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/***************************************************************************
* PHAST: PHylogenetic Analysis with Space/Time models
* Copyright (c) 2002-2005 University of California, 2006-2010 Cornell
* University. All rights reserved.
*
* This source code is distributed under a BSD-style license. See the
* file LICENSE.txt for details.
***************************************************************************/
#include "phast/category_map.h"
#include "phast/gff.h"
#include "phast/stacks.h"
#include "phast/misc.h"
#include <phast/hashtable.h>
#include <unistd.h>
//this has a conflict with RPHAST
#undef prec
static int *prec;
/* Read a CategoryMap from a file */
CategoryMap *cm_read(FILE *F) {
String *line, *name;
List *l;
int cat, cat2, lineno, i, cm_read_error;
CategoryMap *cm = NULL;
CategoryRange *existing_range;
static pcre2_compile_context *cat_range_re = NULL;
static pcre2_compile_context *ncats_re = NULL;
static pcre2_compile_context *fill_re = NULL;
static pcre2_compile_context *label_re = NULL;
static pcre2_compile_context *extend_re = NULL;
int has_dependencies = 0;
line = str_new(STR_SHORT_LEN);
l = lst_new_ptr(3);
if (cat_range_re == NULL) {
cat_range_re = str_re_new("^[[:space:]]*([^[:space:]]+)[[:space:]]+([[:digit:]]+)(-([[:digit:]]+))?([[:space:]]+([[:digit:]].*))?");
ncats_re = str_re_new("^[[:space:]]*NCATS[[:space:]]*=[[:space:]]*([[:digit:]]+)");
fill_re = str_re_new("^[[:space:]]*FILL_PRECEDENCE[[:space:]]*=[[:space:]]*(.*)$");
label_re = str_re_new("^[[:space:]]*LABELLING_PRECEDENCE[[:space:]]*=[[:space:]]*(.*)$");
extend_re = str_re_new("^[[:space:]]*FEATURE_EXTEND[[:space:]]*:[[:space:]]*(.+)[[:space:]]*\\((.+)\\)$");
}
lineno = 0;
while ((str_readline(line, F)) != EOF) {
lineno++;
str_trim(line);
if (str_equals_charstr(line, ""))
continue;
if (str_re_match(line, ncats_re, l, 1) >= 0) {
/* NCATS line */
int ncats;
str_as_int(lst_get_ptr(l, 1), &ncats);
cm = cm_new(ncats);
/* 0th category is "background" */
cm->ranges[0] =
cm_new_category_range(str_new_charstr(BACKGD_CAT_NAME), 0, 0);
}
else if (cm == NULL || cm->ncats == 0)
die("ERROR: NCATS line must appear first, and must specify a positive number of categories.\n");
else if (str_re_match(line, label_re, l, 1) >= 0) {
/* LABELLING_PRECEDENCE line */
List *tmpl = lst_new_ptr(cm->ncats);
int tmpi;
str_split((String*)lst_get_ptr(l, 1), " ,", tmpl);
for (i = 0; i < lst_size(tmpl); i++) {
String *s = (String*)lst_get_ptr(tmpl, i);
if (str_as_int(s, &tmpi) != 0 || tmpi < 0 || tmpi > cm->ncats)
die("ERROR: bad integer in LABELLING_PRECEDENCE.\n");
cm->labelling_precedence[tmpi] = i;
str_free(s);
}
lst_free(tmpl);
}
else if (str_re_match(line, fill_re, l, 1) >= 0) {
/* FILL_PRECEDENCE line */
List *tmpl = lst_new_ptr(cm->ncats);
int tmpi;
str_split(lst_get_ptr(l, 1), " ,", tmpl);
for (i = 0; i < lst_size(tmpl); i++) {
String *s = lst_get_ptr(tmpl, i);
if (str_as_int(s, &tmpi) != 0 || tmpi < 0 || tmpi > cm->ncats)
die("ERROR: bad integer in FILL_PRECEDENCE.\n");
cm->fill_precedence[tmpi] = i;
str_free(s);
}
lst_free(tmpl);
}
else if (str_re_match(line, extend_re, l, 2) >= 0) {
/* FEATURE_EXTEND line */
String *target = lst_get_ptr(l, 2);
List *sources = lst_new_ptr(2);
str_split(lst_get_ptr(l, 1), " ,", sources);
if (cm == NULL || (cat = cm_get_category(cm, target)) == 0)
die("ERROR: FEATURE_EXTEND target must be a previously-defined non-background feature type.\n");
