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LOCUS SCX3_BUTOC 64 aa linear INV 16-OCT-2001
DEFINITION Neurotoxin III.
ACCESSION P01485
PID g134354
VERSION P01485 GI:134354
DBSOURCE swissprot: locus SCX3_BUTOC, accession P01485;
class: standard.
created: Jul 21, 1986.
sequence updated: Jul 21, 1986.
annotation updated: Oct 16, 2001.
xrefs: gi: gi: 69530
xrefs (non-sequence databases): HSSP P01484, InterPro IPR003614,
InterPro IPR002061, InterPro IPR001219, Pfam PF00537, PRINTS
PR00284, ProDom PD000908, SMART SM00505
KEYWORDS Neurotoxin; Sodium channel inhibitor; Amidation.
SOURCE Tunisian scorpion.
ORGANISM Buthus occitanus tunetanus
Eukaryota; Metazoa; Arthropoda; Chelicerata; Arachnida; Scorpiones;
Buthoidea; Buthidae; Buthus.
REFERENCE 1 (residues 1 to 64)
AUTHORS Vargas,O., Gregoire,J., Martin,M.-F., Bechis,G. and Rochat,H.
TITLE Neurotoxins from the venoms of two scorpions: Buthus occitanus
tunetanus and Buthus occitanus mardochei
JOURNAL Toxicon 20, 79-79 (1982)
REMARK SEQUENCE.
COMMENT [FUNCTION] BINDS TO SODIUM CHANNELS AND INHIBITS THE INACTIVATION
OF THE ACTIVATED CHANNELS, THEREBY BLOCKING NEURONAL TRANSMISSION.
[SUBCELLULAR LOCATION] SECRETED.
[SIMILARITY] BELONGS TO THE ALPHA/BETA-SCORPION TOXIN FAMILY.
ALPHA-TOXIN SUBFAMILY.
FEATURES Location/Qualifiers
source 1..64
/organism="Buthus occitanus tunetanus"
/db_xref="taxon:6871"
Protein 1..64
/product="Neurotoxin III"
Bond bond(12,63)
/bond_type="disulfide"
/note="BY SIMILARITY."
Bond bond(16,36)
/bond_type="disulfide"
/note="BY SIMILARITY."
Bond bond(22,46)
/bond_type="disulfide"
/note="BY SIMILARITY."
Bond bond(26,48)
/bond_type="disulfide"
/note="BY SIMILARITY."
Site 64
/site_type="amidation"
ORIGIN
1 vkdgyivddr nctyfcgrna ycneectklk gesgycqwas pygnacycyk vpdhvrtkgp
61 grcn
//
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