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// AlignedFragment.cpp: implementation of the AlignedFragment class.
//
//////////////////////////////////////////////////////////////////////
#include <cstring>
#include "AlignedFragment.h"
#include "Assert.h"
#include "Utilities.h"
//////////////////////////////////////////////////////////////////////
// Construction/Destruction
//////////////////////////////////////////////////////////////////////
AlignedFragment::AlignedFragment()
{
}
AlignedFragment::~AlignedFragment()
{
if(seq[0] != NULL) delete seq[0];
if(seq[1] != NULL) delete seq[1];
}
AlignedFragment::AlignedFragment(int d1, int d2, int beg1, int beg2, int e1, int e2, int *s1, int *s2)
{
id[0] = d1; id[1] = d2;
begin[0] = beg1; begin[1] = beg2;
end[0] = e1; end[1] = e2;
int *p[2];
p[0] = s1;p[1] = s2;
for (int k = 0; k < 2; k++){
if (begin[k] >= end[k]) {
begin[k] = -1;
end[k] = begin[k] - 1;
seq[k] = NULL;
continue;
}
seq[k] = new int[end[k] - begin[k] + 1];
ASSERT(seq[k],"Not enough memory");
for (int i = 0; i <= end[k] - begin[k]; i++)
seq[k][i] = p[k][i];
}
}
AlignedFragment::AlignedFragment(const AlignedFragment& af)
{
for (int k = 0; k < 2; k++){
id [k] = af.id[k];
begin[k] = af.begin[k];
end[k] = af.end[k];
if(begin[k]>=end[k]){
seq[k]=NULL;
continue;
}
seq[k] = new int[end[k] - begin[k] + 1];
ASSERT(seq[k],"Out of memory");
for (int i = 0; i <= end[k] - begin[k]; i++)
seq[k][i] = af.seq[k][i];
}
similarity = af.similarity;
}
AlignedFragment& AlignedFragment::operator =(const AlignedFragment af){
for (int k = 0; k < 2; k++){
id [k] = af.id[k];
begin[k] = af.begin[k];
end[k] = af.end[k];
if(begin[k]>=end[k]){
seq[k]=NULL;
continue;
}
seq[k] = new int[end[k] - begin[k] + 1];
ASSERT(seq[k],"Not enough memory");
for (int i = 0; i <= end[k] - begin[k]; i++)
seq[k][i] = af.seq[k][i];
}
similarity = af.similarity;
return *this;
}
////////////////////////////////////////////////////////////////////
// Returns the position aligned to the given position
////////////////////////////////////////////////////////////////////
std::pair<int, int> *AlignedFragment::GetAlignPos(int sequence, int pos, int &second)
{
int k;
for (k = 0; k < 2; k++){
if(sequence != id[k]) continue;
if (pos >= begin[k] && pos <= end[k]) {
while (pos >= begin[k] && seq[k][pos-begin[k]] == -1) pos--;
second = 1-k;
if (pos < begin[k])
return NULL;
return new std::pair<int, int>(id[1-k], seq[k][pos-begin[k]]);
}
}
return NULL;
}
//////////////////////////////////////////////////////////////////
// Truncats to the overlap with another fragment
//////////////////////////////////////////////////////////////////
int Fragment::Overlap(Fragment &fr)
{
if (id != fr.id) return -1;
int b = begin > fr.begin ? begin : fr.begin;
int e = begin < fr.begin ? begin : fr.begin;
if (e - b > 0){
begin = b;
end = e;
length = e - b + 1;
}
return e - b + 1;
}
////////////////////////////////////////////////////////////////////////////////
// Erases a fragment from AlignedFrament, returns two shorter ones
////////////////////////////////////////////////////////////////////////////////
void AlignedFragment::Adjust(Fragment &fr1, Fragment &fr2, AlignedFragment &rfr1, AlignedFragment &rfr2)
{
ASSERT (fr1.id == id[0] || fr1.id == id[1], "AlignedFragment Adjusting fault");
ASSERT (fr2.id == id[0] || fr2.id == id[1], "AlignedFragment Adjusting fault");
if (fr1.id == id[0] && Overlap(fr1.begin,fr1.end,begin[0],end[0]) > 1){
rfr1 = *SubFragment(begin[0],fr1.begin-1,begin[1],fr2.begin-1);
rfr2 = *SubFragment(fr1.end+1,end[0],fr2.end+1,end[1]);
}
else{
rfr1 = *SubFragment(begin[0],fr2.begin-1,begin[1],fr1.begin-1);
rfr2 = *SubFragment(fr2.end+1,end[0],fr1.end+1,end[1]);
}
}
Fragment::Fragment()
{
}
int AlignedFragment::GetLength()
{
if(begin[0] <=0 || end[0] <=0 || begin[1] <=0 || end[1] <=0) return 0;
if(begin[0] == end[0] || begin[1] == end[1]) return 0;
