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/* asn2ff4.c
* ===========================================================================
*
* PUBLIC DOMAIN NOTICE
* National Center for Biotechnology Information (NCBI)
*
* This software/database is a "United States Government Work" under the
* terms of the United States Copyright Act. It was written as part of
* the author's official duties as a United States Government employee and
* thus cannot be copyrighted. This software/database is freely available
* to the public for use. The National Library of Medicine and the U.S.
* Government do not place any restriction on its use or reproduction.
* We would, however, appreciate having the NCBI and the author cited in
* any work or product based on this material
*
* Although all reasonable efforts have been taken to ensure the accuracy
* and reliability of the software and data, the NLM and the U.S.
* Government do not and cannot warrant the performance or results that
* may be obtained by using this software or data. The NLM and the U.S.
* Government disclaim all warranties, express or implied, including
* warranties of performance, merchantability or fitness for any particular
* purpose.
*
* ===========================================================================
*
* File Name: asn2ff4.c
*
* Author: Karl Sirotkin, Tom Madden, Tatiana Tatusov
*
* Version Creation Date: 7/15/95
*
* $Revision: 6.51 $
*
* File Description:
*
* Modifications:
* --------------------------------------------------------------------------
* Date Name Description of modification
* ------- ---------- -----------------------------------------------------
*
*
* ==========================================================================
*/
/*************************************
*
=======
* $Log: asn2ff4.c,v $
* Revision 6.51 2001/10/02 16:13:15 yaschenk
* GetSeqIdForGI returns SeqIdDup() - needs freeing
*
* Revision 6.50 2001/09/06 19:15:19 yaschenk
* removing memory leak - AsnIoMemCopy is done twice
*
* Revision 6.49 2001/09/05 23:31:34 tatiana
* synonym is added to Genestruct with choice 1
*
* Revision 6.48 2001/08/07 16:49:41 kans
* use NUM_SEQID, added third party annotation SeqIDs to one more place
*
* Revision 6.47 2001/08/07 15:51:08 kans
* use NUM_SEQID, added third party annotation seqids
*
* Revision 6.46 2001/07/18 14:50:13 kans
* gather features with gsc.useSeqMgrIndexes if genpept, raw, indexing requested, and IndexedGetDescrForDiv to speed up finding division
*
* Revision 6.45 2001/06/26 20:41:16 kans
* FlatLocPoint as last resort prints gi|#####
*
* Revision 6.44 2001/06/25 19:18:13 kans
* get_feats SEQFEAT_CDREGION finds core without changing scope, if using indexes it indexes the entity if necessary, never goes to old gather code
*
* Revision 6.43 2001/04/12 22:48:52 yaschenk
* removing excessive ObjMgr calls
*
* Revision 6.42 2001/04/05 21:44:51 tatiana
* additional synonym in GeneRefInfoToGsp()
*
* Revision 6.41 2001/02/01 23:06:32 tatiana
* check for NULL added in MatchNAGeneToFeat
*
* Revision 6.40 2001/01/19 17:32:23 yaschenk
* Removed BioseqLockById when only GetSeqIdForGI is needed
*
* Revision 6.39 2000/12/05 22:24:34 tatiana
* bug fixed in FeatMatch
*
* Revision 6.38 2000/11/21 20:52:44 tatiana
* fixes in CreateImpFeatFromProt
*
* Revision 6.37 2000/11/02 01:53:07 tatiana
* static CompXref() added in FeatMatch
*
* Revision 6.36 2000/06/05 17:52:18 tatiana
* increase size of feature arrays to Int4
*
* Revision 6.35 2000/04/13 14:17:32 ostell
* fixed support for lim->tr. FlatLocHalfCaret alwasy assume lim->tl
*
* Revision 6.34 2000/04/03 23:28:19 tatiana
* added showSeqLoc for web feature view
*
* Revision 6.33 2000/01/21 17:17:52 kans
* MatchAAGeneToFeat now calls SeqMgrGetOverlappingGene on CDS first, avoids multiple targeted gathers, just like MatchNAGeneToFeat has done since feature indexing was first implemented
*
* Revision 6.32 1999/12/22 22:08:19 tatiana
* strand check fixed
*
* Revision 6.31 1999/12/13 19:51:47 tatiana
* Seq_strand_unknown added to strand check
*
* Revision 6.30 1999/12/09 14:33:07 tatiana
* check the starnd for mapping gene
*
* Revision 6.29 1999/11/05 14:55:53 tatiana
* check foe embl_feat added the get_feats in Gather
*
* Revision 6.28 1999/10/07 15:17:20 bazhin
* Bug fixed.
*
* Revision 6.27 1999/10/06 20:21:50 bazhin
* Removed memory leak in get_feats() function.
*
* Revision 6.26 1999/06/04 21:03:52 tatiana
* a bug fixed in MatchAAGeneToFeat()
*
* Revision 6.25 1999/04/29 22:49:20 tatiana
* added REFSEQ dbxrefs in GenPept format
*
* Revision 6.24 1999/03/30 22:23:33 kans
* pseudo can be on grp or sfp
*
* Revision 6.23 1999/03/30 19:47:40 tatiana
* use non-strict binding for REFSEQ
*
* Revision 6.22 1999/03/25 00:26:38 kans
* restored first sort in SortOrganizeFeat
*
* Revision 5.31 1997/06/19 18:37:07 vakatov
* [WIN32,MSVC++] Adopted for the "NCBIOBJ.LIB" DLL'ization
*
* Revision 5.30 1997/04/25 15:35:39 tatiana
* EMBL_PREFNUM added
*
* Revision 5.29 1997/03/13 17:58:27 tatiana
* *** empty log message ***
*
* Revision 5.28 1997/02/27 16:20:23 kans
* check for sfp != NULL in UniqueGeneName
*
* Revision 5.27 1997/01/27 19:14:39 tatiana
* *** empty log message ***
*
* Revision 5.25 1997/01/13 23:27:10 tatiana
* added check for NULL in UniqueGeneNames()
*
* Revision 5.24 1997/01/13 22:32:48 tatiana
* *** empty log message ***
*
* Revision 5.23 1997/01/13 21:44:50 tatiana
* a bug fixed in CreateImpFeatFromProt()
*
* Revision 5.22 1997/01/06 19:55:22 tatiana
* convert site and bond features to dna misc features
*
* Revision 5.21 1997/01/02 22:50:19 tatiana
* *** empty log message ***
*
* Revision 5.20 1996/12/17 22:49:02 tatiana
* StoreFeat() changed to StoreFeatFree for converted peptide feats
*
* Revision 5.19 1996/10/22 17:48:33 tatiana
* check for right-truncated genes added in get_feats callback
*
* Revision 5.17 1996/09/27 22:07:05 tatiana
* no gene binding to repeat_region feature
*
* Revision 5.16 1996/09/25 18:06:23 tatiana
* SEQFEAT_COMMENT is stored in a generic feature list
*
* Revision 5.15 1996/09/17 14:59:40 tatiana
* error msg for identical feats added
*
* Revision 5.14 1996/09/13 17:01:31 kans
* feature field is now excpt, not except, and removed extraneous line
*
* Revision 5.13 1996/09/13 16:48:54 tatiana
* except and exp_ev added in CreateImpFeatFromProt
*
* Revision 5.11 1996/09/13 16:26:55 kans
* get_feats can NULL out sfp, so should test before dereferencing
*
* Revision 5.10 1996/09/12 17:52:53 tatiana
* less peptide fets were missing some qualifiers
*
* Revision 5.9 1996/09/03 19:52:00 tatiana
* extra_loc added in StoreFeat
*
* Revision 5.8 1996/08/06 20:30:46 kans
* SeqIdFindBest called to handle local IDs and genbank IDs coexisting
*
* Revision 5.7 1996/07/30 19:20:44 tatiana
* Don't bind gene to gene in MatchNAToGene()
*
* Revision 5.6 1996/07/30 16:37:16 tatiana
* a bug fixed in UniqueFeat()
*
* Revision 5.5 1996/07/23 22:34:11 tatiana
* prot feats in genpept (piptides)
*
* Revision 5.4 1996/07/16 15:45:24 tatiana
* *** empty log message ***
*
* Revision 5.3 1996/07/02 18:10:50 tatiana
* calculate hash in StoreFeat
*
* Revision 5.2 1996/06/11 17:05:59 tatiana
* *** empty log message ***
*
* Revision 5.1 1996/06/11 15:44:00 tatiana
* Support Prot-ref feature mapping
*
* Revision 4.12 1996/05/16 20:59:50 tatiana
* RemoveRedundantFeats addded
*
* Revision 4.11 1996/03/25 15:21:24 tatiana
* *** empty log message ***
*
* Revision 4.10 1996/03/08 15:03:19 tatiana
* don't bind gene to boisource feature
* a bug fixed in FlatLocPoint
*
* Revision 4.9 1996/03/04 17:11:20 ostell
* added support for ignore_top features
*
* Revision 4.8 1996/02/28 04:53:06 ostell
* changes to support segmented master seeuquences
*
* Revision 4.7 1996/02/15 15:53:43 tatiana
* Gather for temp loaded items added
*
* Revision 4.6 1996/01/29 22:35:36 tatiana
* *** empty log message ***
*
* Revision 4.5 1995/12/20 22:40:55 tatiana
* GetDBXrefFromGene() added
*
* Revision 4.4 1995/11/22 19:14:03 tatiana
* a bug fixed for GenPept
*
* Revision 4.3 1995/11/22 19:01:07 tatiana
* a bug fixed in orphan genes printing
*
* Revision 4.2 1995/11/17 21:28:35 kans
* asn2ff now uses gather (Tatiana)
*
* Revision 4.1 1995/08/01 14:52:03 tatiana
* change SeqIdPrint to SeqIdWrite.
*
* Revision 1.15 1995/07/17 19:33:20 kans
* parameters combined into Asn2ffJobPtr structure
*
* Revision 1.14 1995/06/19 21:40:02 kans
* Tatiana's first major reorganization, moving printing, adding HTML
*
* Revision 1.13 1995/05/15 21:46:05 ostell
* added Log line
*
*
**************************************/
#include <asn2ffp.h>
#include <a2ferrdf.h>
#include <gather.h>
#include <asn2ff6.h>
#include <explore.h>
#define CTX_2GB_LOCATION_TROUBLE 0
#define CTX_2GB_NOT_IMPLEMENTED 1
/******************** Function Prototypes *********************************/
NLM_EXTERN CharPtr FlatLocHalf PROTO ((CharPtr buf, Int4 base, IntFuzzPtr fuzz));
NLM_EXTERN CharPtr FlatLocHalfCaret PROTO ((CharPtr buf, Int4 base, IntFuzzPtr fuzz));
NLM_EXTERN Boolean FlatLocPoint PROTO ((SeqIdPtr pointIdPtr, SeqIdPtr this_sidp, CharPtr piecebuf, Int4 point, IntFuzzPtr pointfuzzPtr));
NLM_EXTERN Boolean FlatLocCaret PROTO ((SeqIdPtr pointIdPtr, SeqIdPtr this_sidp, CharPtr piecebuf, Int4 point, IntFuzzPtr pointfuzzPtr));
NLM_EXTERN Boolean FlatVirtLoc PROTO ((BioseqPtr bsp, ValNodePtr location));
NLM_EXTERN Boolean FlatLocElement PROTO ((BioseqPtr bsp, ValNodePtr location, CharPtr buf));
NLM_EXTERN CharPtr complement_FlatLoc PROTO ((SeqIdPtr this_sidp, Boolean PNTR is_okPt, CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, BioseqPtr bsp, ValNodePtr location));
NLM_EXTERN CharPtr FlatSmartStringMove PROTO ((CharPtr total_buf, Int4Ptr lengthPt, CharPtr temp, CharPtr string));
NLM_EXTERN Boolean FlatNullAhead PROTO ((BioseqPtr bsp, ValNodePtr location));
NLM_EXTERN CharPtr FlatPackedPoint PROTO ((CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, PackSeqPntPtr pspp, SeqIdPtr this_sidp));
NLM_EXTERN CharPtr do_FlatLoc PROTO ((Boolean PNTR is_okPt, Boolean ok_to_complement, SeqIdPtr this_sidp, CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, BioseqPtr bsp, ValNodePtr location));
NLM_EXTERN CharPtr group_FlatLoc PROTO ((SeqIdPtr this_sidp, Boolean PNTR is_okPt, int which, CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, BioseqPtr bsp, ValNodePtr location));
NLM_EXTERN Boolean is_real_id PROTO ((SeqIdPtr pointIdPtr, SeqIdPtr this_sidp));
NLM_EXTERN void Bond PROTO ((SeqBondPtr bondp, SeqIdPtr this_sidp, CharPtr buf));
NLM_EXTERN Boolean LookForFuzz PROTO ((SeqLocPtr head));
/*************************************************************************/
/*--- the number of characters per location element is less
than 130. The maximum would be for a bond with both accessions
and both with (n.m) locations.
