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# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.0 (March 2010); http://hmmer.org/
# Copyright (C) 2010 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: h01.hmm
# target sequence database: /home/bow/db/hmmer/uniprot_sprot.fasta
# output directed to file: hmmer_cases/text_hmmsearch_spc_notextw.out
# per-seq hits tabular output: hmmer_cases/tab_hmmsearch_spc_notextw.out
# per-dom hits tabular output: hmmer_cases/domtab_hmmsearch_spc_notextw.out
# max ASCII text line length: unlimited
# sequence reporting threshold: score >= 480
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: Pkinase [M=260]
Accession: PF00069.17
Description: Protein kinase domain
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
8.4e-147 492.3 0.0 1.1e-72 249.3 0.0 2.1 2 sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha-2 OS=Mus musculus GN=Rps6ka2 PE=2 SV=1
2.7e-146 490.7 0.0 8.7e-73 249.7 0.0 2.1 2 sp|Q63531|KS6A1_RAT Ribosomal protein S6 kinase alpha-1 OS=Rattus norvegicus GN=Rps6ka1 PE=1 SV=1
2.2e-145 487.7 0.0 4.6e-72 247.4 0.0 2.1 2 sp|Q15418|KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens GN=RPS6KA1 PE=1 SV=2
2.5e-145 487.5 0.0 7.5e-72 246.7 0.0 2.1 2 sp|P18652|KS6AA_CHICK Ribosomal protein S6 kinase 2 alpha OS=Gallus gallus GN=RPS6KA PE=2 SV=1
2.4e-144 484.2 0.0 2.4e-70 241.7 0.0 2.1 2 sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 OS=Homo sapiens GN=RPS6KA2 PE=1 SV=2
5e-144 483.2 0.0 3.9e-70 241.0 0.0 2.2 2 sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1
5e-144 483.2 0.0 3.9e-70 241.0 0.0 2.2 2 sp|P18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 OS=Mus musculus GN=Rps6ka3 PE=1 SV=2
Domain annotation for each sequence (and alignments):
>> sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha-2 OS=Mus musculus GN=Rps6ka2 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 241.2 0.0 4.6e-75 3.5e-70 1 260 [] 59 318 .. 59 318 .. 0.95
2 ! 249.3 0.0 1.5e-77 1.1e-72 1 260 [] 415 672 .. 415 672 .. 0.97
Alignments for each domain:
== domain 1 score: 241.2 bits; conditional E-value: 4.6e-75
EEEEEEEEEETTEEEEEEEE...TTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakk...kktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhpwl 260
+ell+ lG+Gs+GkV+ ++k ++ g+ +A+K+lkk + k + + +++ E il++++Hp+ivkl+ +f+t+ +lyl+l++++ggdlf+ l+ke ++ee++k+++ +++ +l++lH gii+rDLKpeNiLld++g++ki+DFGl+k+++ +++++++++gt eYmAPEv++ ++++t+++D+Ws+Gv+++e+ltg+lpf+g+ d++e+++ ilk kl ++ s +e+++l++ l++++p +Rl +eei++hp++
sp|Q9WUT3|KS6A2_MOUSE 59 FELLKVLGQGSYGKVFLVRKvtgSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLTGSLPFQGK---DRKETMALILKAKLGMPQFLS----AEAQSLLRALFKRNPCNRLGagvdgVEEIKRHPFF 318
67899**********7666611155667*****************99999****************************************************************************************************************************.******************************...999999999999999998866....99******************9999999*****997 PP
== domain 2 score: 249.3 bits; conditional E-value: 1.5e-77
EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
ye++e +G Gs+++++++++k t ++AvKi++k++++ ++ E++il + +Hpni++l +v+ + +++ylv+e+++gg+l d + +++++se+e+ +++++i++ ++ylHs+g++HrDLKp+NiL +++ +i+DFG+ak+l +++ l t + t +++APEvl+ +++y++++DvWslG++ly++l g +pf + +++ +e++++i ++k+ + +++s s+ +kd+++k+l+ dp++Rlta ++lkhpw+
sp|Q9WUT3|KS6A2_MOUSE 415 YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWI 672
