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ID 5H4_HUMAN STANDARD; PRT; 388 AA.
AC Q13639; Q9UBM6; Q9UQR6; Q9UE22; Q9UE23; Q9UBT4; Q9NY73;
DT 01-NOV-1997 (Rel. 35, Created)
DT 01-OCT-2000 (Rel. 40, Last sequence update)
DT 01-OCT-2000 (Rel. 40, Last annotation update)
DE 5-HYDROXYTRYPTAMINE 4 RECEPTOR (5-HT-4) (SEROTONIN RECEPTOR) (5-HT4).
GN HTR4.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP SEQUENCE FROM N.A. (ISOFORMS 5-HT4(A); 5-HT4(B); 5-HT4(C); 5-HT4(D)).
RC TISSUE=Gut;
RX PubMed=9603189;
RA Blondel O., Gastineau M., Dahmoune Y., Langlois M., Fischmeister R.;
RT "Cloning, expression, and pharmacology of four human 5-
RT hydroxytryptamine receptor isoforms produced by alternative splicing
RT in the carboxyl terminus.";
RL J. Neurochem. 70:2252-2261(1998).
RN [2]
RP SEQUENCE FROM N.A. (ISOFORMS 5-HT4(A) AND 5HT4(B)).
RC TISSUE=Brain;
RA Van den Wyngaert I., Gommeren W., Jurzak M., Verhasselt P., Gordon R.,
RA Leysen J., Luyten W., Bender E.;
RT "Cloning and expression of 5-HT4 receptor species and splice
RT variants.";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SEQUENCE FROM N.A. (ISOFORM 5-HT4(A)).
RC TISSUE=Heart;
RX PubMed=9351641;
RA Claeysen S., Faye P., Sebben M., Lemaire S., Bockaert J., Dumuis A.;
RT "Cloning and expression of human 5-HT4S receptors. Effect of receptor
RT density on their coupling to adenylyl cyclase.";
RL NeuroReport 8:3189-3195(1997).
RN [4]
RP SEQUENCE FROM N.A. (ISOFORM 5-HT4(E)).
RC TISSUE=Brain;
RA Claeysen S., Sebben M., Becamel C., Bockaert J., Dumuis A.;
RT "Novel brain-specific 5-HT4 receptors splice variants show marked
RT constitutive activity: role of the c-terminal intracellular domain.";
RL Mol. Pharmacol. 55:0-0(1999).
RN [5]
RP SEQUENCE OF 10-388 FROM N.A. (ISOFORM 5-HT4(F)).
RX PubMed=10646498;
RA Bender E., Pindon A., van Oers I., Zhang Y.B., Gommeren W.,
RA Verhasselt P., Jurzak M., Leysen J., Luyten W.;
RT "Structure of the human serotonin 5-HT4 receptor gene and cloning of a
RT novel 5-HT4 splice variant.";
RL J. Neurochem. 74:478-489(2000).
RN [6]
RP SEQUENCE OF 112-255 FROM N.A.
RC TISSUE=Brain;
RX MEDLINE=95385798; PubMed=7656980;
RA Ullmer C., Schmuck K., Kalkman H.O., Lubbert H.;
RT "Expression of serotonin receptor mRNAs in blood vessels.";
RL FEBS Lett. 370:215-221(1995).
CC -!- FUNCTION: THIS IS ONE OF THE SEVERAL DIFFERENT RECEPTORS FOR
CC 5-HYDROXYTRYPTAMINE (SEROTONIN), A BIOGENIC HORMONE THAT FUNCTION
CC AS A NEUROTRANSMITTER, A HORMONE, AND A MITOGEN. THE ACTIVITY OF
CC THIS RECEPTOR IS MEDIATED BY G PROTEINS THAT STIMULATES ADENYLATE
CC CYCLASE.
CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC -!- ALTERNATIVE PRODUCTS: AT LEAST 6 ISOFORMS; 5-HT4(A)/5-HT4S, 5-
CC HT4(B) (SHOWN HERE), 5-HT4(C), 5-HT4(D); 5-HT4(E) AND 5-HT4(F);
CC ARE PRODUCED BY ALTERNATIVE SPLICING.