int i,k,res[2];
for(k=0; k<2;k++){
for (res[k] = 0, i = 0; i <= end[k] - begin[k];i++)
if(seq[k][i] > 0) res[k]++;
}
int result = res[0] < res[1] ? res[0] : res[1];
if (result <=1) return 0;
return result;
}
int AlignedFragment::GetID(int i)
{
return id[i];
}
int AlignedFragment::GetBegin(int i)
{
return begin[i];
}
int AlignedFragment::GetEnd(int i)
{
return end[i];
}
///////////////////////////////////////////////////////////////////////
// Prune unaligned positions at the two ends
///////////////////////////////////////////////////////////////////////
void AlignedFragment::Prune()
{
if(end[0]<=begin[0] || end[1]<=begin[1]) return;
int i,b[2],e[2],k;
for(k=0;k<2;k++){
for(i=end[k]-begin[k],e[k]=0;i>=0 && seq[k][i] < 0;i--) e[k]++;
for(i=0,b[k]=0;i<=end[k]-begin[k] && seq[k][i] < 0;i++) b[k]++;
}
for(k=0;k<2;k++){
if(b[k]+e[k]>0){
int *s = new int[end[k]-begin[k]+1-b[k]-e[k]];
memcpy(s,seq[k]+b[k],sizeof(int)*(end[k]-begin[k]+1-b[k]-e[k]));
delete seq[k];
seq[k]=s;
begin[k] += b[k];
end[k] -= e[k];
}
}
}
Fragment * AlignedFragment::GetFragment(int i)
{
Fragment *fr = new Fragment(begin[i],end[i],0,id[i]);
return fr;
}
int AlignedFragment::ProcessRepeat(AVECT &fragments, int minlength)
{
if(id[0] != id[1]) return 0;
int i;
if(min(end[0],end[1]) >= max(begin[0],begin[1])){//Ovelapping
int bound[2][4];
bound[0][0] = begin[0];bound[0][3] = end[0];
bound[1][0] = begin[1]; bound[1][3] = end[1];
for(int k =0; k <2; k++){
if(begin[k] < begin[1-k]){
for(i=begin[1-k]-begin[k];i>0 && seq[k][i]==-1;i--);
bound[1-k][1] = seq[k][i]+bound[1-k][0];
bound[k][1] = i+begin[k];
for(i=end[k]-begin[1-k];i>0 && seq[1-k][i] == -1; i--);
bound[1-k][2]=i+begin[1-k];
bound[k][2] = seq[1-k][i]+bound[k][0];
}
}
if(bound[0][1] >bound[0][2]){
int tmp;
tmp = bound[0][1];
bound[0][1] = bound[0][2];
bound[0][2] = tmp;
tmp = bound[1][1];
bound[1][1] = bound[1][2];
bound[1][2] = tmp;
}
else{
bound[0][1]--;bound[1][1]--;
bound[0][2]++;bound[1][2]++;
}
for(i=0;i<3;i+=2){
AlignedFragment * sub = this->SubFragment(bound[0][i],bound[0][i+1],
bound[1][i],bound[1][i+1]);
if(sub != NULL && sub->GetLength() >= minlength){
fragments.push_back(*sub);
sub->Print(stderr);
}
if(sub) delete sub;
}
return 1;
}
else{
Print(stderr);
fragments.push_back(*this);
return 0;
}
}
AlignedFragment * AlignedFragment::SubFragment(int begin0, int end0, int begin1, int end1)
{
if(begin0 < begin[0] || end0 > end[0] || begin0 >= end0 ||
begin1 < begin[1] || end1 > end[1] || begin1 >= end1)
return new AlignedFragment(0,0,0,0,0,0,0,0);
int b0,e0;
for(b0 = begin0; b0 < end0 && seq[0][b0-begin[0]] <begin1; b0++);
for(e0 = b0; e0 < end0 && seq[0][e0-begin[0]] < end1; e0++);
if (b0 >= e0) new AlignedFragment(0,0,0,0,0,0,0,0);
AlignedFragment *res = new AlignedFragment(id[0],id[1],b0,seq[0][b0-begin[0]],e0,seq[0][e0-begin[0]],
seq[0]+b0-begin[0],seq[1]+seq[0][b0-begin[0]]-begin[1]);
res->Prune();
return res;
}
void AlignedFragment::Print(FILE *file)
{
fprintf(file,"<%d %d %d><%d %d %d>\n",id[0],begin[0],end[0],id[1],begin[1],end[1]);
}
Fragment * AlignedFragment::GetAlignFragment(Fragment &fr)
{
Fragment *res;
int second1, second2;
std::pair<int, int> *start,*finish;
start = GetAlignPos(fr.id,fr.begin,second1);
finish = GetAlignPos(fr.id,fr.end,second2);
if(start != NULL && finish != NULL && second1 == second2)
res = new Fragment(start->second,finish->second,0,start->first);
else
res = NULL;
if(start) delete start;
if(finish) delete finish;
return res;
}
void AlignedFragment::ShiftRight(int offset1, int offset2)
{
int i,j;
begin[0] += offset1 - 1;
end[0] += offset1 - 1;
for(i = 0, j = begin[0]; j <= end[0]; i++,j++)
if(seq[0][i] >=0 )
seq[0][i] += offset2 - 1;
begin[1] += offset2 - 1;
end[1] += offset2 - 1;
for( i = 0, j = begin[1]; j <= end[1]; i++,j++)
if(seq[1][i] >= 0)
seq[1][i]+= offset1-1;
}
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