7899***********************************98......9*******99**************************************************************************98544444888**********************************.***************************************************************************************7 PP
>> sp|Q63531|KS6A1_RAT Ribosomal protein S6 kinase alpha-1 OS=Rattus norvegicus GN=Rps6ka1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 239.2 0.0 1.9e-74 1.4e-69 1 258 [. 62 319 .. 62 321 .. 0.94
2 ! 249.7 0.0 1.1e-77 8.7e-73 2 260 .] 419 675 .. 418 675 .. 0.97
Alignments for each domain:
== domain 1 score: 239.2 bits; conditional E-value: 1.9e-74
EEEEEEEEEETTEEE...EEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSG CS
Pkinase 1 yelleklGsGsfGkV...ykakkkktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhp 258
+ell+ lG+GsfGkV k+++ ++g+ +A+K+lkk + k + + +++ E il+ ++Hp++vkl+ +f+t+ +lyl+l++++ggdlf+ l+ke ++ee++k+++ +++ gl++lHs gii+rDLKpeNiLld++g++k++DFGl+k++ +++k+++++gt eYmAPEv++ ++++t+++D+Ws+Gv+++e+ltg+lpf+g+ d++e++ ilk kl ++ s +e+++l++ l++++pa+Rl aeei++h
sp|Q63531|KS6A1_RAT 62 FELLKVLGQGSFGKVflvRKVTRPDNGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN-RQGHTHSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS----TEAQSLLRALFKRNPANRLGsgpdgAEEIKRHI 319
67899**********4444555666777****************999999****************************************************************************************************************************.******************************...999999999999999998866....89*****************98888888888885 PP
== domain 2 score: 249.7 bits; conditional E-value: 1.1e-77
EEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
Pkinase 2 elleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
++e++G Gs+++++++++k t+ ++AvK+++k++++ ++ E++il + +Hpni++l +v+ +++++ylv+e+++gg+l d + +++ +se+e+ +++++i + +eylHs+g++HrDLKp+NiL +++ +i+DFG+ak+l +++ l t + t +++APEvl+ +++y++ +D+WslGv+ly++l g +pf + +++ +e++ +i+++k + ++++ se++kdl++k+l+ dp++Rlta+++l+hpw+
sp|Q63531|KS6A1_RAT 419 IVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKPSNILYVDESGNpeclRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEEILTRISSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWI 675
6789**********************************98......9*******99**********************************9***************************************98554445999**********************************.***************************************************************************************7 PP
>> sp|Q15418|KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens GN=RPS6KA1 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 238.6 0.0 2.9e-74 2.2e-69 1 258 [. 62 319 .. 62 321 .. 0.94
2 ! 247.4 0.0 6e-77 4.6e-72 1 260 [] 418 675 .. 418 675 .. 0.97
Alignments for each domain:
== domain 1 score: 238.6 bits; conditional E-value: 2.9e-74
EEEEEEEEEETTEEE...EEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSG CS
Pkinase 1 yelleklGsGsfGkV...ykakkkktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhp 258
+ell+ lG+GsfGkV k+++ ++g+ +A+K+lkk + k + + +++ E il+ ++Hp++vkl+ +f+t+ +lyl+l++++ggdlf+ l+ke ++ee++k+++ +++ gl++lHs gii+rDLKpeNiLld++g++k++DFGl+k++ +++k+++++gt eYmAPEv++ ++++++++D+Ws+Gv+++e+ltg+lpf+g+ d++e++ ilk kl ++ s +e+++l++ l++++pa+Rl aeei++h
sp|Q15418|KS6A1_HUMAN 62 FELLKVLGQGSFGKVflvRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS----TEAQSLLRALFKRNPANRLGsgpdgAEEIKRHV 319
67899**********4444555566667****************999999****************************************************************************************************************************.******************************...999999999999999998866....89*****************98888889988885 PP
