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ENTRY EC 1.1.1.1
NAME Alcohol dehydrogenase
Aldehyde reductase
CLASS Oxidoreductases
Acting on the CH-OH group of donors
With NAD+ or NADP+ as acceptor
SYSNAME Alcohol:NAD+ oxidoreductase
REACTION Alcohol + NAD+ = Aldehyde or Ketone + NADH
SUBSTRATE NAD+
Primary alcohol
Secondary alcohol
Cyclic secondary alcohol
Hemiacetal
PRODUCT Aldehyde
Ketone
NADH
COFACTOR Zinc
COMMENT A zinc protein. Acts on primary or secondary alcohols or
hemiacetals; the animal, but not the yeast, enzyme acts also on
cyclic secondary alcohols
The insect enzyme is a member of the nonmetallo-short-chain
alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
88, 10064-10068).
PATHWAY PATH: MAP00010 Glycolysis / Gluconeogenesis
PATH: MAP00071 Fatty acid metabolism
PATH: MAP00120 Bile acid biosynthesis
PATH: MAP00350 Tyrosine metabolism
PATH: MAP00561 Glycerolipid metabolism
GENES ECO: b0356(adhC) b1241(adhE) b1478(adhP) b3589(yiaY)
ECE: Z0456(adhC) Z2016(adhE) Z2232(adhP) Z5010(yiaY)
ECS: ECs0411 ECs1741 ECs2082 ECs4466
HIN: HI0185(adhC)
XFA: XF1746 XF2389
VCH: VC1147 VC2033
PAE: PA2119 PA2158 PA2188 PA3629(adhC) PA5427(adhA)
PMU: PM1453(adh2)
NME: NMB0546 NMB1304
NMA: NMA0725(adhA) NMA1518(adhC)
MLO: mlr0872 mlr1136 mlr1178
CCR: CC2516 CC3029
BSU: BS2776(adhB) BS3211(gbsB)
BHA: BH1829(adhB)
LLA: L13145(adhE) L55758(adhA)
SPY: SPy0044(adhA)
MTU: Rv0761c(adhB) Rv1862(adhA) Rv2259(adhE2)
MLE: ML1784(adhE2) ML2053
SYN: sll0990
AAE: aq_1240(adh2) aq_1362(adh1)
TMA: TM0111 TM0920
AFU: AF0024 AF0339 AF2019 AF2101
HAL: VNG1821G(adh4)
TAC: Ta0832 Ta0833 Ta0841
TVO: TVG0387048 TVG0995648 TVG1348694
PHO: PH0743
PAB: PAB1511
APE: APE1245 APE1557 APE1963 APE2239
SSO: SSO0472(adh-1) SSO0764(adh-2) SSO1220(adh-3) SSO1300(adh-4)
SSO1646(adh-5) SSO2334(adh-6) SSO2441(adh-7) SSO2494(adh-8)
SSO2501(adh-9) SSO2536(adh-10) SSO2717(adh-11) SSO2800(adh-12)
SSO2878(adh-13)
SCE: YBR145W(ADH5) YDL168W(SFA1) YGL256W(ADH4) YMR083W(ADH3)
YMR303C(ADH2) YOL086C(ADH1)
SPO: ADH1(adh1) SPAC5H10.06C(spac5h10.06c) SPCC13B11.04C
ATH: At1g77120(F22K20_19)
CEL: K12G11.3 K12G11.4
DME: CG3425(T3dh) CG3481(Adh) CG6598(Fdh)
MMU: 1098256(Daq1) 87921(Adh1) 87926(Adh3) 87929(Adh5)
HSA: 124(ADH1) 125(ADH2) 126(ADH3) 127(ADH4) 128(ADH5) 130(ADH6)
131(ADH7)
DISEASE MIM: 103700 Alcohol dehydrogenase (class I), alpha polypeptide
MIM: 103720 Alcohol dehydrogenase (class I), beta polypeptide
MIM: 103730 Alcohol dehydrogenase (class I), gamma polypeptide
MIM: 103740 Alcohol dehydrogenase (class II), pi polypeptide
MIM: 600086 Alcohol dehydrogenase-7
