BLASTP 2.0.12 [Apr-21-2000]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= aaaa 
         (889 letters)

Database: /dbase/swissprot/main/release/sp;
/dbase/swissprot/main/update/spu
           88,201 sequences; 31,957,340 total letters

Searching.................................................done


Results from round 1


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec...  1516  0.0
HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyper...   513  e-145
PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast)....    95  7e-19
RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ...    93  3e-18
NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6...    88  9e-17
NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6...    87  1e-16
URB1_RAT P51593 rattus norvegicus (rat). dna binding protein...    85  4e-16
UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein li...    84  1e-15
HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). ...    83  2e-15
UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein li...    82  6e-15
HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). ...    69  3e-11
UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ...    58  7e-08
Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein...    56  3e-07
TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor int...    50  2e-05
PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-bindin...    49  3e-05
PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-bindin...    49  5e-05
PABP_XENLA P20965 xenopus laevis (african clawed frog). poly...    48  8e-05
PABP_DROME P21187 drosophila melanogaster (fruit fly). polya...    41  0.008
PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress). po...    37  0.15
PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress). po...    34  0.99
MCM3_MOUSE P25206 mus musculus (mouse). dna replication lice...    34  1.7
PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast)....    32  3.8
PROB_SERMA P17856 serratia marcescens. glutamate 5-kinase (e...    32  6.6
ST20_CANAL Q92212 candida albicans (yeast). serine/threonine...    31  8.6
KEND_HUMAN O95613 homo sapiens (human). kendrin (kiaa0402). ...    31  8.6
FIXK_RHIME P13295 rhizobium meliloti (sinorhizobium meliloti...    31  8.6
CC24_YEAST P11433 saccharomyces cerevisiae (baker's yeast). ...    31  8.6

>100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec 6.3.2.-).
           7/1999
           Length = 889
           
 Score = 1516 bits (3882), Expect = 0.0
 Identities = 765/889 (86%), Positives = 765/889 (86%)

Query: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60
           MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT
Sbjct: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60

Query: 61  PQXXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120
           PQ            GI            TSQSATLNDKDDESLPAETGQNHPFFRRSDSM
Sbjct: 61  PQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120

Query: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180
           TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT
Sbjct: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180

Query: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240
           MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK
Sbjct: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240

Query: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300
           SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG
Sbjct: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300

Query: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360
           SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT
Sbjct: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360

Query: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQX 420
           TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQ 
Sbjct: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQR 420

Query: 421 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGNPSDDPDP 480
                                                QLSIDTRPFRPASEGNPSDDPDP
Sbjct: 421 LRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDP 480

Query: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
           LPAHRQALGERLYPRVQAMQPAFASKITGM                   RARVEEAMELI
Sbjct: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVEEAMELI 540

Query: 541 VAHGRENGAXXXXXXXXXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGK 600
           VAHGRENGA            EKVQENRKRHGSSRSVV            NAPLFYQPGK
Sbjct: 541 VAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGK 600

Query: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660
           RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF
Sbjct: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660

Query: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720
           FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN
Sbjct: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720

Query: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780
           VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML
Sbjct: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780

Query: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840
           ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP
Sbjct: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840

Query: 841 SITIRPPDDQHLPTANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
           SITIRPPDDQHLPTANTCISRLYVP                   NFGFV
Sbjct: 841 SITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 889


>HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyperplastic discs
            protein (hyd protein) (ec 6.3.2.-). 12/1998
            Length = 2895
            
 Score =  513 bits (1308), Expect = e-145
 Identities = 281/634 (44%), Positives = 375/634 (58%), Gaps = 32/634 (5%)

Query: 263  QCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEK 322
            Q +F G+   + +L  +  L+L+LFGR FM+DVG E GS+L EL GF VKE +FRR MEK
Sbjct: 2287 QSNFSGIAPCNFLLSAK--LTLDLFGRPFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEK 2344

Query: 323  LRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEG 379
            LRN Q RDL L +++R+R+ LI QT ++LN  FG   R    P+  +RVKVTFKDEPGEG
Sbjct: 2345 LRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEG 2404

Query: 380  SGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQXXXXXXXXXXXXXXXXXXXX 439
            SGVARSFYT+IA+A L++ K+PNL+ +Q      H+  +                     
Sbjct: 2405 SGVARSFYTSIAEALLASAKIPNLESVQVGTN--HSKYVVPFSSILRTTVSGSSRDQSTL 2462

Query: 440  XXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGN---PSDDPDPLPAHRQALGERLYPRV 496
                               L++D RP+ P +  +   P    D L  H Q +GERLYP++
Sbjct: 2463 QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKI 2522

Query: 497  QAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELIVAHGRENGAXXXXXXX 556
             ++    A KITGM                   R +V EA+E+I    +   +       
Sbjct: 2523 HSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSA------ 2576

Query: 557  XXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGKRGFYTPRPGKNTEARL 616
                    Q ++ +   S  VV            N PLFY PGKRGFY PR G  +  R+
Sbjct: 2577 --------QSSQPKKSPSVVVVDPVDDD------NEPLFYSPGKRGFYIPRQGFASFERI 2622

Query: 617  NCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILAS 676
            N FRNIGR++GLCLLQNEL P+ L RHV+K +L RK+ +HD AFFDP +YES RQ+I  +
Sbjct: 2623 NAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILRRKIKFHDLAFFDPALYESFRQIIQNA 2682

Query: 677  QSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVV 736
            Q+ + +   + M+L F +DL KEEG G  ELIP G ++ V+ + +Y       ++   + 
Sbjct: 2683 QTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDV-VSHRVIYSSTSDAIQNIDXIK 2741

Query: 737  A-EQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 795
            + E+ L A++ G+ DVLP NS+ +LTAED RLL+NG G++NV  LIS+T+FNDES E  +
Sbjct: 2742 SQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPD 2801

Query: 796  KLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTA 855
            KL +FK+WFWSIVE+M++ ERQ LVYFWT SP+LPASEEGFQP+PS+TIRP DD HLPTA
Sbjct: 2802 KLXKFKKWFWSIVEKMNIMERQHLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPTA 2861

Query: 856  NTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
            NTCISRLY+P                   NFGFV
Sbjct: 2862 NTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2895


 Score =  110 bits (272), Expect = 1e-23
 Identities = 69/209 (33%), Positives = 107/209 (51%), Gaps = 26/209 (12%)

Query: 3    SARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQ 62
            ++R DF  Y LSLMRSH  EH D LPVLD+ +L+H+AYV  A +Y+++  N     D   
Sbjct: 1913 NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDSGFYDKQD 1970

Query: 63   XXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDE------SLPA--ETGQNHPFF 114
                         I              + A L + + +      S+P+  +  + H FF
Sbjct: 1971 SISGR--------INNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFF 2022

Query: 115  RRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGK 174
             RS+S   LGC  P  FE+PL  A+PLAD+PHLLQPN+++++LF      + +++  SG 
Sbjct: 2023 ARSESTLTLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG- 2081

Query: 175  CLVEVTMD---RNCLEVLPTKMSYAANLK 200
                 T D    +  +  PT++ ++ +LK
Sbjct: 2082 ----ATNDGDGASIFDYTPTRLGFSNSLK 2106


>PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast).
           ubiquitin--protein ligase pub1 (ec 6.3.2.-). 12/1998
           Length = 767
           
 Score = 94.8 bits (232), Expect = 7e-19
 Identities = 69/267 (25%), Positives = 116/267 (42%), Gaps = 22/267 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +               K++L +KV   D    D   
Sbjct: 491 PHSGINPE-HLNYFKFIGRVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEY 549

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++    +   D  FS  D  F   +        ++L PNG NI VT +N  EYV
Sbjct: 550 YRSLVWILDNDITGVLDLTFSVEDNCFGEVVT-------IDLKPNGRNIEVTEENKREYV 602

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
                 R+    E+  +A  +G  +++P+  +      +  LL+ G  E++++     T 
Sbjct: 603 DLVTVWRIQKRIEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTD 662

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQ-------P 838
           +   S  +     Q  +WFW +++  S  ++  L+ F T +  +P +  GF+       P
Sbjct: 663 YRSYSEND-----QIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPVN--GFKDLQGSDGP 715

Query: 839 MPSITIRPPDDQHLPTANTCISRLYVP 865
                 +  +   LP A+TC +RL +P
Sbjct: 716 RKFTIEKAGEPNKLPKAHTCFNRLDLP 742


>RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ubiquitin--protein
           ligase rsp5 (ec 6.3.2.-). 7/1999
           Length = 809
           
 Score = 92.8 bits (227), Expect = 3e-18
 Identities = 71/267 (26%), Positives = 122/267 (45%), Gaps = 22/267 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +             + K++L +KV   D    D  +
Sbjct: 533 PNSGINPE-HLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEV 591

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++  S     D  FSA D  F   +        V+L P+G NI VT  N  EYV
Sbjct: 592 YNSLNWMLENSIDGVLDLTFSADDERFGEVVT-------VDLKPDGRNIEVTDGNKKEYV 644

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
             Y + R++   ++   A   G  +++P++ +      +  LL+ G  E++++     T 
Sbjct: 645 ELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTD 704

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPS---- 841
           +     + +++++Q   WFW  V      +R  L+ F T +  +P +  GF+ +      
Sbjct: 705 Y--RGYQESDEVIQ---WFWKCVSEWDNEQRARLLQFTTGTSRIPVN--GFKDLQGSDGP 757

Query: 842 --ITIRPPDD-QHLPTANTCISRLYVP 865
              TI    + Q LP ++TC +R+ +P
Sbjct: 758 RRFTIEKAGEVQQLPKSHTCFNRVDLP 784


>NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6.3.2.-) (kiaa0093)
           (fragment). 7/1999
           Length = 927
           
 Score = 87.8 bits (214), Expect = 9e-17
 Identities = 72/268 (26%), Positives = 122/268 (44%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 649 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 708

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++     +D     + +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 709 YNSLRWIL----ENDP----TELDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 757

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 758 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 817

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQP 838
            T + +    N + +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 818 HTKYKNGYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 873

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+      + LP A+TC +RL +P
Sbjct: 874 PQSFTVEQWGTPEKLPRAHTCFNRLDLP 901


>NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6.3.2.-)
           (fragment). 11/1997
           Length = 957
           
 Score = 87.0 bits (212), Expect = 1e-16
 Identities = 73/270 (27%), Positives = 120/270 (44%), Gaps = 27/270 (10%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 679 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEY 738

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 739 YSSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKTGGSEIVVTNKNKK 787

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 788 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 847

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQP 838
            T + +    N + +     WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 848 HTKYKNGYSMNHQVI----HWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 903

Query: 839 MPSITIR---PPDDQHLPTANTCISRLYVP 865
             S T+     PD   LP A+TC +RL +P
Sbjct: 904 PQSFTVEQWGTPD--KLPRAHTCFNRLDLP 931


>URB1_RAT P51593 rattus norvegicus (rat). dna binding protein ure-b1 (ec
           6.3.2.-). 10/1996
           Length = 310
           
 Score = 85.4 bits (208), Expect = 4e-16
 Identities = 65/250 (26%), Positives = 110/250 (44%), Gaps = 19/250 (7%)

Query: 623 GRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDAD 682
           GR +   ++   L      R   K +LG+ V + D    D   Y+ L  L+      + D
Sbjct: 45  GRYVAKAVMTTALLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLL------END 98

Query: 683 AVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPL 741
                 DL F+ ++ +E G  +V +L PNG NI VT +N  EYV    + RM     + L
Sbjct: 99  VSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQL 157

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFK 801
            A  +G  +++PK  +   T ++  LL  G   +++  L S T ++     + +      
Sbjct: 158 AAFLEGFYEIIPKRLISIFTEQELELLYTGLPTIDIDDLKSNTEYHKYQSNSIQ-----I 212

Query: 802 RWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQPMPSITIRPPD--DQHLPTA 855
           +WFW  +      +R   + F T +  +P    A+ EG   +    I   D     LP+A
Sbjct: 213 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 272

Query: 856 NTCISRLYVP 865
           +TC ++L +P
Sbjct: 273 HTCFNQLDLP 282


>UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap)
           (human papillomavirus e6-associated protein). 5/2000
           Length = 875
           
 Score = 83.9 bits (204), Expect = 1e-15
 Identities = 68/249 (27%), Positives = 117/249 (46%), Gaps = 12/249 (4%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG +LGL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    +
Sbjct: 612 FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGN 671

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 672 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 726

Query: 738 EQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+ L   E+  LL+ G   ++ Q L   T +  + G   + 
Sbjct: 727 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRDS 784

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +L   R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 785 VL--IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 841

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 842 TCFNVLLLP 850


>HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul5 (ec 6.3.2.-). 5/2000
           Length = 910
           
 Score = 83.1 bits (202), Expect = 2e-15
 Identities = 67/252 (26%), Positives = 125/252 (49%), Gaps = 21/252 (8%)

Query: 622 IGRILGLCLLQNELCPITLNRHVIKVLL----GRKVNWHDFAFFDPVMYESLRQLILASQ 677
           +G+++G CL ++ L  ++     +K LL    G   ++ D   +D V+Y +L +L+  + 
Sbjct: 647 LGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLL--NM 704

Query: 678 SSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
           ++D      ++DL F +D   E     V+LIPNG    VT  NV  YV K  ++++    
Sbjct: 705 TTDE---IKSLDLTFEIDE-PESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRC 760

Query: 738 EQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE-VNVQMLISFTSFNDESGENAEK 796
            +P+ A   GL  ++  + +E   + + ++L++G  + +++  L S T +     E+   
Sbjct: 761 FKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEED--- 817

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIRPPDDQ--HLP 853
             Q    FW ++      E+ + + F TS P  P   +GF+ + P   IR    +   LP
Sbjct: 818 --QTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPL--QGFKALDPKFGIRNAGTEKYRLP 873

Query: 854 TANTCISRLYVP 865
           TA+TC++ L +P
Sbjct: 874 TASTCVNLLKLP 885


>UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap).
           5/2000
           Length = 885
           
 Score = 81.5 bits (198), Expect = 6e-15
 Identities = 67/243 (27%), Positives = 114/243 (46%), Gaps = 12/243 (4%)

Query: 625 ILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAV 684
           ILGL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    S + D  
Sbjct: 628 ILGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDD-- 685

Query: 685 FSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHA 743
              M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    E+   A
Sbjct: 686 ---MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVISYSDYILNKSVEKQFKA 742

Query: 744 MRKGLLDVLPKNSLEDL-TAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKR 802
            R+G   V  ++ L+ L   E+  LL+ G   ++ Q L   T +  + G   E ++   R
Sbjct: 743 FRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRESVV--IR 798

Query: 803 WFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRL 862
            FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++TC + L
Sbjct: 799 EFWEIVHSFTDEQKRLFLLFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVL 857

Query: 863 YVP 865
            +P
Sbjct: 858 LLP 860


>HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul4 (ec 6.3.2.-). 5/2000
           Length = 892
           
 Score = 69.5 bits (167), Expect = 3e-11
 Identities = 58/264 (21%), Positives = 114/264 (42%), Gaps = 16/264 (6%)

Query: 609 GKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYES 668
           GKN++  L  +   G ++GL +  + +  +   + + K L    +++ D++   P    +
Sbjct: 607 GKNSQLEL--YYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRN 664

Query: 669 LRQLILASQSSDADAVFSAMDLAFAV------DLCKEEGGGQVELIPNGVNIPVTPQNVY 722
           L +++  ++ +  D      +  +        D    +    VEL  NG N+P+T  N +
Sbjct: 665 LIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKH 724

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPK-NSLEDLTAEDFRLLVNGCGE---VNVQ 778
           E+V K+ E  +    E   +    G   V  + NS++   +E+   LV G  E    + +
Sbjct: 725 EFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFK 784

Query: 779 MLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQP 838
            L S T +     +++  +     WFW I+E      ++ L+ F T+S  +PA+     P
Sbjct: 785 SLRSVTKYVGGFSDDSRAVC----WFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIP 840

Query: 839 MPSITIRPPDDQHLPTANTCISRL 862
                +   D   LP A+TC + +
Sbjct: 841 FKISLLGSHDSDDLPLAHTCFNEI 864


>UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ubiquitin fusion
            degradation protein 4 (ub fusion protein 4). 11/1997
            Length = 1483
            
 Score = 58.2 bits (138), Expect = 7e-08
 Identities = 51/210 (24%), Positives = 92/210 (43%), Gaps = 17/210 (8%)

Query: 662  DPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNV 721
            DP++ +SL+ ++    + D +    ++ L F V      G   +ELIP G N  +   NV
Sbjct: 1259 DPLLAKSLKYIVA---NKDDNMTLESLSLTFTVP-----GNDDIELIPGGCNKSLNSSNV 1310