== domain 2 score: 247.4 bits; conditional E-value: 6e-77
EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
y ++e++G Gs+++++++++k t+ ++AvK+++k++++ ++ E++il + +Hpni++l +v+ + +++ylv+e+++gg+l d + +++ +se+e+ +++ +i + +eylHs+g++HrDLKp+NiL +++ +i+DFG+ak+l +++ l t + t +++APEvl+ +++y++ +D+WslG++ly++l g +pf + +++ +e++ +i ++k + ++++ se++kdl++k+l+ dp++Rlta+++l+hpw+
sp|Q15418|KS6A1_HUMAN 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNpeclRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWV 675
67899**********************************98......9*******99**********************************9***************************************98554445999**********************************.***************************************************************************************6 PP
>> sp|P18652|KS6AA_CHICK Ribosomal protein S6 kinase 2 alpha OS=Gallus gallus GN=RPS6KA PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 239.0 0.0 2.1e-74 1.6e-69 1 259 [. 80 338 .. 80 339 .. 0.95
2 ! 246.7 0.0 9.8e-77 7.5e-72 1 260 [] 435 692 .. 435 692 .. 0.97
Alignments for each domain:
== domain 1 score: 239.0 bits; conditional E-value: 2.1e-74
EEEEEEEEEETTEEEEEEEET...TTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSGG CS
Pkinase 1 yelleklGsGsfGkVykakkk...ktgkkvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhpw 259
+ell+ lG+GsfGkV+ ++k ++++ +A+K+lkk + k + + +++ E il+ ++Hp++vkl+ +f+t+ +lyl+l++++ggdlf+ l+ke ++ee++k+++ +++ gl++lHs gii+rDLKpeNiLld++g++k++DFGl+k++ +++k+++++gt eYmAPEv++ ++++++++D+Ws+Gv+++e+ltg+lpf+g+ d++e++ ilk kl ++ s +e+++l++ l++++pa+Rl aeei++hp+
sp|P18652|KS6AA_CHICK 80 FELLKVLGQGSFGKVFLVRKItppDSNHLYAMKVLKKATLKVRDRVRTKIERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS----AEAQSLLRALFKRNPANRLGsgpdgAEEIKRHPF 338
67899**********7777661115677**************99999888****************************************************************************************************************************.******************************...999999999999999998866....99*****************999999*******98 PP
== domain 2 score: 246.7 bits; conditional E-value: 9.8e-77
EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
y ++e +G Gs+++++++++k+t+ ++AvK+++k++++ ++ E++il + +Hpni++l +v+ + +++ylv+e+++gg+l d + +++ +se+e+ +++ +i++ +eylHs+g++HrDLKp+NiL +++ +i+DFG+ak+l +++ l t + t +++APEvl+ +++y++ +D+WslGv+ly++l g++pf + +++ +e++ +i ++k + + ++++ s+ +kdl++k+l+ dp++Rlta+++l+hpw+
sp|P18652|KS6AA_CHICK 435 YVVKEAIGVGSYSVCKRCIHKTTNMEYAVKVIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYVDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDEGCDIWSLGVLLYTMLAGCTPFANGPSDTPEEILTRIGGGKFSVNGGNWDTISDVAKDLVSKMLHVDPHQRLTAKQVLQHPWI 692
568899*********************************98......9*******99**********************************9***************************************98554444888**********************************.***************************************************************************************7 PP
>> sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 OS=Homo sapiens GN=RPS6KA2 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 241.7 0.0 3.2e-75 2.4e-70 1 260 [] 59 318 .. 59 318 .. 0.95
2 ! 240.7 0.0 6.4e-75 4.9e-70 1 260 [] 415 672 .. 415 672 .. 0.97
Alignments for each domain:
== domain 1 score: 241.7 bits; conditional E-value: 3.2e-75
EEEEEEEEEETTEEEEEEEETTTTE...EEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgk...kvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhpwl 260
