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ID 143E_HUMAN STANDARD; PRT; 255 AA.
AC P42655; P29360; Q63631;
DT 01-NOV-1995 (REL. 32, CREATED)
DT 01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE)
DT 15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE 14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L
DE SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E).
GN YWHAE.
OS HOMO SAPIENS (HUMAN), RATTUS NORVEGICUS (RAT), MUS MUSCULUS (MOUSE),
OS BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN [1]
RP SEQUENCE FROM N.A.
RC SPECIES=HUMAN;
RX MEDLINE; 95372385.
RA CONKLIN D.S., GALAKTIONOV K., BEACH D.;
RT "14-3-3 proteins associate with cdc25 phosphatases.";
RL PROC. NATL. ACAD. SCI. U.S.A. 92:7892-7896(1995).
RN [2]
RP SEQUENCE FROM N.A.
RC SPECIES=HUMAN; TISSUE=HEART;
RA LUK S.C.W., LEE C.Y., WAYE M.M.Y.;
RL SUBMITTED (JUN-1995) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN [3]
RP SEQUENCE FROM N.A.
RC SPECIES=HUMAN;
RX MEDLINE; 96300316.
RA JIN D.Y., LYU M.S., KOZAK C.A., JEANG K.T.;
RT "Function of 14-3-3 proteins.";
RL NATURE 382:308-308(1996).
RN [4]
RP SEQUENCE FROM N.A.
RC SPECIES=HUMAN; TISSUE=LIVER;
RX MEDLINE; 97011338.
RA CHONG S.S., TANIGAMI A., ROSCHKE A.V., LEDBETTER D.H.;
RT "14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on
RT chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome
RT region.";
RL GENOME RES. 6:735-741(1996).
RN [5]
RP SEQUENCE FROM N.A.
RC SPECIES=HUMAN;
RA TANIGAMI A., CHONG S.S., LEDBETTER D.H.;
RT "14-3-3 epsilon genomic sequence.";
RL SUBMITTED (AUG-1998) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN [6]
RP SEQUENCE FROM N.A.
RC SPECIES=RAT, AND SHEEP; TISSUE=PINEAL GLAND;
RX MEDLINE; 94296566.
RA ROSEBOOM P.H., WELLER J.L., BABILA T., AITKEN A., SELLERS L.A.,
RA MOFFET J.R., NAMBOODIRI M.A., KLEIN D.C.;
RT "Cloning and characterization of the epsilon and zeta isoforms of the
RT 14-3-3 proteins.";
RL DNA CELL BIOL. 13:629-640(1994).
RN [7]
RP SEQUENCE FROM N.A.
RC SPECIES=RAT; TISSUE=LIVER;
RX MEDLINE; 95122474.
RA ALAM R., HACHIYA N., SAKAGUCHI M., SHUN-ICHIRO K., IWANAGA S.,
RA KITAJIMA M., MIHARA K., OMURA T.;
RT "cDNA cloning and characterization of mitochondrial import
RT stimulation factor (MSF) purified from rat liver cytosol.";
RL J. BIOCHEM. 116:416-425(1994).
RN [8]
RP SEQUENCE FROM N.A.
RC SPECIES=RAT; TISSUE=BRAIN;
RX MEDLINE; 96280718.
RA GAO L., GU X.B., YU D.S., YU R.K., ZENG G.;
RT "Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha 2,3-
RT sialyltransferase.";
RL BIOCHEM. BIOPHYS. RES. COMMUN. 224:103-107(1996).
RN [9]
RP SEQUENCE FROM N.A.
RC SPECIES=MOUSE; STRAIN=SWISS; TISSUE=KIDNEY;
RX MEDLINE; 95269876.
RA MCCONNELL J.E., ARMSTRONG J.F., BARD J.B.;
RT "The mouse 14-3-3 epsilon isoform, a kinase regulator whose
RT expression pattern is modulated in mesenchyme and neuronal
RT differentiation.";
RL DEV. BIOL. 169:218-228(1995).