for (i = 0; i < lst_size(sources); i++) {
if (cm_get_category(cm, lst_get_ptr(sources, i)) == 0)
die("ERROR: FEATURE_EXTEND source list must consist of previously-defined non-background feature types.\n");
}
}
else { /* 'range' line */
if (str_re_match(line, cat_range_re, l, 6) < 0)
die("ERROR at line %d: '%s'\n", lineno, line->chars);
name = str_dup((String*)lst_get_ptr(l, 1));
str_as_int((String*)lst_get_ptr(l, 2), &cat);
cat2 = cat;
if (lst_get_ptr(l, 4) != NULL)
str_as_int((String*)lst_get_ptr(l, 4), &cat2);
if (cat < 0 || cat2 < cat || cat2 > cm->ncats)
die("ERROR: Illegal category range.\n");
/* check for existing definitions of the specified category
range. Either no such definition must exist, or one must
exist that spans exactly the same category numbers */
existing_range = NULL;
cm_read_error = 0;
for (i = cat; !cm_read_error && i <= cat2; i++) {
if (cm->ranges[i] != NULL && existing_range == NULL)
existing_range = cm->ranges[i];
else if (cm->ranges[i] != existing_range)
cm_read_error = 1;
}
if (existing_range != NULL && (existing_range->start_cat_no != cat ||
existing_range->end_cat_no != cat2))
cm_read_error = 1;
if (cm_read_error)
die("ERROR: Overlapping category ranges.\n");
/* either add new category range, or add new type to existing one */
if (existing_range != NULL) {
lst_push_ptr(existing_range->feature_types, name);
}
else {
CategoryRange *cr = cm_new_category_range(name, cat, cat2);
for (i = cat; i <= cat2; i++)
cm->ranges[i] = cr;
}
/* now address "conditioned_on" dependencies, if they have been
specified */
if (lst_get_ptr(l, 6) != NULL) {
if (existing_range != NULL)
fprintf(stderr, "WARNING: ignoring 'conditioned on' list for type '%s'\n",
name->chars);
else {
List *tmpl = lst_new_ptr(cm->ncats);
int tmpi;
if (cm->conditioned_on[cat] != NULL)
die("ERROR cm_read: cm->conditioned_on[%i] should be NULL\n",
cat);
str_split((String*)lst_get_ptr(l, 6), " ,", tmpl);
cm->conditioned_on[cat] = lst_new_int(lst_size(tmpl));
for (i = cat + 1; i <= cat2; i++)
cm->conditioned_on[i] = cm->conditioned_on[cat];
/* all categories in range point to
same "conditioned on" list */
for (i = 0; i < lst_size(tmpl); i++) {
String *s = (String*)lst_get_ptr(tmpl, i);
if (str_as_int(s, &tmpi) != 0 || tmpi < 0 || tmpi > cm->ncats)
die("ERROR: bad integer in 'conditioned on' list for type '%s'.\n",
name->chars);
lst_push_int(cm->conditioned_on[cat], tmpi);
str_free(s);
}
lst_free(tmpl);
has_dependencies = 1;
}
}
}
for (i = 0; i < lst_size(l); i++)
if (lst_get_ptr(l, i) != NULL)
str_free((String*)lst_get_ptr(l, i));
}
/* make sure every category has been specified */
for (i = 0; i <= cm->ncats; i++)
if (cm->ranges[i] == 0)
die("ERROR: category %d has not been specified.\n", i);
/* build unspooler, if necessary */
if (has_dependencies)
cm->unspooler = cm_create_unspooler(cm->ncats + 1, cm->conditioned_on);
str_free(line);
lst_free(l);
return cm;
}
/* for use in cm_print (see below) */
int compare_prec(const void* ptr1, const void* ptr2) {
int val1 = *((int*)ptr1);
int val2 = *((int*)ptr2);
return (prec[val1] - prec[val2]);
}
/* Print a CategoryMap to a file */
void cm_print(CategoryMap *cm, FILE *F) {
int i, j, k;
List *tmpl;
fprintf(F, "NCATS = %d\n\n", cm->ncats);
for (i = 1; i <= cm->ncats; i++) {
CategoryRange *cr = cm->ranges[i];
for (j = 0; j < lst_size(cr->feature_types); j++) {
String *s = (String*)lst_get_ptr(cr->feature_types, j);
fprintf(F, "%-15s %d", s->chars, cr->start_cat_no);
