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{PDOC00933}
{PS01213; GLOBIN_FAM_2}
{BEGIN}
**********************************************
* Protozoan/cyanobacterial globins signature *
**********************************************
Globins are heme-containing proteins involved in binding and/or transporting
oxygen [1]. Almost all globins belong to a large family (see <PDOC00793>), the
only exceptions are the following proteins which form a family of their own
[2,3,4]:
- Monomeric hemoglobins from the protozoan Paramecium caudatum, Tetrahymena
pyriformis and Tetrahymena thermophila.
- Cyanoglobins from the cyanobacteria Nostoc commune and Synechocystis PCC
6803.
- Globins LI637 and LI410 from the chloroplast of the alga Chlamydomonas
eugametos.
- Mycobacterium tuberculosis globins glbN and glbO.
These proteins contain a conserved histidine which could be involved in heme-
binding. As a signature pattern, we use a conserved region that ends with this
residue.
-Consensus pattern: F-[LF]-x(4)-[GE]-G-[PAT]-x(2)-[YW]-x-[GSE]-[KRQAE]-x(1,5)-
[LIVM]-x(3)-H
[The H may be a heme ligand]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.
[ 1] Concise Encyclopedia Biochemistry, Second Edition, Walter de Gruyter,
Berlin New-York (1988).
[ 2] Takagi T.
Curr. Opin. Struct. Biol. 3:413-418(1993).
[ 3] Couture M., Chamberland H., St-Pierre B., Lafontaine J., Guertin M.
"Nuclear genes encoding chloroplast hemoglobins in the unicellular
green alga Chlamydomonas eugametos."
Mol. Gen. Genet. 243:185-197(1994).
PubMed=8177215
[ 4] Couture M., Das T.K., Savard P.Y., Ouellet Y., Wittenberg J.B.,
Wittenberg B.A., Rousseau D.L., Guertin M.
"Structural investigations of the hemoglobin of the cyanobacterium
Synechocystis PCC6803 reveal a unique distal heme pocket."
Eur. J. Biochem. 267:4770-4780(2000).
PubMed=10903511
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{END}
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