Query: 722  YEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLI 781
             EY+    +  +    E+ L A  +G   V     +  L  ++  + + G  E +  M  
Sbjct: 1311 EEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDEL-VDIFGRVEEDWSMAT 1369

Query: 782  SFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP-ASEEGFQPMP 840
             +T+ N E G   +  +     F SI+      ER+  + F T SP LP    +   P  
Sbjct: 1370 LYTNLNAEHGYTMDSSIIHD--FISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKF 1427

Query: 841  SITIRPPD-----DQHLPTANTCISRLYVP 865
            ++ ++  +     D++LP+  TC + L +P
Sbjct: 1428 TVVLKHAEDGLTADEYLPSVMTCANYLKLP 1457


>Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein kiaa0032. 5/2000
            Length = 1050
            
 Score = 56.2 bits (133), Expect = 3e-07
 Identities = 60/255 (23%), Positives = 97/255 (37%), Gaps = 21/255 (8%)

Query: 617  NCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILAS 676
            N F  IG   GL +  + +  +     + K LL  K    D     P    SL++L L  
Sbjct: 786  NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL-LDY 844

Query: 677  QSSDADAVFSAMDLAFAVDLCKEEGG--GQVELIPNGVNIPVTPQNVYEYVRKYAEHRML 734
               D +  F    L F +  C+E  G   Q +LIP G N+ V   N  E+V  Y  +   
Sbjct: 845  PGEDVEETFC---LNFTI--CRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQ 899

Query: 735  VVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENA 794
            +   +   A   G L V     LE     + R ++ G    N + L     +  +     
Sbjct: 900  ISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATH 959

Query: 795  EKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITI----RPPDDQ 850
              +    + FW       + +++  + F T S  +P        M S+ I        ++
Sbjct: 960  PTV----KLFWETFHEFPLEKKKKFLLFLTGSDRIP-----IYGMASLQIVIQSTASGEE 1010

Query: 851  HLPTANTCISRLYVP 865
            +LP A+TC + L +P
Sbjct: 1011 YLPVAHTCYNLLDLP 1025


>TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor interacting protein 12
            (trip12) (kiaa0045). 12/1998
            Length = 1992
            
 Score = 50.4 bits (118), Expect = 2e-05
 Identities = 63/289 (21%), Positives = 116/289 (39%), Gaps = 34/289 (11%)

Query: 605  TPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW--HDFAFFD 662
            T +P    + ++  FR +G+++   ++   L  + L     K +L ++ +   HD    D
Sbjct: 1684 TAKPAHIAKVKMK-FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDID 1742

Query: 663  PVMYES---LRQLILASQSSDADAVFSAMDLAFAVDL-----CKEEGGG---------QV 705
            PV+  S   L  ++   +  + D   +   L +A++      C  E  G          +
Sbjct: 1743 PVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNI 1802

Query: 706  ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDF 765
            EL   G +IPVT  N+ EY+R      +     +   + R G   V P + L+    E+ 
Sbjct: 1803 ELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEEL 1862

Query: 766  RLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTS 825
              L+ G                 + G   +   +  ++ + I+      +++  + F T 
Sbjct: 1863 DQLLCGSKADTWDAKTLMECCRPDHGYTHDS--RAVKFLFEILSSFDNEQQRLFLQFVTG 1920

Query: 826  SPSLPASEEGFQPM-PSITI--------RPPDDQHLPTANTCISRLYVP 865
            SP LP    GF+ + P +TI          PDD  LP+  TC++ L +P
Sbjct: 1921 SPRLPVG--GFRSLNPPLTIVRKTFESTENPDD-FLPSVMTCVNYLKLP 1966


>PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 49.2 bits (115), Expect = 3e-05
 Identities = 25/70 (35%), Positives = 36/70 (50%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P    +Q LGERL+P +QAM P+ A KITGM                   R++V+EA+ +
Sbjct: 554 PPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAV 613

Query: 540 IVAHGRENGA 549
           + AH  +  A
Sbjct: 614 LQAHQAKEAA 623


>PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 48.8 bits (114), Expect = 5e-05
 Identities = 25/70 (35%), Positives = 35/70 (49%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P    +Q LGERL+P +QAM P  A KITGM                   R++V+EA+ +
Sbjct: 554 PPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAV 613

Query: 540 IVAHGRENGA 549
           + AH  +  A
Sbjct: 614 LQAHQAKEAA 623


>PABP_XENLA P20965 xenopus laevis (african clawed frog). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 7/1998
           Length = 633
           
 Score = 48.0 bits (112), Expect = 8e-05
 Identities = 25/70 (35%), Positives = 34/70 (47%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P    +Q LGERL+P +QAM P  A KITGM                   R +V+EA+ +
Sbjct: 552 PPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRLKVDEAVAV 611

Query: 540 IVAHGRENGA 549
           + AH  +  A
Sbjct: 612 LQAHQAKEAA 621


>PABP_DROME P21187 drosophila melanogaster (fruit fly). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 2/1995
           Length = 632
           
 Score = 41.4 bits (95), Expect = 0.008
 Identities = 21/59 (35%), Positives = 29/59 (48%)

Query: 485 RQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELIVAH 543
           +Q LGERLYP ++ M    A KITGM                   +A+VEEA+ ++  H
Sbjct: 567 KQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVLQVH 625


>PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 5 (poly(a) binding protein
           5) (pabp 5). 11/1995
           Length = 668
           
 Score = 37.1 bits (84), Expect = 0.15
 Identities = 17/57 (29%), Positives = 29/57 (50%)

Query: 484 HRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
           H + LG+ LYP V+  +PA  +K+TGM                   +A+V EA++++
Sbjct: 590 HPRMLGDHLYPLVEQQEPANPAKVTGMLLEMDQAEILHLLESPEALKAKVSEALDVL 646


>PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 2 (poly(a) binding protein
           2) (pabp 2). 12/1998
           Length = 629
           
 Score = 34.4 bits (77), Expect = 0.99
 Identities = 18/56 (32%), Positives = 28/56 (49%)

Query: 485 RQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
           R  LGE LYP V+ ++   A+K+TGM                   +A+V EAM+++
Sbjct: 556 RTMLGEVLYPLVEQVEAESAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAMDVL 611


>MCM3_MOUSE P25206 mus musculus (mouse). dna replication licensing factor mcm3
           (dna polymerase alpha holoenzyme-associated protein p1)
           (p1-mcm3). 5/2000
           Length = 812
           
 Score = 33.6 bits (75), Expect = 1.7
 Identities = 23/87 (26%), Positives = 38/87 (43%), Gaps = 1/87 (1%)

Query: 141 LADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVTMDRNCLEVLPTKMSYAANLK 200
           L  Q  +    AR   +  R  + L   +    K  +  T+D    E     + YA   K
Sbjct: 597 LRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAY-FK 655

Query: 201 NVMNMQNRQKKAGEDQSMLAEEADSSK 227
            V+  + ++KKA ED+S L +E + S+
Sbjct: 656 KVLEKEKKRKKASEDESDLEDEEEKSQ 682


>PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast).
           polyadenylate-binding protein (poly(a) binding protein)
           (pabp). 7/1998
           Length = 653
           
 Score = 32.5 bits (72), Expect = 3.8
 Identities = 18/61 (29%), Positives = 26/61 (42%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P  + +Q LGE LYP+V   +   + KITGM                     RV EA+ +
Sbjct: 581 PEESRKQVLGELLYPKVFVREEKLSGKITGMLLEMPNSELLELLEDDSALNERVNEAIGV 640

Query: 540 I 540
           +
Sbjct: 641 L 641


>PROB_SERMA P17856 serratia marcescens. glutamate 5-kinase (ec 2.7.2.11)
           (gamma-glutamyl kinase) (gk). 10/1996
           Length = 367
           
 Score = 31.7 bits (70), Expect = 6.6
 Identities = 29/99 (29%), Positives = 40/99 (40%), Gaps = 14/99 (14%)

Query: 279 RWRLSLELFGRVFMEDVGAEP----GSILTELGGFEVKESKFRREMEKLRNQQSRDLSLE 334
           RW       G + ++D   E     GS L   G  EVK    R E+ ++RN   RDL+  
Sbjct: 267 RWIFGAPPAGEITVDDGAVEAMMARGSSLLPKGIREVKGDFSRGEVIRIRNLTGRDLAHG 326

Query: 335 VDRDRDLLIQQTMRQLNNHFGRRCATT------PMAVHR 367
           V R         MR +  H  +  +        P+AVHR
Sbjct: 327 VSRYN----SDAMRMIAGHHSQEISEILGYEYGPVAVHR 361


>ST20_CANAL Q92212 candida albicans (yeast). serine/threonine-protein kinase
           ste20 homolog (ec 2.7.1.-). 5/2000
           Length = 1230
           
 Score = 31.3 bits (69), Expect = 8.6
 Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 3/100 (3%)

Query: 309 FEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRV 368
           +E++++K++   +KLR +++R+L  E+ R R+   +Q  +Q         A+    +   
Sbjct: 839 YEIQQTKYQEAQQKLREKKARELE-EIQRLREKNERQNRQQETGQNNADTASGGSNIAPP 897

Query: 369 KVTFKDEPGEGSGVARSFYTA--IAQAFLSNEKLPNLDCI 406
                 +P  GSG  R    A  IAQ     +K  NL  I
Sbjct: 898 VPVPNKKPPSGSGGGRDAKQAALIAQKKREEKKRKNLQII 937


>KEND_HUMAN O95613 homo sapiens (human). kendrin (kiaa0402). 5/2000
            Length = 3321
            
 Score = 31.3 bits (69), Expect = 8.6
 Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 10/90 (11%)

Query: 176  LVEVTMDRNCLEVLPTKMSYAANLK-NVMNMQNRQKKAGEDQSMLAEEA---------DS 225
            L E+  +   L+V+ T+ S    LK  + N+Q  QK+  ++++   E+          + 
Sbjct: 1683 LRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHEL 1742

Query: 226  SKPGPSAHDVAAQLKSSLLAEIGLTESEGP 255
            S  GP  H+V+     SL +E+  +++ GP
Sbjct: 1743 SLMGPVVHEVSDSQAGSLQSELLCSQAGGP 1772


>FIXK_RHIME P13295 rhizobium meliloti (sinorhizobium meliloti). nitrogen
           fixation regulation protein fixk. 5/2000
           Length = 211
           
 Score = 31.3 bits (69), Expect = 8.6
 Identities = 22/74 (29%), Positives = 39/74 (51%), Gaps = 10/74 (13%)

Query: 691 AFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA---EQPLHAMRKG 747
           AF VDLC+ +GGG+       + +P++ Q++ +Y+    E    VV    E+ L A+R  
Sbjct: 142 AFLVDLCERQGGGR------QLRLPMSRQDIADYLGLTIETVSRVVTKLKERSLIALRDA 195

Query: 748 -LLDVLPKNSLEDL 760
             +D++   +L  L
Sbjct: 196 RTIDIMKPEALRSL 209


>CC24_YEAST P11433 saccharomyces cerevisiae (baker's yeast). cell division
           control protein 24 (calcium regulatory protein). 7/1999
           Length = 854
           
 Score = 31.3 bits (69), Expect = 8.6
 Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 8/78 (10%)

Query: 610 KNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF--FDPVMYE 667
           K  EA L+  +NI R +      NE    T N  V+K L GR VNW  +    F  ++Y 
Sbjct: 435 KELEAALDISKNIARSI------NENQRRTENHQVVKKLYGRVVNWKGYRISKFGELLYF 488

Query: 668 SLRQLILASQSSDADAVF 685
               +   + SS+ +  F
Sbjct: 489 DKVFISTTNSSSEPEREF 506


Searching.................................................done


Results from round 2


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value
Sequences used in model and found again:

100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec...  1236  0.0
HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyper...   709  0.0
NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6...   344  4e-94
PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast)....   343  1e-93
NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6...   343  1e-93
RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ...   325  2e-88
UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein li...   314  6e-85
UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein li...   302  2e-81
HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). ...   281  4e-75
URB1_RAT P51593 rattus norvegicus (rat). dna binding protein...   280  8e-75
TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor int...   272  3e-72
Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein...   270  6e-72
HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). ...   251  6e-66
UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ...   224  4e-58
PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-bindin...    89  5e-17
PABP_XENLA P20965 xenopus laevis (african clawed frog). poly...    88  6e-17
PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-bindin...    88  8e-17

Sequences not found previously or not previously below threshold:

PABP_DROME P21187 drosophila melanogaster (fruit fly). polya...    67  1e-10
PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast)....    44  0.001
PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress). po...    43  0.003
PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress). po...    43  0.003
PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-bin...    41  0.010
RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-....    33  2.2
NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans)...    33  2.9
YK44_YEAST P36023 saccharomyces cerevisiae (baker's yeast). ...    31  8.4
SYQ_YEAST P13188 saccharomyces cerevisiae (baker's yeast). g...    31  8.4

>100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec 6.3.2.-).
           7/1999
           Length = 889
           
 Score = 1236 bits (3163), Expect = 0.0
 Identities = 765/889 (86%), Positives = 765/889 (86%)

Query: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60
           MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT
Sbjct: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60

Query: 61  PQXXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120
           PQ            GI            TSQSATLNDKDDESLPAETGQNHPFFRRSDSM
Sbjct: 61  PQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120

Query: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180
           TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT
Sbjct: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180

Query: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240
           MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK
Sbjct: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240

Query: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300
           SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG
Sbjct: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300

Query: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360
           SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT
Sbjct: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360

Query: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQX 420
           TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQ 
Sbjct: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQR 420

Query: 421 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGNPSDDPDP 480
                                                QLSIDTRPFRPASEGNPSDDPDP
Sbjct: 421 LRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDP 480

Query: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
           LPAHRQALGERLYPRVQAMQPAFASKITGM                   RARVEEAMELI
Sbjct: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVEEAMELI 540

Query: 541 VAHGRENGAXXXXXXXXXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGK 600
           VAHGRENGA            EKVQENRKRHGSSRSVV            NAPLFYQPGK
Sbjct: 541 VAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGK 600

Query: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660
           RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF
Sbjct: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660

Query: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720
           FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN
Sbjct: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720

Query: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780
           VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML
Sbjct: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780

Query: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840
           ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP
Sbjct: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840

Query: 841 SITIRPPDDQHLPTANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
           SITIRPPDDQHLPTANTCISRLYVP                   NFGFV
Sbjct: 841 SITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 889


>HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyperplastic discs
            protein (hyd protein) (ec 6.3.2.-). 12/1998
            Length = 2895
            
 Score =  709 bits (1810), Expect = 0.0
 Identities = 281/635 (44%), Positives = 374/635 (58%), Gaps = 34/635 (5%)

Query: 263  QCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEK 322
            Q +F G+   + +L  +  L+L+LFGR FM+DVG E GS+L EL GF VKE +FRR MEK
Sbjct: 2287 QSNFSGIAPCNFLLSAK--LTLDLFGRPFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEK 2344

Query: 323  LRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEG 379
            LRN Q RDL L +++R+R+ LI QT ++LN  FG   R    P+  +RVKVTFKDEPGEG
Sbjct: 2345 LRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEG 2404

Query: 380  SGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQXXXXXXXXXXXXXXXXXXXX 439
            SGVARSFYT+IA+A L++ K+PNL+ +Q      H+  +                     
Sbjct: 2405 SGVARSFYTSIAEALLASAKIPNLESVQVGTN--HSKYVVPFSSILRTTVSGSSRDQSTL 2462

Query: 440  XXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGN---PSDDPDPLPAHRQALGERLYPRV 496
                               L++D RP+ P +  +   P    D L  H Q +GERLYP++
Sbjct: 2463 QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKI 2522

Query: 497  QAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELIVAHGRENGAXXXXXXX 556
             ++    A KITGM                   R +V EA+E+I    +   +       
Sbjct: 2523 HSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSA------ 2576

Query: 557  XXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGKRGFYTPRPGKNTEARL 616
                    Q ++ +   S  VV            N PLFY PGKRGFY PR G  +  R+
Sbjct: 2577 --------QSSQPKKSPSVVVVDPVDDD------NEPLFYSPGKRGFYIPRQGFASFERI 2622

Query: 617  NCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILAS 676
            N FRNIGR++GLCLLQNEL P+ L RHV+K +L RK+ +HD AFFDP +YES RQ+I  +
Sbjct: 2623 NAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILRRKIKFHDLAFFDPALYESFRQIIQNA 2682

Query: 677  QSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM-LV 735
            Q+ + +   + M+L F +DL KEEG G  ELIP G ++ V+ + +Y       ++   + 
Sbjct: 2683 QTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDV-VSHRVIYSSTSDAIQNIDXIK 2741

Query: 736  VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 795
              E+ L A++ G+ DVLP NS+ +LTAED RLL+NG G++NV  LIS+T+FNDES E  +
Sbjct: 2742 SQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPD 2801

