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<a href="#pub-static-methods">Static Public Member Functions</a> |
<a href="#pro-static-methods">Static Protected Member Functions</a> |
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<div class="title">AAIndex Class Reference<div class="ingroups"><a class="el" href="group__Chemistry.html">Chemistry</a></div></div> </div>
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<p>Representation of selected AAIndex properties.
<a href="classOpenMS_1_1AAIndex.html#details">More...</a></p>
<p><code>#include <<a class="el" href="AAIndex_8h_source.html">OpenMS/CHEMISTRY/AAIndex.h</a>></code></p>
<table class="memberdecls">
<tr class="heading"><td colspan="2"><h2 class="groupheader"><a name="pub-static-methods"></a>
Static Public Member Functions</h2></td></tr>
<tr class="memitem:ab91b07382d63b0739b68ef5ec232de4f"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#ab91b07382d63b0739b68ef5ec232de4f">aliphatic</a> (char aa)</td></tr>
<tr class="memdesc:ab91b07382d63b0739b68ef5ec232de4f"><td class="mdescLeft"> </td><td class="mdescRight">Returns if the residue is aliphatic (1.0 or 0.0) <a href="#ab91b07382d63b0739b68ef5ec232de4f">More...</a><br/></td></tr>
<tr class="separator:ab91b07382d63b0739b68ef5ec232de4f"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a9dfe721ea8c23f1ab211ac5d802615aa"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a9dfe721ea8c23f1ab211ac5d802615aa">acidic</a> (char aa)</td></tr>
<tr class="memdesc:a9dfe721ea8c23f1ab211ac5d802615aa"><td class="mdescLeft"> </td><td class="mdescRight">Returns if the residue is acidic (1.0 or 0.0) <a href="#a9dfe721ea8c23f1ab211ac5d802615aa">More...</a><br/></td></tr>
<tr class="separator:a9dfe721ea8c23f1ab211ac5d802615aa"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a47617770512294da2125390c498a967e"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a47617770512294da2125390c498a967e">basic</a> (char aa)</td></tr>
<tr class="memdesc:a47617770512294da2125390c498a967e"><td class="mdescLeft"> </td><td class="mdescRight">Returns if the residue is basic (1.0 or 0.0) <a href="#a47617770512294da2125390c498a967e">More...</a><br/></td></tr>
<tr class="separator:a47617770512294da2125390c498a967e"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a4e7af7c6ed63039bee4273b3edfdab05"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a4e7af7c6ed63039bee4273b3edfdab05">polar</a> (char aa)</td></tr>
<tr class="memdesc:a4e7af7c6ed63039bee4273b3edfdab05"><td class="mdescLeft"> </td><td class="mdescRight">Returns if the residue is polar (1.0 or 0.0) <a href="#a4e7af7c6ed63039bee4273b3edfdab05">More...</a><br/></td></tr>
<tr class="separator:a4e7af7c6ed63039bee4273b3edfdab05"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:aa53e18a3e6a36426362f17fd0b1e7c74"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#aa53e18a3e6a36426362f17fd0b1e7c74">getKHAG800101</a> (char aa)</td></tr>
<tr class="memdesc:aa53e18a3e6a36426362f17fd0b1e7c74"><td class="mdescLeft"> </td><td class="mdescRight">The Kerr-constant increments (Khanarian-Moore, 1980) <a href="#aa53e18a3e6a36426362f17fd0b1e7c74">More...</a><br/></td></tr>
<tr class="separator:aa53e18a3e6a36426362f17fd0b1e7c74"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a411069d7afbb32b92a70a10217c62e76"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a411069d7afbb32b92a70a10217c62e76">getVASM830103</a> (char aa)</td></tr>
<tr class="memdesc:a411069d7afbb32b92a70a10217c62e76"><td class="mdescLeft"> </td><td class="mdescRight">Relative population of conformational state E (Vasquez et al., 1983) <a href="#a411069d7afbb32b92a70a10217c62e76">More...</a><br/></td></tr>
