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<!doctype html public "-//W3C//DTD HTML 4.0//EN">
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<title>InterPro Entry IPR001171</title></head>
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<table width=600 class=frame border=0><tr><td><table border=0 width=100% cellspacing=1 cellpadding=3><tr><td class=tag>InterPro Entry IPR001171</td></tr></table></td></tr></table>
<h2 class=name>Ergosterol biosynthesis ERG4/ERG24 enzymes</h2>
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<td class=tag valign=top width=110>Database</td>
<td class=inf valign=top width=1200>InterPro</td></tr>
<tr>
<td class=tag valign=top width=110>Accession</td>
<td class=inf valign=top width=1200>IPR001171; ERG4_ERG24 (matches 29 proteins)</td></tr>
<tr>
<td class=tag valign=top width=110>Name</td>
<td class=inf valign=top width=1200>Ergosterol biosynthesis ERG4/ERG24 enzymes</td></tr>
<tr>
<td class=tag valign=top width=110>Type</td>
<td class=inf valign=top width=1200><A href="#" onClick='w=window.open("IHelpServlet?help=Family", "helpwindow", "width=450,height=400,scrollbars=yes,resizable=yes");w.focus();'>
Family
<img src="gifs/help.gif" width=19 height=19 border=0 alt=""></a></td></tr>
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<td class=tag valign=top width=110>Dates</td>
<td class=inf valign=top width=1200>08-OCT-1999 (created)<BR>14-NOV-2000 (last modified)</td></tr>
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<td class=tag valign=top width=110>Signatures</td>
<td class=inf valign=top width=1200>
<a href="http://www.expasy.ch/cgi-bin/nicesite.pl?PS01017">PS01017</a>; ERG4_ERG24_1
(16 proteins)<br><a href="http://www.expasy.ch/cgi-bin/nicesite.pl?PS01018">PS01018</a>; ERG4_ERG24_2
(13 proteins)<br><a href="http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01222">PF01222</a>; ERG4_ERG24
(29 proteins)<br></td></tr>
<tr>
<td class=tag valign=top width=110><A href="#" onClick='w=window.open("IHelpServlet?help=cellularcomponent", "helpwindow", "width=450,height=400,scrollbars=yes,resizable=yes");w.focus();'>
Component
<img src="gifs/helptag.gif" width=19 height=19 border=0 alt=""></a></td>
<td class=inf valign=top width=1200>membrane (<a href="http://www.informatics.jax.org/go/GO.cgi?id=GO:0016020">GO:0016020</a>)<br>
</td></tr>
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<td class=tag valign=top width=110><A href="#" onClick='w=window.open("IHelpServlet?help=abstract", "helpwindow", "width=450,height=400,scrollbars=yes,resizable=yes");w.focus();'>
Abstract
<img src="gifs/helptag.gif" width=19 height=19 border=0 alt=""></a></td>
<td class=inf valign=top width=1200>The two <a href=http://www.ncbi.nlm.nih.gov/htbin-post/Taxonomy/wgetorg?lvl=0&id=4751>fungal</a> enzymes, C-14 sterol reductase (gene ERG24 in <a href=http://www.ncbi.nlm.nih.gov/htbin-post/Taxonomy/wgetorg?lvl=0&id=4892>budding yeast</a> and erg3 in
<a href=http://www.ncbi.nlm.nih.gov/htbin-post/Taxonomy/wgetorg?lvl=0&id=5141>Neurospora Crassa</a>) and C-24(28) sterol reductase (gene ERG4 in <a href=http://www.ncbi.nlm.nih.gov/htbin-post/Taxonomy/wgetorg?lvl=0&id=4892>budding yeast</a> and sts1
in <a href=http://www.ncbi.nlm.nih.gov/htbin-post/Taxonomy/wgetorg?lvl=0&id=4896>fission yeast</a>), are involved in ergosterol biosynthesis. They act by reducing
double bonds in precursors of ergosterol [1].
These proteins are highly hydrophobic and seem to contain seven or eight transmembrane
regions. <a href=http://www.ncbi.nlm.nih.gov/htbin-post/Taxonomy/wgetorg?lvl=0&id=9031>Chicken</a> lamin B receptor that is thought to anchor the lamina to the inner
nuclear membrane belongs to this family.</td></tr>
<tr>
<td class=tag valign=top width=110>Examples</td>
<td class=inf valign=top width=1200><ul>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P38670]">P38670</a> ER24_NEUCR</li>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P23913]">P23913</a> LBR_CHICK</li>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P36209]">P36209</a> STS1_SCHPO</li>
<br><a href="ISpy?ac=P38670,P23913,P36209">View examples</a>
</td></tr>
<tr>
<td class=tag valign=top width=110>References</td>
<td class=inf valign=top width=1200><ol>
<li value=1><a name=PUB00001844>
Lai M.H., Bard M., Pierson C.A., Alexander J.F., Goebl M., Carter G.T., Kirsch D.R.<br>
<i>The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway.</i><br>
Gene 140: 41-49(1994).
<a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=94171077&form=6&db=m&Dopt=b">[MEDLINE:94171077]</a>
[PUB00001844]
</ol></td></tr>
<tr>
<td class=tag valign=top width=110>Database links</td><td class=inf valign=top width=1200>
PROSITE doc; <a href="http://www.expasy.ch/cgi-bin/nicedoc.pl?PDOC00780">PDOC00780</a><br>
Blocks; <a href="http://blocks.fhcrc.org/blocks-bin/getblock.sh?IPB001171">IPB001171</a><br>
</td></tr>
<tr>
<td class=tag valign=top width=110><A href="#" onClick='w=window.open("IHelpServlet?help=matches", "helpwindow", "width=450,height=400,scrollbars=yes,resizable=yes");w.focus();'>
Matches
<img src="gifs/helptag.gif" width=19 height=19 border=0 alt=""></a></td>
<td class=inf valign=top width=1200><a href="ISpy?ipr=IPR001171&display=n">Table</a> <a href="ISpy?ipr=IPR001171&display=n&dmax=20000">all</a> <a href="ISpy?ipr=IPR001171">Graphical</a> <a href="ISpy?ipr=IPR001171&dmax=20000">all</a> <a href="http://www.ebi.ac.uk/~flo/cgi-bin/InterPro_GUI/script/ReqInterPro.pl?list_ipr_ac=IPR001171">Condensed graphical view</a></td></tr>
</table></td></tr></table>
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