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#!/usr/bin/env python
# emacs: -*- mode: python; py-indent-offset: 4; indent-tabs-mode: nil -*-
# vi: set ft=python sts=4 ts=4 sw=4 et:
"""
============================
fMRI: OpenfMRI.org data, FSL
============================
A growing number of datasets are available on `OpenfMRI <http://openfmri.org>`_.
This script demonstrates how to use nipype to analyze a data set.
python fmri_openfmri.py --datasetdir ds107
"""
from glob import glob
import os
import nipype.pipeline.engine as pe
import nipype.algorithms.modelgen as model
import nipype.algorithms.rapidart as ra
import nipype.interfaces.fsl as fsl
import nipype.interfaces.io as nio
import nipype.interfaces.utility as niu
from nipype.workflows.fmri.fsl import (create_featreg_preproc,
create_modelfit_workflow,
create_fixed_effects_flow)
fsl.FSLCommand.set_default_output_type('NIFTI_GZ')
def get_subjectinfo(subject_id, base_dir, task_id, model_id):
"""Get info for a given subject
Parameters
----------
subject_id : string
Subject identifier (e.g., sub001)
base_dir : string
Path to base directory of the dataset
task_id : int
Which task to process
model_id : int
Which model to process
Returns
-------
run_ids : list of ints
Run numbers
conds : list of str
Condition names
TR : float
Repetition time
"""
from glob import glob
import os
import numpy as np
condition_info = []
cond_file = os.path.join(base_dir, 'models', 'model%03d' % model_id,
'condition_key.txt')
with open(cond_file, 'rt') as fp:
for line in fp:
info = line.strip().split()
condition_info.append([info[0], info[1], ' '.join(info[2:])])
if len(condition_info) == 0:
raise ValueError('No condition info found in %s' % cond_file)
taskinfo = np.array(condition_info)
n_tasks = len(np.unique(taskinfo[:, 0]))
conds = []
run_ids = []
if task_id > n_tasks:
raise ValueError('Task id %d does not exist' % task_id)
for idx in range(n_tasks):
taskidx = np.where(taskinfo[:, 0] == 'task%03d' % (idx + 1))
conds.append([condition.replace(' ', '_') for condition
in taskinfo[taskidx[0], 2]])
files = glob(os.path.join(base_dir,
subject_id,
'BOLD',
'task%03d_run*' % (idx + 1)))
run_ids.insert(idx, range(1, len(files) + 1))
TR = np.genfromtxt(os.path.join(base_dir, 'scan_key.txt'))[1]
return run_ids[task_id - 1], conds[task_id - 1], TR
def analyze_openfmri_dataset(data_dir, subject=None, model_id=None, work_dir=None):
"""Analyzes an open fmri dataset
Parameters
----------
data_dir : str
Path to the base data directory
work_dir : str
Nipype working directory (defaults to cwd)
"""
"""
Load nipype workflows
"""
preproc = create_featreg_preproc(whichvol='first')
modelfit = create_modelfit_workflow()
fixed_fx = create_fixed_effects_flow()
"""
Remove the plotting connection so that plot iterables don't propagate
to the model stage
"""
preproc.disconnect(preproc.get_node('plot_motion'), 'out_file',
preproc.get_node('outputspec'), 'motion_plots')
"""
Set up openfmri data specific components
"""
subjects = [path.split(os.path.sep)[-1] for path in
glob(os.path.join(data_dir, 'sub*'))]
infosource = pe.Node(niu.IdentityInterface(fields=['subject_id',
'model_id']),
name='infosource')
if subject is None:
infosource.iterables = [('subject_id', subjects),