Query: 796  KL-LQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPT 854
            KL  +FK+WFWSIVE+M++ ERQ LVYFWT SP+LPASEEGFQP+PS+TIRP DD HLPT
Sbjct: 2802 KLX-KFKKWFWSIVEKMNIMERQHLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPT 2860

Query: 855  ANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
            ANTCISRLY+P                   NFGFV
Sbjct: 2861 ANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2895


 Score =  257 bits (649), Expect = 8e-68
 Identities = 69/209 (33%), Positives = 107/209 (51%), Gaps = 26/209 (12%)

Query: 3    SARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQ 62
            ++R DF  Y LSLMRSH  EH D LPVLD+ +L+H+AYV  A +Y+++  N     D   
Sbjct: 1913 NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDSGFYDKQD 1970

Query: 63   XXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDE------SLPA--ETGQNHPFF 114
                         I              + A L + + +      S+P+  +  + H FF
Sbjct: 1971 SISGR--------INNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFF 2022

Query: 115  RRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGK 174
             RS+S   LGC  P  FE+PL  A+PLAD+PHLLQPN+++++LF      + +++  SG 
Sbjct: 2023 ARSESTLTLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG- 2081

Query: 175  CLVEVTMD---RNCLEVLPTKMSYAANLK 200
                 T D    +  +  PT++ ++ +LK
Sbjct: 2082 ----ATNDGDGASIFDYTPTRLGFSNSLK 2106


>NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6.3.2.-) (kiaa0093)
           (fragment). 7/1999
           Length = 927
           
 Score =  344 bits (873), Expect = 4e-94
 Identities = 72/268 (26%), Positives = 119/268 (43%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 649 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 708

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 709 YNSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 757

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 758 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 817

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQP 838
            T + +    N     Q  +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 818 HTKYKNGYSANH----QVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 873

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+      + LP A+TC +RL +P
Sbjct: 874 PQSFTVEQWGTPEKLPRAHTCFNRLDLP 901


>PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast).
           ubiquitin--protein ligase pub1 (ec 6.3.2.-). 12/1998
           Length = 767
           
 Score =  343 bits (870), Expect = 1e-93
 Identities = 69/265 (26%), Positives = 115/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +               K++L +KV   D    D   
Sbjct: 491 PHSGINPE-HLNYFKFIGRVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEY 549

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++    +   D  FS  D  F   +        ++L PNG NI VT +N  EYV
Sbjct: 550 YRSLVWILDNDITGVLDLTFSVEDNCFGEVVT-------IDLKPNGRNIEVTEENKREYV 602

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
                 R+    E+  +A  +G  +++P+  +      +  LL+ G  E++++     T 
Sbjct: 603 DLVTVWRIQKRIEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTD 662

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +   S  +     Q  +WFW +++  S  ++  L+ F T +  +P +     +G      
Sbjct: 663 YRSYSEND-----QIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRK 717

Query: 842 ITIR-PPDDQHLPTANTCISRLYVP 865
            TI    +   LP A+TC +RL +P
Sbjct: 718 FTIEKAGEPNKLPKAHTCFNRLDLP 742


>NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6.3.2.-)
           (fragment). 11/1997
           Length = 957
           
 Score =  343 bits (870), Expect = 1e-93
 Identities = 72/268 (26%), Positives = 117/268 (42%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 679 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEY 738

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 739 YSSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKTGGSEIVVTNKNKK 787

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 788 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 847

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQP 838
            T + +    N     Q   WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 848 HTKYKNGYSMNH----QVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 903

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+        LP A+TC +RL +P
Sbjct: 904 PQSFTVEQWGTPDKLPRAHTCFNRLDLP 931


>RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ubiquitin--protein
           ligase rsp5 (ec 6.3.2.-). 7/1999
           Length = 809
           
 Score =  325 bits (825), Expect = 2e-88
 Identities = 69/265 (26%), Positives = 116/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +             + K++L +KV   D    D  +
Sbjct: 533 PNSGINPE-HLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEV 591

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++  S     D  FSA D  F   +        V+L P+G NI VT  N  EYV
Sbjct: 592 YNSLNWMLENSIDGVLDLTFSADDERFGEVVT-------VDLKPDGRNIEVTDGNKKEYV 644

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
             Y + R++   ++   A   G  +++P++ +      +  LL+ G  E++++     T 
Sbjct: 645 ELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTD 704

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +      +     +  +WFW  V      +R  L+ F T +  +P +     +G      
Sbjct: 705 YRGYQESD-----EVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRR 759

Query: 842 ITIRPPDD-QHLPTANTCISRLYVP 865
            TI    + Q LP ++TC +R+ +P
Sbjct: 760 FTIEKAGEVQQLPKSHTCFNRVDLP 784


>UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap)
           (human papillomavirus e6-associated protein). 5/2000
           Length = 875
           
 Score =  314 bits (795), Expect = 6e-85
 Identities = 67/249 (26%), Positives = 116/249 (45%), Gaps = 12/249 (4%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG +LGL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    +
Sbjct: 612 FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGN 671

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 672 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 726

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   + 
Sbjct: 727 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRDS 784

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +L   R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 785 VL--IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 841

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 842 TCFNVLLLP 850


>UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap).
           5/2000
           Length = 885
           
 Score =  302 bits (765), Expect = 2e-81
 Identities = 67/249 (26%), Positives = 115/249 (45%), Gaps = 13/249 (5%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG + GL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    S
Sbjct: 623 FTLIGIL-GLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGS 681

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 682 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVISYSDYILNKSV 736

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   E 
Sbjct: 737 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRES 794

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           ++   R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 795 VV--IREFWEIVHSFTDEQKRLFLLFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 851

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 852 TCFNVLLLP 860


>HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul4 (ec 6.3.2.-). 5/2000
           Length = 892
           
 Score =  281 bits (711), Expect = 4e-75
 Identities = 58/271 (21%), Positives = 116/271 (42%), Gaps = 16/271 (5%)

Query: 604 YTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDP 663
           +    GKN++  L  +   G ++GL +  + +  +   + + K L    +++ D++   P
Sbjct: 602 FDKSKGKNSQLEL--YYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFP 659

Query: 664 VMYESLRQLILASQSSDADAVFSAMDLAFAV------DLCKEEGGGQVELIPNGVNIPVT 717
               +L +++  ++ +  D      +  +        D    +    VEL  NG N+P+T
Sbjct: 660 ETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPIT 719

Query: 718 PQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPK-NSLEDLTAEDFRLLVNGCGE-- 774
             N +E+V K+ E  +    E   +    G   V  + NS++   +E+   LV G  E  
Sbjct: 720 QSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQT 779

Query: 775 -VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE 833
             + + L S T +     +++  +     WFW I+E      ++ L+ F T+S  +PA+ 
Sbjct: 780 KFDFKSLRSVTKYVGGFSDDSRAVC----WFWEIIESWDYPLQKKLLQFVTASDRIPATG 835

Query: 834 EGFQPMPSITIRPPDDQHLPTANTCISRLYV 864
               P     +   D   LP A+TC + + +
Sbjct: 836 ISTIPFKISLLGSHDSDDLPLAHTCFNEICL 866


>URB1_RAT P51593 rattus norvegicus (rat). dna binding protein ure-b1 (ec
           6.3.2.-). 10/1996
           Length = 310
           
 Score =  280 bits (709), Expect = 8e-75
 Identities = 65/250 (26%), Positives = 109/250 (43%), Gaps = 19/250 (7%)

Query: 623 GRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDAD 682
           GR +   ++   L      R   K +LG+ V + D    D   Y+ L  L+        D
Sbjct: 45  GRYVAKAVMTTALLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN------D 98

Query: 683 AVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPL 741
                 DL F+ ++ +E G  +V +L PNG NI VT +N  EYV    + RM     + L
Sbjct: 99  VSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQL 157

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFK 801
            A  +G  +++PK  +   T ++  LL  G   +++  L S T ++     + +      
Sbjct: 158 AAFLEGFYEIIPKRLISIFTEQELELLYTGLPTIDIDDLKSNTEYHKYQSNSIQ-----I 212

Query: 802 RWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQPMPSITIRPPD--DQHLPTA 855
           +WFW  +      +R   + F T +  +P    A+ EG   +    I   D     LP+A
Sbjct: 213 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 272

Query: 856 NTCISRLYVP 865
           +TC ++L +P
Sbjct: 273 HTCFNQLDLP 282


>TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor interacting protein 12
            (trip12) (kiaa0045). 12/1998
            Length = 1992
            
 Score =  272 bits (687), Expect = 3e-72
 Identities = 58/286 (20%), Positives = 109/286 (37%), Gaps = 28/286 (9%)

Query: 605  TPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW--HDFAFFD 662
            T +P    + ++  FR +G+++   ++   L  + L     K +L ++ +   HD    D
Sbjct: 1684 TAKPAHIAKVKMK-FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDID 1742

Query: 663  PVMYES---LRQLILASQSSDADAVFSAMDLAFAVDL-----CKEE---------GGGQV 705
            PV+  S   L  ++   +  + D   +   L +A++      C  E         G   +
Sbjct: 1743 PVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNI 1802

Query: 706  ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDF 765
            EL   G +IPVT  N+ EY+R      +     +   + R G   V P + L+    E+ 
Sbjct: 1803 ELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEEL 1862

Query: 766  RLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTS 825
              L+ G                 + G   +   +  ++ + I+      +++  + F T 
Sbjct: 1863 DQLLCGSKADTWDAKTLMECCRPDHGYTHDS--RAVKFLFEILSSFDNEQQRLFLQFVTG 1920

Query: 826  SPSLPASEEGFQPMPSITIRP------PDDQHLPTANTCISRLYVP 865
            SP LP         P   +R         D  LP+  TC++ L +P
Sbjct: 1921 SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLP 1966


>Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein kiaa0032. 5/2000
            Length = 1050
            
 Score =  270 bits (684), Expect = 6e-72
 Identities = 58/256 (22%), Positives = 96/256 (36%), Gaps = 15/256 (5%)

Query: 613  EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL 672
                N F  IG   GL +  + +  +     + K LL  K    D     P    SL++L
Sbjct: 782  FVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL 841

Query: 673  ILASQSSDADAVFSAMDLAFAVDLCKEEGGG--QVELIPNGVNIPVTPQNVYEYVRKYAE 730
            +      D +  F    L F +  C+E  G   Q +LIP G N+ V   N  E+V  Y  
Sbjct: 842  LDY-PGEDVEETFC---LNFTI--CRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVN 895

Query: 731  HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 790
            +   +   +   A   G L V     LE     + R ++ G    N + L     +  + 
Sbjct: 896  YVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDY 955

Query: 791  GENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPS-ITIRPPDD 849
                  +    + FW       + +++  + F T S  +P    G   +   I      +
Sbjct: 956  SATHPTV----KLFWETFHEFPLEKKKKFLLFLTGSDRIPI--YGMASLQIVIQSTASGE 1009

Query: 850  QHLPTANTCISRLYVP 865
            ++LP A+TC + L +P
Sbjct: 1010 EYLPVAHTCYNLLDLP 1025


>HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul5 (ec 6.3.2.-). 5/2000
           Length = 910
           
 Score =  251 bits (633), Expect = 6e-66
 Identities = 68/259 (26%), Positives = 126/259 (48%), Gaps = 21/259 (8%)

Query: 615 RLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLL----GRKVNWHDFAFFDPVMYESLR 670
           +L     +G+++G CL ++ L  ++     +K LL    G   ++ D   +D V+Y +L 
Sbjct: 640 KLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLI 699

Query: 671 QLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 730
           +L+    ++D      ++DL F +D   E     V+LIPNG    VT  NV  YV K  +
Sbjct: 700 KLLN--MTTDE---IKSLDLTFEIDE-PESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTD 753

Query: 731 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE-VNVQMLISFTSFNDE 789
           +++     +P+ A   GL  ++  + +E   + + ++L++G  + +++  L S T +   
Sbjct: 754 YKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGY 813

Query: 790 SGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIRPPD 848
             E+     Q    FW ++      E+ + + F TS P  P   +GF+ + P   IR   
Sbjct: 814 KEED-----QTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAP--LQGFKALDPKFGIRNAG 866

Query: 849 DQ--HLPTANTCISRLYVP 865
            +   LPTA+TC++ L +P
Sbjct: 867 TEKYRLPTASTCVNLLKLP 885


>UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ubiquitin fusion
            degradation protein 4 (ub fusion protein 4). 11/1997
            Length = 1483
            
 Score =  224 bits (566), Expect = 4e-58
 Identities = 60/277 (21%), Positives = 109/277 (38%), Gaps = 29/277 (10%)

Query: 607  RPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG------------RKVN 654
             P  N E  +  F  +G  +   LL N +     ++   ++L               +  
Sbjct: 1192 NPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETC 1251

Query: 655  WHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNI 714
                   DP++ +SL+ ++      D +    ++ L F V      G   +ELIP G N 
Sbjct: 1252 LLMIELVDPLLAKSLKYIVAN---KDDNMTLESLSLTFTVP-----GNDDIELIPGGCNK 1303

Query: 715  PVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE 774
             +   NV EY+    +  +    E+ L A  +G   V     +  L  ++  + + G  E
Sbjct: 1304 SLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDEL-VDIFGRVE 1362

Query: 775  VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP-ASE 833
             +  M   +T+ N E G   +  +     F SI+      ER+  + F T SP LP    
Sbjct: 1363 EDWSMATLYTNLNAEHGYTMDSSI--IHDFISIISAFGKHERRLFLQFLTGSPKLPIGGF 1420

Query: 834  EGFQPMPSITIRPPD-----DQHLPTANTCISRLYVP 865
            +   P  ++ ++  +     D++LP+  TC + L +P
Sbjct: 1421 KSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLP 1457


>PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 88.6 bits (216), Expect = 5e-17
 Identities = 25/70 (35%), Positives = 35/70 (49%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P    +Q LGERL+P +QAM P  A KITGM                   R++V+EA+ +
Sbjct: 554 PPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAV 613

Query: 540 IVAHGRENGA 549
           + AH  +  A
Sbjct: 614 LQAHQAKEAA 623


>PABP_XENLA P20965 xenopus laevis (african clawed frog). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 7/1998
           Length = 633
           
 Score = 88.2 bits (215), Expect = 6e-17
 Identities = 25/70 (35%), Positives = 34/70 (47%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P    +Q LGERL+P +QAM P  A KITGM                   R +V+EA+ +
Sbjct: 552 PPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRLKVDEAVAV 611

Query: 540 IVAHGRENGA 549
           + AH  +  A
Sbjct: 612 LQAHQAKEAA 621


>PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 87.8 bits (214), Expect = 8e-17
 Identities = 25/70 (35%), Positives = 36/70 (50%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P    +Q LGERL+P +QAM P+ A KITGM                   R++V+EA+ +
Sbjct: 554 PPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAV 613

Query: 540 IVAHGRENGA 549
           + AH  +  A
Sbjct: 614 LQAHQAKEAA 623


>PABP_DROME P21187 drosophila melanogaster (fruit fly). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 2/1995
           Length = 632
           
 Score = 67.2 bits (161), Expect = 1e-10
 Identities = 22/72 (30%), Positives = 30/72 (41%)

Query: 478 PDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAM 537
                  +Q LGERLYP ++ M    A KITGM                   +A+VEEA+
Sbjct: 560 NAKPQEQKQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAV 619

Query: 538 ELIVAHGRENGA 549
            ++  H     A
Sbjct: 620 AVLQVHRVTEPA 631


>PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast).
           polyadenylate-binding protein (poly(a) binding protein)
           (pabp). 7/1998
           Length = 653
           
 Score = 44.2 bits (102), Expect = 0.001
 Identities = 18/62 (29%), Positives = 26/62 (41%)

Query: 480 PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMEL 539
           P  + +Q LGE LYP+V   +   + KITGM                     RV EA+ +
Sbjct: 581 PEESRKQVLGELLYPKVFVREEKLSGKITGMLLEMPNSELLELLEDDSALNERVNEAIGV 640

Query: 540 IV 541
           + 
Sbjct: 641 LQ 642


>PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 2 (poly(a) binding protein
           2) (pabp 2). 12/1998
           Length = 629
           
 Score = 43.0 bits (99), Expect = 0.003
 Identities = 18/63 (28%), Positives = 28/63 (43%)

Query: 478 PDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAM 537
                  R  LGE LYP V+ ++   A+K+TGM                   +A+V EAM
Sbjct: 549 NATPEQQRTMLGEVLYPLVEQVEAESAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAM 608

Query: 538 ELI 540
           +++
Sbjct: 609 DVL 611


>PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 5 (poly(a) binding protein
           5) (pabp 5). 11/1995
           Length = 668
           