----*/
#define MAX_CHAR_LOCATION 135
static CharPtr lim_str [5] = {"", ">","<", ">", "<"};
/*----------- FlatLocHalf ()------*/
NLM_EXTERN CharPtr FlatLocHalf
(CharPtr buf, Int4 base, IntFuzzPtr fuzz)
{
char localbuf [30];
Uint1 index;
/*------
typedef struct intfuzz {
Uint1 choice; 1=p-m, 2=range, 3=pct, 4=lim
Int4 a, b; a=p-m,max,pct,orlim, b=min
} IntFuzz, PNTR IntFuzzPtr;
Int-fuzz ::= CHOICE {
p-m INTEGER , -- plus or minus fixed amount
range SEQUENCE { -- max to min
max INTEGER ,
min INTEGER } ,
pct INTEGER , -- % plus or minus (x10) 0-1000
lim ENUMERATED { -- some limit value
unk (0) , -- unknown
gt (1) , -- greater than
lt (2) , -- less than
tr (3) , -- space to right of position
tl (4) , -- space to left of position
other (255) } } -- something else
-------*/
localbuf[0] = '\0';
buf[0] = '\0';
if (fuzz){
/* Fuzz_found = TRUE; */
switch (fuzz -> choice){
case 1:
sprintf(localbuf,"(%ld.%ld)", (long) (base - fuzz -> a),
(long) (base + fuzz -> a));
break;
case 2:
sprintf(localbuf,"(%ld.%ld)", (long) (1+fuzz -> b),
(long) (1+fuzz -> a));
break;
case 3:
sprintf(localbuf,"(%ld.%ld)",
(long) (base - base* ((double) fuzz -> a/1000.0 )),
(long) (base +base*( (double) fuzz -> a/1000.0 )));
break;
case 4:
index = (Uint1) fuzz -> a;
if (index > 4) index = 0;
sprintf(localbuf,"%s%ld", lim_str[index], (long) base);
break;
default:
sprintf(localbuf,"%ld", (long) base);
}
} else {
sprintf(localbuf,"%ld", (long) base);
}
StringMove(buf, localbuf);
return buf;
}
/*----------- FlatLocHalfCaret ()------*/
NLM_EXTERN CharPtr FlatLocHalfCaret
(CharPtr buf, Int4 base, IntFuzzPtr fuzz)
{
char localbuf [30];
Uint1 index;
localbuf[0] = '\0';
buf[0] = '\0';
if (fuzz){
/* Fuzz_found = TRUE; */
switch (fuzz -> choice){
case 1:
sprintf(localbuf,"(%ld.%ld)..(%ld.%ld)",
(long) (base - fuzz -> a), (long) base, (long) base,
(long) (base + fuzz -> a));
break;
case 2:
sprintf(localbuf,"%ld^%ld", (long) (1+fuzz -> b),
(long) (1+fuzz -> a));
break;
case 3:
sprintf(localbuf,"%ld^%ld",
(long) (base - base* ((double) fuzz -> a/1000.0 )),
(long) (base +base*( (double) fuzz -> a/1000.0 )));
break;
case 4:
if (fuzz->a == 3) /* space to right */
{
sprintf(localbuf, "%ld^%ld", (long)(base), (long)(base+1));
}
else if ((fuzz->a == 4) && (base > 1)) /* space to left */
{
sprintf(localbuf, "%ld^%ld", (long)(base-1), (long)(base));
}
else{
index = (Uint1) fuzz -> a;
if (index > 4) index = 0;
sprintf(localbuf,"%s%ld",
lim_str[index], (long) base);
}
break;
default:
sprintf(localbuf,"%ld", (long) base);
break;
}
}else{
sprintf(localbuf,"%ld", (long) base);
}
StringMove(buf, localbuf);
return buf;
}
NLM_EXTERN Boolean FlatLocPoint (SeqIdPtr pointIdPtr, SeqIdPtr this_sidp, CharPtr piecebuf, Int4 point, IntFuzzPtr pointfuzzPtr)
/* FLATLOC_CONTEXT_LOC is removed 08.31.95 */
{
SeqIdPtr use_id,free_seqid=NULL;
Char buf_space[MAX_CHAR_LOCATION +1], halfbuf_space[MAX_CHAR_LOCATION +1];
CharPtr buf, halfbuf, temp;
static Boolean order_initialized = FALSE;
static Uint1 order[NUM_SEQID];
ObjectIdPtr ob;
if ( ! order_initialized){
int dex;
for (dex=0; dex < NUM_SEQID; dex ++)
order[dex] = 255;
order_initialized = TRUE;
order[SEQID_GENBANK ] = 1;
order[SEQID_EMBL ] = 2;
order[SEQID_DDBJ ] = 3;
order[SEQID_LOCAL ] =4;
order[SEQID_OTHER ] =5;
order[SEQID_TPG ] = 6;
order[SEQID_TPE ] = 7;
order[SEQID_TPD ] = 8;
order[SEQID_GIBBSQ ] =9;
order[SEQID_GIBBMT ] =10;
order[SEQID_PRF ] =11;
order[SEQID_PDB ] =12;
order[SEQID_PIR ] =13;
order[SEQID_SWISSPROT ] =14;
order[SEQID_PATENT ] =15;
order[SEQID_GI ] =16;
order[SEQID_GENERAL ] =17;
order[SEQID_GIIM ] =18;
}
buf = buf_space;
halfbuf = halfbuf_space;
piecebuf[0] = '\0';
buf[0] = '\0';
temp = buf;
if (pointIdPtr) {
if ( ! SeqIdIn ( pointIdPtr, this_sidp)){
if (pointIdPtr->choice == SEQID_GI) {
free_seqid = use_id = GetSeqIdForGI(pointIdPtr->data.intvalue); /** returns SeqIdDup **/
} else {
use_id = pointIdPtr;
}
SeqIdWrite( use_id, buf, PRINTID_TEXTID_ACC_VER, MAX_CHAR_LOCATION);
if(*buf == '\0') {
SeqIdWrite(use_id, buf,PRINTID_FASTA_LONG, MAX_CHAR_LOCATION);
}
if (*buf == '\0' && use_id == NULL && pointIdPtr->choice == SEQID_GI) {
SeqIdWrite (pointIdPtr, buf, PRINTID_FASTA_LONG, MAX_CHAR_LOCATION);
}
if (*buf == '\0') {
StringCpy(buf,"?00000");
if (use_id && use_id -> choice == SEQID_LOCAL){
ob = (ObjectIdPtr) use_id -> data.ptrvalue;
if (ob ->str) {
if (*ob -> str) {
StringNCpy(buf, ob ->str, 12);
}
}
}
}
temp = StringMove (temp, buf);
temp = StringMove(temp,":");
}
}
FlatLocHalf(halfbuf, point+1, pointfuzzPtr);
temp = StringMove(temp, halfbuf);
StringMove(piecebuf, buf);
if(free_seqid) SeqIdFree(free_seqid);
return TRUE;
}
NLM_EXTERN Boolean FlatLocCaret
(SeqIdPtr pointIdPtr, SeqIdPtr this_sidp, CharPtr piecebuf, Int4 point, IntFuzzPtr pointfuzzPtr)
{
BioseqPtr bs;
Char buf_space[MAX_CHAR_LOCATION +1], halfbuf_space[MAX_CHAR_LOCATION +1];
CharPtr buf, halfbuf, temp;
SeqIdPtr use_id;
static Boolean order_initialized = FALSE;
static Uint1 order[NUM_SEQID];
if ( ! order_initialized){
int dex;
for (dex=0; dex < NUM_SEQID; dex ++)
order[dex] = 255;
order_initialized = TRUE;
order[SEQID_GENBANK ] = 1;
order[SEQID_EMBL ] = 2;
order[SEQID_DDBJ ] = 3;
order[SEQID_LOCAL ] =4;
order[SEQID_OTHER ] =5;
order[SEQID_TPG ] = 6;
order[SEQID_TPE ] = 7;
order[SEQID_TPD ] = 8;
order[SEQID_GIBBSQ ] =9;
order[SEQID_GIBBMT ] =10;
order[SEQID_PRF ] =11;
order[SEQID_PDB ] =12;
order[SEQID_PIR ] =13;
order[SEQID_SWISSPROT ] =14;
order[SEQID_PATENT ] =15;
order[SEQID_GI ] =16;
order[SEQID_GENERAL ] =17;
order[SEQID_GIIM ] =18;
}
buf = &(buf_space[0]);
halfbuf = &(halfbuf_space[0]);
piecebuf[0] = '\0';
buf[0] = '\0';
temp = buf;
if (pointIdPtr)
if ( ! SeqIdIn ( pointIdPtr, this_sidp)){
use_id = pointIdPtr;
bs = BioseqFind(use_id);
if ( bs ){
use_id = SeqIdSelect ( bs -> id, order,NUM_SEQID);
}
SeqIdWrite( use_id, buf, PRINTID_TEXTID_ACC_VER, MAX_CHAR_LOCATION);
temp = StringMove (temp, buf);
temp = StringMove(temp,":");
}
FlatLocHalfCaret(halfbuf, point+1, pointfuzzPtr);
temp = StringMove(temp, halfbuf);
StringMove(piecebuf, buf);
return TRUE;
}
NLM_EXTERN Boolean FlatVirtLoc(BioseqPtr bsp, ValNodePtr location)
{
Boolean retval = FALSE;
SeqIntPtr sintp;
BioseqPtr this_bsp=NULL;
SeqIdPtr this_sidp=NULL, sidp = NULL;
SeqPntPtr spp;
this_bsp = bsp;
this_sidp = this_bsp -> id;
switch ( location -> choice){
case SEQLOC_MIX:
case SEQLOC_EQUIV:
case SEQLOC_PACKED_INT:
case SEQLOC_PACKED_PNT:
case SEQLOC_NULL:
break;
case SEQLOC_EMPTY:
break;
case SEQLOC_WHOLE:
sidp = (SeqIdPtr) location -> data.ptrvalue;
if (! sidp){
if (ASN2FF_SHOW_ERROR_MSG == TRUE)
ErrPostEx(SEV_INFO, CTX_NCBI2GB,CTX_2GB_LOCATION_TROUBLE,
"FlatLocElement: whole location without ID:");
retval = TRUE;
break;
}
/*--- no break on purpose ---*/
case SEQLOC_INT:
if ( location -> choice == SEQLOC_INT){
sintp = (SeqIntPtr) location -> data.ptrvalue;
sidp = sintp-> id;
}
if ( ! is_real_id(sidp, this_sidp)){
retval = TRUE;
}
break;
case SEQLOC_PNT:
spp = (SeqPntPtr) ( location -> data.ptrvalue);
if ( ! is_real_id(spp-> id, this_sidp)){
retval = TRUE;
}
break;
case SEQLOC_BOND:
break;
case SEQLOC_FEAT:
/*if ( ! (Flat_Be_quiet&1))*/
if (ASN2FF_SHOW_ERROR_MSG == TRUE)
ErrPostEx(SEV_INFO, CTX_NCBI2GB, CTX_2GB_NOT_IMPLEMENTED,
"FlatVirtLoc:SEQLOC_FEAT not implemented");
break;
}
return retval;
}
NLM_EXTERN Boolean FlatLocElement (BioseqPtr bsp, ValNodePtr location, CharPtr buf)
{
Char localbuf_space[MAX_CHAR_LOCATION +1], piecebuf_space[MAX_CHAR_LOCATION +1];
CharPtr localbuf , piecebuf ;
CharPtr temp ;
SeqIntPtr sintp;
SeqPntPtr spp;
SeqIdPtr this_sidp=NULL, sidp=NULL;
SeqIntPtr whole_intPtr =NULL;
Boolean retval=TRUE;
Boolean whole_trouble;
localbuf = &(localbuf_space[0]);
piecebuf = &(piecebuf_space[0]);
temp = localbuf;
this_sidp = bsp->id;
sidp = this_sidp;
localbuf[0] = '\0';
buf[0] = '\0';
switch ( location -> choice){
case SEQLOC_MIX:
case SEQLOC_EQUIV:
case SEQLOC_PACKED_INT:
case SEQLOC_PACKED_PNT:
case SEQLOC_NULL:
if (ASN2FF_SHOW_ERROR_MSG == TRUE)
ErrPostEx(SEV_INFO, CTX_NCBI2GB,CTX_2GB_LOCATION_TROUBLE,
"Unexpected internal complex type");
retval = FALSE;
break;
case SEQLOC_EMPTY:
break;
case SEQLOC_WHOLE:
whole_trouble=TRUE;
sidp = (SeqIdPtr) location -> data.ptrvalue;
if (sidp){
bsp = BioseqFind(sidp);
if (bsp) {
sintp = whole_intPtr = MemNew( sizeof(SeqInt) );
whole_intPtr -> id = sidp;
whole_intPtr -> from = 0;
whole_intPtr -> to = -1;
if ( bsp -> length > 0)
{
whole_intPtr -> to = bsp -> length -1 ;
whole_trouble=FALSE;
}
}
}
if (whole_trouble) {
if (ASN2FF_SHOW_ERROR_MSG == TRUE) {
ErrPostEx(SEV_INFO, CTX_NCBI2GB,CTX_2GB_LOCATION_TROUBLE,