<tr class="separator:a411069d7afbb32b92a70a10217c62e76"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:ac5b823982432c91b1241d7822db1cb38"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#ac5b823982432c91b1241d7822db1cb38">getNADH010106</a> (char aa)</td></tr>
<tr class="memdesc:ac5b823982432c91b1241d7822db1cb38"><td class="mdescLeft"> </td><td class="mdescRight">Hydropathy scale based on self-information values in the two-state model (36% accessibility) (Naderi-Manesh et al., 2001) <a href="#ac5b823982432c91b1241d7822db1cb38">More...</a><br/></td></tr>
<tr class="separator:ac5b823982432c91b1241d7822db1cb38"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a618d77d2588d3550c4eef5925b795905"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a618d77d2588d3550c4eef5925b795905">getNADH010107</a> (char aa)</td></tr>
<tr class="memdesc:a618d77d2588d3550c4eef5925b795905"><td class="mdescLeft"> </td><td class="mdescRight">Hydropathy scale based on self-information values in the two-state model (50% accessibility) (Naderi-Manesh et al., 2001) <a href="#a618d77d2588d3550c4eef5925b795905">More...</a><br/></td></tr>
<tr class="separator:a618d77d2588d3550c4eef5925b795905"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:ab55bf6601096f55e453ccb53661db426"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#ab55bf6601096f55e453ccb53661db426">getWILM950102</a> (char aa)</td></tr>
<tr class="memdesc:ab55bf6601096f55e453ccb53661db426"><td class="mdescLeft"> </td><td class="mdescRight">Hydrophobicity coefficient in RP-HPLC, C8 with 0.1TFA/MeCN/H2O (Wilce et al. 1995) <a href="#ab55bf6601096f55e453ccb53661db426">More...</a><br/></td></tr>
<tr class="separator:ab55bf6601096f55e453ccb53661db426"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a106366b88035f317eb9867ddc3594ba5"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a106366b88035f317eb9867ddc3594ba5">getROBB760107</a> (char aa)</td></tr>
<tr class="memdesc:a106366b88035f317eb9867ddc3594ba5"><td class="mdescLeft"> </td><td class="mdescRight">Information measure for extended without H-bond (Robson-Suzuki, 1976) <a href="#a106366b88035f317eb9867ddc3594ba5">More...</a><br/></td></tr>
<tr class="separator:a106366b88035f317eb9867ddc3594ba5"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a9c6453defaacce21ffcb2f6254eee5f0"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a9c6453defaacce21ffcb2f6254eee5f0">getOOBM850104</a> (char aa)</td></tr>
<tr class="memdesc:a9c6453defaacce21ffcb2f6254eee5f0"><td class="mdescLeft"> </td><td class="mdescRight">Optimized average non-bonded energy per atom (Oobatake et al., 1985) <a href="#a9c6453defaacce21ffcb2f6254eee5f0">More...</a><br/></td></tr>
<tr class="separator:a9c6453defaacce21ffcb2f6254eee5f0"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a09f0c97d0a2361f563850d89cff190d1"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a09f0c97d0a2361f563850d89cff190d1">getFAUJ880111</a> (char aa)</td></tr>
<tr class="memdesc:a09f0c97d0a2361f563850d89cff190d1"><td class="mdescLeft"> </td><td class="mdescRight">Positive charge (Fauchere et al., 1988) <a href="#a09f0c97d0a2361f563850d89cff190d1">More...</a><br/></td></tr>
<tr class="separator:a09f0c97d0a2361f563850d89cff190d1"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:aac1b2d685d6d8332b2540a4fa71d55ac"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#aac1b2d685d6d8332b2540a4fa71d55ac">getFINA770101</a> (char aa)</td></tr>
<tr class="memdesc:aac1b2d685d6d8332b2540a4fa71d55ac"><td class="mdescLeft"> </td><td class="mdescRight">Helix-coil equilibrium constant (Finkelstein-Ptitsyn, 1977) <a href="#aac1b2d685d6d8332b2540a4fa71d55ac">More...</a><br/></td></tr>