STRUCTURES PDB: 1A4U 1A71 1A72 1ADB 1ADC 1ADF 1ADG 1AGN 1AXE 1AXG
1B14 1B15 1B16 1B2L 1BTO 1CDO 1D1S 1D1T 1DDA 1DEH
1E3E 1E3I 1E3L 1EE2 1HDX 1HDY 1HDZ 1HET 1HEU 1HF3
1HLD 1HSO 1HSZ 1HT0 1HTB 1LDE 1LDY 1QLH 1QLJ 1TEH
2OHX 2OXI 3BTO 3HUD 5ADH 6ADH 7ADH
DBLINKS IUBMB Enzyme Nomenclature: 1.1.1.1
ExPASy - ENZYME nomenclature database: 1.1.1.1
WIT (What Is There) Metabolic Reconstruction: 1.1.1.1
BRENDA, the Enzyme Database: 1.1.1.1
SCOP (Structural Classification of Proteins): 1.1.1.1
///
ENTRY EC 1.1.1.62
NAME Estradiol 17beta-dehydrogenase
CLASS Oxidoreductases
Acting on the CH-OH group of donors
With NAD+ or NADP+ as acceptor
SYSNAME Estradiol-17beta:NAD(P)+ 17-oxidoreductase
REACTION Estradiol-17beta + NAD+ or NADP+ = Estrone + NADH or NADPH
SUBSTRATE Estradiol-17beta
(S)-20-Hydroxypregn-4-en-3-one
NAD+
NADP+
PRODUCT Estrone
(S)-Pregn-4-en-3,20-dione
NADH
NADPH
COMMENT Also acts on (S)-20-hydroxypregn-4-en-3-one and related
compounds, oxidizing the (S)-20-group. B-specific with respect
to NAD(P)+ (cf. EC 1.1.1.149).
PATHWAY PATH: MAP00150 Androgen and estrogen metabolism
GENES CEL: F11A5.12
DME: CG1444 CG3415
HSA: 3292(HSD17B1) 3293(HSD17B3) 3294(HSD17B2) 3295(HSD17B4)
3296(HSD17BP1) 51478(HSD17B7)
DISEASE MIM: 109685 Hydroxysteroid (17-beta) dehydrogenase 2
MIM: 264300 Hydroxysteroid (17-beta) dehydrogenase 3
STRUCTURES PDB: 1FDT 1FDS 1FDV 1FDW 1IOL 3DHE 1EQU 1DHT 1BHS 1A27
1FDU
DBLINKS IUBMB Enzyme Nomenclature: 1.1.1.62
ExPASy - ENZYME nomenclature database: 1.1.1.62
WIT (What Is There) Metabolic Reconstruction: 1.1.1.62
BRENDA, the Enzyme Database: 1.1.1.62
SCOP (Structural Classification of Proteins): 1.1.1.62
///
ENTRY EC 1.1.1.68
NAME Transferred to EC 1.7.99.5
CLASS Oxidoreductases
Acting on the CH-OH group of donors
With NAD+ or NADP+ as acceptor
COMMENT Transferred entry. Now EC 1.7.99.5 -
5,10-Methylenetetrahydrofolate reductase (FADH2).
DBLINKS IUBMB Enzyme Nomenclature: 1.1.1.68
ExPASy - ENZYME nomenclature database: 1.1.1.68
WIT (What Is There) Metabolic Reconstruction: 1.1.1.68
///
ENTRY EC 1.6.5.3
NAME NADH dehydrogenase (ubiquinone)
Ubiquinone reductase
Type I dehydrogenase
Complex I dehydrogenase
CLASS Oxidoreductases
Acting on NADH or NADPH
With quinone or related compound as acceptor
SYSNAME NADH:ubiquinone oxidoreductase
REACTION NADH + Ubiquinone = NAD+ + Ubiquinol
SUBSTRATE NADH
Ubiquinone
PRODUCT NAD+
Ubiquinol
COFACTOR FAD
Iron
Sulfur
COMMENT A flavoprotein (FAD) containing iron-sulfur contres. The complex,
present in mitochondria, can be degraded to form EC 1.6.99.3.