CC -!- TISSUE SPECIFICITY: ISOFORM 5-HT4(A)IS EXPRESSED IN ILEUM, BRAIN,
CC AND ATRIUM, BUT NOT IN THE VENTRICLE.
CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC or send an email to license@isb-sib.ch).
CC --------------------------------------------------------------------------
DR EMBL; Y12505; CAA73107.1; -.
DR EMBL; Y12506; CAA73108.1; -.
DR EMBL; Y12507; CAA73109.1; -.
DR EMBL; Y10437; CAA71462.1; -.
DR EMBL; Y08756; CAA70002.1; -.
DR EMBL; Y09586; CAA70774.1; -.
DR EMBL; Y13584; CAA73911.1; -.
DR EMBL; AJ011371; CAA09600.1; -.
DR EMBL; AJ243213; CAB71316.1; -.
DR EMBL; Z48150; CAA88167.1; -.
DR GCRDb; GCR_1064; -.
DR MIM; 602164; -.
DR InterPro; IPR000276; -.
DR InterPro; IPR001520; -.
DR InterPro; IPR002233; -.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01059; 5HT4RECEPTR.
DR PRINTS; PR01103; ADRENERGICR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW G-protein coupled receptor; Transmembrane; Glycoprotein;
KW Multigene family; Lipoprotein; Palmitate; Alternative splicing.
FT DOMAIN 1 19 EXTRACELLULAR (POTENTIAL).
FT TRANSMEM 20 40 1 (POTENTIAL).
FT DOMAIN 41 58 CYTOPLASMIC (POTENTIAL).
FT TRANSMEM 59 79 2 (POTENTIAL).
FT DOMAIN 80 93 EXTRACELLULAR (POTENTIAL).
FT TRANSMEM 94 116 3 (POTENTIAL).
FT DOMAIN 117 137 CYTOPLASMIC (POTENTIAL).
FT TRANSMEM 138 158 4 (POTENTIAL).
FT DOMAIN 159 192 EXTRACELLULAR (POTENTIAL).
FT TRANSMEM 193 213 5 (POTENTIAL).
FT DOMAIN 214 260 CYTOPLASMIC (POTENTIAL).
FT TRANSMEM 261 281 6 (POTENTIAL).
FT DOMAIN 282 294 EXTRACELLULAR (POTENTIAL).
FT TRANSMEM 295 315 7 (POTENTIAL).
FT DOMAIN 316 388 CYTOPLASMIC (POTENTIAL).
FT CARBOHYD 7 7 N-LINKED (GLCNAC...) (POTENTIAL).
FT DISULFID 93 184 BY SIMILARITY.
FT LIPID 329 329 PALMITATE (BY SIMILARITY).
FT VARSPLIC 169 169 L -> LERSLNQGLGQDFHA (IN ISOFORM 5-
FT HT4(F)).
FT VARSPLIC 359 388 RDAVECGGQWESQCHPPATSPLVAAQPSDT -> SGCSPVS
FT SFLLLFCNRPVPV (IN ISOFORM 5-HT4(E)).
FT VARSPLIC 359 388 RDAVECGGQWESQCHPPATSPLVAAQPSDT -> SSGTETD
FT RRNFGIRKRRLTKPS (IN ISOFORM 5-HT4(D)).
FT VARSPLIC 360 388 DAVECGGQWESQCHPPATSPLVAAQPSDT -> F (IN
FT ISOFORM 5-HT4(C)).
FT VARSPLIC 360 388 DAVECGGQWESQCHPPATSPLVAAQPSDT -> YTVLHRGH
FT HQELEKLPIHNDPESLESCF (IN ISOFORM 5-
FT HT4(A)).
SQ SEQUENCE 388 AA; 43761 MW; 7FCFEC60E7BDF560 CRC64;
MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV
SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY
AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN
STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP
QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL
GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD
AVECGGQWES QCHPPATSPL VAAQPSDT
//
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