<tr class="separator:aac1b2d685d6d8332b2540a4fa71d55ac"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a7f1de0b0ad7357f31be37b5fd84825a0"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a7f1de0b0ad7357f31be37b5fd84825a0">getARGP820102</a> (char aa)</td></tr>
<tr class="memdesc:a7f1de0b0ad7357f31be37b5fd84825a0"><td class="mdescLeft"> </td><td class="mdescRight">Signal sequence helical potential (Argos et al., 1982) <a href="#a7f1de0b0ad7357f31be37b5fd84825a0">More...</a><br/></td></tr>
<tr class="separator:a7f1de0b0ad7357f31be37b5fd84825a0"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:ad1c6ae31304ecc2776a8777ea58d2786"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#ad1c6ae31304ecc2776a8777ea58d2786">calculateGB</a> (const <a class="el" href="classOpenMS_1_1AASequence.html">AASequence</a> &seq, <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> T=500.0)</td></tr>
<tr class="memdesc:ad1c6ae31304ecc2776a8777ea58d2786"><td class="mdescLeft"> </td><td class="mdescRight">Calculates an estimated gas-phase basicity for an amino acid sequence at a given temperature. <a href="#ad1c6ae31304ecc2776a8777ea58d2786">More...</a><br/></td></tr>
<tr class="separator:ad1c6ae31304ecc2776a8777ea58d2786"><td class="memSeparator" colspan="2"> </td></tr>
</table><table class="memberdecls">
<tr class="heading"><td colspan="2"><h2 class="groupheader"><a name="pro-static-methods"></a>
Static Protected Member Functions</h2></td></tr>
<tr class="memitem:abe949f2754c1a436f871644f882118c0"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#abe949f2754c1a436f871644f882118c0">GBsidechain_</a> (char aa)</td></tr>
<tr class="memdesc:abe949f2754c1a436f871644f882118c0"><td class="mdescLeft"> </td><td class="mdescRight">Calculates part of the gas-phase basicity. <a href="#abe949f2754c1a436f871644f882118c0">More...</a><br/></td></tr>
<tr class="separator:abe949f2754c1a436f871644f882118c0"><td class="memSeparator" colspan="2"> </td></tr>
<tr class="memitem:a875cd73c1c6e3cd6b59beba3bc362f3d"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a875cd73c1c6e3cd6b59beba3bc362f3d">GBleft_</a> (char aa)</td></tr>
<tr class="memdesc:a875cd73c1c6e3cd6b59beba3bc362f3d"><td class="mdescLeft"> </td><td class="mdescRight">Calculates part of the gas-phase basicity. <a href="#a875cd73c1c6e3cd6b59beba3bc362f3d">More...</a><br/></td></tr>
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<tr class="memitem:a4f3ea4b7f5131d5e1bf556e57ff958a9"><td class="memItemLeft" align="right" valign="top">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#a4f3ea4b7f5131d5e1bf556e57ff958a9">GBdeltaright_</a> (char aa)</td></tr>
<tr class="memdesc:a4f3ea4b7f5131d5e1bf556e57ff958a9"><td class="mdescLeft"> </td><td class="mdescRight">Calculates part of the gas-phase basicity. <a href="#a4f3ea4b7f5131d5e1bf556e57ff958a9">More...</a><br/></td></tr>
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<tr class="heading"><td colspan="2"><h2 class="groupheader"><a name="pri-methods"></a>
Private Member Functions</h2></td></tr>
<tr class="memitem:ab4812f4a3a40ad323db68b25b5b1ddcd"><td class="memItemLeft" align="right" valign="top"> </td><td class="memItemRight" valign="bottom"><a class="el" href="classOpenMS_1_1AAIndex.html#ab4812f4a3a40ad323db68b25b5b1ddcd">AAIndex</a> ()</td></tr>
<tr class="memdesc:ab4812f4a3a40ad323db68b25b5b1ddcd"><td class="mdescLeft"> </td><td class="mdescRight">Constructor not implemented => private. <a href="#ab4812f4a3a40ad323db68b25b5b1ddcd">More...</a><br/></td></tr>
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<a name="details" id="details"></a><h2 class="groupheader">Detailed Description</h2>
