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ENTRY EC 6.2.1.25 Enzyme
NAME benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
CLASS Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
SYSNAME benzoate:CoA ligase (AMP-forming)
REACTION ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
ALL_REAC R01422
SUBSTRATE ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
PRODUCT AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
COMMENT Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
REFERENCE 1
AUTHORS Hutber, G.N. and Ribbons, D.W.
TITLE Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
JOURNAL J. Gen. Microbiol. 129 (1983) 2413-2420.
REFERENCE 2 [PMID:2857161]
AUTHORS Schennen U, Braun K, Knackmuss HJ.
TITLE Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
JOURNAL J. Bacteriol. 161 (1985) 321-5.
ORGANISM Pseudomonas sp.
PATHWAY ec00362 Benzoate degradation
ec00627 Aminobenzoate degradation
ec01100 Metabolic pathways
ec01120 Microbial metabolism in diverse environments
ORTHOLOGY K04105 4-hydroxybenzoate-CoA ligase
K04110 benzoate-CoA ligase
GENES REU: Reut_A1327
REH: H16_A1412(h16_A1412) H16_B1918
RME: Rmet_1224(bzdA)
CTI: RALTA_A1325 RALTA_B1617
CNC: CNE_1c14400(bclA) CNE_2c18780(boxD)
BXE: Bxe_A1419 Bxe_C0896
BPH: Bphy_1543
BPY: Bphyt_2700
BGL: bglu_2g11460
BUG: BC1001_2395
BGE: BC1002_1980
BGF: BC1003_1063
BRH: RBRH_00494
BPT: Bpet3574
AXY: AXYL_05035
AKA: TKWG_07570
RFR: Rfer_0216
POL: Bpro_1624 Bpro_2983
PNA: Pnap_2948
VEI: Veis_0730
DAC: Daci_0076
DEL: DelCs14_0077
VAP: Vapar_0089
VPE: Varpa_0102
CTT: CtCNB1_0097
RTA: Rta_22340
LCH: Lcho_3655
EBA: ebA2757(bclA) ebA5301(bclA)
AZO: azo3052(bzdA)
TMZ: Tmz1t_3136
GME: Gmet_2143
GLO: Glov_2397
GEO: Geob_0200
GEM: GM21_2825
DMA: DMR_19390
DAS: Daes_3238
DPR: Despr_3172
DTI: Desti_5323
BJA: blr1077
BRA: BRADO6791
BBT: BBta_0747 BBta_6637(badA)
RPA: RPA0661(badA) RPA0669(hbaA)
RPB: RPB_4656
RPC: RPC_1016 RPC_1025
RPD: RPD_1526 RPD_1534
RPE: RPE_0592 RPE_0604
RPT: Rpal_0728 Rpal_0736
RPX: Rpdx1_4117 Rpdx1_4125
RVA: Rvan_0044
SIL: SPO3697(badA-1)
JAN: Jann_0669
SWI: Swit_0829
RPM: RSPPHO_01133
MAG: amb2869
GYC: GYMC61_2828
GYA: GYMC52_1957
GCT: GC56T3_1519
SCB: SCAB_8391
SCT: SCAT_5491
SCY: SCATT_54890
BSD: BLASA_2555(badA)
AMD: AMED_8609(badA)
AMN: RAM_35745 RAM_44185
AMM: AMES_6861(badA) AMES_8478(badA)
PDX: Psed_1491
DBLINKS ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2
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