"FlatLocElement: whole location without being able to look up limits: %s",
sidp?SeqIdWrite (sidp, localbuf, PRINTID_FASTA_LONG,
MAX_CHAR_LOCATION):"No Id");
}
retval = FALSE;
break;
}
/*
else if (whole_trouble) {
SeqIdWrite (sidp, localbuf,
PRINTID_FASTA_LONG, MAX_CHAR_LOCATION);
break;
}
*/
/*--- no break on purpose ---*/
case SEQLOC_INT:
if ( location -> choice == SEQLOC_INT){
sintp = (SeqIntPtr) location -> data.ptrvalue;
}
if (is_real_id(sintp-> id, this_sidp)){
if (sintp -> strand == 2) /* minus strand */
temp = StringMove(temp, "complement("); /* ) vi match */
FlatLocPoint (sintp->id, this_sidp, piecebuf,
sintp -> from, sintp -> if_from );
temp = StringMove(temp, piecebuf);
if ( sintp -> to >0 && (sintp -> to != sintp -> from
|| sintp -> if_from || sintp -> if_to )){
temp = StringMove(temp,"..");
FlatLocPoint(NULL, this_sidp, piecebuf,
sintp -> to, sintp -> if_to);
temp = StringMove(temp, piecebuf);
}
if (sintp -> strand == 2) /* minus strand */
/* ( vi match */ temp = StringMove(temp, ")");
}else{
#ifdef VIRTUALS_NOT_TREATED_AS_NULLS
StringCpy(localbuf,"No id");
if (sintp -> id){
SeqIdWrite (sintp -> id, localbuf,
PRINTID_FASTA_LONG, MAX_CHAR_LOCATION);
if (ASN2FF_SHOW_ERROR_MSG == TRUE)
ErrPostEx(SEV_INFO, CTX_NCBI2GB,CTX_2GB_LOCATION_TROUBLE,
"FlatLocElement: interval without being able to use id: %s",
localbuf);
}
retval = FALSE;
#endif
}
break;
case SEQLOC_PNT:
spp = (SeqPntPtr) ( location -> data.ptrvalue);
if (is_real_id(spp-> id, this_sidp)){
if (spp -> strand == 2) /* minus strand */
temp = StringMove(temp, "complement("); /* ) vi match */
if ( spp -> fuzz){
/*--------
* points with fuzz treated as if always come from '^':
* not best, perhaps, but pretty close
*-------*/
FlatLocCaret (spp -> id, this_sidp, piecebuf,
spp -> point, spp -> fuzz );
} else {
FlatLocPoint(spp -> id, this_sidp, piecebuf,
spp -> point, spp -> fuzz );
}
temp = StringMove(temp, piecebuf);
if (spp -> strand == 2) /* minus strand */
/* ( vi match */ temp = StringMove(temp, ")");
} else {
#ifdef VIRTUALS_NOT_TREATED_AS_NULLS
ErrPostEx(SEV_INFO, CTX_NCBI2GB,CTX_2GB_LOCATION_TROUBLE,
"FlatLocElement: point without being able to use id: %s", sidp?SeqIdWrite (sidp, localbuf, PRINTID_FASTA_LONG):"No Id", MAX_CHAR_LOCATION);
retval = FALSE;
#endif
}
break;
case SEQLOC_BOND:
/*
bondp = (SeqBondPtr) location -> data.ptrvalue;
spp = bondp -> a;
FlatLocPoint(spp -> id, this_sidp, piecebuf,
spp -> point, spp -> fuzz );
temp = StringMove(temp, piecebuf);
temp = StringMove(temp,",");
spp = bondp -> b;
FlatLocPoint(NULL, this_sidp, piecebuf, spp -> point, spp -> fuzz );
temp = StringMove(temp, piecebuf);
*/
Bond((SeqBondPtr)location->data.ptrvalue, this_sidp, localbuf);
break;
case SEQLOC_FEAT:
/* if ( ! (Flat_Be_quiet&1)) */
if (ASN2FF_SHOW_ERROR_MSG == TRUE)
ErrPostEx(SEV_INFO, CTX_NCBI2GB, CTX_2GB_NOT_IMPLEMENTED,
"FlatLocElement:SEQLOC_FEAT not implemented");
break;
}
if (whole_intPtr)
MemFree(whole_intPtr); /* NOT object free ! ! ! */
if (! retval){
*buf = '\0';
}else{
StringMove(buf, localbuf);
}
return retval;
}
/****************************************************************************
*Bond
*
* This function takes a SeqBondPtr and a CharPtr, in buf, and returns a
* string, in buf. If both ends of the bond exist, the output
* is bond(a, b); if only one end exists, the output is bond(a).
*
* Tom Madden
*
**************************************************************************/
NLM_EXTERN void Bond(SeqBondPtr bondp, SeqIdPtr this_sidp, CharPtr buf)
{
Char piecebuf1[MAX_CHAR_LOCATION+1];
Char piecebuf2[MAX_CHAR_LOCATION+1];
SeqPntPtr spp;
spp = bondp -> a;
FlatLocPoint(spp -> id, this_sidp, &(piecebuf1[0]),
spp -> point, spp -> fuzz );
if (bondp->b)
{
spp = bondp -> b;
FlatLocPoint(NULL, this_sidp, &(piecebuf2[0]),
spp -> point, spp -> fuzz );
sprintf(buf, "bond(%s,%s)", piecebuf1, piecebuf2);
}
else
{
sprintf(buf, "bond(%s)", piecebuf1);
}
}
/*----------- FlatLoc ()------*/
NLM_EXTERN CharPtr FlatLoc (BioseqPtr bsp, ValNodePtr location)
{
CharPtr retval = NULL;
Int4 max_length, len_used;
Boolean is_ok = TRUE;
SeqIdPtr this_sidp;
if (location){
this_sidp = bsp -> id;
max_length = 0;
do_FlatLoc(& is_ok, TRUE, this_sidp, NULL, NULL,
& max_length, bsp, location);
if (is_ok){
retval = (CharPtr) MemNew((size_t) (max_length + 10));
len_used = 0;
do_FlatLoc(&is_ok, TRUE, this_sidp, retval, retval,
&len_used, bsp, location);
}
}
return retval;
}
/*-------------complement_FlatLoc ()---------------*/
NLM_EXTERN CharPtr
complement_FlatLoc (SeqIdPtr this_sidp, Boolean PNTR is_okPt, CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, BioseqPtr bsp, ValNodePtr location)
{
SeqLocRevCmp(location);
temp = FlatSmartStringMove(total_buf, lengthPt, temp,"complement(");
temp = do_FlatLoc (is_okPt, FALSE, this_sidp, total_buf,
temp, lengthPt, bsp, location);
temp = FlatSmartStringMove(total_buf, lengthPt, temp,")");
SeqLocRevCmp(location);
return temp;
}
/*-------- FlatSmartStringMove()-------*/
NLM_EXTERN CharPtr
FlatSmartStringMove(CharPtr total_buf, Int4Ptr lengthPt, CharPtr temp, CharPtr string)
{
CharPtr retval = temp;
if ( lengthPt){
(*lengthPt) += StringLen(string);
}
if (total_buf){
retval = StringMove(temp,string);
}
return retval;
}
#define FLAT_EQUIV 0
#define FLAT_JOIN 1
#define FLAT_ORDER 2
static CharPtr group_names []= {
"one-of","join","order"};
/*--------- FlatNullAhead()---------*/
NLM_EXTERN Boolean
FlatNullAhead(BioseqPtr bsp, ValNodePtr location)
{
Boolean retval = FALSE;
SeqLocPtr next;
if (location){
next = location -> next;
if (next){
if ( next -> choice == SEQLOC_NULL)
retval = TRUE;
if (FlatVirtLoc(bsp, next))
retval = TRUE;
}else{
retval = TRUE; /* last one always true */
}
}
return retval;
}
/*---------- FlatPackedPoint() -----------*/
NLM_EXTERN CharPtr
FlatPackedPoint (CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, PackSeqPntPtr pspp, SeqIdPtr this_sidp)
{
Char buf_space[MAX_CHAR_LOCATION +1];
CharPtr buf;
int dex;
buf = &(buf_space[0]);
for (dex=0; dex < (int) pspp -> used; dex ++){
FlatLocPoint(pspp -> id, this_sidp, buf, (pspp->pnts)[dex], pspp->fuzz);
temp = FlatSmartStringMove(total_buf, lengthPt, temp,buf);
}
return temp;
}
/*--------- group_FlatLoc ()-----------*/
NLM_EXTERN CharPtr group_FlatLoc (SeqIdPtr this_sidp, Boolean PNTR is_okPt, int which, CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, BioseqPtr bsp, ValNodePtr location)
{
Char buf_space[MAX_CHAR_LOCATION +1];
CharPtr buf;
SeqLocPtr this_loc;
Boolean special_mode = FALSE; /* join in order */
int parens = 1;
Boolean found_non_virt = FALSE;
buf = &(buf_space[0]);
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,group_names[which]);
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,"(");
for (this_loc = (SeqLocPtr) location -> data.ptrvalue;
this_loc && *is_okPt; this_loc = this_loc -> next){
if ( FlatVirtLoc(bsp, this_loc)) {
if ( this_loc != location && this_loc -> next){
if (special_mode ){
special_mode = FALSE;
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,")");
parens --;
}
}
continue;
}
if ( found_non_virt &&
this_loc -> choice != SEQLOC_EMPTY &&
this_loc -> choice != SEQLOC_NULL ){
temp = FlatSmartStringMove(total_buf, lengthPt, temp,",");
}
switch ( this_loc -> choice ){
case SEQLOC_NULL :
if ( this_loc != location && this_loc -> next){
if (special_mode ){
special_mode = FALSE;
temp = FlatSmartStringMove(total_buf, lengthPt, temp,")");
parens --;
}
}
break;
case SEQLOC_EMPTY :
break;
case SEQLOC_WHOLE :
case SEQLOC_PNT :
case SEQLOC_BOND :
case SEQLOC_FEAT :
found_non_virt = TRUE;
if (FlatVirtLoc(bsp, this_loc)){
if ( this_loc != location && this_loc -> next){
if (special_mode ){
special_mode = FALSE;
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,"),");
parens --;
}
}
}else{
if( FlatLocElement(bsp, this_loc, buf)){
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,buf);
}else{
temp = NULL;
* is_okPt = FALSE;
}
}
break;
case SEQLOC_INT :
found_non_virt = TRUE;
if ( which == FLAT_ORDER
&& ! FlatNullAhead(bsp, this_loc)){
special_mode = TRUE;
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,group_names[FLAT_JOIN]);
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,"(");
parens ++;
}
if( FlatLocElement(bsp, this_loc, buf)){
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,buf);
}else{
temp = NULL;
* is_okPt = FALSE;
}
break;
case SEQLOC_PACKED_PNT :
found_non_virt = TRUE;
temp = FlatPackedPoint(total_buf, temp, lengthPt,
(PackSeqPntPtr)this_loc->data.ptrvalue, this_sidp);
break;
case SEQLOC_PACKED_INT :
case SEQLOC_MIX :
case SEQLOC_EQUIV :
{