 Score = 42.6 bits (98), Expect = 0.003
 Identities = 17/60 (28%), Positives = 29/60 (48%)

Query: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
              H + LG+ LYP V+  +PA  +K+TGM                   +A+V EA++++
Sbjct: 587 PDKHPRMLGDHLYPLVEQQEPANPAKVTGMLLEMDQAEILHLLESPEALKAKVSEALDVL 646


>PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-binding protein,
           cytoplasmic and nuclear (pabp) (ars consensus binding
           protein acbp-67) (polyadenylate tail-binding protein).
           2/1996
           Length = 576
           
 Score = 41.1 bits (94), Expect = 0.010
 Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 6/49 (12%)

Query: 468 PASEGNPSDDPDP----LPAHRQALGERLYPRVQA--MQPAFASKITGM 510
           P   G P +  D         RQALGE+LY +V A       A KITGM
Sbjct: 484 PPQGGFPRNANDNNQFYQQKQRQALGEQLYKKVSAKTSNEEAAGKITGM 532


>RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-.-) (rnase r)
           (vacb protein homolog). 5/2000
           Length = 705
           
 Score = 33.3 bits (74), Expect = 2.2
 Identities = 17/92 (18%), Positives = 25/92 (26%), Gaps = 13/92 (14%)

Query: 686 SAMDLAFAVDLCKEEGGGQ---VELIPNGVNIPVTPQNVYEYVRKY-AEHRMLVVAEQPL 741
               L F +D  K         +EL P G            YV      + +    E   
Sbjct: 243 LREQLCFTIDPEKAGDFDDAVAIELTPEGY--------YKLYVHIADVSYYVREGTETDK 294

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG 773
            A ++G     P  +L  L  E     +    
Sbjct: 295 EAYKRGFTYYFPDRALHML-PEKLSAKLCSLR 325


>NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans). nitrogen
           assimilation transcription factor nira. 4/1993
           Length = 892
           
 Score = 32.9 bits (73), Expect = 2.9
 Identities = 22/95 (23%), Positives = 35/95 (36%)

Query: 219 LAEEADSSKPGPSAHDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLG 278
           +A +  S+  GP +      ++ S  A++   E+  P  T  RP  +  G V S      
Sbjct: 702 VASQYSSTPSGPVSVSAMRAVQRSFSAQLAHNEARQPEPTYLRPVSTSYGPVPSTQSAQE 761

Query: 279 RWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKE 313
           +W    E   R F         S  + L  F+  E
Sbjct: 762 QWYSPTEAQFRAFTAAHSMPTTSAQSPLTTFDTPE 796


>YK44_YEAST P36023 saccharomyces cerevisiae (baker's yeast). putative 101.8 kda
           transcriptional regulatory protein in las1-ccp1
           intergenic region. 2/1995
           Length = 863
           
 Score = 31.3 bits (69), Expect = 8.4
 Identities = 26/238 (10%), Positives = 59/238 (23%), Gaps = 45/238 (18%)

Query: 600 KRGFYTPRP-GKNTEARLNCFRN----IGRILGLCLLQNELC----PITLNRHVIKVLLG 650
           KR F+  +   KN +  +  F      I  +  L LL  E+        + +   K    
Sbjct: 523 KRNFHILKSLSKNEKETMRHFDFEMEWIIDLFSLSLLHGEMIFYEYDCNITK-FYK---- 577

Query: 651 RKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPN 710
              ++ D       + E        S + + D++           +  +        I  
Sbjct: 578 ---SFQDLWDMVIHISEKCYNYFFNSDALEVDSLTKFYTNRIVEIVANKVLVIVPAFILR 634

Query: 711 GVN-IPVTPQNVY---EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKN----------- 755
           G     +   +     E++   +         +     RK     +              
Sbjct: 635 GDRFKTIQYADKKKMIEFLYGVSSVYFNEFGFEYYRCFRKMFTAKIAYKILNRSCEKDAW 694

Query: 756 -SLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMS 812
             +      + +L  NG   ++   +                +      F   V++  
Sbjct: 695 RIILKFLLNELKLEDNGDSYIDYNDMRLN------------DICPIILEFQETVQKYD 740


>SYQ_YEAST P13188 saccharomyces cerevisiae (baker's yeast). glutaminyl-trna
           synthetase (ec 6.1.1.18) (glutamine--trna ligase)
           (glnrs). 11/1997
           Length = 809
           
 Score = 31.3 bits (69), Expect = 8.4
 Identities = 20/117 (17%), Positives = 44/117 (37%), Gaps = 18/117 (15%)

Query: 671 QLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPN-GVNIPVTPQNVYEYVRKYA 729
           +LI+    +        +D AF       E   ++ +  N GV I +T   V  YV +Y 
Sbjct: 71  ELIVNGIINGDLKTSLQVDAAFKYVKANGEASTKMGMNENSGVGIEITEDQVRNYVMQYI 130

Query: 730 E----------HRMLVVAEQPLHAMRK-------GLLDVLPKNSLEDLTAEDFRLLV 769
           +          ++++      +  +++           ++ +  L+ L  +D R L+
Sbjct: 131 QENKERILTERYKLVPGIFADVKNLKELKWADPRSFKPIIDQEVLKLLGPKDERDLI 187


Searching.................................................done


Results from round 3


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value
Sequences used in model and found again:

100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec...  1228  0.0
HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyper...   702  0.0
PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast)....   340  5e-93
NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6...   339  1e-92
NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6...   339  2e-92
RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ...   330  1e-89
UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein li...   316  1e-85
UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein li...   306  1e-82
HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). ...   289  1e-77
TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor int...   284  5e-76
URB1_RAT P51593 rattus norvegicus (rat). dna binding protein...   279  1e-74
Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein...   274  4e-73
UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ...   259  2e-68
HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). ...   257  8e-68
PABP_DROME P21187 drosophila melanogaster (fruit fly). polya...    88  6e-17
PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-bindin...    87  1e-16
PABP_XENLA P20965 xenopus laevis (african clawed frog). poly...    86  2e-16
PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-bindin...    86  3e-16

Sequences not found previously or not previously below threshold:

PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress). po...    48  1e-04
PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast)....    45  7e-04
PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress). po...    44  0.001
PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-bin...    42  0.006
NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans)...    33  2.9
RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-....    32  3.7

>100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec 6.3.2.-).
           7/1999
           Length = 889
           
 Score = 1228 bits (3143), Expect = 0.0
 Identities = 765/889 (86%), Positives = 765/889 (86%)

Query: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60
           MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT
Sbjct: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60

Query: 61  PQXXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120
           PQ            GI            TSQSATLNDKDDESLPAETGQNHPFFRRSDSM
Sbjct: 61  PQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120

Query: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180
           TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT
Sbjct: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180

Query: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240
           MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK
Sbjct: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240

Query: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300
           SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG
Sbjct: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300

Query: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360
           SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT
Sbjct: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360

Query: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQX 420
           TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQ 
Sbjct: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQR 420

Query: 421 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGNPSDDPDP 480
                                                QLSIDTRPFRPASEGNPSDDPDP
Sbjct: 421 LRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDP 480

Query: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
           LPAHRQALGERLYPRVQAMQPAFASKITGM                   RARVEEAMELI
Sbjct: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVEEAMELI 540

Query: 541 VAHGRENGAXXXXXXXXXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGK 600
           VAHGRENGA            EKVQENRKRHGSSRSVV            NAPLFYQPGK
Sbjct: 541 VAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGK 600

Query: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660
           RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF
Sbjct: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660

Query: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720
           FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN
Sbjct: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720

Query: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780
           VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML
Sbjct: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780

Query: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840
           ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP
Sbjct: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840

Query: 841 SITIRPPDDQHLPTANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
           SITIRPPDDQHLPTANTCISRLYVP                   NFGFV
Sbjct: 841 SITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 889


>HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyperplastic discs
            protein (hyd protein) (ec 6.3.2.-). 12/1998
            Length = 2895
            
 Score =  702 bits (1792), Expect = 0.0
 Identities = 281/635 (44%), Positives = 374/635 (58%), Gaps = 34/635 (5%)

Query: 263  QCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEK 322
            Q +F G+   + +L  +  L+L+LFGR FM+DVG E GS+L EL GF VKE +FRR MEK
Sbjct: 2287 QSNFSGIAPCNFLLSAK--LTLDLFGRPFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEK 2344

Query: 323  LRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEG 379
            LRN Q RDL L +++R+R+ LI QT ++LN  FG   R    P+  +RVKVTFKDEPGEG
Sbjct: 2345 LRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEG 2404

Query: 380  SGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQXXXXXXXXXXXXXXXXXXXX 439
            SGVARSFYT+IA+A L++ K+PNL+ +Q      H+  +                     
Sbjct: 2405 SGVARSFYTSIAEALLASAKIPNLESVQVGTN--HSKYVVPFSSILRTTVSGSSRDQSTL 2462

Query: 440  XXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGN---PSDDPDPLPAHRQALGERLYPRV 496
                               L++D RP+ P +  +   P    D L  H Q +GERLYP++
Sbjct: 2463 QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKI 2522

Query: 497  QAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELIVAHGRENGAXXXXXXX 556
             ++    A KITGM                   R +V EA+E+I    +   +       
Sbjct: 2523 HSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSA------ 2576

Query: 557  XXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGKRGFYTPRPGKNTEARL 616
                    Q ++ +   S  VV            N PLFY PGKRGFY PR G  +  R+
Sbjct: 2577 --------QSSQPKKSPSVVVVDPVDDD------NEPLFYSPGKRGFYIPRQGFASFERI 2622

Query: 617  NCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILAS 676
            N FRNIGR++GLCLLQNEL P+ L RHV+K +L RK+ +HD AFFDP +YES RQ+I  +
Sbjct: 2623 NAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILRRKIKFHDLAFFDPALYESFRQIIQNA 2682

Query: 677  QSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM-LV 735
            Q+ + +   + M+L F +DL KEEG G  ELIP G ++ V+ + +Y       ++   + 
Sbjct: 2683 QTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDV-VSHRVIYSSTSDAIQNIDXIK 2741

Query: 736  VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 795
              E+ L A++ G+ DVLP NS+ +LTAED RLL+NG G++NV  LIS+T+FNDES E  +
Sbjct: 2742 SQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPD 2801

Query: 796  KLL-QFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPT 854
            K L +FK+WFWSIVE+M++ ERQ LVYFWT SP+LPASEEGFQP+PS+TIRP DD HLPT
Sbjct: 2802 K-LXKFKKWFWSIVEKMNIMERQHLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPT 2860

Query: 855  ANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
            ANTCISRLY+P                   NFGFV
Sbjct: 2861 ANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2895


 Score =  254 bits (643), Expect = 4e-67
 Identities = 69/209 (33%), Positives = 107/209 (51%), Gaps = 26/209 (12%)

Query: 3    SARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQ 62
            ++R DF  Y LSLMRSH  EH D LPVLD+ +L+H+AYV  A +Y+++  N     D   
Sbjct: 1913 NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDSGFYDKQD 1970

Query: 63   XXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDE------SLPA--ETGQNHPFF 114
                         I              + A L + + +      S+P+  +  + H FF
Sbjct: 1971 SISGR--------INNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFF 2022

Query: 115  RRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGK 174
             RS+S   LGC  P  FE+PL  A+PLAD+PHLLQPN+++++LF      + +++  SG 
Sbjct: 2023 ARSESTLTLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG- 2081

Query: 175  CLVEVTMD---RNCLEVLPTKMSYAANLK 200
                 T D    +  +  PT++ ++ +LK
Sbjct: 2082 ----ATNDGDGASIFDYTPTRLGFSNSLK 2106


>PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast).
           ubiquitin--protein ligase pub1 (ec 6.3.2.-). 12/1998
           Length = 767
           
 Score =  340 bits (864), Expect = 5e-93
 Identities = 69/265 (26%), Positives = 115/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +               K++L +KV   D    D   
Sbjct: 491 PHSGINPE-HLNYFKFIGRVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEY 549

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++    +   D  FS  D  F   +        ++L PNG NI VT +N  EYV
Sbjct: 550 YRSLVWILDNDITGVLDLTFSVEDNCFGEVVT-------IDLKPNGRNIEVTEENKREYV 602

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
                 R+    E+  +A  +G  +++P+  +      +  LL+ G  E++++     T 
Sbjct: 603 DLVTVWRIQKRIEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTD 662

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +   S  +     Q  +WFW +++  S  ++  L+ F T +  +P +     +G      
Sbjct: 663 YRSYSEND-----QIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRK 717

Query: 842 ITIRPP-DDQHLPTANTCISRLYVP 865
            TI    +   LP A+TC +RL +P
Sbjct: 718 FTIEKAGEPNKLPKAHTCFNRLDLP 742


>NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6.3.2.-) (kiaa0093)
           (fragment). 7/1999
           Length = 927
           
 Score =  339 bits (860), Expect = 1e-92
 Identities = 72/268 (26%), Positives = 119/268 (43%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 649 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 708

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 709 YNSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 757

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 758 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 817

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQP 838
            T + +    N     Q  +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 818 HTKYKNGYSANH----QVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 873

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+      + LP A+TC +RL +P
Sbjct: 874 PQSFTVEQWGTPEKLPRAHTCFNRLDLP 901


>NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6.3.2.-)
           (fragment). 11/1997
           Length = 957
           
 Score =  339 bits (859), Expect = 2e-92
 Identities = 72/268 (26%), Positives = 117/268 (42%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 679 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEY 738

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 739 YSSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKTGGSEIVVTNKNKK 787

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 788 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 847

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQP 838
            T + +    N     Q   WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 848 HTKYKNGYSMNH----QVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 903

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+        LP A+TC +RL +P
Sbjct: 904 PQSFTVEQWGTPDKLPRAHTCFNRLDLP 931


>RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ubiquitin--protein
           ligase rsp5 (ec 6.3.2.-). 7/1999
           Length = 809
           
 Score =  330 bits (836), Expect = 1e-89
 Identities = 69/265 (26%), Positives = 116/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +             + K++L +KV   D    D  +
Sbjct: 533 PNSGINPE-HLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEV 591

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++  S     D  FSA D  F   +        V+L P+G NI VT  N  EYV
Sbjct: 592 YNSLNWMLENSIDGVLDLTFSADDERFGEVVT-------VDLKPDGRNIEVTDGNKKEYV 644

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
             Y + R++   ++   A   G  +++P++ +      +  LL+ G  E++++     T 
Sbjct: 645 ELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTD 704

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +      +     +  +WFW  V      +R  L+ F T +  +P +     +G      
Sbjct: 705 YRGYQESD-----EVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRR 759

Query: 842 ITIRPPDD-QHLPTANTCISRLYVP 865
            TI    + Q LP ++TC +R+ +P
Sbjct: 760 FTIEKAGEVQQLPKSHTCFNRVDLP 784


>UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap)
           (human papillomavirus e6-associated protein). 5/2000
           Length = 875
           
 Score =  316 bits (801), Expect = 1e-85
 Identities = 67/249 (26%), Positives = 116/249 (45%), Gaps = 12/249 (4%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG +LGL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    +
Sbjct: 612 FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGN 671

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 672 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 726

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   + 
Sbjct: 727 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRDS 784

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +L   R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 785 VL--IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 841

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 842 TCFNVLLLP 850


>UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap).
           5/2000
           Length = 885
           
 Score =  306 bits (775), Expect = 1e-82
 Identities = 67/249 (26%), Positives = 114/249 (44%), Gaps = 13/249 (5%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG + GL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    S
Sbjct: 623 FTLIGIL-GLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGS 681

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 682 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVISYSDYILNKSV 736

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   E 
Sbjct: 737 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRES 794

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +    R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 795 V--VIREFWEIVHSFTDEQKRLFLLFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 851

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 852 TCFNVLLLP 860


>HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul4 (ec 6.3.2.-). 5/2000
           Length = 892
           
 Score =  289 bits (733), Expect = 1e-77
 Identities = 58/271 (21%), Positives = 116/271 (42%), Gaps = 16/271 (5%)

Query: 604 YTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDP 663
           +    GKN++  L  +   G ++GL +  + +  +   + + K L    +++ D++   P
Sbjct: 602 FDKSKGKNSQLEL--YYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFP 659

Query: 664 VMYESLRQLILASQSSDADAVFSAMDLAFAV------DLCKEEGGGQVELIPNGVNIPVT 717
               +L +++  ++ +  D      +  +        D    +    VEL  NG N+P+T
Sbjct: 660 ETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPIT 719

Query: 718 PQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPK-NSLEDLTAEDFRLLVNGCGE-- 774
             N +E+V K+ E  +    E   +    G   V  + NS++   +E+   LV G  E  
Sbjct: 720 QSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQT 779

