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LOCUS NP_001832 360 aa linear PRI 18-DEC-2001
DEFINITION cannabinoid receptor 2 (macrophage) [Homo sapiens].
ACCESSION NP_001832
PID g4502929
VERSION NP_001832.1 GI:4502929
DBSOURCE REFSEQ: accession NM_001841.1
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 360)
AUTHORS Munro,S., Thomas,K.L. and Abu-Shaar,M.
TITLE Molecular characterization of a peripheral receptor for
cannabinoids
JOURNAL Nature 365 (6441), 61-65 (1993)
MEDLINE 93368659
PUBMED 7689702
REFERENCE 2 (residues 1 to 360)
AUTHORS Galiegue,S., Mary,S., Marchand,J., Dussossoy,D., Carriere,D.,
Carayon,P., Bouaboula,M., Shire,D., Le Fur,G. and Casellas,P.
TITLE Expression of central and peripheral cannabinoid receptors in human
immune tissues and leukocyte subpopulations
JOURNAL Eur. J. Biochem. 232 (1), 54-61 (1995)
MEDLINE 96048028
PUBMED 7556170
REFERENCE 3 (residues 1 to 360)
AUTHORS Shire,D., Calandra,B., Rinaldi-Carmona,M., Oustric,D., Pessegue,B.,
Bonnin-Cabanne,O., Le Fur,G., Caput,D. and Ferrara,P.
TITLE Molecular cloning, expression and function of the murine CB2
peripheral cannabinoid receptor
JOURNAL Biochim. Biophys. Acta 1307 (2), 132-136 (1996)
MEDLINE 96283804
PUBMED 8679694
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from X74328.1.
Summary: The cannabinoid delta-9-tetrahydrocannabinol is the
principal psychoactive ingredient of marijuana. The proteins
encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1)
gene have the characteristics of a guanine nucleotide-binding
protein (G-protein)-coupled receptor for cannabinoids. They inhibit
adenylate cyclase activity in a dose-dependent, stereoselective,
and pertussis toxin-sensitive manner. These proteins have been
found to be involved in the cannabinoid-induced CNS effects
(including alterations in mood and cognition) experienced by users
of marijuana. The cannabinoid receptors are members of family 1 of
the G-protein-coupled receptors.
FEATURES Location/Qualifiers
source 1..360
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.11"
Protein 1..360
/product="cannabinoid receptor 2 (macrophage)"
Region 50..299
/region_name="7 transmembrane receptor (rhodopsin family)"
/db_xref="CDD:pfam00001"
/note="7tm_1"
CDS 1..360
/pseudo
/gene="CNR2"
/db_xref="LocusID:1269"
/db_xref="MIM:605051"
/coded_by="NM_001841.1:127..1209"
ORIGIN
1 meecwvteia ngskdgldsn pmkdymilsg pqktavavlc tllgllsale nvavlylils
61 shqlrrkpsy lfigslagad flasvvfacs fvnfhvfhgv dskavfllki gsvtmtftas
121 vgsllltaid rylclrypps ykalltrgra lvtlgimwvl salvsylplm gwtccprpcs
181 elfplipndy llswllfiaf lfsgiiytyg hvlwkahqhv aslsghqdrq vpgmarmrld
241 vrlaktlglv lavllicwfp vlalmahsla ttlsdqvkka fafcsmlcli nsmvnpviya
301 lrsgeirssa hhclahwkkc vrglgseake eaprssvtet eadgkitpwp dsrdldlsdc
361
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