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TITLE Cardiac L-type Calcium channel
: from BEELER & REUTER, J.Physiol, 1977
NEURON {
THREADSAFE
SUFFIX Is
USEION ca READ cai WRITE ica
USEION cs WRITE ics VALENCE 2
USEION ns WRITE ins VALENCE 2
RANGE gsbar, ica, ics
GLOBAL minf, ninf, mtau, ntau
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(mM) = (milli/liter)
(S) = (siemens)
}
PARAMETER {
gsbar= 5e-05(S/cm2) <0,1e9>
}
STATE { : d f
m n
}
ASSIGNED {
v (mV)
celsius (degC) : 37
cai (mM)
ica (mA/cm2)
ics (mA/cm2)
ins (mA/cm2)
minf ninf
mtau (ms)
ntau (ms)
lca
}
INITIAL {
rates(v)
m = minf
n = ninf
}
BREAKPOINT {
LOCAL Es
SOLVE states METHOD derivimplicit
Es = -82.3-13.0287*log(cai)
ics = gsbar*m*n*(v - Es)
ica = ics
ins = -ics
}
DERIVATIVE states {
rates(v)
m' = (minf - m)/mtau
n' = (ninf - n)/ntau
}
UNITSOFF
FUNCTION alp(v(mV),i) (ms) {
if (i==0) {
alp = 0.095*exp(-0.01*(v - 5))/(exp(-0.072*(v - 5))+1)
}else if (i==1){
alp = 0.012*exp(-0.008*(v + 28))/(exp(0.15*(v + 28))+1)
}
}
FUNCTION bet(v(mV),i) {
if (i==0) {
bet = 0.07*exp(-0.017*(v + 44))/(exp(0.05*(v + 44))+1)
}else if (i==1){
bet = 0.0065*exp(-0.02*(v + 30))/(exp(-0.2*(v + 30))+1)
}
}
UNITSON
PROCEDURE rates(v(mV))
{
LOCAL a, b
:TABLE minf, ninf, mtau, ntau DEPEND celsius FROM -100 TO 100 WITH 200
a = alp(v,0) b=bet(v,0)
mtau = 1/(a + b)
minf = a/(a + b)
a = alp(v,1) b=bet(v,1)
ntau = 1/(a + b)
ninf = a/(a + b)
}
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