Query: 775 -VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE 833
             + + L S T +     +++  +     WFW I+E      ++ L+ F T+S  +PA+ 
Sbjct: 780 KFDFKSLRSVTKYVGGFSDDSRAVC----WFWEIIESWDYPLQKKLLQFVTASDRIPATG 835

Query: 834 EGFQPMPSITIRPPDDQHLPTANTCISRLYV 864
               P     +   D   LP A+TC + + +
Sbjct: 836 ISTIPFKISLLGSHDSDDLPLAHTCFNEICL 866


>TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor interacting protein 12
            (trip12) (kiaa0045). 12/1998
            Length = 1992
            
 Score =  284 bits (719), Expect = 5e-76
 Identities = 58/286 (20%), Positives = 109/286 (37%), Gaps = 28/286 (9%)

Query: 605  TPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW--HDFAFFD 662
            T +P    + ++  FR +G+++   ++   L  + L     K +L ++ +   HD    D
Sbjct: 1684 TAKPAHIAKVKMK-FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDID 1742

Query: 663  PVMYES---LRQLILASQSSDADAVFSAMDLAFAVDL-----CKEE---------GGGQV 705
            PV+  S   L  ++   +  + D   +   L +A++      C  E         G   +
Sbjct: 1743 PVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNI 1802

Query: 706  ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDF 765
            EL   G +IPVT  N+ EY+R      +     +   + R G   V P + L+    E+ 
Sbjct: 1803 ELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEEL 1862

Query: 766  RLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTS 825
              L+ G                 + G   +   +  ++ + I+      +++  + F T 
Sbjct: 1863 DQLLCGSKADTWDAKTLMECCRPDHGYTHDS--RAVKFLFEILSSFDNEQQRLFLQFVTG 1920

Query: 826  SPSLPASEEGFQPMPSITIRP------PDDQHLPTANTCISRLYVP 865
            SP LP         P   +R         D  LP+  TC++ L +P
Sbjct: 1921 SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLP 1966


>URB1_RAT P51593 rattus norvegicus (rat). dna binding protein ure-b1 (ec
           6.3.2.-). 10/1996
           Length = 310
           
 Score =  279 bits (707), Expect = 1e-74
 Identities = 65/250 (26%), Positives = 109/250 (43%), Gaps = 19/250 (7%)

Query: 623 GRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDAD 682
           GR +   ++   L      R   K +LG+ V + D    D   Y+ L  L+        D
Sbjct: 45  GRYVAKAVMTTALLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN------D 98

Query: 683 AVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPL 741
                 DL F+ ++ +E G  +V +L PNG NI VT +N  EYV    + RM     + L
Sbjct: 99  VSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQL 157

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFK 801
            A  +G  +++PK  +   T ++  LL  G   +++  L S T ++     + +      
Sbjct: 158 AAFLEGFYEIIPKRLISIFTEQELELLYTGLPTIDIDDLKSNTEYHKYQSNSIQ-----I 212

Query: 802 RWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQPMPSITIRPPD--DQHLPTA 855
           +WFW  +      +R   + F T +  +P    A+ EG   +    I   D     LP+A
Sbjct: 213 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 272

Query: 856 NTCISRLYVP 865
           +TC ++L +P
Sbjct: 273 HTCFNQLDLP 282


>Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein kiaa0032. 5/2000
            Length = 1050
            
 Score =  274 bits (694), Expect = 4e-73
 Identities = 58/256 (22%), Positives = 96/256 (36%), Gaps = 15/256 (5%)

Query: 613  EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL 672
                N F  IG   GL +  + +  +     + K LL  K    D     P    SL++L
Sbjct: 782  FVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL 841

Query: 673  ILASQSSDADAVFSAMDLAFAVDLCKEEGGG--QVELIPNGVNIPVTPQNVYEYVRKYAE 730
            +      D +  F    L F +  C+E  G   Q +LIP G N+ V   N  E+V  Y  
Sbjct: 842  LDY-PGEDVEETFC---LNFTI--CRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVN 895

Query: 731  HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 790
            +   +   +   A   G L V     LE     + R ++ G    N + L     +  + 
Sbjct: 896  YVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDY 955

Query: 791  GENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPS-ITIRPPDD 849
                  +    + FW       + +++  + F T S  +P    G   +   I      +
Sbjct: 956  SATHPTV----KLFWETFHEFPLEKKKKFLLFLTGSDRIPI--YGMASLQIVIQSTASGE 1009

Query: 850  QHLPTANTCISRLYVP 865
            ++LP A+TC + L +P
Sbjct: 1010 EYLPVAHTCYNLLDLP 1025


>UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ubiquitin fusion
            degradation protein 4 (ub fusion protein 4). 11/1997
            Length = 1483
            
 Score =  259 bits (655), Expect = 2e-68
 Identities = 60/277 (21%), Positives = 109/277 (38%), Gaps = 29/277 (10%)

Query: 607  RPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG------------RKVN 654
             P  N E  +  F  +G  +   LL N +     ++   ++L               +  
Sbjct: 1192 NPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETC 1251

Query: 655  WHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNI 714
                   DP++ +SL+ ++      D +    ++ L F V      G   +ELIP G N 
Sbjct: 1252 LLMIELVDPLLAKSLKYIVAN---KDDNMTLESLSLTFTVP-----GNDDIELIPGGCNK 1303

Query: 715  PVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE 774
             +   NV EY+    +  +    E+ L A  +G   V     +  L  ++  + + G  E
Sbjct: 1304 SLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDEL-VDIFGRVE 1362

Query: 775  VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE- 833
             +  M   +T+ N E G   +  +     F SI+      ER+  + F T SP LP    
Sbjct: 1363 EDWSMATLYTNLNAEHGYTMDSSI--IHDFISIISAFGKHERRLFLQFLTGSPKLPIGGF 1420

Query: 834  EGFQPMPSITIRPPD-----DQHLPTANTCISRLYVP 865
            +   P  ++ ++  +     D++LP+  TC + L +P
Sbjct: 1421 KSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLP 1457


>HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul5 (ec 6.3.2.-). 5/2000
           Length = 910
           
 Score =  257 bits (649), Expect = 8e-68
 Identities = 68/259 (26%), Positives = 125/259 (48%), Gaps = 21/259 (8%)

Query: 615 RLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLL----GRKVNWHDFAFFDPVMYESLR 670
           +L     +G+++G CL ++ L  ++     +K LL    G   ++ D   +D V+Y +L 
Sbjct: 640 KLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLI 699

Query: 671 QLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 730
           +L+    ++D      ++DL F +D   E     V+LIPNG    VT  NV  YV K  +
Sbjct: 700 KLLN--MTTDE---IKSLDLTFEIDE-PESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTD 753

Query: 731 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG-EVNVQMLISFTSFNDE 789
           +++     +P+ A   GL  ++  + +E   + + ++L++G    +++  L S T +   
Sbjct: 754 YKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGY 813

Query: 790 SGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIRPPD 848
             E+     Q    FW ++      E+ + + F TS P  P   +GF+ + P   IR   
Sbjct: 814 KEED-----QTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAP--LQGFKALDPKFGIRNAG 866

Query: 849 DQ--HLPTANTCISRLYVP 865
            +   LPTA+TC++ L +P
Sbjct: 867 TEKYRLPTASTCVNLLKLP 885


>PABP_DROME P21187 drosophila melanogaster (fruit fly). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 2/1995
           Length = 632
           
 Score = 88.2 bits (215), Expect = 6e-17
 Identities = 22/72 (30%), Positives = 30/72 (41%)

Query: 478 PDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAM 537
                  +Q LGERLYP ++ M    A KITGM                   +A+VEEA+
Sbjct: 560 NAKPQEQKQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAV 619

Query: 538 ELIVAHGRENGA 549
            ++  H     A
Sbjct: 620 AVLQVHRVTEPA 631


>PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 87.4 bits (213), Expect = 1e-16
 Identities = 25/71 (35%), Positives = 35/71 (49%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
            P    +Q LGERL+P +QAM P  A KITGM                   R++V+EA+ 
Sbjct: 553 APPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVA 612

Query: 539 LIVAHGRENGA 549
           ++ AH  +  A
Sbjct: 613 VLQAHQAKEAA 623


>PABP_XENLA P20965 xenopus laevis (african clawed frog). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 7/1998
           Length = 633
           
 Score = 86.2 bits (210), Expect = 2e-16
 Identities = 25/71 (35%), Positives = 34/71 (47%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
            P    +Q LGERL+P +QAM P  A KITGM                   R +V+EA+ 
Sbjct: 551 APPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRLKVDEAVA 610

Query: 539 LIVAHGRENGA 549
           ++ AH  +  A
Sbjct: 611 VLQAHQAKEAA 621


>PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 85.9 bits (209), Expect = 3e-16
 Identities = 25/71 (35%), Positives = 36/71 (50%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
            P    +Q LGERL+P +QAM P+ A KITGM                   R++V+EA+ 
Sbjct: 553 APPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVA 612

Query: 539 LIVAHGRENGA 549
           ++ AH  +  A
Sbjct: 613 VLQAHQAKEAA 623


>PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 2 (poly(a) binding protein
           2) (pabp 2). 12/1998
           Length = 629
           
 Score = 47.7 bits (111), Expect = 1e-04
 Identities = 18/63 (28%), Positives = 28/63 (43%)

Query: 478 PDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAM 537
                  R  LGE LYP V+ ++   A+K+TGM                   +A+V EAM
Sbjct: 549 NATPEQQRTMLGEVLYPLVEQVEAESAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAM 608

Query: 538 ELI 540
           +++
Sbjct: 609 DVL 611


>PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast).
           polyadenylate-binding protein (poly(a) binding protein)
           (pabp). 7/1998
           Length = 653
           
 Score = 45.0 bits (104), Expect = 7e-04
 Identities = 22/80 (27%), Positives = 30/80 (37%), Gaps = 6/80 (7%)

Query: 468 PASEGNPSDDPD------PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXX 521
           PA  G P           P  + +Q LGE LYP+V   +   + KITGM           
Sbjct: 563 PAVPGMPERFTAADLAAVPEESRKQVLGELLYPKVFVREEKLSGKITGMLLEMPNSELLE 622

Query: 522 XXXXXXXXRARVEEAMELIV 541
                     RV EA+ ++ 
Sbjct: 623 LLEDDSALNERVNEAIGVLQ 642


>PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 5 (poly(a) binding protein
           5) (pabp 5). 11/1995
           Length = 668
           
 Score = 43.8 bits (101), Expect = 0.001
 Identities = 17/62 (27%), Positives = 29/62 (46%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
                H + LG+ LYP V+  +PA  +K+TGM                   +A+V EA++
Sbjct: 585 ASPDKHPRMLGDHLYPLVEQQEPANPAKVTGMLLEMDQAEILHLLESPEALKAKVSEALD 644

Query: 539 LI 540
           ++
Sbjct: 645 VL 646


>PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-binding protein,
           cytoplasmic and nuclear (pabp) (ars consensus binding
           protein acbp-67) (polyadenylate tail-binding protein).
           2/1996
           Length = 576
           
 Score = 41.8 bits (96), Expect = 0.006
 Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 6/49 (12%)

Query: 468 PASEGNPSDDPDP----LPAHRQALGERLYPRVQA--MQPAFASKITGM 510
           P   G P +  D         RQALGE+LY +V A       A KITGM
Sbjct: 484 PPQGGFPRNANDNNQFYQQKQRQALGEQLYKKVSAKTSNEEAAGKITGM 532


>NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans). nitrogen
           assimilation transcription factor nira. 4/1993
           Length = 892
           
 Score = 32.9 bits (73), Expect = 2.9
 Identities = 22/95 (23%), Positives = 35/95 (36%)

Query: 219 LAEEADSSKPGPSAHDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLG 278
           +A +  S+  GP +      ++ S  A++   E+  P  T  RP  +  G V S      
Sbjct: 702 VASQYSSTPSGPVSVSAMRAVQRSFSAQLAHNEARQPEPTYLRPVSTSYGPVPSTQSAQE 761

Query: 279 RWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKE 313
           +W    E   R F         S  + L  F+  E
Sbjct: 762 QWYSPTEAQFRAFTAAHSMPTTSAQSPLTTFDTPE 796


>RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-.-) (rnase r)
           (vacb protein homolog). 5/2000
           Length = 705
           
 Score = 32.5 bits (72), Expect = 3.7
 Identities = 17/92 (18%), Positives = 25/92 (26%), Gaps = 13/92 (14%)

Query: 686 SAMDLAFAVDLCKEEGGGQ---VELIPNGVNIPVTPQNVYEYVRKY-AEHRMLVVAEQPL 741
               L F +D  K         +EL P G            YV      + +    E   
Sbjct: 243 LREQLCFTIDPEKAGDFDDAVAIELTPEGY--------YKLYVHIADVSYYVREGTETDK 294

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG 773
            A ++G     P  +L  L  E     +    
Sbjct: 295 EAYKRGFTYYFPDRALHML-PEKLSAKLCSLR 325


Searching.................................................done


Results from round 4


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value
Sequences used in model and found again:

100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec...  1225  0.0
HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyper...   696  0.0
PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast)....   341  3e-93
NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6...   340  9e-93
NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6...   339  1e-92
RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ...   331  4e-90
UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein li...   316  9e-86
UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein li...   307  8e-83
HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). ...   290  7e-78
TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor int...   284  4e-76
URB1_RAT P51593 rattus norvegicus (rat). dna binding protein...   280  1e-74
Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein...   275  3e-73
UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ...   259  1e-68
HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). ...   258  4e-68
PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-bindin...    87  2e-16
PABP_DROME P21187 drosophila melanogaster (fruit fly). polya...    86  3e-16
PABP_XENLA P20965 xenopus laevis (african clawed frog). poly...    85  4e-16
PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-bindin...    85  4e-16
PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast)....    78  7e-14
PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress). po...    66  3e-10

Sequences not found previously or not previously below threshold:

PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress). po...    51  9e-06
PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-bin...    45  5e-04
RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-....    33  2.9
NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans)...    33  2.9

>100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec 6.3.2.-).
           7/1999
           Length = 889
           
 Score = 1225 bits (3136), Expect = 0.0
 Identities = 765/889 (86%), Positives = 765/889 (86%)

Query: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60
           MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT
Sbjct: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60

Query: 61  PQXXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120
           PQ            GI            TSQSATLNDKDDESLPAETGQNHPFFRRSDSM
Sbjct: 61  PQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120

Query: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180
           TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT
Sbjct: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180

Query: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240
           MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK
Sbjct: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240

Query: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300
           SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG
Sbjct: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300

Query: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360
           SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT
Sbjct: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360

Query: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQX 420
           TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQ 
Sbjct: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQR 420

Query: 421 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGNPSDDPDP 480
                                                QLSIDTRPFRPASEGNPSDDPDP
Sbjct: 421 LRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDP 480

Query: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
           LPAHRQALGERLYPRVQAMQPAFASKITGM                   RARVEEAMELI
Sbjct: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVEEAMELI 540

Query: 541 VAHGRENGAXXXXXXXXXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGK 600
           VAHGRENGA            EKVQENRKRHGSSRSVV            NAPLFYQPGK
Sbjct: 541 VAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGK 600

Query: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660
           RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF
Sbjct: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660

Query: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720
           FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN
Sbjct: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720

Query: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780
           VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML
Sbjct: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780

Query: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840
           ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP
Sbjct: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840

Query: 841 SITIRPPDDQHLPTANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
           SITIRPPDDQHLPTANTCISRLYVP                   NFGFV
Sbjct: 841 SITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 889


>HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyperplastic discs
            protein (hyd protein) (ec 6.3.2.-). 12/1998
            Length = 2895
            
 Score =  696 bits (1776), Expect = 0.0
 Identities = 281/635 (44%), Positives = 374/635 (58%), Gaps = 34/635 (5%)

Query: 263  QCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEK 322
            Q +F G+   + +L  +  L+L+LFGR FM+DVG E GS+L EL GF VKE +FRR MEK
Sbjct: 2287 QSNFSGIAPCNFLLSAK--LTLDLFGRPFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEK 2344

Query: 323  LRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEG 379
            LRN Q RDL L +++R+R+ LI QT ++LN  FG   R    P+  +RVKVTFKDEPGEG
Sbjct: 2345 LRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEG 2404

Query: 380  SGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQXXXXXXXXXXXXXXXXXXXX 439
            SGVARSFYT+IA+A L++ K+PNL+ +Q      H+  +                     
Sbjct: 2405 SGVARSFYTSIAEALLASAKIPNLESVQVGTN--HSKYVVPFSSILRTTVSGSSRDQSTL 2462

Query: 440  XXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGN---PSDDPDPLPAHRQALGERLYPRV 496
                               L++D RP+ P +  +   P    D L  H Q +GERLYP++
Sbjct: 2463 QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKI 2522