PATHWAY PATH: MAP00130 Ubiquinone biosynthesis
PATH: MAP00190 Oxidative phosphorylation
GENES ECO: b2276(nuoN) b2277(nuoM) b2278(nuoL) b2279(nuoK) b2280(nuoJ)
b2281(nuoI) b2282(nuoH) b2283(nuoG) b2284(nuoF) b2285(nuoE)
b2286 b2287(nuoB) b2288(nuoA)
ECE: Z3534(nuoN) Z3536(nuoM) Z3537(nuoL) Z3538(nuoK) Z3539(nuoJ)
Z3540(nuoI) Z3541(nuoH) Z3542(nuoG) Z3543(nuoF) Z3544(nuoE)
Z3545(nuoC) Z3546(nuoB) Z3547(nuoA)
ECS: ECs3160 ECs3161 ECs3162 ECs3163 ECs3164 ECs3165 ECs3166
ECs3167 ECs3168 ECs3169 ECs3170 ECs3171 ECs3172
XFA: XF0305 XF0306 XF0307 XF0308 XF0309 XF0310 XF0311 XF0312
XF0313 XF0314 XF0315 XF0316 XF0317 XF0318
VCH: VC1581 VCA0155 VCA0157
PAE: PA1054 PA1056 PA1883 PA2637(nuoA) PA2638(nuoB) PA2639(nuoD)
PA2640(nuoE) PA2641(nuoF) PA2642(nuoG) PA2643(nuoH)
PA2644(nuoI) PA2645(nuoJ) PA2646(nuoK) PA2647(nuoL)
PA2648(nuoM) PA2649(nuoN)
BUC: BU154(nuoA) BU155(nuoB) BU156(nuoCD) BU157(nuoE) BU158(nuoF)
BU159(nuoG) BU160(nuoH) BU161(nuoI) BU162(nuoJ) BU163(nuoK)
BU164(nuoL) BU165(nuoM) BU166(nuoN)
NME: NMB0241 NMB0242 NMB0243 NMB0244 NMB0245 NMB0246 NMB0249
NMB0250 NMB0251 NMB0253 NMB0254 NMB0257 NMB0258 NMB0259
NMA: NMA0002(nuoL) NMA0005(nuoK) NMA0006(nuoJ) NMA0008(nuoI)
NMA0009(nuoH) NMA0010(nuoG) NMA0014(nuoF) NMA0015(nuoE)
NMA0016(nuoD) NMA0017(nuoC) NMA0018(nuoB) NMA0019(nuoA)
NMA0747(nqrF) NMA2228(nuoN) NMA2229(nuoM)
HPY: HP1260(NQO7) HP1261(NQO6) HP1262(NQO5) HP1263 HP1264 HP1265
HP1266(NQO3) HP1267(NQO8) HP1268(NQO9) HP1269(NQO10) HP1270
HP1271(NQO12) HP1272(NQO13) HP1273(NQO14)
HPJ: jhp1181 jhp1182 jhp1183 jhp1184 jhp1185 jhp1186 jhp1187
jhp1188 jhp1189 jhp1190 jhp1191 jhp1192 jhp1193 jhp1194
CJE: Cj1566c(nuoN) Cj1567c(nuoM) Cj1568c(nuoL) Cj1569c(nuoK)
Cj1570c(nuoJ) Cj1571c(nuoI) Cj1572c(nuoH) Cj1573c(nuoG)
Cj1574c Cj1575c Cj1576c(nuoD) Cj1577c(nuoC) Cj1578c(nuoB)
Cj1579c(nuoA)
RPR: RP115(nuoF) RP282(nuoL3) RP283(nuoL2) RP284(nuoN2)
RP353(nuoE) RP354(nuoD) RP355(nuoC) RP356(nuoB) RP357(nuoA)
RP537(nuoN1) RP790(nuoJ) RP791(nuoK) RP792(nuoL1) RP793(nuoM)
RP795(nuoI) RP796(nuoH) RP797(nuoG)
MLO: mll1352 mll1354 mll1355 mll1357 mll1358 mll1359 mll1361
mll1362 mll1364 mll1365 mll1366 mll1367 mll1369 mll1371
mll1372 mll5193 mll5397 mll5398
CCR: CC1937 CC1938 CC1939 CC1940 CC1941 CC1942 CC1945 CC1946