if (cr->end_cat_no > cr->start_cat_no)
fprintf(F, "-%d", cr->end_cat_no);
if (cm->conditioned_on[i] != NULL) {
fprintf(F, "\t");
for (k = 0; k < lst_size(cm->conditioned_on[i]); k++)
fprintf(F, "%d%s", lst_get_int(cm->conditioned_on[i], k),
k + 1 == lst_size(cm->conditioned_on[i]) ? "" : ",");
}
fprintf(F, "\n");
}
i = cr->end_cat_no; /* avoid looking multiple times at the
same range */
}
/* reconstruct precedence lists */
tmpl = lst_new_int(cm->ncats + 1);
for (i = 0; i <= cm->ncats; i++)
lst_push_int(tmpl, i);
prec = cm->labelling_precedence;
lst_qsort(tmpl, compare_prec);
fprintf(F, "\nLABELLING_PRECEDENCE = ");
for (i = 0; i <= cm->ncats; i++) {
int cat = lst_get_int(tmpl, i);
if (cm->labelling_precedence[cat] != -1)
fprintf(F, "%d%s", cat, i < cm->ncats ? "," : "");
}
fprintf(F, "\n");
lst_clear(tmpl);
for (i = 0; i <= cm->ncats; i++)
lst_push_int(tmpl, i);
prec = cm->fill_precedence;
lst_qsort(tmpl, compare_prec);
fprintf(F, "FILL_PRECEDENCE = ");
for (i = 0; i <= cm->ncats; i++) {
int cat = lst_get_int(tmpl, i);
if (cm->fill_precedence[cat] != -1)
fprintf(F, "%d%s", cat, i < cm->ncats ? "," : "");
}
fprintf(F, "\n");
lst_free(tmpl);
}
/* Return the 'base' category for a given feature type (first
category in range). Returns 0 (background) if no match. */
int cm_get_category(CategoryMap *cm, String *type) {
int i, j;
if (cm->ncats == 0) return 0;
for (i = 0; i <= cm->ncats; i++) {
CategoryRange *cr = cm->ranges[i];
if (cr == NULL) return 0; /* possible if called in cm_read
before object is complete */
for (j = 0; j < lst_size(cr->feature_types); j++)
if (str_equals(type, (String*)lst_get_ptr(cr->feature_types, j)))
return i;
i = cr->end_cat_no; /* avoid looking multiple times at the
same range */
}
return 0;
}
/* Return a list of category numbers corresponding to a given list of
category names and or numbers. */
List *cm_get_category_list(CategoryMap *cm, List *names, int ignore_missing) {
int i, j, cat;
List *retval = lst_new_int(lst_size(names));
for (i = 0; i < lst_size(names); i++) {
String *n = lst_get_ptr(names, i);
if (str_as_int(n, &cat) == 0) {
if (cat < 0 || (cm != NULL && cat > cm->ncats))
die("ERROR: category number %d is out of bounds.\n", cat);
lst_push_int(retval, cat);
}
else {
if (cm == NULL)
die("ERROR: if categories are specified by name, a category map is required.\n");
cat = cm_get_category(cm, n);
if (cat == 0 && !ignore_missing && !str_equals(n, cm_get_feature(cm, 0)))
die("ERROR: illegal category name (\"%s\")\n", n->chars);
for (j = cm->ranges[cat]->start_cat_no;
j <= cm->ranges[cat]->end_cat_no; j++)
lst_push_int(retval, j);
}
}
return retval;
}
/* Return a list of category names corresponding to a given list of
category names and or numbers. Doesn't allocate new names,
just pointers to Strings in the CategoryMap object or the
provided List */
List *cm_get_category_str_list(CategoryMap *cm, List *names, int ignore_missing) {
int i, cat;
List *retval = lst_new_ptr(lst_size(names));
for (i = 0; i < lst_size(names); i++) {
String *n = lst_get_ptr(names, i);
if (str_as_int(n, &cat) == 0) {
if (cm == NULL)
die("ERROR: if categories are specified by number, a category map is required\n");
if (cat < 0 || (cm != NULL && cat > cm->ncats))
die("ERROR: category number %d is out of bounds.\n", cat);
lst_push_ptr(retval, cm_get_feature(cm, cat));
}
else {
if (cm != NULL) {
cat = cm_get_category(cm, n);
if (cat == 0 && !ignore_missing && !str_equals(n, cm_get_feature(cm, 0))) {