Query: 497  QAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELIVAHGRENGAXXXXXXX 556
             ++    A KITGM                   R +V EA+E+I    +   +       
Sbjct: 2523 HSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSA------ 2576

Query: 557  XXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGKRGFYTPRPGKNTEARL 616
                    Q ++ +   S  VV            N PLFY PGKRGFY PR G  +  R+
Sbjct: 2577 --------QSSQPKKSPSVVVVDPVDDD------NEPLFYSPGKRGFYIPRQGFASFERI 2622

Query: 617  NCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILAS 676
            N FRNIGR++GLCLLQNEL P+ L RHV+K +L RK+ +HD AFFDP +YES RQ+I  +
Sbjct: 2623 NAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILRRKIKFHDLAFFDPALYESFRQIIQNA 2682

Query: 677  QSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM-LV 735
            Q+ + +   + M+L F +DL KEEG G  ELIP G ++ V+ + +Y       ++   + 
Sbjct: 2683 QTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDV-VSHRVIYSSTSDAIQNIDXIK 2741

Query: 736  VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 795
              E+ L A++ G+ DVLP NS+ +LTAED RLL+NG G++NV  LIS+T+FNDES E  +
Sbjct: 2742 SQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPD 2801

Query: 796  KLL-QFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPT 854
            K L +FK+WFWSIVE+M++ ERQ LVYFWT SP+LPASEEGFQP+PS+TIRP DD HLPT
Sbjct: 2802 K-LXKFKKWFWSIVEKMNIMERQHLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPT 2860

Query: 855  ANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
            ANTCISRLY+P                   NFGFV
Sbjct: 2861 ANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2895


 Score =  254 bits (643), Expect = 4e-67
 Identities = 69/209 (33%), Positives = 107/209 (51%), Gaps = 26/209 (12%)

Query: 3    SARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQ 62
            ++R DF  Y LSLMRSH  EH D LPVLD+ +L+H+AYV  A +Y+++  N     D   
Sbjct: 1913 NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDSGFYDKQD 1970

Query: 63   XXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDE------SLPA--ETGQNHPFF 114
                         I              + A L + + +      S+P+  +  + H FF
Sbjct: 1971 SISGR--------INNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFF 2022

Query: 115  RRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGK 174
             RS+S   LGC  P  FE+PL  A+PLAD+PHLLQPN+++++LF      + +++  SG 
Sbjct: 2023 ARSESTLTLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG- 2081

Query: 175  CLVEVTMD---RNCLEVLPTKMSYAANLK 200
                 T D    +  +  PT++ ++ +LK
Sbjct: 2082 ----ATNDGDGASIFDYTPTRLGFSNSLK 2106


>PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast).
           ubiquitin--protein ligase pub1 (ec 6.3.2.-). 12/1998
           Length = 767
           
 Score =  341 bits (866), Expect = 3e-93
 Identities = 69/265 (26%), Positives = 115/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +               K++L +KV   D    D   
Sbjct: 491 PHSGINPE-HLNYFKFIGRVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEY 549

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++    +   D  FS  D  F   +        ++L PNG NI VT +N  EYV
Sbjct: 550 YRSLVWILDNDITGVLDLTFSVEDNCFGEVVT-------IDLKPNGRNIEVTEENKREYV 602

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
                 R+    E+  +A  +G  +++P+  +      +  LL+ G  E++++     T 
Sbjct: 603 DLVTVWRIQKRIEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTD 662

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +   S  +     Q  +WFW +++  S  ++  L+ F T +  +P +     +G      
Sbjct: 663 YRSYSEND-----QIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRK 717

Query: 842 ITIRPP-DDQHLPTANTCISRLYVP 865
            TI    +   LP A+TC +RL +P
Sbjct: 718 FTIEKAGEPNKLPKAHTCFNRLDLP 742


>NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6.3.2.-) (kiaa0093)
           (fragment). 7/1999
           Length = 927
           
 Score =  340 bits (862), Expect = 9e-93
 Identities = 71/268 (26%), Positives = 119/268 (43%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 649 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 708

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 709 YNSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 757

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 758 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 817

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQP 838
            T + +    N     Q  +WFW  V  M   +R  L+ F T +  +P +      G   
Sbjct: 818 HTKYKNGYSANH----QVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 873

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+      + LP A+TC +RL +P
Sbjct: 874 PQSFTVEQWGTPEKLPRAHTCFNRLDLP 901


>NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6.3.2.-)
           (fragment). 11/1997
           Length = 957
           
 Score =  339 bits (861), Expect = 1e-92
 Identities = 71/268 (26%), Positives = 117/268 (43%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 679 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEY 738

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 739 YSSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKTGGSEIVVTNKNKK 787

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 788 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 847

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQP 838
            T + +    N     Q   WFW  V  M   +R  L+ F T +  +P +      G   
Sbjct: 848 HTKYKNGYSMNH----QVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 903

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+        LP A+TC +RL +P
Sbjct: 904 PQSFTVEQWGTPDKLPRAHTCFNRLDLP 931


>RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ubiquitin--protein
           ligase rsp5 (ec 6.3.2.-). 7/1999
           Length = 809
           
 Score =  331 bits (839), Expect = 4e-90
 Identities = 69/265 (26%), Positives = 116/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +             + K++L +KV   D    D  +
Sbjct: 533 PNSGINPE-HLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEV 591

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++  S     D  FSA D  F   +        V+L P+G NI VT  N  EYV
Sbjct: 592 YNSLNWMLENSIDGVLDLTFSADDERFGEVVT-------VDLKPDGRNIEVTDGNKKEYV 644

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
             Y + R++   ++   A   G  +++P++ +      +  LL+ G  E++++     T 
Sbjct: 645 ELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTD 704

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +      +     +  +WFW  V      +R  L+ F T +  +P +     +G      
Sbjct: 705 YRGYQESD-----EVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRR 759

Query: 842 ITIRPPDD-QHLPTANTCISRLYVP 865
            TI    + Q LP ++TC +R+ +P
Sbjct: 760 FTIEKAGEVQQLPKSHTCFNRVDLP 784


>UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap)
           (human papillomavirus e6-associated protein). 5/2000
           Length = 875
           
 Score =  316 bits (802), Expect = 9e-86
 Identities = 67/249 (26%), Positives = 116/249 (45%), Gaps = 12/249 (4%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG +LGL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    +
Sbjct: 612 FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGN 671

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 672 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 726

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   + 
Sbjct: 727 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRDS 784

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +L   R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 785 VL--IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 841

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 842 TCFNVLLLP 850


>UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap).
           5/2000
           Length = 885
           
 Score =  307 bits (777), Expect = 8e-83
 Identities = 67/249 (26%), Positives = 114/249 (44%), Gaps = 13/249 (5%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG + GL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    S
Sbjct: 623 FTLIGIL-GLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGS 681

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 682 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVISYSDYILNKSV 736

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   E 
Sbjct: 737 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRES 794

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +    R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 795 V--VIREFWEIVHSFTDEQKRLFLLFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 851

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 852 TCFNVLLLP 860


>HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul4 (ec 6.3.2.-). 5/2000
           Length = 892
           
 Score =  290 bits (735), Expect = 7e-78
 Identities = 58/271 (21%), Positives = 116/271 (42%), Gaps = 16/271 (5%)

Query: 604 YTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDP 663
           +    GKN++  L  +   G ++GL +  + +  +   + + K L    +++ D++   P
Sbjct: 602 FDKSKGKNSQLEL--YYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFP 659

Query: 664 VMYESLRQLILASQSSDADAVFSAMDLAFAV------DLCKEEGGGQVELIPNGVNIPVT 717
               +L +++  ++ +  D      +  +        D    +    VEL  NG N+P+T
Sbjct: 660 ETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPIT 719

Query: 718 PQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPK-NSLEDLTAEDFRLLVNGCGE-- 774
             N +E+V K+ E  +    E   +    G   V  + NS++   +E+   LV G  E  
Sbjct: 720 QSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQT 779

Query: 775 -VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE 833
             + + L S T +     +++  +     WFW I+E      ++ L+ F T+S  +PA+ 
Sbjct: 780 KFDFKSLRSVTKYVGGFSDDSRAVC----WFWEIIESWDYPLQKKLLQFVTASDRIPATG 835

Query: 834 EGFQPMPSITIRPPDDQHLPTANTCISRLYV 864
               P     +   D   LP A+TC + + +
Sbjct: 836 ISTIPFKISLLGSHDSDDLPLAHTCFNEICL 866


>TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor interacting protein 12
            (trip12) (kiaa0045). 12/1998
            Length = 1992
            
 Score =  284 bits (720), Expect = 4e-76
 Identities = 58/286 (20%), Positives = 109/286 (37%), Gaps = 28/286 (9%)

Query: 605  TPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW--HDFAFFD 662
            T +P    + ++  FR +G+++   ++   L  + L     K +L ++ +   HD    D
Sbjct: 1684 TAKPAHIAKVKMK-FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDID 1742

Query: 663  PVMYES---LRQLILASQSSDADAVFSAMDLAFAVDL-----CKEE---------GGGQV 705
            PV+  S   L  ++   +  + D   +   L +A++      C  E         G   +
Sbjct: 1743 PVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNI 1802

Query: 706  ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDF 765
            EL   G +IPVT  N+ EY+R      +     +   + R G   V P + L+    E+ 
Sbjct: 1803 ELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEEL 1862

Query: 766  RLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTS 825
              L+ G                 + G   +   +  ++ + I+      +++  + F T 
Sbjct: 1863 DQLLCGSKADTWDAKTLMECCRPDHGYTHDS--RAVKFLFEILSSFDNEQQRLFLQFVTG 1920

Query: 826  SPSLPASEEGFQPMPSITIRP------PDDQHLPTANTCISRLYVP 865
            SP LP         P   +R         D  LP+  TC++ L +P
Sbjct: 1921 SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLP 1966


>URB1_RAT P51593 rattus norvegicus (rat). dna binding protein ure-b1 (ec
           6.3.2.-). 10/1996
           Length = 310
           
 Score =  280 bits (708), Expect = 1e-74
 Identities = 65/250 (26%), Positives = 109/250 (43%), Gaps = 19/250 (7%)

Query: 623 GRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDAD 682
           GR +   ++   L      R   K +LG+ V + D    D   Y+ L  L+        D
Sbjct: 45  GRYVAKAVMTTALLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN------D 98

Query: 683 AVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPL 741
                 DL F+ ++ +E G  +V +L PNG NI VT +N  EYV    + RM     + L
Sbjct: 99  VSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQL 157

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFK 801
            A  +G  +++PK  +   T ++  LL  G   +++  L S T ++     + +      
Sbjct: 158 AAFLEGFYEIIPKRLISIFTEQELELLYTGLPTIDIDDLKSNTEYHKYQSNSIQ-----I 212

Query: 802 RWFWSIVERMSMTERQDLVYFWTSSPSLP----ASEEGFQPMPSITIRPPD--DQHLPTA 855
           +WFW  +      +R   + F T +  +P    A+ EG   +    I   D     LP+A
Sbjct: 213 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 272

Query: 856 NTCISRLYVP 865
           +TC ++L +P
Sbjct: 273 HTCFNQLDLP 282


>Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein kiaa0032. 5/2000
            Length = 1050
            
 Score =  275 bits (696), Expect = 3e-73
 Identities = 58/256 (22%), Positives = 96/256 (36%), Gaps = 15/256 (5%)

Query: 613  EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL 672
                N F  IG   GL +  + +  +     + K LL  K    D     P    SL++L
Sbjct: 782  FVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL 841

Query: 673  ILASQSSDADAVFSAMDLAFAVDLCKEEGGG--QVELIPNGVNIPVTPQNVYEYVRKYAE 730
            +      D +  F    L F +  C+E  G   Q +LIP G N+ V   N  E+V  Y  
Sbjct: 842  LDY-PGEDVEETFC---LNFTI--CRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVN 895

Query: 731  HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 790
            +   +   +   A   G L V     LE     + R ++ G    N + L     +  + 
Sbjct: 896  YVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDY 955

Query: 791  GENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPS-ITIRPPDD 849
                  +    + FW       + +++  + F T S  +P    G   +   I      +
Sbjct: 956  SATHPTV----KLFWETFHEFPLEKKKKFLLFLTGSDRIPI--YGMASLQIVIQSTASGE 1009

Query: 850  QHLPTANTCISRLYVP 865
            ++LP A+TC + L +P
Sbjct: 1010 EYLPVAHTCYNLLDLP 1025


>UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ubiquitin fusion
            degradation protein 4 (ub fusion protein 4). 11/1997
            Length = 1483
            
 Score =  259 bits (656), Expect = 1e-68
 Identities = 60/277 (21%), Positives = 109/277 (38%), Gaps = 29/277 (10%)

Query: 607  RPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG------------RKVN 654
             P  N E  +  F  +G  +   LL N +     ++   ++L               +  
Sbjct: 1192 NPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETC 1251

Query: 655  WHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNI 714
                   DP++ +SL+ ++      D +    ++ L F V      G   +ELIP G N 
Sbjct: 1252 LLMIELVDPLLAKSLKYIVAN---KDDNMTLESLSLTFTVP-----GNDDIELIPGGCNK 1303

Query: 715  PVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE 774
             +   NV EY+    +  +    E+ L A  +G   V     +  L  ++  + + G  E
Sbjct: 1304 SLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDEL-VDIFGRVE 1362

Query: 775  VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE- 833
             +  M   +T+ N E G   +  +     F SI+      ER+  + F T SP LP    
Sbjct: 1363 EDWSMATLYTNLNAEHGYTMDSSI--IHDFISIISAFGKHERRLFLQFLTGSPKLPIGGF 1420

Query: 834  EGFQPMPSITIRPPD-----DQHLPTANTCISRLYVP 865
            +   P  ++ ++  +     D++LP+  TC + L +P
Sbjct: 1421 KSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLP 1457


>HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul5 (ec 6.3.2.-). 5/2000
           Length = 910
           
 Score =  258 bits (652), Expect = 4e-68
 Identities = 68/259 (26%), Positives = 125/259 (48%), Gaps = 21/259 (8%)

Query: 615 RLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLL----GRKVNWHDFAFFDPVMYESLR 670
           +L     +G+++G CL ++ L  ++     +K LL    G   ++ D   +D V+Y +L 
Sbjct: 640 KLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLI 699

Query: 671 QLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 730
           +L+    ++D      ++DL F +D   E     V+LIPNG    VT  NV  YV K  +
Sbjct: 700 KLLN--MTTDE---IKSLDLTFEIDE-PESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTD 753

Query: 731 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG-EVNVQMLISFTSFNDE 789
           +++     +P+ A   GL  ++  + +E   + + ++L++G    +++  L S T +   
Sbjct: 754 YKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGY 813

Query: 790 SGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIRPPD 848
             E+     Q    FW ++      E+ + + F TS P  P   +GF+ + P   IR   
Sbjct: 814 KEED-----QTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAP--LQGFKALDPKFGIRNAG 866

Query: 849 DQ--HLPTANTCISRLYVP 865
            +   LPTA+TC++ L +P
Sbjct: 867 TEKYRLPTASTCVNLLKLP 885


>PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 86.6 bits (211), Expect = 2e-16
 Identities = 25/71 (35%), Positives = 35/71 (49%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
            P    +Q LGERL+P +QAM P  A KITGM                   R++V+EA+ 
Sbjct: 553 APPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVA 612

Query: 539 LIVAHGRENGA 549
           ++ AH  +  A
Sbjct: 613 VLQAHQAKEAA 623


>PABP_DROME P21187 drosophila melanogaster (fruit fly). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 2/1995
           Length = 632
           
 Score = 85.9 bits (209), Expect = 3e-16
 Identities = 22/72 (30%), Positives = 30/72 (41%)

Query: 478 PDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAM 537
                  +Q LGERLYP ++ M    A KITGM                   +A+VEEA+
Sbjct: 560 NAKPQEQKQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAV 619

Query: 538 ELIVAHGRENGA 549
            ++  H     A
Sbjct: 620 AVLQVHRVTEPA 631


>PABP_XENLA P20965 xenopus laevis (african clawed frog). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 7/1998
           Length = 633
           
 Score = 85.5 bits (208), Expect = 4e-16
 Identities = 25/71 (35%), Positives = 34/71 (47%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
            P    +Q LGERL+P +QAM P  A KITGM                   R +V+EA+ 
Sbjct: 551 APPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRLKVDEAVA 610

Query: 539 LIVAHGRENGA 549
           ++ AH  +  A
Sbjct: 611 VLQAHQAKEAA 621


>PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 85.5 bits (208), Expect = 4e-16
 Identities = 25/71 (35%), Positives = 36/71 (50%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
            P    +Q LGERL+P +QAM P+ A KITGM                   R++V+EA+ 
Sbjct: 553 APPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVA 612

