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ID CLD1_HUMAN STANDARD; PRT; 211 AA.
AC O95832;
DT 15-FEB-2000 (Rel. 39, Created)
DT 15-FEB-2000 (Rel. 39, Last sequence update)
DT 15-FEB-2000 (Rel. 39, Last annotation update)
DE CLAUDIN-1 (SENESCENCE-ASSOCIATED EPITHELIAL MEMBRANE PROTEIN).
GN CLDN1 OR CLD1 OR SEMP1.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 99132301. [NCBI, ExPASy, Israel, Japan]
RA Swisshelm K.L., Machl A., Planitzer S., Robertson R., Kubbies M.,
RA Hosier S.;
RT "SEMP1, a senescence-associated cDNA isolated from human mammary
RT epithelial cells, is a member of an epithelial membrane protein
RT superfamily.";
RL Gene 226:285-295(1999).
RN [2]
RP SEQUENCE FROM N.A.
RA Mitic L.M., Anderson J.M.;
RT "Human claudin-1 isolated from Caco-2 mRNA.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: COMPONENT OF TIGHT JUNCTION (TJ) STRANDS.
CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC -!- SIMILARITY: BELONGS TO THE CLAUDIN FAMILY.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
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DR EMBL; AF101051; AAD16433.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF115546; AAD22962.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR GeneCards; CLDN1.
DR MIM; 603718; -.
DR PROSITE; PS01346; CLAUDIN; 1.
DR PRODOM [Domain structure / List of seq. sharing at least 1 domain]
DR BLOCKS; O95832.
DR DOMO; O95832.
DR PROTOMAP; O95832.
DR PRESAGE; O95832.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Tight junction; Transmembrane.
FT TRANSMEM 8 28 POTENTIAL.
FT TRANSMEM 82 102 POTENTIAL.
FT TRANSMEM 116 136 POTENTIAL.
FT TRANSMEM 164 184 POTENTIAL.
FT CONFLICT 62 62 I -> V (IN REF. 2).
FT CONFLICT 135 135 V -> A (IN REF. 2).
SQ SEQUENCE 211 AA; 22744 MW; 07269000E6C214F0 CRC64;
MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG
QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV
IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA
LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V
//
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