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//////////////////////////////////////////////////////////////////////
// Tree.cc
//////////////////////////////////////////////////////////////////////
#include <stdio.h>
#include "Tree.h"
#include "GlobalAlign.h"
//////////////////////////////////////////////////////////////////////
// TreeNode constructor
//////////////////////////////////////////////////////////////////////
Tree::TreeNode::TreeNode (bool isLeaf, int numSequences, MultiSequence *seqs,
TreeNode *leftChild, TreeNode *rightChild) :
isLeaf(isLeaf), numSequences(numSequences), seqs(seqs),
leftChild(leftChild), rightChild(rightChild) {}
//////////////////////////////////////////////////////////////////////
// TreeNode destructor
//////////////////////////////////////////////////////////////////////
Tree::TreeNode::~TreeNode (){
if (seqs) delete seqs;
if (!isLeaf){
if (leftChild) delete leftChild;
if (rightChild) delete rightChild;
}
}
//////////////////////////////////////////////////////////////////////
// Returns whether this node is a leaf or not
//////////////////////////////////////////////////////////////////////
const bool Tree::TreeNode::GetIsLeaf() const {
return isLeaf;
}
//////////////////////////////////////////////////////////////////////
// Returns number of sequences in this subtree
//////////////////////////////////////////////////////////////////////
const int Tree::TreeNode::GetNumSequences() const {
return numSequences;
}
//////////////////////////////////////////////////////////////////////
// Returns the MultiSequence data associated with this node.
//////////////////////////////////////////////////////////////////////
const MultiSequence *Tree::TreeNode::GetSequences() const {
return seqs;
}
//////////////////////////////////////////////////////////////////////
// Returns the left child TreeNode
//////////////////////////////////////////////////////////////////////
const Tree::TreeNode *Tree::TreeNode::GetLeftChild() const {
return leftChild;
}
//////////////////////////////////////////////////////////////////////
// Returns the right child TreeNode
//////////////////////////////////////////////////////////////////////
const Tree::TreeNode *Tree::TreeNode::GetRightChild() const {
return rightChild;
}
//////////////////////////////////////////////////////////////////////
// Print out subtree recursively
//////////////////////////////////////////////////////////////////////
void Tree::TreeNode::Print (FILE *file) const {
if (isLeaf){
fprintf (file, "%s", seqs->GetSequence(0).GetName());
} else {
fprintf (file, "(");
leftChild->Print(file);
if (leftChild->isLeaf || rightChild->isLeaf)
fprintf (file, " ");
rightChild->Print(file);
fprintf (file, ")");
}
}
//////////////////////////////////////////////////////////////////////
// Perform progressive alignment for subtree
//////////////////////////////////////////////////////////////////////
void Tree::TreeNode::ProgressiveAlignment (int numSequences, SparseMatrix **posteriors){
if (seqs) return;
leftChild->ProgressiveAlignment (numSequences, posteriors);
rightChild->ProgressiveAlignment (numSequences, posteriors);
seqs = GlobalAlign::AlignGroups (numSequences, posteriors,
*leftChild->seqs, *rightChild->seqs);
seqs->Sort();
}
void Tree::TreeNode::GetIDs(IVECT &ids)
{
if(isLeaf){
ids.push_back(seqs->GetSequence(0).GetID());
Sequence *ptr = seqs->GetSequencePtr(0);
ptr->SetID(ids.size()-1);
}
else{
leftChild->GetIDs(ids);
rightChild->GetIDs(ids);
}
}
void Tree::TreeNode::UpdateIDs(int *used)
{
if(isLeaf){
Sequence *ptr = seqs->GetSequencePtr(0);
ptr->SetID(used[ptr->GetID()]);
}
else{
leftChild->UpdateIDs(used);
rightChild->UpdateIDs(used);
}
}
//////////////////////////////////////////////////////////////////////
// Tree constructor
//////////////////////////////////////////////////////////////////////
typedef Tree::TreeNode *TreeNodePtr;
Tree::Tree (Matrix similarity, const MultiSequence &seqs, float threshold){
// get number of sequences
int n = similarity.GetNumRows();
ASSERT (n == similarity.GetNumCols(), "Similarity matrix not square.");
int i,j,k;
// initialize diagonal of distance matrix
for (i = 0; i < n; i++)
similarity(0,i,i) = -1;
// build initial set of trees
TreeNode **trees = new TreeNodePtr[n];
ASSERT (trees, "Out of memory.");
for (i = 0; i < n; i++){
MultiSequence *tempSeqs = new MultiSequence();
ASSERT (tempSeqs, "Out of memory.");
Sequence *seq = new Sequence (seqs.GetSequence (i));
ASSERT (seq, "Out of memory.");
tempSeqs->AddSequence (seq);
trees[i] = new TreeNode (true, 1, tempSeqs, NULL, NULL);
}
// perform n - 1 merges
for (k = 0; k < n-1; k++){
// find nearest neighbors
int bi = 0, bj = 0;
for (i = 0; i < n; i++){
for (j = i+1; j < n; j++) if (i != j){
if (similarity(0,i,j) > similarity(0,bi,bj)){
bi = i;
bj = j;
}
}
}
//stop if similarity drops bellow the threshold
int numSeq = trees[bi]->GetNumSequences() + trees[bj]->GetNumSequences();
if((similarity(0,bi,bj) < threshold && numSeq <= 2) ||
similarity(0,bi,bj) < threshold - 0.2) break;
// merge trees
TreeNode *temp = new TreeNode (false, numSeq,
NULL, trees[bi], trees[bj]);
ASSERT (temp, "Out of memory.");
trees[bi] = temp;
trees[bj] = NULL;
// update distances
similarity(0,bi,bj) = similarity(0,bj,bi) = -1;
for (int m = 0; m < n; m++) if (m != bi && m != bj){
similarity(0,bi,m) = similarity(0,m,bi) =
(similarity(0,bi,m) * temp->GetLeftChild()->GetNumSequences() +
similarity(0,bj,m) * temp->GetRightChild()->GetNumSequences()) /
temp->GetNumSequences();
similarity(0,bj,m) = similarity(0,m,bj) = -1;
}
}
root = trees[0];
if( root->GetNumSequences() == 1) {
for (i = 1; i < n; i++){
if (trees[i] != NULL && trees[i]->GetNumSequences() > root->GetNumSequences()){
root = trees[i];
}
}
}
for (i = 0; i < n; i++){
if(trees[i] && trees[i] != root)
delete trees[i];
}
delete[] trees;
}
//////////////////////////////////////////////////////////////////////
// Tree destructor
//////////////////////////////////////////////////////////////////////
Tree::~Tree (){
delete root;
}
//////////////////////////////////////////////////////////////////////
// Print tree
//////////////////////////////////////////////////////////////////////
void Tree::Print (FILE *file) const {
ASSERT (root, "Tree not created.");
root->Print (file);
fprintf (file, "\n");
}
//////////////////////////////////////////////////////////////////////
// Perform progressive alignment on the tree
//////////////////////////////////////////////////////////////////////
MultiSequence *Tree::ProgressiveAlignment (int numSequences, SparseMatrix **posteriors){
root->ProgressiveAlignment (numSequences, posteriors);
return new MultiSequence(*root->GetSequences());
}
int Tree::GetNumSequences()
{
if(root)
return root->GetNumSequences();
else return 0;
}
void Tree::GetIDs(IVECT &ids)
{
root->GetIDs(ids);
}
void Tree::UpdateIDs(int *used)
{
root->UpdateIDs(used);
}
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