Query: 539 LIVAHGRENGA 549
           ++ AH  +  A
Sbjct: 613 VLQAHQAKEAA 623


>PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast).
           polyadenylate-binding protein (poly(a) binding protein)
           (pabp). 7/1998
           Length = 653
           
 Score = 78.1 bits (189), Expect = 7e-14
 Identities = 22/80 (27%), Positives = 30/80 (37%), Gaps = 6/80 (7%)

Query: 468 PASEGNPSDDPD------PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXX 521
           PA  G P           P  + +Q LGE LYP+V   +   + KITGM           
Sbjct: 563 PAVPGMPERFTAADLAAVPEESRKQVLGELLYPKVFVREEKLSGKITGMLLEMPNSELLE 622

Query: 522 XXXXXXXXRARVEEAMELIV 541
                     RV EA+ ++ 
Sbjct: 623 LLEDDSALNERVNEAIGVLQ 642


>PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 2 (poly(a) binding protein
           2) (pabp 2). 12/1998
           Length = 629
           
 Score = 66.0 bits (158), Expect = 3e-10
 Identities = 18/63 (28%), Positives = 28/63 (43%)

Query: 478 PDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAM 537
                  R  LGE LYP V+ ++   A+K+TGM                   +A+V EAM
Sbjct: 549 NATPEQQRTMLGEVLYPLVEQVEAESAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAM 608

Query: 538 ELI 540
           +++
Sbjct: 609 DVL 611


>PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 5 (poly(a) binding protein
           5) (pabp 5). 11/1995
           Length = 668
           
 Score = 51.2 bits (120), Expect = 9e-06
 Identities = 17/62 (27%), Positives = 29/62 (46%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
                H + LG+ LYP V+  +PA  +K+TGM                   +A+V EA++
Sbjct: 585 ASPDKHPRMLGDHLYPLVEQQEPANPAKVTGMLLEMDQAEILHLLESPEALKAKVSEALD 644

Query: 539 LI 540
           ++
Sbjct: 645 VL 646


>PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-binding protein,
           cytoplasmic and nuclear (pabp) (ars consensus binding
           protein acbp-67) (polyadenylate tail-binding protein).
           2/1996
           Length = 576
           
 Score = 45.3 bits (105), Expect = 5e-04
 Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 6/49 (12%)

Query: 468 PASEGNPSDDPDP----LPAHRQALGERLYPRVQAM--QPAFASKITGM 510
           P   G P +  D         RQALGE+LY +V A       A KITGM
Sbjct: 484 PPQGGFPRNANDNNQFYQQKQRQALGEQLYKKVSAKTSNEEAAGKITGM 532


>RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-.-) (rnase r)
           (vacb protein homolog). 5/2000
           Length = 705
           
 Score = 32.9 bits (73), Expect = 2.9
 Identities = 17/92 (18%), Positives = 25/92 (26%), Gaps = 13/92 (14%)

Query: 686 SAMDLAFAVDLCKEEGGGQ---VELIPNGVNIPVTPQNVYEYVRKY-AEHRMLVVAEQPL 741
               L F +D  K         +EL P G            YV      + +    E   
Sbjct: 243 LREQLCFTIDPEKAGDFDDAVAIELTPEGY--------YKLYVHIADVSYYVREGTETDK 294

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG 773
            A ++G     P  +L  L  E     +    
Sbjct: 295 EAYKRGFTYYFPDRALHML-PEKLSAKLCSLR 325


>NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans). nitrogen
           assimilation transcription factor nira. 4/1993
           Length = 892
           
 Score = 32.9 bits (73), Expect = 2.9
 Identities = 22/95 (23%), Positives = 35/95 (36%)

Query: 219 LAEEADSSKPGPSAHDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLG 278
           +A +  S+  GP +      ++ S  A++   E+  P  T  RP  +  G V S      
Sbjct: 702 VASQYSSTPSGPVSVSAMRAVQRSFSAQLAHNEARQPEPTYLRPVSTSYGPVPSTQSAQE 761

Query: 279 RWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKE 313
           +W    E   R F         S  + L  F+  E
Sbjct: 762 QWYSPTEAQFRAFTAAHSMPTTSAQSPLTTFDTPE 796


Searching.................................................done


Results from round 5


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value
Sequences used in model and found again:

100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec...  1214  0.0
HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyper...   689  0.0
PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast)....   342  2e-93
NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6...   341  4e-93
NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6...   340  5e-93
RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ...   331  3e-90
UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein li...   316  9e-86
UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein li...   307  8e-83
HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). ...   290  7e-78
TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor int...   284  4e-76
URB1_RAT P51593 rattus norvegicus (rat). dna binding protein...   280  8e-75
Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein...   275  2e-73
UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ...   260  9e-69
HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). ...   258  5e-68
PABP_DROME P21187 drosophila melanogaster (fruit fly). polya...    81  1e-14
PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-bindin...    80  2e-14
PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-bindin...    79  3e-14
PABP_XENLA P20965 xenopus laevis (african clawed frog). poly...    78  5e-14
PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast)....    70  2e-11
PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress). po...    65  7e-10
PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress). po...    64  9e-10
PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-bin...    58  9e-08

Sequences not found previously or not previously below threshold:

RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-....    33  2.2
NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans)...    33  2.9


CONVERGED!
>100K_RAT Q62671 rattus norvegicus (rat). 100 kda protein (ec 6.3.2.-).
           7/1999
           Length = 889
           
 Score = 1214 bits (3106), Expect = 0.0
 Identities = 765/889 (86%), Positives = 765/889 (86%)

Query: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60
           MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT
Sbjct: 1   MMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDT 60

Query: 61  PQXXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120
           PQ            GI            TSQSATLNDKDDESLPAETGQNHPFFRRSDSM
Sbjct: 61  PQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDESLPAETGQNHPFFRRSDSM 120

Query: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180
           TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT
Sbjct: 121 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVT 180

Query: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240
           MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK
Sbjct: 181 MDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLK 240

Query: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300
           SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG
Sbjct: 241 SSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPG 300

Query: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360
           SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT
Sbjct: 301 SILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT 360

Query: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQX 420
           TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQ 
Sbjct: 361 TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQR 420

Query: 421 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGNPSDDPDP 480
                                                QLSIDTRPFRPASEGNPSDDPDP
Sbjct: 421 LRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDP 480

Query: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELI 540
           LPAHRQALGERLYPRVQAMQPAFASKITGM                   RARVEEAMELI
Sbjct: 481 LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVEEAMELI 540

Query: 541 VAHGRENGAXXXXXXXXXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGK 600
           VAHGRENGA            EKVQENRKRHGSSRSVV            NAPLFYQPGK
Sbjct: 541 VAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGK 600

Query: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660
           RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF
Sbjct: 601 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 660

Query: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720
           FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN
Sbjct: 661 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQN 720

Query: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780
           VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML
Sbjct: 721 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 780

Query: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840
           ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP
Sbjct: 781 ISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMP 840

Query: 841 SITIRPPDDQHLPTANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
           SITIRPPDDQHLPTANTCISRLYVP                   NFGFV
Sbjct: 841 SITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 889


>HYDP_DROME P51592 drosophila melanogaster (fruit fly). hyperplastic discs
            protein (hyd protein) (ec 6.3.2.-). 12/1998
            Length = 2895
            
 Score =  689 bits (1758), Expect = 0.0
 Identities = 281/635 (44%), Positives = 374/635 (58%), Gaps = 34/635 (5%)

Query: 263  QCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEK 322
            Q +F G+   + +L  +  L+L+LFGR FM+DVG E GS+L EL GF VKE +FRR MEK
Sbjct: 2287 QSNFSGIAPCNFLLSAK--LTLDLFGRPFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEK 2344

Query: 323  LRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEG 379
            LRN Q RDL L +++R+R+ LI QT ++LN  FG   R    P+  +RVKVTFKDEPGEG
Sbjct: 2345 LRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEG 2404

Query: 380  SGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQXXXXXXXXXXXXXXXXXXXX 439
            SGVARSFYT+IA+A L++ K+PNL+ +Q      H+  +                     
Sbjct: 2405 SGVARSFYTSIAEALLASAKIPNLESVQVGTN--HSKYVVPFSSILRTTVSGSSRDQSTL 2462

Query: 440  XXXXXXXXXXXXXXXXXXQLSIDTRPFRPASEGN---PSDDPDPLPAHRQALGERLYPRV 496
                               L++D RP+ P +  +   P    D L  H Q +GERLYP++
Sbjct: 2463 QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKI 2522

Query: 497  QAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAMELIVAHGRENGAXXXXXXX 556
             ++    A KITGM                   R +V EA+E+I    +   +       
Sbjct: 2523 HSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSA------ 2576

Query: 557  XXXXXEKVQENRKRHGSSRSVVXXXXXXXXXXXXNAPLFYQPGKRGFYTPRPGKNTEARL 616
                    Q ++ +   S  VV            N PLFY PGKRGFY PR G  +  R+
Sbjct: 2577 --------QSSQPKKSPSVVVVDPVDDD------NEPLFYSPGKRGFYIPRQGFASFERI 2622

Query: 617  NCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILAS 676
            N FRNIGR++GLCLLQNEL P+ L RHV+K +L RK+ +HD AFFDP +YES RQ+I  +
Sbjct: 2623 NAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILRRKIKFHDLAFFDPALYESFRQIIQNA 2682

Query: 677  QSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM-LV 735
            Q+ + +   + M+L F +DL KEEG G  ELIP G ++ V+ + +Y       ++   + 
Sbjct: 2683 QTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDV-VSHRVIYSSTSDAIQNIDXIK 2741

Query: 736  VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 795
              E+ L A++ G+ DVLP NS+ +LTAED RLL+NG G++NV  LIS+T+FNDES E  +
Sbjct: 2742 SQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPD 2801

Query: 796  KLL-QFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPT 854
            K L +FK+WFWSIVE+M++ ERQ LVYFWT SP+LPASEEGFQP+PS+TIRP DD HLPT
Sbjct: 2802 K-LXKFKKWFWSIVEKMNIMERQHLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPT 2860

Query: 855  ANTCISRLYVPXXXXXXXXXXXXXXXXXXXNFGFV 889
            ANTCISRLY+P                   NFGFV
Sbjct: 2861 ANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2895


 Score =  255 bits (644), Expect = 3e-67
 Identities = 69/209 (33%), Positives = 107/209 (51%), Gaps = 26/209 (12%)

Query: 3    SARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQ 62
            ++R DF  Y LSLMRSH  EH D LPVLD+ +L+H+AYV  A +Y+++  N     D   
Sbjct: 1913 NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDSGFYDKQD 1970

Query: 63   XXXXXXXXXXXXGIXXXXXXXXXXXXTSQSATLNDKDDE------SLPA--ETGQNHPFF 114
                         I              + A L + + +      S+P+  +  + H FF
Sbjct: 1971 SISGR--------INNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFF 2022

Query: 115  RRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGK 174
             RS+S   LGC  P  FE+PL  A+PLAD+PHLLQPN+++++LF      + +++  SG 
Sbjct: 2023 ARSESTLTLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG- 2081

Query: 175  CLVEVTMD---RNCLEVLPTKMSYAANLK 200
                 T D    +  +  PT++ ++ +LK
Sbjct: 2082 ----ATNDGDGASIFDYTPTRLGFSNSLK 2106


>PUB1_SCHPO Q92462 schizosaccharomyces pombe (fission yeast).
           ubiquitin--protein ligase pub1 (ec 6.3.2.-). 12/1998
           Length = 767
           
 Score =  342 bits (867), Expect = 2e-93
 Identities = 69/265 (26%), Positives = 115/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +               K++L +KV   D    D   
Sbjct: 491 PHSGINPE-HLNYFKFIGRVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEY 549

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++    +   D  FS  D  F   +        ++L PNG NI VT +N  EYV
Sbjct: 550 YRSLVWILDNDITGVLDLTFSVEDNCFGEVVT-------IDLKPNGRNIEVTEENKREYV 602

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
                 R+    E+  +A  +G  +++P+  +      +  LL+ G  E++++     T 
Sbjct: 603 DLVTVWRIQKRIEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTD 662

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +   S  +     Q  +WFW +++  S  ++  L+ F T +  +P +     +G      
Sbjct: 663 YRSYSEND-----QIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRK 717

Query: 842 ITIRPP-DDQHLPTANTCISRLYVP 865
            TI    +   LP A+TC +RL +P
Sbjct: 718 FTIEKAGEPNKLPKAHTCFNRLDLP 742


>NED4_HUMAN P46934 homo sapiens (human). nedd-4 protein (ec 6.3.2.-) (kiaa0093)
           (fragment). 7/1999
           Length = 927
           
 Score =  341 bits (865), Expect = 4e-93
 Identities = 71/268 (26%), Positives = 119/268 (43%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 649 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 708

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 709 YNSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 757

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 758 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 817

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQP 838
            T + +    N     Q  +WFW  V  M   +R  L+ F T +  +P +      G   
Sbjct: 818 HTKYKNGYSANH----QVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 873

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+      + LP A+TC +RL +P
Sbjct: 874 PQSFTVEQWGTPEKLPRAHTCFNRLDLP 901


>NED4_MOUSE P46935 mus musculus (mouse). nedd-4 protein (ec 6.3.2.-)
           (fragment). 11/1997
           Length = 957
           
 Score =  340 bits (864), Expect = 5e-93
 Identities = 71/268 (26%), Positives = 117/268 (43%), Gaps = 23/268 (8%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 679 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEY 738

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 722
           Y SLR ++    +         +DL F +D   EE  GQ    EL   G  I VT +N  
Sbjct: 739 YSSLRWILENDPTE--------LDLRFIID---EELFGQTHQHELKTGGSEIVVTNKNKK 787

Query: 723 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 782
           EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 788 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 847

Query: 783 FTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQP 838
            T + +    N     Q   WFW  V  M   +R  L+ F T +  +P +      G   
Sbjct: 848 HTKYKNGYSMNH----QVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 903

Query: 839 MPSITIRP-PDDQHLPTANTCISRLYVP 865
             S T+        LP A+TC +RL +P
Sbjct: 904 PQSFTVEQWGTPDKLPRAHTCFNRLDLP 931


>RSP5_YEAST P39940 saccharomyces cerevisiae (baker's yeast). ubiquitin--protein
           ligase rsp5 (ec 6.3.2.-). 7/1999
           Length = 809
           
 Score =  331 bits (840), Expect = 3e-90
 Identities = 69/265 (26%), Positives = 116/265 (43%), Gaps = 18/265 (6%)

Query: 606 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 665
           P  G N E  LN F+ IGR++GL +             + K++L +KV   D    D  +
Sbjct: 533 PNSGINPE-HLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEV 591

Query: 666 YESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYV 725
           Y SL  ++  S     D  FSA D  F   +        V+L P+G NI VT  N  EYV
Sbjct: 592 YNSLNWMLENSIDGVLDLTFSADDERFGEVVT-------VDLKPDGRNIEVTDGNKKEYV 644

Query: 726 RKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 785
             Y + R++   ++   A   G  +++P++ +      +  LL+ G  E++++     T 
Sbjct: 645 ELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTD 704

Query: 786 FNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPS 841
           +      +     +  +WFW  V      +R  L+ F T +  +P +     +G      
Sbjct: 705 YRGYQESD-----EVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRR 759

Query: 842 ITIRPPDD-QHLPTANTCISRLYVP 865
            TI    + Q LP ++TC +R+ +P
Sbjct: 760 FTIEKAGEVQQLPKSHTCFNRVDLP 784


>UE3A_HUMAN Q05086 homo sapiens (human). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap)
           (human papillomavirus e6-associated protein). 5/2000
           Length = 875
           
 Score =  316 bits (802), Expect = 9e-86
 Identities = 67/249 (26%), Positives = 116/249 (45%), Gaps = 12/249 (4%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG +LGL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    +
Sbjct: 612 FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGN 671

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 672 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 726

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   + 
Sbjct: 727 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRDS 784

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +L   R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 785 VL--IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 841

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 842 TCFNVLLLP 850


>UE3A_MOUSE O08759 mus musculus (mouse). ubiquitin-protein ligase e3a (ec
           6.3.2.-) (oncogenic protein- associated protein e6-ap).
           5/2000
           Length = 885
           
 Score =  307 bits (777), Expect = 8e-83
 Identities = 67/249 (26%), Positives = 114/249 (44%), Gaps = 13/249 (5%)

Query: 619 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 678
           F  IG + GL +  N +  +     V + L+G+K  + D     PV+Y+SL+ L+    S
Sbjct: 623 FTLIGIL-GLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGS 681

Query: 679 SDADAVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 737
            + D     M + F +      G   + +L  NG  IP+T +N  E+V  Y+++ +    
Sbjct: 682 VEDD-----MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVISYSDYILNKSV 736

