! CdMountEntrezVolume (flp->cdnum, root, sizeof (root))) {
Message (MSG_FATAL, "CdMountEntrezVolume failed");
root [0] = '\0';
}
}
ProcessFile (flp, root, outputfile);
device = flp->cdnum;
flp = next;
}
}
}
/*****************************************************************************
*
* Add a new file list element
*
*****************************************************************************/
static FileListPtr FileListNew (FileListPtr flp, Int2 cdnum,
CharPtr fdir, CharPtr fname)
{
FileListPtr newnode;
newnode = (FileListPtr) MemNew (sizeof (FileList));
if (newnode != NULL) {
if (flp != NULL) {
while (flp->next != NULL && flp->next->cdnum <= cdnum) {
flp = flp->next;
}
newnode->next = flp->next;
flp->next = newnode;
}
newnode->cdnum = cdnum;
if (fdir != NULL && *fdir != '\0') {
newnode->fdir = StringSave (fdir);
}
if (fname != NULL && *fname != '\0') {
newnode->fname = StringSave (fname);
}
}
return newnode;
}
/*****************************************************************************
*
* Get all appropriate files to search
*
*****************************************************************************/
static Boolean LIBCALLBACK EnumerateFiles (int cdnum, const char *fdir,
const char *fname, long fsize,
void *opaque_data)
{
FileListPtr flp;
FileListPtr PNTR head;
head = (FileListPtr PNTR) opaque_data;
flp = NULL;
if (head != NULL) {
flp = FileListNew (*head, (Int2) cdnum, (CharPtr) fdir, (CharPtr) fname);
if (*head == NULL) {
*head = flp;
}
} else {
flp = FileListNew (NULL, (Int2) cdnum, (CharPtr) fdir, (CharPtr) fname);
}
return TRUE;
}
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