CC1947 CC1950 CC1952 CC1954 CC1955 CC1956
BSU: BS0231(ndhF)
MTU: Rv3145(nuoA) Rv3146(nuoB) Rv3147(nuoC) Rv3148(nuoD)
Rv3149(nuoE) Rv3150(nuoF) Rv3151(nuoG) Rv3152(nuoH)
Rv3153(nuoI) Rv3154(nuoJ) Rv3155(nuoK) Rv3156(nuoL)
Rv3157(nuoM) Rv3158(nuoN)
SYN: sll0026(ndhF) sll0027(ndhD4) sll0223(ndhB) sll0519(ndhA)
sll0520(ndhI) sll0521(ndhG) sll0522(ndhE) sll1220
sll1221(hoxF) sll1223(hoxU) sll1732(ndhF) sll1733(ndhD3)
slr0261(ndhH) slr0331(ndhD1) slr0844(ndhF) slr1279(ndhC)
slr1280(psbg1) slr1281(ndhJ) slr1291(ndhD2) slr2007(ndhD5)
slr2009(ndhD6)
DRA: DR0880 DR1492 DR1493 DR1494 DR1495 DR1496 DR1497 DR1498
DR1499 DR1500 DR1501 DR1503 DR1504 DR1505 DR1506
AAE: aq_1310(nuoA2) aq_1312(nuoB) aq_1314(nuoD2) aq_1315(nuoH1)
aq_1317(nuoI1) aq_1318(nuoJ1) aq_1319(nuoK1) aq_1320(nuoL1)
aq_1321(nuoM1) aq_1322(nuoN1) aq_135(nueM) aq_1373(nuoH2)
aq_1374(nuoH3) aq_1375(nuoI2) aq_1377(nuoJ2) aq_1378(nuoK2)
aq_1379(nuoL3) aq_1382(nuoM2) aq_1383(nuoN2) aq_1385(nuoA1)
aq_437(nuoG) aq_551(nuoD1) aq_573(nuoF) aq_574(nuoE)
aq_866(nuoL2)
TMA: TM0010 TM0011 TM0012 TM0201 TM0228 TM1105 TM1211 TM1212
TM1213 TM1214 TM1215 TM1216 TM1424 TM1425 TM1426
MJA: MJ0520 MJ1309(cooM) MJ1362
MTH: MTH1237 MTH1246 MTH1548 MTH1549 MTH393
AFU: AF1823 AF1824 AF1825(nuoM) AF1826(nuoL) AF1827 AF1828 AF1829
AF1830(nuoD) AF1831
HAL: VNG0635G(nolB) VNG0636G(ndhG1) VNG0637G(ndhG5)
VNG0639G(ndhG4) VNG0640G(nolD) VNG0641C VNG0643G(nolC)
VNG0646G(nuoL) VNG0647G(nuoM) VNG0648G(ndhG3)
TAC: Ta0959 Ta0960 Ta0961 Ta0962 Ta0964 Ta0965 Ta0966 Ta0967
Ta0968 Ta0969 Ta0970
TVO: TVG1157047 TVG1158465 TVG1160017 TVG1161017 TVG1162018
TVG1162541 TVG1162786 TVG1163214 TVG1164251 TVG1165354
TVG1165809 TVG1166270
PHO: PH0941 PH0942 PH1431 PH1446 PH1447 PH1448 PH1449 PH1450
PH1451 PH1452 PH1453
PAB: PAB0488 PAB0490(nuoM) PAB0492(nuoH) PAB0493(nuoB)
PAB0494(nuoC) PAB0495(nuoD) PAB0496(nuoI) PAB0805 PAB0806
PAB1888 PAB2416(nuoN)
APE: APE1410 APE1411 APE1415 APE1417 APE1418 APE1419 APE1421
APE1422 APE1426 APE1428 APE1430
SSO: SSO0322(NuoA) SSO0323(NuoC) SSO0324(NuoD) SSO0325(NuoH)
SSO0326(NuoI) SSO0327(NuoJ) SSO0328(NuoL) SSO0329(NuoN)
SSO0665(NuoB)
SCE: YKL192C(ACP1)
SPO: SPAC11E3.12(spac11e3.12) SPAC4H3.09(spac4h3.09)
SPBC18E5.10(spbc18e5.10)