ValNodePtr hold_next = this_loc -> next;
found_non_virt = TRUE;
this_loc -> next = NULL;
temp = do_FlatLoc(is_okPt, FALSE, this_sidp, total_buf, temp, lengthPt, bsp, this_loc);
this_loc-> next = hold_next;
}
break;
}
}
if (* is_okPt){
while ( parens > 0){
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,")");
parens --;
}
}
return temp;
}
NLM_EXTERN CharPtr
do_FlatLoc (Boolean PNTR is_okPt, Boolean ok_to_complement, SeqIdPtr this_sidp, CharPtr total_buf, CharPtr temp, Int4Ptr lengthPt, BioseqPtr bsp, ValNodePtr location)
{
Char buf_space[MAX_CHAR_LOCATION +1];
CharPtr buf;
SeqLocPtr slp;
SeqLocPtr next_loc = NULL;
buf = &(buf_space[0]);
if (location == NULL) {
return NULL;
}
if ( ok_to_complement &&
SeqLocStrand(location) == Seq_strand_minus ){
temp = complement_FlatLoc (this_sidp, is_okPt, total_buf,
temp, lengthPt, bsp, location);
return temp;
}
for ( slp = location; slp && *is_okPt; slp = slp -> next){
if ( slp -> choice == SEQLOC_NULL ||
FlatVirtLoc(bsp, slp))
continue;
if ( slp != location){
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,",");
}
switch( slp -> choice){
case SEQLOC_NULL:
break;
case SEQLOC_MIX:
case SEQLOC_PACKED_INT:
{
Boolean found_null = FALSE;
for (next_loc = (SeqLocPtr) slp ->
data.ptrvalue; next_loc;
next_loc = next_loc -> next){
if ( next_loc -> choice == SEQLOC_NULL
|| FlatVirtLoc( bsp, next_loc)){
found_null = TRUE;
temp=group_FlatLoc(this_sidp, is_okPt,
FLAT_ORDER, total_buf, temp, lengthPt,
bsp, slp);
break;
}
}
if ( ! found_null){
temp=group_FlatLoc(this_sidp, is_okPt,
FLAT_JOIN, total_buf, temp, lengthPt,
bsp, slp);
}
}
break;
case SEQLOC_EQUIV:
temp=group_FlatLoc(this_sidp, is_okPt,
FLAT_EQUIV, total_buf, temp,
lengthPt, bsp, slp);
break;
case SEQLOC_PACKED_PNT:
temp = FlatPackedPoint(total_buf, temp, lengthPt,
(PackSeqPntPtr)slp->data.ptrvalue, this_sidp);
break;
default:
if ( ! FlatVirtLoc( bsp, slp))
if( FlatLocElement(bsp, slp, buf)){
temp = FlatSmartStringMove(total_buf, lengthPt,
temp,buf);
}else{
temp = NULL;
*is_okPt = FALSE;
}
}
}
return temp;
}
NLM_EXTERN Boolean is_real_id(SeqIdPtr pointIdPtr, SeqIdPtr this_sidp)
{
Boolean retval = TRUE;
BioseqPtr bs;
SeqIdPtr use_id;
if ( ! SeqIdIn ( pointIdPtr, this_sidp)){
use_id = pointIdPtr;
bs = BioseqFind(use_id);
if ( bs ){
if (bs -> repr == Seq_repr_virtual)
retval = FALSE;
}
}
return retval;
}
NLM_EXTERN Boolean FlatAnnotPartial (SeqFeatPtr sfp, Boolean use_product)
{
Boolean fuzz=FALSE, retval = TRUE;
CharPtr str;
ImpFeatPtr imp;
if ( sfp -> data.choice == 8) /* Imp-feat */
{
imp = (ImpFeatPtr) (sfp -> data.value.ptrvalue);
if (imp ->loc != NULL)
for( str = imp -> loc; *str; str ++){
if ( *str == '<' || *str == '>'){
retval = FALSE;
break;
}else if (*str == 'r' && *(str +1) == 'e'){
if (StringNCmp ("replace",str, (size_t) 7) == 0){
retval = FALSE;
break;
}
}
}
if (retval == TRUE) /* Look for fuzz in the ASN.1 location */
{
if (use_product)
fuzz = LookForFuzz (sfp->product);
else
fuzz = LookForFuzz (sfp->location);
if (fuzz == TRUE)
retval = FALSE;
}
}
return retval;
}
/************************************************************************
*Boolean LookForFuzz (SeqLocPtr slp)
*
* Look for fuzz in the location. For use in FlatAnnotPartial.
************************************************************************/
NLM_EXTERN Boolean LookForFuzz (SeqLocPtr head)
{
Boolean retval=FALSE;
IntFuzzPtr ifp;
PackSeqPntPtr pspp;
SeqIntPtr sip;
SeqLocPtr slp;
SeqPntPtr spp;
if (head == NULL)
return retval;
slp=NULL;
while ((slp = SeqLocFindNext(head, slp)) != NULL)
{
switch (slp->choice)
{
case SEQLOC_INT:
sip = (SeqIntPtr)(slp->data.ptrvalue);
ifp = sip->if_from;
if (ifp != NULL)
{
if (ifp->choice == 4)
{
if (ifp->a != 0)
retval=TRUE;
}
else
retval = TRUE;
}
ifp = sip->if_to;
if (ifp != NULL)
{
if (ifp->choice == 4)
{
if (ifp->a != 0)
retval=TRUE;
}
else
retval = TRUE;
}
break;
case SEQLOC_PNT:
spp = (SeqPntPtr)(slp->data.ptrvalue);
ifp = spp->fuzz;
if (ifp != NULL)
{
if (ifp->choice == 4)
{
if (ifp->a != 0)
retval=TRUE;
}
else
retval = TRUE;
}
break;
case SEQLOC_PACKED_PNT:
pspp = (PackSeqPntPtr)(slp->data.ptrvalue);
ifp = pspp->fuzz;
if (ifp != NULL)
{
if (ifp->choice == 4)
{
if (ifp->a != 0)
retval=TRUE;
}
else
retval = TRUE;
}
break;
default:
break;
}
if (retval == TRUE)
break;
}
return retval;
} /* LookForFuzz */
/*****************************************************************************
* modified by Tatiana 12.08.97
* collecting and soritng the features features
*
******************************************************************************/
static OrganizeFeatPtr CreateOrganizeFeat(void)
{
OrganizeFeatPtr ofp;
ofp = (OrganizeFeatPtr) MemNew(sizeof(OrganizeFeat));
MemSet ((Pointer) ofp, 0, sizeof (OrganizeFeat));
return ofp;
}
static void UniqueGeneName(Boolean error_msgs, OrganizeFeatPtr ofp)
{
SortStructPtr newp, p;
SeqFeatPtr sfp;
GeneRefPtr grp;
CharPtr gene;
CharPtr s, ss;
SeqLocPtr slp;
Int4 index, size;
if (ofp == NULL)
return;
if ((size = ofp->sfpGenesize) == 0)
return;
newp = (SortStructPtr) MemNew((size)*sizeof(SortStruct));
newp = MemCopy(newp, ofp->Genelist, (size * sizeof(SortStruct)));
HeapSort((VoidPtr) (newp),
(size_t) (size), sizeof(SortStruct), CompareGeneName);
p = newp;
if ((sfp = p->sfp) == NULL) {
MemFree (newp);
return;
}
slp = sfp->location;
grp = (GeneRefPtr) sfp->data.value.ptrvalue;
gene = grp->locus;
for (index = 1, p++; index < size; index++, p++) {
sfp = p->sfp;
grp = (GeneRefPtr) sfp->data.value.ptrvalue;
if (gene == NULL) {
gene = grp->locus;
slp = sfp->location;
continue;
}
if (error_msgs) {
if (grp->locus == NULL) {
ErrPostEx(SEV_WARNING,ERR_FEATURE_NULLGeneLocus, "No gene locus in %s:", SeqLocPrint(sfp->location));
continue;
}
if (StringCmp(gene, grp->locus) == 0) {
s = SeqLocPrint(slp);
ss = SeqLocPrint(sfp->location);
ErrPostEx(SEV_WARNING, ERR_FEATURE_IdenticalGeneName, "Identical gene locus name [%s] in %s and %s", gene, s, ss);
MemFree(s);
MemFree(ss);
}
}
gene = grp->locus;
slp = sfp->location;
}
MemFree (newp);
return;
}
/*****************************************************************************
* Compare two ImpFeats by name and location
* returns 1 for matching features otherwise returns 0
******************************************************************************/
static CmpImpFeat (ImpFeatPtr f1, ImpFeatPtr f2)
{
if (f1 == NULL && f2)
return 0;
if (f2 == NULL && f1)
return 0;
if (StringCmp(f1->key, f2->key) != 0)
return 0;
if (StringCmp(f1->loc, f2->loc) != 0)
return 0;
return 1;
}
static Int2 CompXref (ValNodePtr x1, ValNodePtr x2)
{
DbtagPtr db1 = NULL, db2;
CharPtr s1=NULL, s2=NULL;
if (x1 == NULL && x2)
return 0;
if (x2 == NULL && x1)
return 0;
db1 = x1->data.ptrvalue;
db2 = x2->data.ptrvalue;
if (StringCmp(db1->db, db2->db) != 0) {
return 0;
}
if (db1->tag && db1->tag->str) {
s1 = db1->tag->str;
}
if (db2->tag && db2->tag->str) {
s2 = db2->tag->str;
}
if (s1 == NULL && s2)
return 0;
if (s2 == NULL && s1)
return 0;
if (s1 && s2) {
if (StringCmp(s1, s2) == 0) {
return 1;
} else {
return 0;
}
} else {
if (db1->tag->id == db2->tag->id) {
return 1;
}
}
return 0;
}
/*****************************************************************************
* compare features by location and choice
*
******************************************************************************/
static Int2 FeatMatch (SeqFeatPtr f1, SeqFeatPtr f2)
{
Int2 retval = 0;
if (f1 == NULL && f2)
return 0;
if (f2 == NULL && f1)
return 0;
if ((SeqLocCompare(f1->location, f2->location)) != SLC_A_EQ_B)
return 0;
if (f1->data.choice != f2->data.choice)
return 0;
switch (f1->data.choice)
{
case SEQFEAT_IMP:
retval =
CmpImpFeat(f1->data.value.ptrvalue, f2->data.value.ptrvalue);
break;
case SEQFEAT_REGION:
if (f1->dbxref != NULL || f2->dbxref != NULL) {
retval = CompXref(f1->dbxref, f2->dbxref);
}
break;
default:
break;
}
return retval;
}
/*****************************************************************************
* mark (with boolean 'dup') identical features in the List
*
******************************************************************************/
static void UniqueFeat(SortStructPtr List, Int4 size)
{
Int4 i, j, jj, ii;
Int4 start;
SortStructPtr p, pp;
for (i = 0, p = List; i < size; i = ii) {
ii = i + 1;
if (p->sfp == NULL) {
continue;
}
start = SeqLocStart(p->sfp->location);
for (pp = p+1; ii < size; ii++, pp++) {
if (pp->sfp == NULL) {
continue;
}
if (start != SeqLocStart(pp->sfp->location)) {
break;
}
}
for (j = i; j < ii; j++, p++) {
for (jj = j+1, pp = p+1; jj < ii; jj++, pp++) {
if (p->hash == pp->hash) {
if (FeatMatch(p->sfp, pp->sfp) == 1) {
