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Enzymes</A></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></FORM><PRE>ENTRY EC <A href="http://www.genome.ad.jp/dbget-bin/www_bget?ec:3.5.4.4">3.5.4.4</A>
NAME Adenosine deaminase
CLASS Hydrolases
Acting on carbon-nitrogen bonds, other than peptide bonds
In cyclic amidines
SYSNAME Adenosine aminohydrolase
REACTION Adenosine + H2O = Inosine + NH3
SUBSTRATE Adenosine
H2O
PRODUCT Inosine
NH3
INHIBITOR Nebularine
6-Hydroxyl-1,6-dihydropurine ribonucleoside
COMMENT Inhibited by Nebularine and 6-hydroxyl-1,6-dihydropurine
ribonucleoside (Science (1989) 243, 1591-1593).
PATHWAY PATH: MAP00230 Purine metabolism
DISEASE MIM: 102700 Adenosine deaminase; Severe combined immunodeficiency
due to ADA deficiency (3); Hemolytic anemia due to ADA
excess (1)
MOTIF PS: PS00485 S-[LIVM]-[NS]-T-D-D-P
GENES ECO: ECOLI_1582(add)
SCE: YNL141W(N1208)
HSA: 119649(ADA)
DBLINKS University of Geneva ENZYME DATA BANK: 3.5.4.4
WIT (What Is There) Metabolic Reconstruction: 3.5.4.4
SCOP (Structural Classificaion of Proteins): 3.5.4.4
PDB: 1ADD 1FKW 1FKX 2ADA
PIR: DUMSA DUHUA A37943
///
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