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LOCUS NC_005816 9609 bp DNA circular BCT 21-JUL-2008
DEFINITION Yersinia pestis biovar Microtus str. 91001 plasmid pPCP1, complete
sequence.
ACCESSION NC_005816
VERSION NC_005816.1 GI:45478711
DBLINK Project: 58037
KEYWORDS .
SOURCE Yersinia pestis biovar Microtus str. 91001
ORGANISM Yersinia pestis biovar Microtus str. 91001
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
Enterobacteriaceae; Yersinia.
REFERENCE 1 (bases 1 to 9609)
AUTHORS Zhou,D., Tong,Z., Song,Y., Han,Y., Pei,D., Pang,X., Zhai,J., Li,M.,
Cui,B., Qi,Z., Jin,L., Dai,R., Du,Z., Wang,J., Guo,Z., Wang,J.,
Huang,P. and Yang,R.
TITLE Genetics of metabolic variations between Yersinia pestis biovars
and the proposal of a new biovar, microtus
JOURNAL J. Bacteriol. 186 (15), 5147-5152 (2004)
PUBMED 15262951
REFERENCE 2 (bases 1 to 9609)
AUTHORS Song,Y., Tong,Z., Wang,J., Wang,L., Guo,Z., Han,Y., Zhang,J.,
Pei,D., Zhou,D., Qin,H., Pang,X., Han,Y., Zhai,J., Li,M., Cui,B.,
Qi,Z., Jin,L., Dai,R., Chen,F., Li,S., Ye,C., Du,Z., Lin,W.,
Wang,J., Yu,J., Yang,H., Wang,J., Huang,P. and Yang,R.
TITLE Complete genome sequence of Yersinia pestis strain 91001, an
isolate avirulent to humans
JOURNAL DNA Res. 11 (3), 179-197 (2004)
PUBMED 15368893
REFERENCE 3 (bases 1 to 9609)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (16-MAR-2004) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 4 (bases 1 to 9609)
AUTHORS Song,Y., Tong,Z., Wang,L., Han,Y., Zhang,J., Pei,D., Wang,J.,
Zhou,D., Han,Y., Pang,X., Zhai,J., Chen,F., Qin,H., Wang,J., Li,S.,
Guo,Z., Ye,C., Du,Z., Lin,W., Wang,J., Yu,J., Yang,H., Wang,J.,
Huang,P. and Yang,R.
TITLE Direct Submission
JOURNAL Submitted (24-APR-2003) The Institute of Microbiology and
Epidemiology, Academy of Military Medical Sciences, No. 20,
Dongdajie Street, Fengtai District, Beijing 100071, People's
Republic of China
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AE017046.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..9609
/organism="Yersinia pestis biovar Microtus str. 91001"
/mol_type="genomic DNA"
/strain="91001"
/db_xref="taxon:229193"
/plasmid="pPCP1"
/biovar="Microtus"
repeat_region 1..1954
gene 87..1109
/locus_tag="YP_pPCP01"
/db_xref="GeneID:2767718"
CDS 87..1109
/locus_tag="YP_pPCP01"
/note="similar to corresponding CDS from previously
sequenced pPCP plasmid of Yersinia pestis KIM (AF053945)
and CO92 (AL109969), also many transposase entries for
insertion sequence IS100 of Yersinia pestis. Contains
IS21-like element transposase, HTH domain
(Interpro|IPR007101)"
/codon_start=1
/transl_table=11
/product="putative transposase"
/protein_id="NP_995567.1"
/db_xref="GI:45478712"
/db_xref="GeneID:2767718"
/translation="MVTFETVMEIKILHKQGMSSRAIARELGISRNTVKRYLQAKSEP
PKYTPRPAVASLLDEYRDYIRQRIADAHPYKIPATVIAREIRDQGYRGGMTILRAFIR
SLSVPQEQEPAVRFETEPGRQMQVDWGTMRNGRSPLHVFVAVLGYSRMLYIEFTDNMR
YDTLETCHRNAFRFFGGVPREVLYDNMKTVVLQRDAYQTGQHRFHPSLWQFGKEMGFS
PRLCRPFRAQTKGKVERMVQYTRNSFYIPLMTRLRPMGITVDVETANRHGLRWLHDVA
NQRKHETIQARPCDRWLEEQQSMLALPPEKKEYDVHLDENLVNFDKHPLHHPLSIYDS
FCRGVA"
misc_feature 87..959
/locus_tag="YP_pPCP01"
/note="Transposase and inactivated derivatives [DNA
replication, recombination, and repair]; Region: COG4584"
/db_xref="CDD:34222"
misc_feature <111..209
/locus_tag="YP_pPCP01"
/note="Helix-turn-helix domain of Hin and related
proteins, a family of DNA-binding domains unique to
bacteria and represented by the Hin protein of Salmonella.