Query: 738 EQPLHAMRKGLLDVLPKNSLED-LTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEK 796
           E+   A R+G   V  ++ L+     E+  LL+ G   ++ Q L   T +  + G   E 
Sbjct: 737 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY--DGGYTRES 794

Query: 797 LLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTAN 856
           +    R FW IV   +  +++  + F T +   P    G   M  I    PD + LPT++
Sbjct: 795 V--VIREFWEIVHSFTDEQKRLFLLFTTGTDRAPVGGLGKLKM-IIAKNGPDTERLPTSH 851

Query: 857 TCISRLYVP 865
           TC + L +P
Sbjct: 852 TCFNVLLLP 860


>HUL4_YEAST P40985 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul4 (ec 6.3.2.-). 5/2000
           Length = 892
           
 Score =  290 bits (735), Expect = 7e-78
 Identities = 58/271 (21%), Positives = 116/271 (42%), Gaps = 16/271 (5%)

Query: 604 YTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDP 663
           +    GKN++  L  +   G ++GL +  + +  +   + + K L    +++ D++   P
Sbjct: 602 FDKSKGKNSQLEL--YYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFP 659

Query: 664 VMYESLRQLILASQSSDADAVFSAMDLAFAV------DLCKEEGGGQVELIPNGVNIPVT 717
               +L +++  ++ +  D      +  +        D    +    VEL  NG N+P+T
Sbjct: 660 ETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPIT 719

Query: 718 PQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPK-NSLEDLTAEDFRLLVNGCGE-- 774
             N +E+V K+ E  +    E   +    G   V  + NS++   +E+   LV G  E  
Sbjct: 720 QSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQT 779

Query: 775 -VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE 833
             + + L S T +     +++  +     WFW I+E      ++ L+ F T+S  +PA+ 
Sbjct: 780 KFDFKSLRSVTKYVGGFSDDSRAVC----WFWEIIESWDYPLQKKLLQFVTASDRIPATG 835

Query: 834 EGFQPMPSITIRPPDDQHLPTANTCISRLYV 864
               P     +   D   LP A+TC + + +
Sbjct: 836 ISTIPFKISLLGSHDSDDLPLAHTCFNEICL 866


>TR12_HUMAN Q14669 homo sapiens (human). thyroid receptor interacting protein 12
            (trip12) (kiaa0045). 12/1998
            Length = 1992
            
 Score =  284 bits (720), Expect = 4e-76
 Identities = 58/286 (20%), Positives = 109/286 (37%), Gaps = 28/286 (9%)

Query: 605  TPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW--HDFAFFD 662
            T +P    + ++  FR +G+++   ++   L  + L     K +L ++ +   HD    D
Sbjct: 1684 TAKPAHIAKVKMK-FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDID 1742

Query: 663  PVMYES---LRQLILASQSSDADAVFSAMDLAFAVDL-----CKEE---------GGGQV 705
            PV+  S   L  ++   +  + D   +   L +A++      C  E         G   +
Sbjct: 1743 PVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNI 1802

Query: 706  ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDF 765
            EL   G +IPVT  N+ EY+R      +     +   + R G   V P + L+    E+ 
Sbjct: 1803 ELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEEL 1862

Query: 766  RLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTS 825
              L+ G                 + G   +   +  ++ + I+      +++  + F T 
Sbjct: 1863 DQLLCGSKADTWDAKTLMECCRPDHGYTHDS--RAVKFLFEILSSFDNEQQRLFLQFVTG 1920

Query: 826  SPSLPASEEGFQPMPSITIRP------PDDQHLPTANTCISRLYVP 865
            SP LP         P   +R         D  LP+  TC++ L +P
Sbjct: 1921 SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLP 1966


>URB1_RAT P51593 rattus norvegicus (rat). dna binding protein ure-b1 (ec
           6.3.2.-). 10/1996
           Length = 310
           
 Score =  280 bits (709), Expect = 8e-75
 Identities = 64/250 (25%), Positives = 107/250 (42%), Gaps = 19/250 (7%)

Query: 623 GRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDAD 682
           GR +   ++   L      R   K +LG+ V + D    D   Y+ L  L+        D
Sbjct: 45  GRYVAKAVMTTALLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN------D 98

Query: 683 AVFSAMDLAFAVDLCKEEGGGQV-ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPL 741
                 DL F+ ++ +E G  +V +L PNG NI VT +N  EYV    + RM     + L
Sbjct: 99  VSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQL 157

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFK 801
            A  +G  +++PK  +   T ++  LL  G   +++  L S T ++     + +      
Sbjct: 158 AAFLEGFYEIIPKRLISIFTEQELELLYTGLPTIDIDDLKSNTEYHKYQSNSIQ-----I 212

Query: 802 RWFWSIVERMSMTERQDLVYFWTSSPSLPASE----EGFQPMPSITIRPPD--DQHLPTA 855
           +WFW  +      +R   + F T +  +P       EG   +    I   D     LP+A
Sbjct: 213 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 272

Query: 856 NTCISRLYVP 865
           +TC ++L +P
Sbjct: 273 HTCFNQLDLP 282


>Y032_HUMAN Q15034 homo sapiens (human). hypothetical protein kiaa0032. 5/2000
            Length = 1050
            
 Score =  275 bits (697), Expect = 2e-73
 Identities = 58/256 (22%), Positives = 96/256 (36%), Gaps = 15/256 (5%)

Query: 613  EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL 672
                N F  IG   GL +  + +  +     + K LL  K    D     P    SL++L
Sbjct: 782  FVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL 841

Query: 673  ILASQSSDADAVFSAMDLAFAVDLCKEEGGG--QVELIPNGVNIPVTPQNVYEYVRKYAE 730
            +      D +  F    L F +  C+E  G   Q +LIP G N+ V   N  E+V  Y  
Sbjct: 842  LDY-PGEDVEETFC---LNFTI--CRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVN 895

Query: 731  HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 790
            +   +   +   A   G L V     LE     + R ++ G    N + L     +  + 
Sbjct: 896  YVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDY 955

Query: 791  GENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPS-ITIRPPDD 849
                  +    + FW       + +++  + F T S  +P    G   +   I      +
Sbjct: 956  SATHPTV----KLFWETFHEFPLEKKKKFLLFLTGSDRIPI--YGMASLQIVIQSTASGE 1009

Query: 850  QHLPTANTCISRLYVP 865
            ++LP A+TC + L +P
Sbjct: 1010 EYLPVAHTCYNLLDLP 1025


>UFD4_YEAST P33202 saccharomyces cerevisiae (baker's yeast). ubiquitin fusion
            degradation protein 4 (ub fusion protein 4). 11/1997
            Length = 1483
            
 Score =  260 bits (657), Expect = 9e-69
 Identities = 60/277 (21%), Positives = 109/277 (38%), Gaps = 29/277 (10%)

Query: 607  RPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG------------RKVN 654
             P  N E  +  F  +G  +   LL N +     ++   ++L               +  
Sbjct: 1192 NPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETC 1251

Query: 655  WHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNI 714
                   DP++ +SL+ ++      D +    ++ L F V      G   +ELIP G N 
Sbjct: 1252 LLMIELVDPLLAKSLKYIVAN---KDDNMTLESLSLTFTVP-----GNDDIELIPGGCNK 1303

Query: 715  PVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE 774
             +   NV EY+    +  +    E+ L A  +G   V     +  L  ++  + + G  E
Sbjct: 1304 SLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDEL-VDIFGRVE 1362

Query: 775  VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASE- 833
             +  M   +T+ N E G   +  +     F SI+      ER+  + F T SP LP    
Sbjct: 1363 EDWSMATLYTNLNAEHGYTMDSSI--IHDFISIISAFGKHERRLFLQFLTGSPKLPIGGF 1420

Query: 834  EGFQPMPSITIRPPD-----DQHLPTANTCISRLYVP 865
            +   P  ++ ++  +     D++LP+  TC + L +P
Sbjct: 1421 KSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLP 1457


>HUL5_YEAST P53119 saccharomyces cerevisiae (baker's yeast). probable
           ubiquitin--protein ligase hul5 (ec 6.3.2.-). 5/2000
           Length = 910
           
 Score =  258 bits (651), Expect = 5e-68
 Identities = 66/258 (25%), Positives = 120/258 (45%), Gaps = 19/258 (7%)

Query: 615 RLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLL----GRKVNWHDFAFFDPVMYESLR 670
           +L     +G+++G CL ++ L  ++     +K LL    G   ++ D   +D V+Y +L 
Sbjct: 640 KLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLI 699

Query: 671 QLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 730
           +L+    ++D      ++DL F +D   E     V+LIPNG    VT  NV  YV K  +
Sbjct: 700 KLLN--MTTDE---IKSLDLTFEIDE-PESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTD 753

Query: 731 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG-EVNVQMLISFTSFNDE 789
           +++     +P+ A   GL  ++  + +E   + + ++L++G    +++  L S T +   
Sbjct: 754 YKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGY 813

Query: 790 SGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDD 849
             E+     Q    FW ++      E+ + + F TS P  P         P   IR    
Sbjct: 814 KEED-----QTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALD-PKFGIRNAGT 867

Query: 850 Q--HLPTANTCISRLYVP 865
           +   LPTA+TC++ L +P
Sbjct: 868 EKYRLPTASTCVNLLKLP 885


>PABP_DROME P21187 drosophila melanogaster (fruit fly). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 2/1995
           Length = 632
           
 Score = 80.8 bits (196), Expect = 1e-14
 Identities = 22/73 (30%), Positives = 30/73 (40%)

Query: 477 DPDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEA 536
                   +Q LGERLYP ++ M    A KITGM                   +A+VEEA
Sbjct: 559 ANAKPQEQKQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEA 618

Query: 537 MELIVAHGRENGA 549
           + ++  H     A
Sbjct: 619 VAVLQVHRVTEPA 631


>PAB1_HUMAN P11940 homo sapiens (human). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 80.0 bits (194), Expect = 2e-14
 Identities = 25/73 (34%), Positives = 35/73 (47%)

Query: 477 DPDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEA 536
              P    +Q LGERL+P +QAM P  A KITGM                   R++V+EA
Sbjct: 551 ASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEA 610

Query: 537 MELIVAHGRENGA 549
           + ++ AH  +  A
Sbjct: 611 VAVLQAHQAKEAA 623


>PAB1_MOUSE P29341 mus musculus (mouse). polyadenylate-binding protein 1
           (poly(a) binding protein 1) (pabp 1). 7/1998
           Length = 636
           
 Score = 79.2 bits (192), Expect = 3e-14
 Identities = 25/73 (34%), Positives = 36/73 (49%)

Query: 477 DPDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEA 536
              P    +Q LGERL+P +QAM P+ A KITGM                   R++V+EA
Sbjct: 551 ASAPPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEA 610

Query: 537 MELIVAHGRENGA 549
           + ++ AH  +  A
Sbjct: 611 VAVLQAHQAKEAA 623


>PABP_XENLA P20965 xenopus laevis (african clawed frog). polyadenylate-binding
           protein (poly(a) binding protein) (pabp). 7/1998
           Length = 633
           
 Score = 78.5 bits (190), Expect = 5e-14
 Identities = 25/71 (35%), Positives = 34/71 (47%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
            P    +Q LGERL+P +QAM P  A KITGM                   R +V+EA+ 
Sbjct: 551 APPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRLKVDEAVA 610

Query: 539 LIVAHGRENGA 549
           ++ AH  +  A
Sbjct: 611 VLQAHQAKEAA 621


>PABP_SCHPO P31209 schizosaccharomyces pombe (fission yeast).
           polyadenylate-binding protein (poly(a) binding protein)
           (pabp). 7/1998
           Length = 653
           
 Score = 69.9 bits (168), Expect = 2e-11
 Identities = 22/80 (27%), Positives = 30/80 (37%), Gaps = 6/80 (7%)

Query: 468 PASEGNPSDDPD------PLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXX 521
           PA  G P           P  + +Q LGE LYP+V   +   + KITGM           
Sbjct: 563 PAVPGMPERFTAADLAAVPEESRKQVLGELLYPKVFVREEKLSGKITGMLLEMPNSELLE 622

Query: 522 XXXXXXXXRARVEEAMELIV 541
                     RV EA+ ++ 
Sbjct: 623 LLEDDSALNERVNEAIGVLQ 642


>PAB2_ARATH P42731 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 2 (poly(a) binding protein
           2) (pabp 2). 12/1998
           Length = 629
           
 Score = 64.8 bits (155), Expect = 7e-10
 Identities = 18/63 (28%), Positives = 28/63 (43%)

Query: 478 PDPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAM 537
                  R  LGE LYP V+ ++   A+K+TGM                   +A+V EAM
Sbjct: 549 NATPEQQRTMLGEVLYPLVEQVEAESAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAM 608

Query: 538 ELI 540
           +++
Sbjct: 609 DVL 611


>PAB5_ARATH Q05196 arabidopsis thaliana (mouse-ear cress).
           polyadenylate-binding protein 5 (poly(a) binding protein
           5) (pabp 5). 11/1995
           Length = 668
           
 Score = 64.4 bits (154), Expect = 9e-10
 Identities = 17/62 (27%), Positives = 29/62 (46%)

Query: 479 DPLPAHRQALGERLYPRVQAMQPAFASKITGMXXXXXXXXXXXXXXXXXXXRARVEEAME 538
                H + LG+ LYP V+  +PA  +K+TGM                   +A+V EA++
Sbjct: 585 ASPDKHPRMLGDHLYPLVEQQEPANPAKVTGMLLEMDQAEILHLLESPEALKAKVSEALD 644

Query: 539 LI 540
           ++
Sbjct: 645 VL 646


>PABP_YEAST P04147 saccharomyces cerevisiae polyadenylate-binding protein,
           cytoplasmic and nuclear (pabp) (ars consensus binding
           protein acbp-67) (polyadenylate tail-binding protein).
           2/1996
           Length = 576
           
 Score = 57.8 bits (137), Expect = 9e-08
 Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 6/49 (12%)

Query: 468 PASEGNPSDDPDP----LPAHRQALGERLYPRVQAM--QPAFASKITGM 510
           P   G P +  D         RQALGE+LY +V A       A KITGM
Sbjct: 484 PPQGGFPRNANDNNQFYQQKQRQALGEQLYKKVSAKTSNEEAAGKITGM 532


>RNR_AQUAE O67834 aquifex aeolicus. ribonuclease r (ec 3.1.-.-) (rnase r)
           (vacb protein homolog). 5/2000
           Length = 705
           
 Score = 33.3 bits (74), Expect = 2.2
 Identities = 17/92 (18%), Positives = 25/92 (26%), Gaps = 13/92 (14%)

Query: 686 SAMDLAFAVDLCKEEGGGQ---VELIPNGVNIPVTPQNVYEYVRKY-AEHRMLVVAEQPL 741
               L F +D  K         +EL P G            YV      + +    E   
Sbjct: 243 LREQLCFTIDPEKAGDFDDAVAIELTPEGY--------YKLYVHIADVSYYVREGTETDK 294

Query: 742 HAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG 773
            A ++G     P  +L  L  E     +    
Sbjct: 295 EAYKRGFTYYFPDRALHML-PEKLSAKLCSLR 325


>NIRA_EMENI P28348 emericella nidulans (aspergillus nidulans). nitrogen
           assimilation transcription factor nira. 4/1993
           Length = 892
           
 Score = 32.9 bits (73), Expect = 2.9
 Identities = 22/95 (23%), Positives = 35/95 (36%)

Query: 219 LAEEADSSKPGPSAHDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLG 278
           +A +  S+  GP +      ++ S  A++   E+  P  T  RP  +  G V S      
Sbjct: 702 VASQYSSTPSGPVSVSAMRAVQRSFSAQLAHNEARQPEPTYLRPVSTSYGPVPSTQSAQE 761

Query: 279 RWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKE 313
           +W    E   R F         S  + L  F+  E
Sbjct: 762 QWYSPTEAQFRAFTAAHSMPTTSAQSPLTTFDTPE 796


  Database: /dbase/swissprot/main/release/sp
    Posted date:  Jun 21, 2000 12:39 PM
  Number of letters in database: 31,411,157
  Number of sequences in database:  86,593
  
  Database: /dbase/swissprot/main/update/spu
    Posted date:  Nov 3, 1999  8:09 PM
  Number of letters in database: 546,183
  Number of sequences in database:  1608
  
Lambda     K      H
   0.318    0.131    0.369 

Lambda     K      H
   0.270   0.0458    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 221707272
Number of Sequences: 88201
Number of extensions: 8189338
Number of successful extensions: 22743
Number of sequences better than 10.0: 125
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 22304
Number of HSP's gapped (non-prelim): 150
length of query: 889
length of database: 31,957,340
effective HSP length: 55
effective length of query: 834
effective length of database: 27,106,285
effective search space: 22606641690
effective search space used: 22606641690
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 69 (31.3 bits)