die("ERROR: illegal category name (\"%s\")\n", n->chars);
}
//return pointers to cm if possible
lst_push_ptr(retval, cm_get_feature(cm, cat));
}
//otherwise return pointers to strings in list
else lst_push_ptr(retval, n);
}
}
return retval;
}
/** Retrieve the (primary) feature type associated with the specified
category number. Note: return value is passed by reference -- do
not alter. */
String *cm_get_feature(CategoryMap *cm, int cat) {
if (!(cat >= 0 && cat <= cm->ncats))
die("ERROR cm_get_feature: cat=%i, should be in [0, %i]\n",
cat, cm->ncats);
return lst_get_ptr(cm->ranges[cat]->feature_types, 0);
}
/* Obtain a unique name based on the (primary) feature type
associated with the specified category number. Returns a pointer
to a newly allocated String.*/
String *cm_get_feature_unique(CategoryMap *cm, int cat) {
String *retval = str_dup(lst_get_ptr(cm->ranges[cat]->feature_types, 0));
if (! (cat >= 0 && cat <= cm->ncats))
die("ERROR cm_get_feature_unique: cat=%i, should be in [0,%i]\n",
cat, cm->ncats);
if (cm->ranges[cat]->start_cat_no != cm->ranges[cat]->end_cat_no) {
str_append_char(retval, '-');
str_append_int(retval, cat - cm->ranges[cat]->start_cat_no + 1);
}
return retval;
}
/* return list of category names corresponding to list of category
numbers */
List *cm_get_features(CategoryMap *cm, List *catnos) {
int mark[cm->ncats+1];
List *retval = lst_new_ptr(lst_size(catnos));
int i, cat;
for (i = 0; i <= cm->ncats; i++) mark[i] = 0;
for (i = 0; i < lst_size(catnos); i++) {
cat = lst_get_int(catnos, i);
if (!mark[cm->ranges[cat]->start_cat_no]) {
lst_push_ptr(retval, cm_get_feature(cm, cat));
mark[cm->ranges[cat]->start_cat_no] = 1;
}
}
return retval;
}
CategoryMap *cm_new(int ncats) {
int i;
CategoryMap *cm = (CategoryMap*)smalloc(sizeof(CategoryMap));
cm->ncats = ncats;
cm->ranges = smalloc((cm->ncats + 1) * sizeof(CategoryRange*));
cm->conditioned_on = smalloc((cm->ncats + 1) * sizeof(List*));
cm->labelling_precedence = smalloc((cm->ncats + 1) * sizeof(int));
cm->fill_precedence = smalloc((cm->ncats + 1) * sizeof(int));
for (i = 0; i <= cm->ncats; i++) {
cm->ranges[i] = NULL;
cm->conditioned_on[i] = NULL;
cm->labelling_precedence[i] = -1;
cm->fill_precedence[i] = -1;
}
cm->unspooler = NULL;
return cm;
}
CategoryMap *cm_create_copy(CategoryMap *src) {
int i, has_dependencies = 0;
CategoryMap *retval = cm_new(src->ncats);
for (i = 0; i <= src->ncats; i++) {
retval->ranges[i] = cm_category_range_create_copy(src->ranges[i]);
if (retval->conditioned_on[i] != NULL) {
retval->conditioned_on[i] = lst_new_int(lst_size(src->conditioned_on[i]));
lst_cpy(retval->conditioned_on[i], src->conditioned_on[i]);
has_dependencies = 1;
}
retval->labelling_precedence[i] = src->labelling_precedence[i];
retval->fill_precedence[i] = src->fill_precedence[i];
}
if (has_dependencies) cm_create_unspooler(retval->ncats + 1,
retval->conditioned_on);
return retval;
}
/* Create a trivial CategoryMap, with feature types equal to category
numbers (plus an optional prefix) and ranges all of size one. */
CategoryMap* cm_create_trivial(int ncats, char *feature_prefix) {
int i;
CategoryMap *retval = cm_new(ncats);
for (i = 0; i <= ncats; i++) {
String *type = str_new(STR_SHORT_LEN);
if (feature_prefix != NULL) str_append_charstr(type, feature_prefix);
str_append_int(type, i);
retval->ranges[i] = cm_new_category_range(type, i, i);
}
return retval;
}
/* Create a category map with a category for each feature type in a