ATH: AT4g02580(T10P11_14) AT5g08530(MAH20_9) AT5g11770(T22P22_160)
AT5g37510(mpa22_p_40) At1g16700(F19K19_1) At1g65290(T8F5_6)
At1g79010(YUP8H12R_21) At1g79200(YUP8H12R_37)
At2g02050(F14H20.12) At2g20360(F11A3.9) At2g44620(F16B22.11)
CEL: C09H10.3 C16A3.4 C18E9.4 C25A1.13 C33A12.1 D2030.4 F16B4.6
F22D6.4 F37C12.3 F44G4.2 F53F4.10 F59C6.5 K04G7.4
K09A9.5(gas-1) T10E9.7 T20H4.5 T26A5.3 W10D5.2 Y51H1A.3a
Y51H1A.3b Y57G11C.12 Y63D3A.7
DME: CG10320 CG11423 CG11913 CG12079 CG15328 CG15434 CG1970 CG2014
CG2286(ND75) CG3192 CG3621(EG:152A3.7) CG3683 CG3944 CG5548
CG5703 CG6020 CG6343(ND42) CG6463 CG6485 CG6914 CG7712 CG8102
CG8844 CG9140 CG9160(mtacp1) CG9160_1(mtacp1) CG9172 CG9306
CG9762
HSA: 4535(MTND1) 4536(MTND2) 4537(MTND3) 4538(MTND4) 4539(MTND4L)
4540(MTND5) 4541(MTND6) 4694(NDUFA1) 4695(NDUFA2) 4696(NDUFA3)
4697(NDUFA4) 4698(NDUFA5) 4700(NDUFA6) 4701(NDUFA7)
4702(NDUFA8) 4704(NDUFA9) 4705(NDUFA10) 4706(NDUFAB1)
4707(NDUFB1) 4708(NDUFB2) 4709(NDUFB3) 4710(NDUFB4)
4711(NDUFB5) 4712(NDUFB6) 4713(NDUFB7) 4714(NDUFB8)
4715(NDUFB9) 4716(NDUFB10) 4717(NDUFC1) 4718(NDUFC2)
4719(NDUFS1) 4720(NDUFS2) 4722(NDUFS3) 4723(NDUFV1)
4724(NDUFS4) 4725(NDUFS5) 4726(NDUFS6) 4727(NDUFS7)
4728(NDUFS8) 4729(NDUFV2) 4731(NDUFV3)
DISEASE MIM: 300078 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1,
7.5kD
MIM: 601677 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
(13kD, B13)
DBLINKS IUBMB Enzyme Nomenclature: 1.6.5.3
ExPASy - ENZYME nomenclature database: 1.6.5.3
WIT (What Is There) Metabolic Reconstruction: 1.6.5.3
BRENDA, the Enzyme Database: 1.6.5.3
///
ENTRY EC 1.14.13.28
NAME 3,9-Dihydroxypterocarpan 6a-monooxygenase
3,9-Dihydroxypterocarpan 6a-hydroxylase
CLASS Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen
SYSNAME (6aR,11aR)-3,9-Dihydroxypterocarpan,NADPH:oxygen oxidoreductase
$ (6a-hydroxylating)
REACTION (6aR,11aR)-3,9-Dihydroxypterocarpan + NADPH + O2 =
(6aS,11aS)-3,6a,9-Trihydroxypterocarpan + NADP+ + H2O
SUBSTRATE (6aR,11aR)-3,9-Dihydroxypterocarpan
NADPH
O2
PRODUCT (6aS,11aS)-3,6a,9-Trihydroxypterocarpan
NADP+
H2O
COFACTOR Heme
COMMENT Possibly a heme-thiolate protein (P-450). The product of the
reaction is the biosynthetic precursor of the phytoalexin
glyceollin in soybean.
