1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
|
LOCUS HSTMPO1 2509 bp DNA PRI 01-JUL-1995
DEFINITION Human thymopoietin (TMPO) gene, exon 1.
ACCESSION U18266
VERSION U18266.1 GI:885676
KEYWORDS .
SEGMENT 1 of 6
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2509)
AUTHORS Harris,C.A., Andryuk,P.J., Cline,S.W., Siekierka,J.J. and
Goldstein,G.
TITLE Structure and mapping of the human thymopoietin (TMPO) gene and
relationship of TMPO beta to rat lamin-associated polypeptide 2
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2509)
AUTHORS Harris,C.A.
TITLE Direct Submission
JOURNAL Submitted (07-DEC-1994) Crafford A. Harris, Immunobiology Research
Institute, Route 22 East, Annandale, NJ 08801-0999, USA
FEATURES Location/Qualifiers
source 1..2509
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q22; 64% (% distance from centromere to telomere)"
/clone="P1.516 (DMPC-HFFno.1B-0943F)"
/clone_lib="DuPont Merck Hum Fibroblast P1 Library no.1
Series B (compressed) (Genome Systems Inc)"
5'UTR one-of(1888,1901)..2200
/gene="TMPO"
gene join(1888..2509,U18267.1:1..270,U18268.1:1..309,
U18270.1:1..6905,U18269.1:1..128,U18271.1:1..3234)
/gene="TMPO"
exon one-of(1888,1901)..2479
/gene="TMPO"
/number=1
CDS join(2201..2479,U18267.1:120..246,U18268.1:130..288,
U18270.1:4691..4788,U18269.1:82..>128)
/gene="TMPO"
/codon_start=1
/product="thymopoietin beta"
/protein_id="AAB60434.1"
/db_xref="GI:885684"
/translation="MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQH
LTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKP
RQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSST
PLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVE
HNQSYSQAGITETEWTSGS"
CDS join(2201..2479,U18267.1:120..246,U18268.1:130..288,
U18270.1:39..1558)
/gene="TMPO"
/codon_start=1
/product="thymopoietin alpha"
/protein_id="AAB60433.1"
/db_xref="GI:885683"
/translation="MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQH
LTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKP
RQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSST
PLPTISSSAENTRQNGSNDSDRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGF
FQGISFPEISTRPPLGSTELQAAKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNL
FISCKSSHDRCLEKSSSSSSQPEHSAMLVSTAASPSLIKETTTGYYKDIVENICGREK
SGIQPLCPERSHISDQSPLSSKRKALEESESSQLISPPLAQAIRDYVNSLLVQGGVGS
LPGTSNSMPPLDVENIQKRIDQSKFQETEFLSPPRKVPRLSEKSVEERDSGSFVAFQN
IPGSELMSSFAKTVVSHSLTTLGLEVAKQSQHDKIDASELSFPFHESILKVIEEEWQQ
VDRQLPSLACKYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTESCNQQLD
LALCRAYEAAASALQIATHTAFVAKAMQADISEAAQILSSDPSRTHQALGILSKTYDA
ASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGE
VCKVIKKRGNKH"
BASE COUNT 667 a 587 c 656 g 599 t
ORIGIN
1 gaattcagat agaatgtaga caagagggat ggtgaggaaa acctacggca agcagctcta
61 taatttctgg aaagtgacca ggaggctcgt ggatgatggc aggaaggaga gtagaaagtg