pp->dup = TRUE;
}
}
}
}
}
return;
}
/*****************************************************************************
* collect landmarks from map (Gather is not used)
*
******************************************************************************/
NLM_EXTERN Int2 GetMapFeats(Asn2ffJobPtr ajp, GBEntryPtr gbp)
{
BioseqPtr bsp;
SeqFeatPtr sfp;
OrganizeFeatPtr ofp;
if (gbp == NULL || gbp->bsp == NULL) {
return 0;
}
bsp = gbp->bsp;
BioseqLock(bsp);
ofp = CreateOrganizeFeat();
ofp->bsp = bsp;
ofp->useSeqMgrIndexes = ajp->useSeqMgrIndexes;
if (bsp->seq_ext_type == 3) { /* map-ext */
for (sfp = (SeqFeatPtr) bsp->seq_ext; sfp; sfp=sfp->next) {
switch (sfp->data.choice) {
case SEQFEAT_GENE:
ofp->List = EnlargeSortList(ofp->List,
ofp->sfpListsize);
ofp->sfpListsize = StoreFeat(ofp->List, sfp,
ofp->sfpListsize, bsp, NULL, 0, 0, 0, NULL, NULL, 0);
break;
default:
ofp->List = EnlargeSortList(ofp->List,
ofp->sfpListsize);
ofp->sfpListsize = StoreFeat(ofp->List, sfp,
ofp->sfpListsize, bsp, NULL, 0, 0, 0, NULL, NULL, 0);
break;
}
}
}
SortOrganizeFeat(ofp);
gbp->feat = ofp;
if (ofp == NULL) {
return 0;
}
return (gbp->feat->sfpListsize);
}
/*****************************************************************************
* function and activity for proteins
*
******************************************************************************/
static SeqFeatPtr AddProtRefInfo(SeqFeatPtr sfp, ProtRefPtr prot)
{
ValNodePtr vnp;
for (vnp=prot->name; vnp; vnp=vnp->next) {
if (GBQualPresent("product", sfp->qual) == FALSE) {
sfp->qual = AddGBQual(sfp->qual, "product", vnp->data.ptrvalue);
} else {
sfp->qual = AddGBQual(sfp->qual, "note", vnp->data.ptrvalue);
}
}
if (prot->desc) {
sfp->qual = AddGBQual(sfp->qual, "note", prot->desc);
}
for (vnp=prot->ec; vnp; vnp=vnp->next) {
sfp->qual=AddGBQual(sfp->qual, "EC_number", vnp->data.ptrvalue);
}
for (vnp=prot->activity; vnp; vnp=vnp->next) {
sfp->qual=AddGBQual(sfp->qual, "function", vnp->data.ptrvalue);
}
return sfp;
}
/*****************************************************************************
* add site description notes
*
******************************************************************************/
NLM_EXTERN void AddSiteNoteQual(SeqFeatPtr sfp_in, SeqFeatPtr sfp)
{
if (sfp_in == NULL) {
return;
}
if (sfp_in->data.choice != SEQFEAT_SITE) {
return;
}
switch (sfp_in->data.value.intvalue) {
case 1:
sfp->qual = AddGBQual(sfp->qual, "note", "active site");
break;
case 2:
sfp->qual = AddGBQual(sfp->qual, "note", "binding site");
break;
case 3:
sfp->qual = AddGBQual(sfp->qual, "note", "cleavage site");
break;
case 4:
sfp->qual = AddGBQual(sfp->qual, "note", "inhibit site");
break;
case 5:
sfp->qual = AddGBQual(sfp->qual, "note", "modified site");
break;
case 6:
sfp->qual = AddGBQual(sfp->qual, "note", "glycosylation site");
break;
case 7:
sfp->qual = AddGBQual(sfp->qual, "note", "myristoylation site");
break;
case 8:
sfp->qual = AddGBQual(sfp->qual, "note", "mutagenized site");
break;
case 9:
sfp->qual = AddGBQual(sfp->qual, "note", "metal-binding site");
break;
case 10:
sfp->qual = AddGBQual(sfp->qual, "note", "phosphorylation site");
break;
case 11:
sfp->qual = AddGBQual(sfp->qual, "note", "acetylation site");
break;
case 12:
sfp->qual = AddGBQual(sfp->qual, "note", "amidation site");
break;
case 13:
sfp->qual = AddGBQual(sfp->qual, "note", "methylation site");
break;
case 14:
sfp->qual = AddGBQual(sfp->qual, "note", "hydroxylation site");
break;
case 15:
sfp->qual = AddGBQual(sfp->qual, "note", "sulfatation site");
break;
case 16:
sfp->qual = AddGBQual(sfp->qual, "note",
"oxidative-deamination site");
break;
case 17:
sfp->qual = AddGBQual(sfp->qual, "note",
"pyrrolidone-carboxylic-acid site");
break;
case 18:
sfp->qual = AddGBQual(sfp->qual, "note",
"gamma-carboxyglutamic-acid site");
break;
case 19:
sfp->qual = AddGBQual(sfp->qual, "note", "blocked site");
break;
case 20:
sfp->qual = AddGBQual(sfp->qual, "note", "lipid-binding site");
break;
case 21:
sfp->qual = AddGBQual(sfp->qual, "note", "np-binding site");
break;
case 22:
sfp->qual = AddGBQual(sfp->qual, "note", "DNA binding site");
break;
case 23:
sfp->qual = AddGBQual(sfp->qual, "note", "signal-peptide site");
break;
case 24:
sfp->qual = AddGBQual(sfp->qual, "note",
"transit-peptide site");
break;
case 25:
sfp->qual = AddGBQual(sfp->qual, "note",
"transmembrane-region site");
break;
default:
sfp->qual = AddGBQual(sfp->qual, "note", "unclassified site");
break;
}
}
/*****************************************************************************
* protein features are shown as misc_feats on nucleotide records
*
******************************************************************************/
static SeqFeatPtr CreateImpFeatFromProt(Uint1 format, SeqFeatPtr psfp, SeqFeatPtr cds, SeqLocPtr new_loc)
{
SeqFeatPtr sfp;
ImpFeatPtr ifp;
ProtRefPtr prot;
GBQualPtr q;
Uint2 retval;
Char buf[2];
CdRegionPtr cdr;
CharPtr tmp;
GeneRefPtr grp;
SeqFeatXrefPtr xrp;
if (psfp->data.choice == SEQFEAT_PSEC_STR) {
return NULL;
}
sfp = SeqFeatNew();
ifp = ImpFeatNew();
sfp->data.choice = SEQFEAT_IMP;
sfp->data.value.ptrvalue = ifp;
ifp->key = StringSave("misc_feature");
if (psfp->data.choice == SEQFEAT_PROT) {
prot = psfp->data.value.ptrvalue;
if (prot->processed == 0 || prot->processed == 1) {
SeqFeatFree(sfp);
return NULL;
}
if (prot->processed == 2) {
MemFree(ifp->key);
ifp->key = StringSave("mat_peptide");
} else if (prot->processed == 3) {
MemFree(ifp->key);
ifp->key = StringSave("sig_peptide");
} else if (prot->processed == 4) {
MemFree(ifp->key);
ifp->key = StringSave("transit_peptide");
}
sfp = AddProtRefInfo(sfp, prot);
} else if (psfp->data.choice == SEQFEAT_BOND) {
if (psfp->data.value.intvalue == 1) {
sfp->qual = AddGBQual(sfp->qual, "note", "disulfide bond");
} else if (psfp->data.value.intvalue == 2) {
sfp->qual = AddGBQual(sfp->qual, "note", "thiolester bond");
} else if (psfp->data.value.intvalue == 3) {
sfp->qual = AddGBQual(sfp->qual, "note", "xlink bond");
} else if (psfp->data.value.intvalue == 4) {
sfp->qual = AddGBQual(sfp->qual, "note", "thioether bond");
} else {
sfp->qual = AddGBQual(sfp->qual, "note", "bond");
}
} else if (psfp->data.choice == SEQFEAT_SITE) {
AddSiteNoteQual(psfp, sfp);
} else if (psfp->data.choice == SEQFEAT_REGION) {
tmp = MemNew(StringLen(psfp->data.value.ptrvalue) + 9);
sprintf(tmp, "Region: %s", (CharPtr) psfp->data.value.ptrvalue);
sfp->qual = AddGBQual(sfp->qual, "note", tmp);
tmp = MemFree(tmp);
} else {
SeqFeatFree(sfp);
return NULL;
}
sfp->excpt = psfp->excpt;
for (xrp=psfp->xref; xrp; xrp=xrp->next) {
if (xrp->data.choice == SEQFEAT_GENE) {
grp = (GeneRefPtr) xrp->data.value.ptrvalue;
sfp->xref = AsnIoMemCopy(xrp,
(AsnReadFunc) SeqFeatXrefAsnRead,
(AsnWriteFunc) SeqFeatXrefAsnWrite);
break;
}
}
if ((sfp->partial = psfp->partial) == TRUE) {
cdr = (CdRegionPtr) cds->data.value.ptrvalue;
if (cdr->frame) {
sprintf(buf, "%d", cdr->frame);
} else {
sprintf(buf, "1");
}
sfp->qual = AddGBQualEx(&(ifp->key), sfp->qual, "codon_start", buf);
}
sfp->exp_ev = psfp->exp_ev;
if (psfp->comment)
sfp->comment = StringSave(psfp->comment);
if (psfp->title)
sfp->comment = StringSave(psfp->title);
for (q=psfp->qual; q; q=q->next) {
sfp->qual = AddGBQual(sfp->qual, q->qual, q->val);
}
if (format == GENPEPT_FMT || format == EMBLPEPT_FMT) {
sfp->location = AsnIoMemCopy(psfp->location,
(AsnReadFunc) SeqLocAsnRead, (AsnWriteFunc) SeqLocAsnWrite);
return sfp;
}
if (new_loc) {
sfp->location = aaFeatLoc_to_dnaFeatLoc(cds, new_loc);
} else {
sfp->location = aaFeatLoc_to_dnaFeatLoc(cds, psfp->location);
}
if (sfp->location == NULL) {
SeqFeatFree(sfp);
return NULL;
}
if (sfp->partial == FALSE) {
retval = SeqLocPartialCheck(sfp->location);
if (retval > SLP_COMPLETE && retval < SLP_NOSTART) {
sfp->partial = TRUE;
}
}
return sfp;
}
static Boolean CheckNewSfpLoc(SeqFeatPtr sfp, BioseqPtr bsp)
{
SeqLocPtr slp, slp1 = NULL;
while ((slp1=SeqLocFindNext(sfp->location, slp1)) != NULL) {
slp = slp1;
}
if (SeqIdForSameBioseq(SeqLocId(slp), bsp->id)) {
if (SeqLocLen(slp) <= BioseqGetLen(bsp)) {
return TRUE;
}
}
return FALSE;
}
/*****************************************************************************
* gather callback for collecting gene features
*
******************************************************************************/
static Boolean get_genes (GatherContextPtr gcp)
{
BioseqPtr bsp = NULL;
OrganizeFeatPtr ofp;
SeqFeatPtr sfp;
Boolean temp=FALSE;
ofp = gcp->userdata;
if (gcp->thistype != OBJ_SEQFEAT) {
return TRUE;
}
sfp = (SeqFeatPtr) (gcp->thisitem);
bsp = ofp->bsp;
if (sfp->data.choice != SEQFEAT_GENE) {