GFF_Set. Category numbers are assigned in order of appearance of
types */
CategoryMap* cm_new_from_features(GFF_Set *feats) {
int i;
CategoryMap *retval;
Hashtable *hash;
List *types;
/* first scan features for all types */
hash = hsh_new(10);
types = lst_new_ptr(10);
for (i = 0; i < lst_size(feats->features); i++) {
GFF_Feature *f = lst_get_ptr(feats->features, i);
checkInterruptN(i, 10000);
if (hsh_get(hash, f->feature->chars) == (void*)-1) {
lst_push_ptr(types, f->feature);
hsh_put_int(hash, f->feature->chars, 1);
}
}
hsh_free(hash);
/* now create a simple category map */
retval = cm_new(lst_size(types));
for (i = 0; i <= retval->ncats; i++) {
String *type = i == 0 ? str_new_charstr(BACKGD_CAT_NAME) :
str_dup(lst_get_ptr(types, i-1));
retval->ranges[i] = cm_new_category_range(type, i, i);
}
lst_free(types);
return retval;
}
/* Create a new category map from a string that can
either be a filename or a brief "inlined" category map, e.g.,
"NCATS = 3 ; CDS 1-3". Useful for command-line arguments. */
CategoryMap* cm_new_string_or_file(const char *optarg) {
int i;
char fname[STR_SHORT_LEN];
String *str = str_new_charstr(optarg);
FILE *F;
CategoryMap *retval = NULL;
str_double_trim(str);
if (str_starts_with_charstr(str, "NCATS")) {
/* replace semicolons with carriage returns */
for (i = 0; i < str->length; i++)
if (str->chars[i] == ';') str->chars[i] = '\n';
/* we'll just dump a little tmp file and read it with cm_read */
sprintf(fname, "cm.tmp.%d", getpid());
F = phast_fopen(fname, "w+");
fprintf(F, "%s", str->chars);
phast_fclose(F);
F = phast_fopen(fname, "r");
retval = cm_read(F);
phast_fclose(F);
unlink(fname);
}
else {
F = phast_fopen(str->chars, "r");
retval = cm_read(F);
phast_fclose(F);
}
str_free(str);
return retval;
}
/* Reallocate a category map to allow for the specified size. */
void cm_realloc(CategoryMap *cm, int new_ncats) {
int i;
int old_ncats = cm->ncats;
cm->ncats = new_ncats;
cm->ranges = srealloc(cm->ranges, (cm->ncats + 1) * sizeof(CategoryRange*));
cm->conditioned_on = srealloc(cm->conditioned_on,
(cm->ncats + 1) * sizeof(List*));
cm->labelling_precedence = srealloc(cm->labelling_precedence,
(cm->ncats + 1) * sizeof(int));
cm->fill_precedence = srealloc(cm->fill_precedence,
(cm->ncats + 1) * sizeof(int));
for (i = old_ncats+1; i <= cm->ncats; i++) {
cm->ranges[i] = NULL;
cm->conditioned_on[i] = NULL;
cm->labelling_precedence[i] = -1;
cm->fill_precedence[i] = -1;
}
}
/* Free memory associated with category map. */
void cm_free(CategoryMap *cm) {
int i;
for (i = 0; i <= cm->ncats; i++) {
int len = 0;
if (cm->ranges[i] != NULL) {
len = cm->ranges[i]->end_cat_no - cm->ranges[i]->start_cat_no;
cm_free_category_range(cm->ranges[i]);
}
if (cm->conditioned_on[i] != NULL)
lst_free(cm->conditioned_on[i]);
i += len;
}
sfree(cm->ranges);
sfree(cm->conditioned_on);
sfree(cm->labelling_precedence);
sfree(cm->fill_precedence);
if (cm->unspooler != NULL)
cm_free_unspooler(cm->unspooler);
sfree(cm);
return;
}
CategoryRange* cm_new_category_range(String *type, int start_cat_no,
int end_cat_no) {
CategoryRange *cr = (CategoryRange*)smalloc(sizeof(CategoryRange));
cr->feature_types = lst_new_ptr(1);
lst_push_ptr(cr->feature_types, type);
cr->start_cat_no = start_cat_no;
cr->end_cat_no = end_cat_no;
return cr;
}
CategoryRange* cm_category_range_create_copy(CategoryRange *src) {
int i;
CategoryRange *retval =
cm_new_category_range(str_dup(lst_get_ptr(src->feature_types, 0)),