<div class="textblock"><p>Representation of selected AAIndex properties. </p>
<p>The literature that describe the indices can be found with: <br/>
Kawashima, S., Ogata, H., and Kanehisa, M. (1999). <br/>
<em>AAindex: Amino Acid Index Database</em>, <br/>
Nucleic Acids Res, 27(1), 368–369.</p>
<p>The provided values are:</p>
<ul>
<li>GB500 Estimated gas-phase basicity at 500 K,</li>
<li>VASM830103 Relative population of conformational state E,</li>
<li>NADH010106 Hydropathy scale (36% accessibility),</li>
<li>FAUJ880111 Positive charge,</li>
<li>WILM950102 Hydrophobicity coefficient in RP-HPLC, C8 with 0.1TFA/MeCN/H2 O,</li>
</ul>
<p>OOBM850104 Optimized average non-bonded energy per atom,</p>
<ul>
<li>KHAG800101 The Kerr-constant increments,</li>
<li>NADH010107 Hydropathy scale (50% accessibility),</li>
<li>ROBB760107 Information measure for extended without H-bond,</li>
<li>FINA770101 Helix-coil equilibrium constant,</li>
<li>ARGP820102 Signal sequence helical potential.</li>
</ul>
<p>Upper-case one-letter-code can be used to access the properties of a single amino acid. </p>
</div><h2 class="groupheader">Constructor & Destructor Documentation</h2>
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<p>Constructor not implemented => private. </p>
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<h2 class="groupheader">Member Function Documentation</h2>
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<p>Returns if the residue is acidic (1.0 or 0.0) </p>
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<p>Returns if the residue is aliphatic (1.0 or 0.0) </p>
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<p>Returns if the residue is basic (1.0 or 0.0) </p>
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<p>Calculates an estimated gas-phase basicity for an amino acid sequence at a given temperature. </p>
<p>Energy level E at each protonation site i is -GB(i) fractional proton population of a microstate k is <br/>
P_k = exp (- E_k/(RT)) / ( sum_i exp (- E_i/(RT))) <br/>
The apparent proton association constant K_app: K_app = sum_i GB(i)/(RT)<br/>
Then the apparent GB is GB_app^ion = R * T * ln(K_app)</p>
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<p>References <a class="el" href="namespaceOpenMS_1_1Constants.html#a759de767b7a587aad48d103a69b61143">OpenMS::Constants::GAS_CONSTANT</a>, <a class="el" href="classOpenMS_1_1Residue.html#a2a13c7e89803cb66d9d7f1ab5c8bfa72">Residue::getOneLetterCode()</a>, <a class="el" href="namespaceOpenMS_1_1Constants.html#a0877420f3d7b1f47b871d2ccb47168d8">OpenMS::Constants::R</a>, and <a class="el" href="classOpenMS_1_1AASequence.html#a9d78a687cf2a391198bb3cbc08bc06cb">AASequence::size()</a>.</p>
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<p>Calculates part of the gas-phase basicity. </p>
<p>For a detailed description see <a class="el" href="classOpenMS_1_1AAIndex.html#ad1c6ae31304ecc2776a8777ea58d2786">calculateGB(const AASequence&, DoubleReal)</a> .</p>
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<p>Calculates part of the gas-phase basicity. </p>
<p>For a detailed description see <a class="el" href="classOpenMS_1_1AAIndex.html#ad1c6ae31304ecc2776a8777ea58d2786">calculateGB(const AASequence&, DoubleReal)</a> .</p>
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<p>Calculates part of the gas-phase basicity. </p>
<p>For a detailed description see <a class="el" href="classOpenMS_1_1AAIndex.html#ad1c6ae31304ecc2776a8777ea58d2786">calculateGB(const AASequence&, DoubleReal)</a> .</p>
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<p>Signal sequence helical potential (Argos et al., 1982) </p>
<p>LIT:0901079b PMID:7151796<br/>
Argos, P., Rao, J.K.M. and Hargrave, P.A.<br/>
