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TITLE A slow Sodium current
COMMENT
Used in Role of a Striatal Slowly Inactivating Potassion Current in Short-term
Facilitation of Corticostriatal Inputs" A computer Simulation Study" (Mahon et al. 2000)
Implemented by Kevin M. Biddell kevin.biddell@gmail.com
7/17/06
NOTE: 1S=1mho Neuron wants the units in mhos not millisiemens, please note the conversion!
ENDCOMMENT
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
NEURON {
SUFFIX NaSm
USEION na WRITE ina
RANGE gnasmbar, gnasm, minf, mtau
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
ena = 40 (mV)
gnasmbar= 0.00011 (mho/cm2) :0.11mS
Etemp = 21 :delord correspondence 11/15/06
Vsm = -16.0
ksm = 9.4
tom = 637.8
Vtm = -33.5
ktm = 26.3
}
STATE {
m
}
ASSIGNED {
v (mV)
ina (mA/cm2)
celsius (degC)
mtau[2]
minf
gnasm[1]
}
BREAKPOINT {
SOLVE states METHOD cnexp
gnasm[0] = gnasmbar*m
ina = gnasm[0]*(v - ena)
}
UNITSOFF
INITIAL {
rates(v)
m= minf
}
DERIVATIVE states { :Computes states variable m at the current v and dt.
rates(v)
m' = ( minf - m ) / mtau[1]
}
PROCEDURE rates(v) { :Computes rate and other constants at current v. Call once from HOC to initialize inf at resting v.
LOCAL q10,tadj
q10 = 2.5
tadj=q10^((celsius-Etemp)/10)
minf=1/(1+exp(-(v-Vsm)/ksm))
mtau[1]=tom/(exp(-(v-Vtm)/ktm)+exp((v-Vtm)/ktm))/tadj
}
UNITSON
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