return TRUE;
}
if ((gcp->tempload == TRUE) && (! gcp->hold)) {
temp = TRUE;
}
ofp->Genelist = EnlargeSortList(ofp->Genelist,ofp->sfpGenesize);
ofp->sfpGenesize = StoreFeatTemp(ofp->Genelist, sfp,
ofp->sfpGenesize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
return TRUE;
}
/*****************************************************************************
* gather callback for collecting all features
*
******************************************************************************/
static Boolean get_feats (GatherContextPtr gcp)
{
BioseqPtr bsp = NULL;
OrganizeFeatPtr ofp;
SeqFeatPtr sfp;
ImpFeatPtr ifp;
SeqIdPtr xid;
GatherRange gr;
Boolean r_trunc;
OrganizeProtPtr opp;
BioseqPtr p_bsp;
SeqEntryPtr sep;
GatherScope gs;
SeqFeatPtr new_sfp, psfp;
Int4 index;
Boolean temp = FALSE;
Uint2 entityID;
SeqMgrFeatContext fcontext;
ofp = gcp->userdata;
if (gcp->thistype != OBJ_SEQFEAT) {
return TRUE;
}
sfp = (SeqFeatPtr) (gcp->thisitem);
/* do sorting within EntityId */
if (gcp->entityID != ofp->oldID) {
ofp->lock_bsp = BioseqFindCore(SeqLocId(sfp->location));
BioseqLock(ofp->lock_bsp);
SortOrganizeFeat(ofp);
ofp->oldID = gcp->entityID;
}
gr = gcp->extremes;
r_trunc = gr.r_trunc;
if (sfp->data.choice != SEQFEAT_CDREGION &&
sfp->data.choice != SEQFEAT_GENE) {
if ((!ofp->embl_feat && ASN2FF_SHOW_GB_STYLE
&& !(ofp->showSeqLoc)) && r_trunc) {
return TRUE;
}
}
bsp = ofp->bsp;
if ((gcp->tempload == TRUE) && (! gcp->hold)) {
temp = TRUE;
}
switch (sfp->data.choice) {
case SEQFEAT_GENE:
ofp->Genelist = EnlargeSortList(ofp->Genelist,ofp->sfpGenesize);
ofp->sfpGenesize = StoreFeatTemp(ofp->Genelist, sfp,
ofp->sfpGenesize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
if (ofp->show_gene) {
if (r_trunc && !ofp->embl_feat && ASN2FF_SHOW_GB_STYLE
&& !(ofp->showSeqLoc)) {
break;
}
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize = StoreFeatTemp(ofp->List, sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
}
break;
case SEQFEAT_BIOSRC: /* save in both lists */
ofp->Biosrclist =
EnlargeSortList(ofp->Biosrclist, ofp->biosrcsize);
ofp->biosrcsize = StoreFeatTemp(ofp->Biosrclist, sfp,
ofp->biosrcsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize = StoreFeatTemp(ofp->List, sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
break;
case SEQFEAT_ORG:
ofp->Orglist =
EnlargeSortList(ofp->Orglist, ofp->sfpOrgsize);
ofp->sfpOrgsize = StoreFeatTemp(ofp->Orglist, sfp,
ofp->sfpOrgsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
break;
case SEQFEAT_PUB: /* Pubs are already captured by "StorePubInfo". */
break;
case SEQFEAT_IMP: /* This case must be before the generic case */
ifp = (ImpFeatPtr) sfp->data.value.ptrvalue;
if (StringCmp(ifp->key, "source") == 0) {
/* Capture only the first source feat that covers the
entire entry, the others go among the generic features.*/
if (ofp->sfpSourcesize == 0) {
if (bsp->length != -1 &&
bsp->length == SeqLocLen(sfp->location)) {
ofp->Sourcelist =
EnlargeSortList(ofp->Sourcelist,
ofp->sfpSourcesize);
ofp->sfpSourcesize =
StoreFeatTemp(ofp->Sourcelist, sfp, ofp->sfpSourcesize,
bsp, ofp->seg_bsp,gcp->entityID, gcp->itemID,
gcp->thistype, gcp->new_loc, NULL, 0, temp);
break;
}
}
} else if (StringCmp(ifp->key, "Site-ref") == 0 && sfp->cit == NULL) {
/* if "Site-ref" has a pub, put out info as a pub */
ofp->Siteslist =
EnlargeSortList(ofp->Siteslist, ofp->sfpSitesize);
ofp->sfpSitesize =
StoreFeatTemp(ofp->Siteslist, sfp, ofp->sfpSitesize, bsp,
ofp->seg_bsp, gcp->entityID, gcp->itemID,
gcp->thistype, gcp->new_loc, NULL, 0, temp);
break;
} else if (StringCmp(ifp->key, "Site-ref") == 0 && sfp->cit != NULL) {
/* Check to see if this was already put out as a pub*/
break;
} else {
/* If none of the above is true, execute generic. */
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize =
StoreFeatTemp(ofp->List, sfp, ofp->sfpListsize, bsp,
ofp->seg_bsp, gcp->entityID, gcp->itemID,
gcp->thistype, gcp->new_loc, NULL, 0, temp);
}
break;
/* Look to see if an Xref goes out as a SeqFeat or as a 2nd accession */
case SEQFEAT_SEQ:
xid=CheckXrefFeat(bsp, sfp);
if (xid == NULL) {
ofp->Xreflist = EnlargeSortList(ofp->Xreflist,
ofp->sfpXrefsize);
ofp->sfpXrefsize = StoreFeatTemp(ofp->Xreflist, sfp,
ofp->sfpXrefsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
break;
}
break;
case SEQFEAT_COMMENT:
/* The following assures a valid comment */
if (sfp->comment == NULL || StringLen(sfp->comment) == 0)
break;
if (bsp && bsp->length != -1 &&
bsp->length == SeqLocLen(sfp->location)) {
/** will go to COMMENT field **/
ofp->Commlist =
EnlargeSortList(ofp->Commlist, ofp->sfpCommsize);
ofp->sfpCommsize =
StoreFeatTemp(ofp->Commlist, sfp, ofp->sfpCommsize,
bsp, ofp->seg_bsp, gcp->entityID, gcp->itemID,
gcp->thistype, gcp->new_loc, NULL, 0, temp);
} else {
/** will go to misc_feature **/
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize = StoreFeatTemp(ofp->List, sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
}
break;
case SEQFEAT_CDREGION:
if (r_trunc != TRUE || ofp->embl_feat || ofp->showSeqLoc
|| !ASN2FF_SHOW_GB_STYLE) {
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize = StoreFeatTemp(ofp->List, sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, gcp->extra_loc,
gcp->extra_loc_cnt, temp);
}
/* Look for Prot-ref features, create ImpFeats */
if (sfp != NULL && sfp->product != NULL && ofp->format != GENPEPT_FMT) {
p_bsp = BioseqFindCore(SeqLocId(sfp->product));
if (p_bsp != NULL) /*Bioseq is (or has been) in memory */
{
if (ofp->useSeqMgrIndexes) {
entityID = ObjMgrGetEntityIDForPointer (p_bsp);
if (SeqMgrFeaturesAreIndexed (entityID) == 0) {
SeqMgrIndexFeatures (entityID, NULL);
}
psfp = SeqMgrGetBestProteinFeature (p_bsp, NULL);
if (psfp != NULL) {
psfp = SeqMgrGetNextFeature (p_bsp, NULL, 0, 0, &fcontext);
while (psfp != NULL) {
new_sfp = CreateImpFeatFromProt(ofp->format, psfp, sfp, NULL);
if (new_sfp != NULL) {
if (CheckNewSfpLoc(new_sfp, bsp)) {
ofp->List = EnlargeSortList(ofp->List,
ofp->sfpListsize);
ofp->sfpListsize =
StoreFeatFree(ofp->List,new_sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp,
fcontext.entityID, fcontext.itemID,
OBJ_SEQFEAT, NULL, NULL, 0, TRUE);
}
/* if opp->list[index].slp !=NULL I shoud use it*/
}
psfp = SeqMgrGetNextFeature (p_bsp, psfp, 0, 0, &fcontext);
}
}
return TRUE;
}
opp = (OrganizeProtPtr) MemNew(sizeof(OrganizeProt));
opp->size = 0;
sep = SeqEntryNew();
sep->choice = 1;
sep->data.ptrvalue = p_bsp;
MemSet ((Pointer) (&gs), 0, sizeof (GatherScope));
gs.get_feats_location = TRUE;
gs.target = sfp->product;
GatherSeqEntry(sep, opp, get_prot_feats, &gs);
for (index=0; index < opp->size; index++) {
if ((psfp = opp->list[index].sfp) == NULL) {
continue;
}
new_sfp = CreateImpFeatFromProt(ofp->format, psfp, sfp,
opp->list[index].slp);
if (new_sfp != NULL) {
if (CheckNewSfpLoc(new_sfp, bsp)) {
ofp->List = EnlargeSortList(ofp->List,
ofp->sfpListsize);
ofp->sfpListsize =
StoreFeatFree(ofp->List,new_sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp,
opp->list[index].entityID,
opp->list[index].itemID,
opp->list[index].itemtype,
NULL, NULL, 0, TRUE);
}
/* if opp->list[index].slp !=NULL I shoud use it*/
}
}
if(opp->list != NULL && opp->list->nsp != NULL)
NoteStructFree(opp->list->nsp);
MemFree(opp->list);
MemFree(opp);
MemFree(sep);
}
}
break;
case SEQFEAT_RNA:
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize = StoreFeatTemp(ofp->List, sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, gcp->extra_loc,
gcp->extra_loc_cnt, temp);
break;
case SEQFEAT_RSITE:
/* do not gather this type*/
break;
default:
/* If none of the above is true, execute generic. */
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize = StoreFeatTemp(ofp->List, sfp,
ofp->sfpListsize, bsp, ofp->seg_bsp, gcp->entityID,
gcp->itemID, gcp->thistype, gcp->new_loc, NULL, 0, temp);
break;
}
return TRUE;
}
static Boolean is_embl(GBEntryPtr gbp)
{
CharPtr prefix = EMBL_AC;
static CharPtr embl_accpref[EMBL_PREFNUM] = {"AJ", "AL", "AM", "AN", "AX"};
Boolean retval = FALSE;
Int2 i;
if (gbp == NULL || gbp->accession == NULL)
return FALSE;
if (IS_DIGIT(gbp->accession[1]) &&
StringChr(prefix, gbp->accession[0]) != NULL) {
retval = TRUE;
} else {
for (i = 0; i < EMBL_PREFNUM; i++) {
if (StringNCmp(gbp->accession, embl_accpref[i], 2) == 0) {
retval = TRUE;
}
}
}
return retval;
}
/****************************************************************************
* void GetGeneRefInfo (GeneStructPtr gsp, NoteStructPtr nsp, GeneRefPtr grp)
*
* gsp: GeneStructPtr containing gene information
* grp: GeneRefPtr from a sfp of type gene or a sfp xref.