+ell+ lG+Gs+GkV+ ++k k ++ +A+K+lkk + k + + +++ E il++++Hp+ivkl+ +f+t+ +lyl+l++++ggdlf+ l+ke ++ee++k+++ +++ +l++lHs gii+rDLKpeNiLld++g++ki+DFGl+k++ +++++++++gt eYmAPEv++ ++++t+++D+Ws+Gv+++e+ltg+lpf+g+ d++e+++ ilk kl ++ s e+++l++ l++++p +Rl +eei++hp++
sp|Q15349|KS6A2_HUMAN 59 FELLKVLGQGSYGKVFLVRKVKGSDagqLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLTGSLPFQGK---DRKETMALILKAKLGMPQFLS----GEAQSLLRALFKRNPCNRLGagidgVEEIKRHPFF 318
67899**********7777665544444*****************99999****************************************************************************************************************************.******************************...999999999999999888866....89******************9999999*****997 PP
== domain 2 score: 240.7 bits; conditional E-value: 6.4e-75
EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
ye++e +G Gs+++++++++k t +++AvKi++k++++ ++ E++il + +Hpni++l +v+ + + +ylv+e+++gg+l d + +++ +se+e+ +++ +i + ++ylHs+g++HrDLKp+NiL +++ +++DFG+ak+l ++ l t + t +++APEvl+ +++y++++D+WslG++ly++l g +pf + +++ +e++++i ++k+ + +++s s+ +kd+++k+l+ dp++Rlta+++lkhpw+
sp|Q15349|KS6A2_HUMAN 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSE------EIEILLRYgQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSpesiRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLK-RQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
7899***********************************98......9*******99***************************************************************************9554445888**********************************.***************************************************************************************6 PP
>> sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 240.3 0.0 8.7e-75 6.6e-70 1 260 [] 68 327 .. 68 327 .. 0.95
2 ! 241.0 0.0 5.1e-75 3.9e-70 1 260 [] 422 679 .. 422 679 .. 0.97
Alignments for each domain:
== domain 1 score: 240.3 bits; conditional E-value: 8.7e-75
EEEEEEEEEETTEEEEEEEETTTTE...EEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgk...kvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhpwl 260
+ell+ lG+GsfGkV+ +kk + ++ +A+K+lkk + k + + +++ E il +++Hp+ivkl+ +f+t+ +lyl+l++++ggdlf+ l+ke ++ee++k+++ +++ +l++lHs gii+rDLKpeNiLld++g++k++DFGl+k+ +++k+++++gt eYmAPEv++ ++++t+++D+Ws+Gv+++e+ltg+lpf+g+ d++e++ +ilk kl ++ s +e+++l++ l++++pa+Rl +eei++h+++
sp|P51812|KS6A3_HUMAN 68 FELLKVLGQGSFGKVFLVKKISGSDarqLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLTGTLPFQGK---DRKETMTMILKAKLGMPQFLS----PEAQSLLRMLFKRNPANRLGagpdgVEEIKRHSFF 327
67899**********8888876655455****************999999****************************************************************************************************9***********************.******************************...999999999999988888866....9******************9888888999999886 PP
== domain 2 score: 241.0 bits; conditional E-value: 5.1e-75
EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
ye++e +G Gs+++++++++k t+ ++AvKi++k++++ ++ E++il + +Hpni++l +v+ + +++y+v+e+++gg+l d + +++ +se+e+ ++ +i + +eylH +g++HrDLKp+NiL +++ +i+DFG+ak+l +++ l t + t +++APEvl+ +++y++++D+WslGv+ly++ltg +pf + +++ +e++++i ++k + + ++s s+++kdl++k+l+ dp++Rlta+ +l+hpw+
sp|P51812|KS6A3_HUMAN 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------EIEILLRYgQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
7899***********************************88......9*******99**********************************9***************************************98554444888**********************************.***************************************************************************************7 PP