The basic HTH domain is a simple fold comprised of three
core helices that form a right-handed...; Region:
HTH_Hin_like; cl01116"
/db_xref="CDD:186341"
misc_feature 438..812
/locus_tag="YP_pPCP01"
/note="Integrase core domain; Region: rve; cl01316"
/db_xref="CDD:194099"
gene 1106..1888
/locus_tag="YP_pPCP02"
/db_xref="GeneID:2767716"
CDS 1106..1888
/locus_tag="YP_pPCP02"
/note="similar to corresponding CDS form previously
sequenced pPCP plasmid of Yersinia pestis KIM (AF053945)
and CO92 (AL109969), also many ATP-binding protein entries
for insertion sequence IS100 of Yersinia pestis. Contains
Chaperonin clpA/B (Interpro|IPR001270). Contains
ATP/GTP-binding site motif A (P-loop) (Interpro|IPR001687,
Molecular Function: ATP binding (GO:0005524)). Contains
Bacterial chromosomal replication initiator protein, DnaA
(Interpro|IPR001957, Molecular Function: DNA binding
(GO:0003677), Molecular Function: DNA replication origin
binding (GO:0003688), Molecular Function: ATP binding
(GO:0005524), Biological Process: DNA replication
initiation (GO:0006270), Biological Process: regulation of
DNA replication (GO:0006275)). Contains AAA ATPase
(Interpro|IPR003593, Molecular Function: nucleotide
binding (GO:0000166))"
/codon_start=1
/transl_table=11
/product="transposase/IS protein"
/protein_id="NP_995568.1"
/db_xref="GI:45478713"
/db_xref="GeneID:2767716"
/translation="MMMELQHQRLMALAGQLQLESLISAAPALSQQAVDQEWSYMDFL
EHLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQLQSLRSLSFIER
NENIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQ
RGVMAPRLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGD
AALTSAMLDRILHHSHVVQIKGESYRLRQKRKAGVIAEANPE"
misc_feature 1109..1885
/locus_tag="YP_pPCP02"
/note="transposase/IS protein; Provisional; Region:
PRK09183"
/db_xref="CDD:181681"
misc_feature 1367..>1669
/locus_tag="YP_pPCP02"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes...; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature 1433..1456
/locus_tag="YP_pPCP02"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature order(1436..1459,1619..1621)
/locus_tag="YP_pPCP02"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature 1607..1624
/locus_tag="YP_pPCP02"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
gene 2925..3119
/gene="rop"
/locus_tag="YP_pPCP03"
/gene_synonym="rom"
/db_xref="GeneID:2767717"
CDS 2925..3119
/gene="rop"
/locus_tag="YP_pPCP03"
/gene_synonym="rom"
/note="Best Blastp hit =gi|16082682|ref|NP_395229.1|
(NC_003132) putative replication regulatory protein
[Yersinia pestis], gi|5763813|emb|CAB531 66.1| (AL109969)
putative replication regulatory protein [Yersinia pestis];
similar to gb|AAK91579.1| (AY048853), RNAI modulator
protein Rom [Salmonella choleraesuis], Contains Regulatory
protein Rop (Interpro|IPR000769)"
/codon_start=1
/transl_table=11
/product="putative replication regulatory protein"
/protein_id="NP_995569.1"
/db_xref="GI:45478714"
/db_xref="GeneID:2767717"
/translation="MNKQQQTALNMARFIRSQSLILLEKLDALDADEQAAMCERLHEL
AEELQNSIQARFEAESETGT"
misc_feature 2925..3107
/gene="rop"
/locus_tag="YP_pPCP03"
/gene_synonym="rom"
/note="Rop protein; Region: Rop; pfam01815"
/db_xref="CDD:145136"
gene 3486..3857
/locus_tag="YP_pPCP04"
/db_xref="GeneID:2767720"
CDS 3486..3857
/locus_tag="YP_pPCP04"
/note="Best Blastp hit = gi|321919|pir||JQ1541
hypothetical 16.9K protein - Salmonella typhi murium
plasmid NTP16."