src->start_cat_no, src->end_cat_no);
for (i = 1; i < lst_size(src->feature_types); i++)
lst_push_ptr(retval->feature_types,
str_dup(lst_get_ptr(src->feature_types, i)));
return retval;
}
void cm_free_category_range(CategoryRange *cr) {
int i;
for (i = 0; i < lst_size(cr->feature_types); i++) {
String *s = (String*)lst_get_ptr(cr->feature_types, i);
if (s != NULL) str_free(s);
}
lst_free(cr->feature_types);
sfree(cr);
}
/* Add new feature to CategoryMap. Assumes a feature of the
specified type does not already exist. */
void cm_add_feature_type(CategoryMap *cm, String *type, int cycle_size) {
int catstart = cm->ncats + 1;
int catend = cm->ncats + cycle_size;
int i;
CategoryRange *cr = cm_new_category_range(type, catstart, catend);
cm->ncats = catend;
cm->ranges = (CategoryRange**)srealloc(cm->ranges, (cm->ncats + 1) *
sizeof(CategoryRange*));
cm->labelling_precedence = (int*)srealloc(cm->labelling_precedence,
(cm->ncats + 1) * sizeof(int));
cm->fill_precedence = (int*)srealloc(cm->fill_precedence,
(cm->ncats + 1) * sizeof(int));
cm->conditioned_on = (List**)srealloc(cm->conditioned_on,
(cm->ncats + 1) * sizeof(List*));
for (i = catstart; i <= catend; i++) {
cm->ranges[i] = cr;
cm->labelling_precedence[i] = -1;
cm->fill_precedence[i] = -1;
cm->conditioned_on[i] = NULL;
}
}
/* Create a GFF_Set from a sequence of category/state numbers, using
a specified category map and mapping from raw state numbers to
category numbers. */
GFF_Set *cm_labeling_as_gff(CategoryMap *cm, int *path,
int length, int *path_to_cat,
int *reverse_compl, char *seqname,
char *source, List *frame_cats,
char *grouptag, char *idpref
) {
int beg, end, i, cat, frame, groupno;
GFF_Set *gff = gff_new_set_init("PHAST", PHAST_VERSION);
int do_frame[cm->ncats+1];
char strand;
char groupstr[STR_SHORT_LEN];
int ignore_0 = str_equals_charstr(cm_get_feature(cm, 0), BACKGD_CAT_NAME);
/* ignore category 0 if background */
if (length <= 0) return gff;
for (i = 0; i <= cm->ncats; i++) do_frame[i] = 0;
if (frame_cats != NULL)
for (i = 0; i < lst_size(frame_cats); i++) {
int cat = cm_get_category(cm, lst_get_ptr(frame_cats, i));
if (cat != 0) /* ignore background or unrecognized name */
do_frame[cat] = 1;
}
groupno = 1;
if (idpref != NULL)
sprintf(groupstr, "%s \"%s.%d\"", grouptag != NULL ? grouptag : "id",
idpref, groupno);
else
sprintf(groupstr, "%s \"%d\"", grouptag != NULL ? grouptag : "id", groupno);
i = 0;
while (i < length) {
checkInterruptN(i, 10000);
cat = cm->ranges[path_to_cat[path[i]]]->start_cat_no;
strand = reverse_compl[path[i]] ? '-' : '+';
frame = do_frame[cat] ? path_to_cat[path[i]] - cat : GFF_NULL_FRAME;
/* scan ahead until enter new category range (or reach end of seq) */
beg = i + 1; /* begin of feature (GFF coords) */
for (i++; i < length &&
cm->ranges[path_to_cat[path[i]]]->start_cat_no == cat; i++);
end = i; /* end of feature (GFF coords) */
/* if minus strand, adjust frame to reflect end */
if (strand == '-' && do_frame[cat])
frame = path_to_cat[path[i-1]] - cat;
/* if legitimate feature (non-background), then incorp into GFF_Set */
if (cat != 0 || !ignore_0) /* create new feature and add */
lst_push_ptr(gff->features,
gff_new_feature(str_new_charstr(seqname),
str_new_charstr(source),
str_dup(cm_get_feature(cm, cat)),
beg, end, 0, strand, frame,
str_new_charstr(groupstr), TRUE));
if (cat == 0 && beg > 1) {
groupno++; /* increment group number each time a
sequence of 0s is encountered */