('model_id', [model_id])]
else:
infosource.iterables = [('subject_id',
[subjects[subjects.index(subject)]]),
('model_id', [model_id])]
subjinfo = pe.Node(niu.Function(input_names=['subject_id', 'base_dir',
'task_id', 'model_id'],
output_names=['run_id', 'conds', 'TR'],
function=get_subjectinfo),
name='subjectinfo')
subjinfo.inputs.base_dir = data_dir
"""
Return data components as anat, bold and behav
"""
datasource = pe.Node(nio.DataGrabber(infields=['subject_id', 'run_id',
'model_id'],
outfields=['anat', 'bold', 'behav']),
name='datasource')
datasource.inputs.base_directory = data_dir
datasource.inputs.template = '*'
datasource.inputs.field_template = {'anat': '%s/anatomy/highres001.nii.gz',
'bold': '%s/BOLD/task001_r*/bold.nii.gz',
'behav': ('%s/model/model%03d/onsets/task001_'
'run%03d/cond*.txt')}
datasource.inputs.template_args = {'anat': [['subject_id']],
'bold': [['subject_id']],
'behav': [['subject_id', 'model_id',
'run_id']]}
datasource.inputs.sorted = True
"""
Create meta workflow
"""
wf = pe.Workflow(name='openfmri')
wf.connect(infosource, 'subject_id', subjinfo, 'subject_id')
wf.connect(infosource, 'model_id', subjinfo, 'model_id')
wf.connect(infosource, 'subject_id', datasource, 'subject_id')
wf.connect(infosource, 'model_id', datasource, 'model_id')
wf.connect(subjinfo, 'run_id', datasource, 'run_id')
wf.connect([(datasource, preproc, [('bold', 'inputspec.func')]),
])
def get_highpass(TR, hpcutoff):
return hpcutoff / (2 * TR)
gethighpass = pe.Node(niu.Function(input_names=['TR', 'hpcutoff'],
output_names=['highpass'],
function=get_highpass),
name='gethighpass')
wf.connect(subjinfo, 'TR', gethighpass, 'TR')
wf.connect(gethighpass, 'highpass', preproc, 'inputspec.highpass')
"""
Setup a basic set of contrasts, a t-test per condition
"""
def get_contrasts(base_dir, model_id, conds):
import numpy as np
import os
contrast_file = os.path.join(base_dir, 'models', 'model%03d' % model_id,
'task_contrasts.txt')
contrast_def = np.genfromtxt(contrast_file, dtype=object)
contrasts = []
for row in contrast_def:
con = [row[0], 'T', ['cond%03d' % i for i in range(len(conds))],
row[1:].astype(float).tolist()]
contrasts.append(con)
return contrasts
contrastgen = pe.Node(niu.Function(input_names=['base_dir', 'model_id',
'conds'],
output_names=['contrasts'],
function=get_contrasts),
name='contrastgen')
contrastgen.inputs.base_dir = data_dir
art = pe.MapNode(interface=ra.ArtifactDetect(use_differences=[True, False],
use_norm=True,
norm_threshold=1,
zintensity_threshold=3,
parameter_source='FSL',
mask_type='file'),
iterfield=['realigned_files', 'realignment_parameters',
'mask_file'],
name="art")
modelspec = pe.Node(interface=model.SpecifyModel(),
name="modelspec")
modelspec.inputs.input_units = 'secs'
wf.connect(subjinfo, 'TR', modelspec, 'time_repetition')
wf.connect(datasource, 'behav', modelspec, 'event_files')
wf.connect(subjinfo, 'TR', modelfit, 'inputspec.interscan_interval')
wf.connect(subjinfo, 'conds', contrastgen, 'conds')
wf.connect(infosource, 'model_id', contrastgen, 'model_id')
wf.connect(contrastgen, 'contrasts', modelfit, 'inputspec.contrasts')
wf.connect([(preproc, art, [('outputspec.motion_parameters',
'realignment_parameters'),
('outputspec.realigned_files',