*
* If fields are empty on the gsp, and the relevant information
* is given by the grp, that field is filled on the gsp
****************************************************************************/
static void GeneRefInfoToGsp (GeneStructPtr gsp, GeneRefPtr grp, SeqFeatPtr sfp)
{
ValNodePtr syn, vsyn = NULL;
if (grp == NULL) {
return;
}
syn=grp->syn;
if (grp->locus != NULL) {
if (gsp->gene != NULL &&
StringCmp(gsp->gene->data.ptrvalue, grp->locus) != 0) {
if (syn != NULL) {
vsyn = ValNodeCopyStr(&(vsyn), 1, syn->data.ptrvalue);
gsp->gene->next=vsyn;
}
return;
}
if (gsp->gene == NULL) {
gsp->gene = ValNodeCopyStr(&(gsp->gene), 0, grp->locus);
}
} else if (grp->desc != NULL) {
gsp->gene = ValNodeCopyStr(&(gsp->gene), 0, grp->desc);
}
if (syn != NULL) {
vsyn = ValNodeCopyStr(&(vsyn), 1, syn->data.ptrvalue);
if (gsp->gene == NULL) {
gsp->gene = vsyn;
} else {
gsp->gene->next=vsyn;
}
}
if (gsp->map[0] == NULL && grp->maploc)
gsp->map[0] = grp->maploc;
if (grp->pseudo) {
gsp->pseudo = TRUE;
} else if (sfp != NULL && sfp->pseudo) {
gsp->pseudo = TRUE;
} else {
gsp->pseudo = FALSE;
}
gsp->grp = AsnIoMemCopy((GeneRefPtr)grp, (AsnReadFunc) GeneRefAsnRead, (AsnWriteFunc) GeneRefAsnWrite);
return;
}
/*****************************************************************************
* gather genes for particular CDS (for GenPept an d EmblPept
*
******************************************************************************/
static OrganizeFeatPtr GetGeneListForCds(Uint2 entityID, BioseqPtr bsp)
{
OrganizeFeatPtr ofp=NULL;
GatherScope gsc;
SeqLocPtr slp;
ofp = CreateOrganizeFeat();
MemSet ((Pointer) (&gsc), 0, sizeof (GatherScope));
MemSet ((Pointer) (gsc.ignore), (int)(TRUE),
(size_t) (OBJ_MAX * sizeof(Boolean)));
gsc.ignore[OBJ_SEQANNOT] = FALSE;
gsc.ignore[OBJ_SEQFEAT] = FALSE;
gsc.get_feats_location = TRUE;
gsc.seglevels = 1;
if (bsp != NULL) {
slp = ValNodeNew(NULL);
slp->choice = SEQLOC_WHOLE;
slp->data.ptrvalue = (SeqIdPtr) SeqIdDup (SeqIdFindBest (bsp->id, 0));
gsc.target = slp;
} else {
gsc.target = NULL;
}
ofp->bsp = bsp;
ofp->seg_bsp = NULL;
GatherEntity(entityID, ofp, get_genes, &gsc);
if((slp = gsc.target) != NULL) {
SeqIdFree(slp->data.ptrvalue);
ValNodeFree(slp);
}
return ofp;
}
/***************************************************************************
* This function assigns genes to the given sfp by comparing locations.
* of sfp with the location from the list of genes using SeqLocAinB
* (sfp have to be in the gene).
* If SeqLocAinB returns "0", there is an exact match and this gene
* is judged "the best" match to the sfp.`
* If SeqLocAinB returns the diff > 0, slp is contained within
* gene_loc and the difference between the two features is measured.
* The lowest difference gives the "best_gene"
* and that information is stored in the GeneStructPtr (gsp) by
* GeneRefInfoToGsp.
***************************************************************************/
NLM_EXTERN void MatchNAGeneToFeat (Boolean non_strict, OrganizeFeatPtr ofp, SortStructPtr p)
{
Boolean bind_to_feat=FALSE;
NoteStructPtr nsp; /* UNUSED */
GeneStructPtr gsp;
GeneRefPtr grp=NULL;
ImpFeatPtr ifp;
Int4 best_gene = -1, index;
Int4 diff_lowest, diff_current;
SeqFeatPtr gene = NULL, best_gene_feat = NULL, sfp;
Uint1 sg, sf;
if (p == NULL)
return;
if ((sfp = p->sfp) == NULL)
return;
if (sfp->data.choice == SEQFEAT_BIOSRC || sfp->data.choice == SEQFEAT_GENE)
return;
if (sfp->data.choice == SEQFEAT_IMP) {
ifp = sfp->data.value.ptrvalue;
if (ifp && StringCmp(ifp->key, "repeat_region") == 0) {
return;
}
}
if (non_strict == FALSE) { /* binding is limited to RNA and CDS */
if (sfp->data.choice == SEQFEAT_CDREGION ||
sfp->data.choice == SEQFEAT_RNA) {
bind_to_feat = TRUE;
} else if (sfp->data.choice == SEQFEAT_IMP) {
ifp = (ImpFeatPtr) sfp->data.value.ptrvalue;
if (StringCmp(ifp->key, "CDS") == 0)
bind_to_feat = TRUE;
}
} else {
bind_to_feat = TRUE;
}
if (bind_to_feat == FALSE)
return;
best_gene_feat = SeqMgrGetOverlappingGene (sfp->location, NULL);
if (best_gene_feat != NULL) {
grp = best_gene_feat->data.value.ptrvalue;
if (grp != NULL) {
gsp = p->gsp;
/* GetDBXrefFromGene(grp, sfp);*/
/******** gsp->grp = AsnIoMemCopy(grp,
(AsnReadFunc) GeneRefAsnRead, (AsnWriteFunc) GeneRefAsnWrite); ****/ /*** it is redone in GeneRefInfoToGsp (EY) */
GeneRefInfoToGsp(gsp, grp, best_gene_feat); /*copy GeRefInfo to GeneStruct */
GetGeneQuals(sfp, gsp); /* copy quals info to GenStruct */
return;
}
}
nsp = p->nsp;
gsp = p->gsp;
diff_lowest = -1;
p = ofp->Genelist;
for (index=0; index < ofp->sfpGenesize; index++, p++) {
if ((gene = p->sfp) == NULL) {
continue;
}
sg = SeqLocStrand(gene->location);
sf = SeqLocStrand(sfp->location);
if (sf == sg ||
(sg == Seq_strand_unknown && sf != Seq_strand_minus) ||
(sf == Seq_strand_unknown && sg != Seq_strand_minus)) {
diff_current = SeqLocAinB(sfp->location, gene->location);
} else {
continue;
}
if (! diff_current) /* perfect match */ {
best_gene = index;
best_gene_feat = gene;
break;
} else if (diff_current > 0) {
if ((diff_lowest == -1) || (diff_current < diff_lowest)) {
diff_lowest = diff_current;
best_gene = index;
best_gene_feat = gene;
}
}
}
if (best_gene == -1) { /*no gene found that completely contains CDS*/
return;
} else {
if (best_gene_feat != NULL) {
grp = best_gene_feat->data.value.ptrvalue;
}
}
/* GetDBXrefFromGene(grp, sfp);*/
gsp->grp = AsnIoMemCopy(grp,
(AsnReadFunc) GeneRefAsnRead, (AsnWriteFunc) GeneRefAsnWrite);
GeneRefInfoToGsp(gsp, grp, best_gene_feat); /*copy GeRefInfo to GeneStruct */
GetGeneQuals(sfp, gsp); /* copy quals info to GenStruct */
return;
}
static Boolean CheckCdregionGeneXref (SortStructPtr p, Uint1 format)
{
SeqFeatPtr sfp;
GeneRefPtr grp;
GeneStructPtr gsp;
NoteStructPtr nsp;
ProtRefPtr prp;
SeqFeatXrefPtr xrp;
Boolean retval = FALSE;
if (p == NULL) {
return retval;
}
if ((sfp = p->sfp) == NULL)
return retval;
gsp = p->gsp;
nsp = p->nsp;
for (xrp=sfp->xref; xrp; xrp=xrp->next) {
if (xrp->data.choice == SEQFEAT_GENE) {
retval = TRUE;
grp = (GeneRefPtr) xrp->data.value.ptrvalue;
GeneRefInfoToGsp(gsp, grp, sfp);
} else if (xrp->data.choice == SEQFEAT_PROT) {
prp = (ProtRefPtr) xrp->data.value.ptrvalue;
GetProtRefInfo(format, gsp, nsp, prp);
}
}
return retval;
}
NLM_EXTERN Boolean GetGeneQuals(SeqFeatPtr sfp_in, GeneStructPtr gsp)
{
Boolean has_gene = FALSE;
GBQualPtr qual1;
for (qual1=sfp_in->qual; qual1; qual1=qual1->next) {
if (StringCmp(qual1->qual, "gene") == 0) {
has_gene = TRUE;
if (gsp->gene == NULL) {
gsp->gene = ValNodeCopyStr(&(gsp->gene), 0, qual1->val);
}
} else if (StringCmp(qual1->qual, "product") == 0) {
if (gsp->product)
ValNodeCopyStr(&(gsp->product), 0, qual1->val);
else
gsp->product = ValNodeCopyStr(&(gsp->product), 0, qual1->val);
} else if (StringCmp(qual1->qual, "standard_name") == 0) {
if (gsp->standard_name)
ValNodeCopyStr(&(gsp->standard_name), 0, qual1->val);
else
gsp->standard_name = ValNodeCopyStr(&(gsp->standard_name), 0, qual1->val);
} else if (gsp->map[0] == NULL
&& StringCmp(qual1->qual, "map") == 0) {
gsp->map[0] = qual1->val;
} else if (StringCmp(qual1->qual, "EC_number") == 0) {
if (gsp->ECNum)
ValNodeCopyStr(&(gsp->ECNum), 0, qual1->val);
else
gsp->ECNum = ValNodeCopyStr(&(gsp->ECNum), 0, qual1->val);
}
}
return has_gene;
}
/*****************************************************************************
* see MatchNAGeneToFeat (above) for details
*
******************************************************************************/
NLM_EXTERN void MatchAAGeneToFeat (OrganizeFeatPtr ofp, SortStructPtr p)
{
GeneRefPtr grp = NULL;
Int4 best_gene = -1, index;
SeqFeatPtr gene = NULL, best_gene_feat = NULL, sfp;
NoteStructPtr nsp; /* UNUSED */
GeneStructPtr gsp;
BioseqPtr bsp;
Int4 diff_lowest, diff_current;
OrganizeFeatPtr gofp;
if (p == NULL)
return;
if ((sfp = p->sfp) == NULL)
return;
if (SeqLocLen(sfp->location) == -1)
return; /*SeqLocLen failed on CDS location */
/* Only look on the CDS!! for genpept. */
if (sfp->data.choice != SEQFEAT_CDREGION) {
return;
}
bsp = BioseqFind(SeqLocId(sfp->location));
best_gene_feat = SeqMgrGetOverlappingGene (sfp->location, NULL);