>> sp|P18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 OS=Mus musculus GN=Rps6ka3 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 240.3 0.0 8.7e-75 6.6e-70 1 260 [] 68 327 .. 68 327 .. 0.95
2 ! 241.0 0.0 5.1e-75 3.9e-70 1 260 [] 422 679 .. 422 679 .. 0.97
Alignments for each domain:
== domain 1 score: 240.3 bits; conditional E-value: 8.7e-75
EEEEEEEEEETTEEEEEEEETTTTE...EEEEEEEEHHHCCCCCCHHHHHHHHHHHHHSSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEEEE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTT.....HHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgk...kvAvKilkkeeekskkektavrElkilkklsHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgevkiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRlt.....aeeilkhpwl 260
+ell+ lG+GsfGkV+ +kk + ++ +A+K+lkk + k + + +++ E il +++Hp+ivkl+ +f+t+ +lyl+l++++ggdlf+ l+ke ++ee++k+++ +++ +l++lHs gii+rDLKpeNiLld++g++k++DFGl+k+ +++k+++++gt eYmAPEv++ ++++t+++D+Ws+Gv+++e+ltg+lpf+g+ d++e++ +ilk kl ++ s +e+++l++ l++++pa+Rl +eei++h+++
sp|P18654|KS6A3_MOUSE 68 FELLKVLGQGSFGKVFLVKKISGSDarqLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLTGTLPFQGK---DRKETMTMILKAKLGMPQFLS----PEAQSLLRMLFKRNPANRLGagpdgVEEIKRHSFF 327
67899**********8888876655455****************999999****************************************************************************************************9***********************.******************************...999999999999988888866....9******************9888888999999886 PP
== domain 2 score: 241.0 bits; conditional E-value: 5.1e-75
EEEEEEEEEETTEEEEEEEETTTTEEEEEEEEEHHHCCCCCCHHHHHHHHHHHHH.SSSSB--EEEEEEETTEEEEEEE--TS-BHHHHHHHHHST-HHHHHHHHHHHHHHHHHHHHTTEE-S--SGGGEEEETTTEE....EE--GTT.E..EECSS-C-S--S-GGGS-HHHHCCS-CTHHHHHHHHHHHHHHHHHHSS-TTSSSHHCCTHHHHSSHHH......TTS.....HHHHHHHHHHT-SSGGGSTTHHHHHTSGGG CS
Pkinase 1 yelleklGsGsfGkVykakkkktgkkvAvKilkkeeekskkektavrElkilkkl.sHpnivkllevfetkdelylvleyveggdlfdllkkegklseeeikkialqilegleylHsngiiHrDLKpeNiLldkkgev....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgklpfsgeseedqleliekilkkkleedepkssskseelkdlikkllekdpakRltaeeilkhpwl 260
ye++e +G Gs+++++++++k t+ ++AvKi++k++++ ++ E++il + +Hpni++l +v+ + +++y+v+e+++gg+l d + +++ +se+e+ ++ +i + +eylH +g++HrDLKp+NiL +++ +i+DFG+ak+l +++ l t + t +++APEvl+ +++y++++D+WslGv+ly++ltg +pf + +++ +e++++i ++k + + ++s s+++kdl++k+l+ dp++Rlta+ +l+hpw+
sp|P18654|KS6A3_MOUSE 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------EIEILLRYgQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNpesiRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
7899***********************************88......9*******99**********************************9***************************************98554444888**********************************.***************************************************************************************7 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (260 nodes)
Target sequences: 535698 (190107059 residues)
Passed MSV filter: 21115 (0.0394159); expected 10714.0 (0.02)
Passed bias filter: 15859 (0.0296044); expected 10714.0 (0.02)
Passed Vit filter: 4968 (0.00927388); expected 535.7 (0.001)
Passed Fwd filter: 3953 (0.00737916); expected 5.4 (1e-05)
Initial search space (Z): 535698 [actual number of targets]
Domain search space (domZ): 7 [number of targets reported over threshold]
# CPU time: 39.18u 0.36s 00:00:39.54 Elapsed: 00:00:10.84
# Mc/sec: 4559.76
//
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