'realigned_files'),
('outputspec.mask', 'mask_file')]),
(preproc, modelspec, [('outputspec.highpassed_files',
'functional_runs'),
('outputspec.motion_parameters',
'realignment_parameters')]),
(art, modelspec, [('outlier_files', 'outlier_files')]),
(modelspec, modelfit, [('session_info',
'inputspec.session_info')]),
(preproc, modelfit, [('outputspec.highpassed_files',
'inputspec.functional_data')])
])
"""
Reorder the copes so that now it combines across runs
"""
def sort_copes(files):
numelements = len(files[0])
outfiles = []
for i in range(numelements):
outfiles.insert(i, [])
for j, elements in enumerate(files):
outfiles[i].append(elements[i])
return outfiles
def num_copes(files):
return len(files)
pickfirst = lambda x: x[0]
wf.connect([(preproc, fixed_fx, [(('outputspec.mask', pickfirst),
'flameo.mask_file')]),
(modelfit, fixed_fx, [(('outputspec.copes', sort_copes),
'inputspec.copes'),
('outputspec.dof_file',
'inputspec.dof_files'),
(('outputspec.varcopes',
sort_copes),
'inputspec.varcopes'),
(('outputspec.copes', num_copes),
'l2model.num_copes'),
])
])
"""
Connect to a datasink
"""
def get_subs(subject_id, conds):
subs = [('_subject_id_%s/' % subject_id, '')]
for i in range(len(conds)):
subs.append(('_flameo%d/cope1.' % i, 'cope%02d.' % (i + 1)))
subs.append(('_flameo%d/varcope1.' % i, 'varcope%02d.' % (i + 1)))
subs.append(('_flameo%d/zstat1.' % i, 'zstat%02d.' % (i + 1)))
subs.append(('_flameo%d/tstat1.' % i, 'tstat%02d.' % (i + 1)))
subs.append(('_flameo%d/res4d.' % i, 'res4d%02d.' % (i + 1)))
return subs
subsgen = pe.Node(niu.Function(input_names=['subject_id', 'conds'],
output_names=['substitutions'],
function=get_subs),
name='subsgen')
datasink = pe.Node(interface=nio.DataSink(),
name="datasink")
wf.connect(infosource, 'subject_id', datasink, 'container')
wf.connect(infosource, 'subject_id', subsgen, 'subject_id')
wf.connect(subjinfo, 'conds', subsgen, 'conds')
wf.connect(subsgen, 'substitutions', datasink, 'substitutions')
wf.connect([(fixed_fx.get_node('outputspec'), datasink,
[('res4d', 'res4d'),
('copes', 'copes'),
('varcopes', 'varcopes'),
('zstats', 'zstats'),
('tstats', 'tstats')])
])
"""
Set processing parameters
"""
hpcutoff = 120.
subjinfo.inputs.task_id = 1
preproc.inputs.inputspec.fwhm = 6.0
gethighpass.inputs.hpcutoff = hpcutoff
modelspec.inputs.high_pass_filter_cutoff = hpcutoff
modelfit.inputs.inputspec.bases = {'dgamma': {'derivs': True}}
modelfit.inputs.inputspec.model_serial_correlations = True
modelfit.inputs.inputspec.film_threshold = 1000
if work_dir is None:
work_dir = os.path.join(os.getcwd(), 'working')
wf.base_dir = work_dir
datasink.inputs.base_directory = os.path.join(work_dir, 'output')
wf.config['execution'] = dict(crashdump_dir=os.path.join(work_dir,
'crashdumps'),
stop_on_first_crash=True)
wf.run('MultiProc', plugin_args={'n_procs': 2})
if __name__ == '__main__':
import argparse
parser = argparse.ArgumentParser(prog='fmri_openfmri.py',
description=__doc__)
parser.add_argument('--datasetdir', required=True)
parser.add_argument('--subject', default=None)
parser.add_argument('--model', default=1)
args = parser.parse_args()
analyze_openfmri_dataset(data_dir=os.path.abspath(args.datasetdir),
subject=args.subject,
model_id=int(args.model))
|