if (idpref != NULL)
sprintf(groupstr, "%s \"%s.%d\"", grouptag != NULL ? grouptag : "id",
idpref, groupno);
else
sprintf(groupstr, "%s \"%d\"", grouptag != NULL ? grouptag : "id",
groupno);
}
}
return gff;
}
/** maps a sequence (array) of category numbers from the spooled space to
the unspooled space, using the current unspooler. Original
sequence is overwritten */
void cm_spooled_to_unspooled(CategoryMap *cm, int *path, int pathlen) {
int j, sp_state, prev_sp_state;
List *pred;
if (cm->unspooler == NULL) return;
pred = lst_new_int(cm->unspooler->nstates_spooled);
prev_sp_state = -1;
for (j = 0; j < pathlen; j++) {
if (!(path[j] >= 0 && path[j] <= cm->unspooler->nstates_spooled))
die("ERROR cm_spooled_to_unspooled: path[%i]=%i, should be in [0, %i]\n",
j, path[j], cm->unspooler->nstates_spooled);
sp_state = path[j];
path[j] = cm_get_unspooled_state(cm, path[j], pred);
if (path[j] == -1)
die("ERROR: failure mapping to uspooled state at position %d.\n", j);
if (sp_state != prev_sp_state) {
/* if the current (spooled) state is not conditioned on any
other state, then its predecessor cannot matter, so the list
can be cleared */
if (lst_size(cm->unspooler->spooled_to_unspooled[sp_state]->children) == 0)
lst_clear(pred);
lst_push_int(pred, sp_state);
}
prev_sp_state = sp_state;
}
lst_free(pred);
}
/* maps a sequence (array) of category numbers from the unspooled space to
the spooled space, using the current unspooler. Original
sequence is overwritten */
void cm_unspooled_to_spooled(CategoryMap *cm, int *path, int pathlen) {
int j;
if (cm->unspooler == NULL) return;
for (j = 0; j < pathlen; j++) {
if (!(path[j] >= 0 && path[j] <= cm->unspooler->nstates_unspooled))
die("ERROR cm_unspooled_to_spooled: path[%i]=%i, should be in [0,%i]\n",
j, path[j], cm->unspooler->nstates_unspooled);
path[j] = cm->unspooler->unspooled_to_spooled[path[j]];
}
}
/* returns the spooled category number corresponding to a given
unspooled category number; simplifies calling code by taking care
of cases with and without unspooler */
int cm_unspooled_to_spooled_cat(CategoryMap *cm, int spooled_cat) {
return (cm->unspooler != NULL ?
cm->unspooler->unspooled_to_spooled[spooled_cat] :
spooled_cat);
}
/* conditioned_on must be an array of integer lists; specifically, the
ith element must be the list of state numbers on which the ith
state is conditioned. */
Unspooler *cm_create_unspooler(int nstates_spooled, List **conditioned_on) {
UnspoolNode *n;
int i, j;
Stack *s;
Unspooler *unsp;
int *mark;
int capacity;
unsp = (Unspooler*)smalloc(sizeof(Unspooler));
unsp->nstates_spooled = nstates_spooled;
unsp->nstates_unspooled = 0;
unsp->spooled_to_unspooled =
(UnspoolNode**)smalloc(nstates_spooled * sizeof(UnspoolNode*));
capacity = nstates_spooled * nstates_spooled;
unsp->unspooled_to_spooled = (int*)smalloc(capacity * sizeof(int));
mark = (int*)smalloc(nstates_spooled * sizeof(int));
s = stk_new_ptr(nstates_spooled);
for (i = 0; i < nstates_spooled; i++) {
/* erase marks (used to detect cycles) */
for (j = 0; j < nstates_spooled; j++) mark[j] = 0;
unsp->spooled_to_unspooled[i] = cm_new_unspool_node(i);
stk_push_ptr(s, unsp->spooled_to_unspooled[i]);
while ((n = (UnspoolNode*)stk_pop_ptr(s)) != NULL) {
if (conditioned_on[n->oldstate] == NULL ||
lst_size(conditioned_on[n->oldstate]) == 0) {
n->newstate = unsp->nstates_unspooled++;
/* mapping to spooled space */
if (n->newstate >= capacity) {
capacity *= 2;