DBLINKS IUBMB Enzyme Nomenclature: 1.14.13.28
ExPASy - ENZYME nomenclature database: 1.14.13.28
WIT (What Is There) Metabolic Reconstruction: 1.14.13.28
BRENDA, the Enzyme Database: 1.14.13.28
///
ENTRY EC 2.4.1.68
NAME Glycoprotein 6-alpha-L-fucosyltransferase
GDPfucose--glycoprotein fucosyltransferase
CLASS Transferases
Glycosyltransferases
Hexosyltransferases
SYSNAME GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked
$ N-acetylglucosamine of N-acetyl-beta-D-glucosaminyl-1,2-alpha-
$D-mannosyl-1,3-(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-
$D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl)asparagine 6-alpha-L-
$fucosyltransferase
REACTION GDP-L-fucose + N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-
$mannosyl-1,3-(R1-alpha-1,6)-beta-D-mannosyl-beta-N-acetyl-1,4-
$D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl)asparagine = GDP +
N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
$(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-D-glucosaminyl-
$1,4-(alpha-L-fucosyl-1,6)-N-acetyl-D-glucosaminyl)asparagine
SUBSTRATE GDP-L-fucose
N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
$(R1-alpha-1,6)-beta-D-mannosyl-beta-N-acetyl-1,4-D-glucosaminyl-
$1,4-N-acetyl-D-glucosaminyl)asparagine
PRODUCT GDP
N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
$(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-D-glucosaminyl-
$1,4-(alpha-L-fucosyl-1,6)-N-acetyl-D-glucosaminyl)asparagine
PATHWAY PATH: MAP00510 Glycoprotein biosynthesis
DBLINKS IUBMB Enzyme Nomenclature: 2.4.1.68
ExPASy - ENZYME nomenclature database: 2.4.1.68
WIT (What Is There) Metabolic Reconstruction: 2.4.1.68
BRENDA, the Enzyme Database: 2.4.1.68
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ENTRY EC 3.1.1.6
NAME Acetylesterase
C-esterase (in animal tissues)
CLASS Hydrolases
Acting on ester bonds
Carboxylic ester hydrolases
SYSNAME Acetic-ester acetylhydrolase
REACTION an Acetic ester + H2O = an Alcohol + Acetate
SUBSTRATE Acetic ester
H2O
PRODUCT Alcohol
Acetate
GENES MMU: 95428(Es17)
STRUCTURES PDB: 1BS9 1G66 2AXE
DBLINKS IUBMB Enzyme Nomenclature: 3.1.1.6
ExPASy - ENZYME nomenclature database: 3.1.1.6
WIT (What Is There) Metabolic Reconstruction: 3.1.1.6
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.6
BRENDA, the Enzyme Database: 3.1.1.6
SCOP (Structural Classification of Proteins): 3.1.1.6
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ENTRY EC 2.7.2.1
NAME Acetate kinase
Acetokinase
CLASS Transferases
Transferring phosphorus-containing groups
Phosphotransferases with a carboxyl group as acceptor
SYSNAME ATP:acetate phosphotransferase
REACTION ATP + Acetate = ADP + Acetyl phosphate
SUBSTRATE ATP
Acetate
Propanoate
PRODUCT ADP
Acetyl phosphate
Propanoyl phosphate
COMMENT Propanoate also acts as acceptor, but more slowly.
PATHWAY PATH: MAP00620 Pyruvate metabolism
PATH: MAP00640 Propanoate metabolism
GENES ECO: ECOLI_2245(ackA)
HIN: HI1204(ackA)
BSU: ackA
MGE: MG357(ackA)
MPN: G12_orf390(ackA)
SYN: sll1299(ackA)
DBLINKS University of Geneva ENZYME DATA BANK: 2.7.2.1
WIT (What Is There) Metabolic Reconstruction: 2.7.2.1
PIR: B49338 B49935 E64239 KIECAA
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