if (best_gene_feat != NULL) {
grp = best_gene_feat->data.value.ptrvalue;
gsp = p->gsp;
GeneRefInfoToGsp(gsp, grp, best_gene_feat); /*copy GeRefInfo to GeneStruct */
if (bsp && bsp->id->choice == SEQID_OTHER) {
GetDBXrefFromGene(grp, sfp);
}
return;
}
gofp = GetGeneListForCds(p->entityID, bsp);
if (gofp == NULL) {
return;
}
nsp = p->nsp;
gsp = p->gsp;
if (bsp == NULL && gofp->sfpGenesize == 1) {
gene = gofp->Genelist->sfp;
if (gene != NULL) {
grp = gene->data.value.ptrvalue;
GeneRefInfoToGsp(gsp, grp, gene); /*copy GeRefInfo to GeneStruct */
}
MemFree(gofp->Genelist);
MemFree(gofp);
return; /* first and best gene */
}
diff_lowest = -1;
for (p=gofp->Genelist, index=0; index < gofp->sfpGenesize; p++, index++) {
if ((gene = p->sfp) == NULL) {
continue;
}
diff_current = SeqLocAinB(sfp->location, gene->location);
if (! diff_current) /* perfect match */ {
best_gene = index;
best_gene_feat = gene;
break;
} else if (diff_current > 0) {
if ((diff_lowest == -1) || (diff_current < diff_lowest)) {
diff_lowest = diff_current;
best_gene = index;
best_gene_feat = gene;
}
}
}
if (best_gene == -1) {
return;
}
if (best_gene_feat != NULL) {
grp = best_gene_feat->data.value.ptrvalue;
GeneRefInfoToGsp(gsp, grp, best_gene_feat); /*copy GeRefInfo to GeneStruct */
if (bsp && bsp->id->choice == SEQID_OTHER) {
GetDBXrefFromGene(grp, sfp);
}
}
MemFree(gofp->Genelist);
MemFree(gofp);
return;
}
/*****************************************************************************
* do sorting and gene mapping within one entity (that should be locked)
*
******************************************************************************/
NLM_EXTERN void SortOrganizeFeat(OrganizeFeatPtr ofp)
{
SortStructPtr p;
GeneStructPtr gsp;
Int4 index;
SeqFeatPtr sfp;
if (ofp == NULL)
return;
if (ofp->sfpListsize > 0 && ofp->sortListsize < ofp->sfpListsize) {
HeapSort((VoidPtr) (ofp->List + ofp->sortListsize),
(size_t) (ofp->sfpListsize - ofp->sortListsize),
sizeof(SortStruct), CompareSfpForHeap);
UniqueFeat(ofp->List + ofp->sortListsize,
ofp->sfpListsize - ofp->sortListsize);
}
if (ofp->sfpCommsize > 0 && ofp->sortCommsize < ofp->sfpCommsize)
HeapSort((VoidPtr) (ofp->Commlist + ofp->sortCommsize),
(size_t) (ofp->sfpCommsize - ofp->sortCommsize),
sizeof(SortStruct), CompareSfpForHeap);
if (ofp->sfpGenesize > 0 && ofp->sortGenesize < ofp->sfpGenesize)
HeapSort((VoidPtr) (ofp->Genelist + ofp->sortGenesize),
(size_t) (ofp->sfpGenesize - ofp->sortGenesize),
sizeof(SortStruct), CompareSfpForHeap);
if (ofp->sfpOrgsize > 0 && ofp->sortOrgsize < ofp->sfpOrgsize)
HeapSort((VoidPtr) (ofp->Orglist + ofp->sortOrgsize),
(size_t) (ofp->sfpOrgsize - ofp->sortOrgsize),
sizeof(SortStruct), CompareSfpForHeap);
if (ofp->sfpSitesize > 0 && ofp->sortSitesize < ofp->sfpSitesize)
HeapSort((VoidPtr) (ofp->Siteslist + ofp->sortSitesize),
(size_t) (ofp->sfpSitesize - ofp->sortSitesize),
sizeof(SortStruct), CompareSfpForHeap);
if (ofp->sfpSourcesize > 0 && ofp->sortSourcesize < ofp->sfpSourcesize)
HeapSort((VoidPtr) (ofp->Sourcelist + ofp->sortSourcesize),
(size_t) (ofp->sfpSourcesize - ofp->sortSourcesize),
sizeof(SortStruct),
CompareSfpForHeap);
ofp->sortListsize = ofp->sfpListsize;
ofp->sortCommsize = ofp->sfpCommsize;
ofp->sortGenesize = ofp->sfpGenesize;
ofp->sortOrgsize = ofp->sfpOrgsize;
ofp->sortSitesize = ofp->sfpSitesize;
ofp->sortSourcesize = ofp->sfpSourcesize;
p = ofp->List;
for (index=0; index < ofp->sfpListsize; index++, p++) {
sfp = p->sfp;
if (p == NULL)
continue;
gsp = GeneStructNew();
p->gsp = gsp;
if (CheckCdregionGeneXref(p, ofp->format) == FALSE) {
if (ofp->format == EMBLPEPT_FMT || ofp->format == GENPEPT_FMT) {
MatchAAGeneToFeat(ofp, p);
} else {
MatchNAGeneToFeat(ofp->non_strict, ofp, p);
}
}
GetGeneQuals(sfp, gsp);
}
/* if (ofp->sfpListsize > 0) {
BioseqUnlock(ofp->lock_bsp);
}
*/
BioseqUnlock(ofp->lock_bsp);
return;
}
/*
static Boolean is_mRNA_set(SeqEntryPtr sep, BioseqPtr bsp)
{
BioseqSetPtr bssp;
ValNodePtr vnp;
MolInfoPtr mip = NULL;
if (sep == NULL) {
return FALSE;
}
if (IS_Bioseq(sep)) {
return FALSE;
}
bssp = (BioseqSetPtr) sep->data.ptrvalue;
if (bssp->_class != BioseqseqSet_class_gen_prod_set) {
return FALSE;
}
for (vnp = bsp->descr; vnp; vnp=vnp->next) {
if (vnp->choice == Seq_descr_molinfo) {
mip = (MolInfoPtr) vnp->data.ptrvalue;
break;
}
}
if (mip == NULL) {
return FALSE;
}
if (mip->biomol != 3) {
return FALSE;
}
return TRUE;
}
*/
/*****************************************************************************
* Gather all features in one GBEntry and process within
* each entity (in callback)
*
******************************************************************************/
NLM_EXTERN void OrganizeSeqFeat(Asn2ffJobPtr ajp, GBEntryPtr gbp)
{
BioseqPtr bsp;
GatherScope gsc;
ValNodePtr slp = NULL;
OrganizeFeatPtr ofp;
SeqFeatPtr mrna, gene = NULL, newg;
GeneRefPtr grp;
SeqMgrFeatContext fcontext;
SeqIdPtr sip;
ofp = CreateOrganizeFeat();
ofp->lock_bsp = NULL;
if ((bsp = gbp->bsp) == NULL)
return;
ofp->embl_feat = is_embl(gbp);
MemSet ((Pointer) (&gsc), 0, sizeof (GatherScope));
MemSet ((Pointer) (gsc.ignore), (int)(TRUE),
(size_t) (OBJ_MAX * sizeof(Boolean)));
gsc.ignore[OBJ_SEQANNOT] = FALSE;
gsc.ignore[OBJ_SEQFEAT] = FALSE;
gsc.get_feats_location = TRUE;
if (ajp->ignore_top)
gsc.ignore_top = TRUE;
gsc.seglevels = 1;
if (ajp->format == GENPEPT_FMT) {
gsc.get_feats_product = TRUE;
}
gsc.seglevels = 0;
if (ajp->slp != NULL) {
gsc.target = ajp->slp;
gsc.convert_loc = TRUE;
gsc.newid = bsp->id;
} else {
slp = ValNodeNew(NULL);
slp->choice = SEQLOC_WHOLE;
slp->data.ptrvalue = (SeqIdPtr) SeqIdDup (SeqIdFindBest (bsp->id, 0));
gsc.target = slp;
if (ajp->only_one) {
gsc.convert_loc = TRUE;
gsc.newid = bsp->id;
}
}
ofp->bsp = bsp;
ofp->showSeqLoc = (ajp->slp) ? TRUE : FALSE;
ofp->useSeqMgrIndexes = ajp->useSeqMgrIndexes;
ofp->seg_bsp = ajp->asn2ffwep->seg;
ofp->format = ajp->format;
ofp->non_strict = ajp->non_strict;
for (sip=bsp->id; sip; sip=sip->next) { /* non_strict binding for REFSEQ*/
if (sip->choice == SEQID_OTHER) {
ofp->non_strict = FALSE;
}
}
ofp->show_gene = ajp->show_gene;
if (ajp->format == GENPEPT_FMT && bsp->repr == Seq_repr_raw && ajp->useSeqMgrIndexes) {
gsc.useSeqMgrIndexes = TRUE;
}
GatherEntity(ajp->entityID, ofp, get_feats, &gsc);
if (slp) {
SeqLocFree(slp);
}
ofp->lock_bsp = ofp->bsp;
BioseqLock(ofp->lock_bsp);
if (/* is_mRNA_set(ajp->sep, bsp) && */ ajp->useSeqMgrIndexes) {
mrna = SeqMgrGetRNAgivenProduct(bsp, NULL);
if (mrna) {
gene = SeqMgrGetOverlappingGene(mrna->location, &fcontext);
}
if (gene) {
grp = (GeneRefPtr) gene->data.value.ptrvalue;
newg = SeqFeatNew();
newg->data.choice = SEQFEAT_GENE;
newg->location = SeqLocIntNew(0, bsp->length-1,
SeqLocStrand(gene->location), SeqIdDup(bsp->id));
newg->data.value.ptrvalue = AsnIoMemCopy(grp,
(AsnReadFunc) GeneRefAsnRead, (AsnWriteFunc) GeneRefAsnWrite);
ofp->Genelist = EnlargeSortList(ofp->Genelist,ofp->sfpGenesize);
ofp->sfpGenesize = StoreFeat(ofp->Genelist, newg,
ofp->sfpGenesize, bsp, ofp->seg_bsp, fcontext.entityID, fcontext.itemID, OBJ_SEQFEAT, NULL, NULL, 0);
ofp->List = EnlargeSortList(ofp->List, ofp->sfpListsize);
ofp->sfpListsize = StoreFeat(ofp->List, newg,
ofp->sfpListsize, bsp, ofp->seg_bsp, fcontext.entityID, fcontext.itemID, OBJ_SEQFEAT, NULL, NULL, 0);
}
}
SortOrganizeFeat(ofp); /* for the last entity */
UniqueGeneName(ajp->error_msgs, ofp);
ofp->source_notes = NoteStructNew(ofp->source_notes);
gbp->feat = ofp;
return;
}
/*****************************************************************************
* Gather all features
*
******************************************************************************/
NLM_EXTERN void GetSeqFeat(Asn2ffJobPtr ajp)
{
GBEntryPtr gbp;
for (gbp = ajp->asn2ffwep->gbp; gbp; gbp = gbp->next) {
if (gbp->locus) {
flat2asn_delete_locus_user_string();
flat2asn_install_locus_user_string(gbp->locus);
}
if (gbp->accession) {
flat2asn_delete_accession_user_string();
flat2asn_install_accession_user_string(gbp->accession);
}
OrganizeSeqFeat(ajp, gbp);
}
}
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