Structural prediction of membrane-bound proteins<br/>
Eur. J. Biochem. 128, 565-575 (1982)</p>
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<p>Positive charge (Fauchere et al., 1988) </p>
<p>LIT:1414114 PMID:3209351<br/>
Fauchere, J.L., Charton, M., Kier, L.B., Verloop, A. and Pliska, V.<br/>
Amino acid side chain parameters for correlation studies in biology and pharmacology<br/>
Int. J. Peptide Protein Res. 32, 269-278 (1988)</p>
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<p>Helix-coil equilibrium constant (Finkelstein-Ptitsyn, 1977) </p>
<p>LIT:2004052b PMID:843599<br/>
Finkelstein, A.V. and Ptitsyn, O.B.<br/>
Theory of protein molecule self-organization. II. A comparison of calculated thermodynamic parameters of local secondary structures with experiments<br/>
Biopolymers 16, 497-524 (1977) (Pro 0.096)</p>
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<p>The Kerr-constant increments (Khanarian-Moore, 1980) </p>
<p>LIT:0611050b<br/>
Khanarian, G. and Moore, W.J.<br/>
The Kerr effect of amino acids in water<br/>
Aust. J. Chem. 33, 1727-1741 (1980) (Cys Lys Tyr !)</p>
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<p>Hydropathy scale based on self-information values in the two-state model (36% accessibility) (Naderi-Manesh et al., 2001) </p>
<p>PMID:11170200<br/>
Naderi-Manesh, H., Sadeghi, M., Arab, S. and Moosavi Movahedi, A.A.<br/>
Prediction of protein surface accessibility with information theory<br/>
Proteins. 42, 452-459 (2001)</p>
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<p>Hydropathy scale based on self-information values in the two-state model (50% accessibility) (Naderi-Manesh et al., 2001) </p>
<p>PMID:11170200<br/>
Naderi-Manesh, H., Sadeghi, M., Arab, S. and Moosavi Movahedi, A.A.<br/>
Prediction of protein surface accessibility with information theory<br/>
Proteins. 42, 452-459 (2001)</p>
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<p>Optimized average non-bonded energy per atom (Oobatake et al., 1985) </p>
<p>LIT:1207075b<br/>
Oobatake, M., Kubota, Y. and Ooi, T.<br/>
Optimization of amino acid parameters for correspondence of sequence to tertiary structures of proteins<br/>
Bull. Inst. Chem. Res., Kyoto Univ. 63, 82-94 (1985)</p>
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<td class="memname">static <a class="el" href="group__Concept.html#gace75bfb1aba684e874dffee13738bd15">DoubleReal</a> getROBB760107 </td>
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<p>Information measure for extended without H-bond (Robson-Suzuki, 1976) </p>
<p>PMID:1003471<br/>
Robson, B. and Suzuki, E.<br/>
Conformational properties of amino acid residues in globular proteins<br/>
J. Mol. Biol. 107, 327-356 (1976)</p>
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<p>Relative population of conformational state E (Vasquez et al., 1983) </p>
<p>LIT:0908110<br/>
Vasquez, M., Nemethy, G. and Scheraga, H.A.<br/>
Computed conformational states of the 20 naturally occurring amino acid residues and of the prototype residue alpha-aminobutyric acid<br/>
Macromolecules 16, 1043-1049 (1983) (Pro !)</p>
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<p>Hydrophobicity coefficient in RP-HPLC, C8 with 0.1TFA/MeCN/H2O (Wilce et al. 1995) </p>
<p>Wilce, M.C., Aguilar, M.I. and Hearn, M.T.<br/>
Physicochemical basis of amino acid hydrophobicity scales: evaluation of four new scales of amino acid hydrophobicity coefficients derived from RP-HPLC of peptides<br/>
Anal Chem. 67, 1210-1219 (1995)</p>
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<p>Returns if the residue is polar (1.0 or 0.0) </p>
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