unsp->unspooled_to_spooled =
(int*)srealloc(unsp->unspooled_to_spooled,
capacity * sizeof(int));
}
unsp->unspooled_to_spooled[n->newstate] = i;
}
else {
for (j = 0; j < lst_size(conditioned_on[n->oldstate]); j++) {
int oldstate = lst_get_int(conditioned_on[n->oldstate], j);
UnspoolNode *m;
if (mark[oldstate] == 1)
die("ERROR: cycle in 'conditioned_on' dependencies.\n");
mark[oldstate] = 1;
m = cm_new_unspool_node(oldstate);
lst_push_ptr(n->children, m);
stk_push_ptr(s, m);
}
}
}
}
stk_free(s);
sfree(mark);
return unsp;
}
UnspoolNode *cm_new_unspool_node(int oldstate) {
UnspoolNode *uspn = (UnspoolNode*)smalloc(sizeof(UnspoolNode));
uspn->oldstate = oldstate;
uspn->newstate = -1;
uspn->children = lst_new_ptr(3);
return uspn;
}
void cm_free_unspool_node(UnspoolNode *n) {
lst_free(n->children);
sfree(n);
}
void cm_free_unspooler(Unspooler *unsp) {
int i, j;
UnspoolNode *n;
Stack *s = stk_new_ptr(unsp->nstates_unspooled);
/* free all nodes in tree */
for (i = 0; i < unsp->nstates_spooled; i++)
stk_push_ptr(s, unsp->spooled_to_unspooled[i]);
while ((n = stk_pop_ptr(s)) != NULL) {
for (j = 0; j < lst_size(n->children); j++)
stk_push_ptr(s, lst_get_ptr(n->children, j));
cm_free_unspool_node(n);
}
sfree(unsp->spooled_to_unspooled);
sfree(unsp->unspooled_to_spooled);
stk_free(s);
sfree(unsp);
}
/* last item in predecessors is assumed to be the most recently visited */
int cm_get_unspooled_state(CategoryMap *cm, int spooled_state,
List *predecessors) {
UnspoolNode *n, *child;
int p, pred_idx, i;
pred_idx = lst_size(predecessors) - 1;
n = cm->unspooler->spooled_to_unspooled[spooled_state];
while (n->newstate == -1) {
child = NULL;
while (n != child && pred_idx >= 0) {
p = lst_get_int(predecessors, pred_idx--);
for (i = 0; n != child && i < lst_size(n->children); i++) {
child = (UnspoolNode*)lst_get_ptr(n->children, i);
if (child->oldstate == p)
n = child;
}
}
if (n != child) {
fprintf(stderr, "ERROR (cm_get_unspooled_state): no match for state %d preceded by state(s) ", spooled_state);
for (i = 0; i < lst_size(predecessors); i++)
fprintf(stderr, "%d ", lst_get_int(predecessors, i));
fprintf(stderr, "\n");
return -1;
}
if (n != child)
die("ERROR cm_get_unspooled_state: n != child\n");
}
return n->newstate;
}
/* simple wrapper for cm_read that opens specified filename and reads
a category map from it; aborts with error message if unable to open
the file. Saves typing in mains for command-line programs */
CategoryMap* cm_read_from_fname(char *fname) {
CategoryMap *cm = NULL;
FILE *F;
F = phast_fopen(fname, "r");
if ((cm = cm_read(F)) == NULL)
die("ERROR: cannot read category map from %s.\n", fname);
phast_fclose(F);
return cm;
}
/* given list of spooled category names/numbers, return a list of
corresponding unspooled category numbers */
List *cm_get_unspooled_list(CategoryMap *cm, List *spooled) {
List *spooled_catnos, *unspooled_catnos;
int mark[cm->ncats+1];
int i;
spooled_catnos = cm_get_category_list(cm, spooled, 0);
if (cm->unspooler == NULL) return spooled_catnos;
unspooled_catnos = lst_new_int(lst_size(spooled_catnos) * 3);
for (i = 0; i <= cm->ncats; i++) mark[i] = 0;
for (i = 0; i < lst_size(spooled_catnos); i++)
mark[lst_get_int(spooled_catnos, i)] = 1;
for (i = 0; i < cm->unspooler->nstates_unspooled; i++)
if (mark[cm->unspooler->unspooled_to_spooled[i]])
lst_push_int(unspooled_catnos, i);
lst_free(spooled_catnos);
return unspooled_catnos;
}
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