121 atttagccag aagatatgaa cttcaaatat ttttgaagca gaaaagagca gaaatggttt
181 ggaagtagca atcaggacca aagagaccac ccaaactcaa tagcccaacc tcttagcctt
241 agggtatgca gaatctgaaa agtgtaatct caattttgga gctctacagc agtaaatctg
301 caagtaacca cctgtagcta atgtccaggg attaaaaaaa agataatgaa aatgtttttg
361 cccaggaaac attaatttca ggcgtatcta gaatgcagtt cttgcattat acgtactggg
421 ttaccagtca ttgcaaagtc atggtccttt gcctctcagc tcagttcccc ttctgaagat
481 aaaaacattt gcctatgtgt ccagggaagc tgtgaggaca aaaaaccaag caacttttac
541 aagggatcat aaaaacctac ctaacaactt gctaattaaa acctgatttt taatttgcat
601 tattgagctt aataccattg cttaaatgta tgtgaatact gagattttta taaaggaatt
661 agttacctct aggaaaataa ttatcactaa aagaaataat atcgcaattt gaataaaagt
721 aagtcgctta aatcatagga aacattttta gtgaaggcgt ttgttttaaa tgtattctaa
781 cctagcaatg tagaaagcag gcaaacattt aaaaaaaatt taaccagttt ctaaaacata
841 gtttggagct cagattctgg ggaaatgatt aacacaccct acatccaagg tctcctttcc
901 tttctagaaa gaaagcatct ttaaacatac atattcatca gaaatacaaa tatttgtcat
961 cagtgatact aatttccagg caaacatttt aattgcagtc aatgtattag attctaccag
1021 gttttaattt ggatcggtaa tacgggtttg attagggttc taggcctaat tataggtcac
1081 tagtcttcct ttaggattat gtaccatctg ttattttaaa ttgaccattg agggggttcc
1141 caagggttct ccttcgtttt gttatcaaac gttaggttta ggattcttgc gggtggtggg
1201 atccaaagcc agagacggtt tcaacaaaaa tgcaagcgcg aatttgtctt gcgtctgaac
1261 gcactgttca aattaaacaa tttagacatg ccccaactat gacactaaga agtgaatggt
1321 atagtacact tttgtcacaa attcaagggt aatttaagtg cccgatggta gaggtctggc
1381 ttcccctggg tttctggaac aaaagaagcg ttcgcgagga gaggggtaac tccccgccct
1441 ccccctccca aagtaaatca aatcaaggaa tatgagtgcc tgcagacaag cctcgcttct
1501 tttcttcccc ttcagggcta gcgtttgggg aaggcaaggc tgcggctact cttggagctt
1561 cagtgtcccg ggaggaagaa aggcccagcc aagggtcctc acactggcgt ggaattcggc
1621 gcgttcgtag gcgatcgacc ccagagacga aagctgcttc tcaagctggg ggagggagag
1681 gaaacggcgc acaaaagcag tacgacctgt cccttatcgg cgtctaaggg gaagggtgga
1741 gaaaacgaaa acagaagcgg gccgggagcc tcggctcccg ccccagcgcc ttttaaactg
1801 cgtttctacc tcctctcgct cagcgcggcg gctaatggaa cccgcgcgag ccgtctcgcc
1861 aatcaccgcc gcgcttcctc ccgtcgcccg ccaatggcgg cgcgcgttct tggggcgtgg
1921 gcgaagcagg ctgctcgcct cctgcctgta gtgtgtgggc tggggttggt gcgagcttcc
1981 agcttggccg cagttggttc gtagttcggc tctggggtct tttgtgtccg ggtctggctt
2041 ggctttgtgt ccgcgagttt ttgttccgct ccgcagcgct cttcccgggc aggagccgtg
2101 aggctcggag gcggcagcgc ggtccccggc caggagcaag cgcgccggcg tgagcggcgg
2161 cggcaaaggc tgtggggagg gggcttcgca gatccccgag atgccggagt tcctggaaga
2221 cccctcggtc ctgacaaaag acaagttgaa gagtgagttg gtcgccaaca atgtgacgct
2281 gccggccggg gagcagcgca aagacgtgta cgtccagctc tacctgcagc acctcacggc
2341 tcgcaaccgg ccgccgctcc ccgccggcac caacagcaag gggcccccgg acttctccag
2401 tgacgaagag cgcgagccca ccccggtcct cggctctggg gccgccgccg cgggccggag
2461 ccgagcagcc gtcggcaggg taaggacgcg gggccggggc tacaaaggc
//
|