RN [10]
RP SEQUENCE FROM N.A.
RC SPECIES=MOUSE; STRAIN=129/SV;
RA TAKIHARA Y., IRIE K., NOMURA M., MOTALEB M., MATSUMOTO K.,
RA SHIMADA K.;
RL SUBMITTED (SEP-1996) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN [11]
RP SEQUENCE FROM N.A.
RC SPECIES=BOVINE;
RA JONES J.M., NIIKURA T., PINKE R.M., GUO W., MOLDAY L., LEYKAM J.,
RA MCCONNELL D.G.;
RT "Expression of 14-3-3 proteins in bovine retinal photoreceptors.";
RL SUBMITTED (JAN-1998) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN [12]
RP SEQUENCE OF 1-152; 165-184 AND 216-255.
RC SPECIES=SHEEP; TISSUE=BRAIN;
RX MEDLINE; 92283271.
RA TOKER A., SELLERS L.A., AMESS B., PATEL Y., HARRIS A., AITKEN A.;
RT "Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3)
RT from sheep brain. Amino acid sequence of phosphorylated forms.";
RL EUR. J. BIOCHEM. 206:453-461(1992).
RN [13]
RP SEQUENCE OF 1-23 AND 125-140.
RC SPECIES=SHEEP; TISSUE=BRAIN;
RX MEDLINE; 90345949.
RA TOKER A., ELLIS C.A., SELLERS L.A., AITKEN A.;
RT "Protein kinase C inhibitor proteins. Purification from sheep brain
RT and sequence similarity to lipocortins and 14-3-3 protein.";
RL EUR. J. BIOCHEM. 191:421-429(1990).
CC -!- FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE
CC PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND
CC STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL
CC REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH
CC KINASES.
CC -!- SUBUNIT: HOMODIMER.
CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC.
CC -!- TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND
CC ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO
CC PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES.
CC -!- SIMILARITY: BELONGS TO THE 14-3-3 FAMILY.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC or send an email to license@isb-sib.ch).
CC --------------------------------------------------------------------------
DR EMBL; U28936; G984319; -.
DR EMBL; U20972; G902787; -.
DR EMBL; U43399; G1184725; -.
DR EMBL; U54778; G1561719; -.
DR EMBL; AB017103; D1033501; -.
DR EMBL; AB017098; D1033501; JOINED.
DR EMBL; AB017099; D1033501; JOINED.
DR EMBL; AB017100; D1033501; JOINED.
DR EMBL; AB017101; D1033501; JOINED.
DR EMBL; AB017102; D1033501; JOINED.
DR EMBL; M84416; G294504; -.
DR EMBL; D30739; G487918; -.
DR EMBL; Z19599; G57966; -.
DR EMBL; U53882; G1469948; -.
DR EMBL; L07914; G530049; -.
DR EMBL; D87663; G1526545; -.
DR EMBL; AF043735; G3676399; -.
DR PIR; S10806; S10806.
DR PIR; S10807; S10807.
DR MGD; MGI:894689; YWHAE.
DR PROSITE; PS00796; 1433_1; 1.
DR PROSITE; PS00797; 1433_2; 1.
DR PFAM; PF00244; 14-3-3; 1.
KW BRAIN; NEURONE; ACETYLATION; MULTIGENE FAMILY.
FT MOD_RES 1 1 ACETYLATION.
FT CONFLICT 73 73 K -> T (IN REF. 8).
FT CONFLICT 120 120 F -> S (IN REF. 8).
FT CONFLICT 123 123 K -> Y (IN REF. 8).
FT CONFLICT 129 129 H -> Y (IN REF. 13).
SQ SEQUENCE 255 AA; 29174 MW; 40A43E62 CRC32;
MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW
RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF
YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF
YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE
EQNKEALQDV EDENQ
//
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