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ID TCMO_STRGA STANDARD; PRT; 339 AA.
AC P39896;
DT 01-FEB-1995 (REL. 31, CREATED)
DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE)
DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE)
DE TETRACENOMYCIN POLYKETIDE SYNTHESIS 8-O-METHYL TRANSFERASE TCMO
DE (EC 2.1.1.-).
GN TCMO.
OS STREPTOMYCES GLAUCESCENS.
OC BACTERIA; FIRMICUTES; ACTINOBACTERIA; ACTINOBACTERIDAE;
OC ACTINOMYCETALES; STREPTOMYCINEAE; STREPTOMYCETACEAE; STREPTOMYCES.
RN [1]
RP SEQUENCE FROM N.A.
RC STRAIN=GLA.0;
RX MEDLINE; 92193265.
RA SUMMERS R.G., WENDT-PIENKOWSKI E., MOTAMEDI H., HUTCHINSON C.R.;
RT "Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin
RT C biosynthetic gene cluster of Streptomyces glaucescens and evidence
RT that the tcmN gene encodes a multifunctional
RT cyclase-dehydratase-O-methyl transferase.";
RL J. BACTERIOL. 174:1810-1820(1992).
CC TETRACENOMYCIN B3 TO TETRACENOMYCIN E. METHYLATES AS WELL TCM D3
CC INTO 8-O-METHYL-TCM D3, A SIDE REACTION.
CC -!- PATHWAY: SECOND STEP IN THE BIOSYNTHESIS OF THE POLYKETIDE
CC ANTIBIOTIC TETRACENOMYCIN C (TCM C) FROM TCM D3.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC or send an email to license@isb-sib.ch).
CC --------------------------------------------------------------------------
DR EMBL; M80674; G153500; -.
DR PIR; S27697; S27697.
DR PIR; C42276; C42276.
DR PFAM; PF00891; Methyltransf; 1.
KW ANTIBIOTIC BIOSYNTHESIS; TRANSFERASE; METHYLTRANSFERASE.
SQ SEQUENCE 339 AA; 37035 MW; 848B7337 CRC32;
MTPHTHVRGP GDILQLTMAF YGSRALISAV ELDLFTLLAG KPLPLGELCE RAGIHPRGAR
DFLDALVALG LLEREGEDTY RNSPAADRHL DRRKPGYVGG YARLADTKLF PVWARLTEAL
RTGEKQVPSQ GGFFGGYADP EAARGFLGAM DAVNGGVGHS LAGALDWTEY SSFVDLGGAR
GNLAAHLHRA HPHLRATCFD LPEMEPFFQE HMKSLETTDQ VRFAGGDFFT DPLPRADVFI
VGHILHYFGL RQREALIARI HQALTPGGAV LVYDRMIDDD RRSAALSLLG SLNMLLTSDE
GREYTPAECV RWLSDAGFTD VRTTAVSGPD TLAIGRKPR
//
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