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="NP_995570.1"
/db_xref="GI:45478715"
/db_xref="GeneID:2767720"
/translation="MSKKRRPQKRPRRRRFFHRLRPPDEHHKNRRSSQRWRNPTGLKD
TRRFPPEAPSCALLFRPCRLPDTSPPFSLREAWRFLIAHAVGISVRCRSFAPSWAVCT
NPPFSPTTAPYPVTIVLSPTR"
misc_feature 3498..3626
/locus_tag="YP_pPCP04"
/note="ProfileScan match to entry PS50323 ARG_RICH,
E-value 8.981"
gene 4343..4780
/gene="pim"
/locus_tag="YP_pPCP05"
/db_xref="GeneID:2767712"
CDS 4343..4780
/gene="pim"
/locus_tag="YP_pPCP05"
/note="similar to many previously sequenced pesticin
immunity protein entries of Yersinia pestis plasmid pPCP,
e.g. gi| 16082683|,ref|NP_395230.1| (NC_003132) ,
gi|1200166|emb|CAA90861.1| (Z54145 ) , gi|1488655|
emb|CAA63439.1| (X92856) , gi|2996219|gb|AAC62543.1|
(AF053945) , and gi|5763814|emb|CAB531 67.1| (AL109969)"
/codon_start=1
/transl_table=11
/product="pesticin immunity protein"
/protein_id="NP_995571.1"
/db_xref="GI:45478716"
/db_xref="GeneID:2767712"
/translation="MGGGMISKLFCLALIFLSSSGLAEKNTYTAKDILQNLELNTFGN
SLSHGIYGKQTTFKQTEFTNIKSNTKKHIALINKDNSWMISLKILGIKRDEYTVCFED
FSLIRPPTYVAIHPLLIKKVKSGNFIVVKEIKKSIPGCTVYYH"
gene complement(4815..5888)
/gene="pst"
/locus_tag="YP_pPCP06"
/db_xref="GeneID:2767721"
CDS complement(4815..5888)
/gene="pst"
/locus_tag="YP_pPCP06"
/note="Best Blastp hit =|16082684|ref|NP_395231.1|
(NC_003132) pesticin [Yersinia pestis],
gi|984824|gb|AAA75369.1| (U31974) pesticin [Yersinia
pestis], gi|1488654|emb|CAA63438.1| (X92856) pesticin
[Yersinia pestis], gi|2996220|gb|AAC62544.1| (AF053945)
pesticin [Yersinia pestis], gi|5763815|emb|CAB53168.1|
(AL1099 69) pesticin [Yersinia pestis]"
/codon_start=1
/transl_table=11
/product="pesticin"
/protein_id="NP_995572.1"
/db_xref="GI:45478717"
/db_xref="GeneID:2767721"
/translation="MSDTMVVNGSGGVPAFLFSGSTLSSYRPNFEANSITIALPHYVD
LPGRSNFKLMYIMGFPIDTEMEKDSEYSNKIRQESKISKTEGTVSYEQKITVETGQEK
DGVKVYRVMVLEGTIAESIEHLDKKENEDILNNNRNRIVLADNTVINFDNISQLKEFL
RRSVNIVDHDIFSSNGFEGFNPTSHFPSNPSSDYFNSTGVTFGSGVDLGQRSKQDLLN
DGVPQYIADRLDGYYMLRGKEAYDKVRTAPLTLSDNEAHLLSNIYIDKFSHKIEGLFN
DANIGLRFSDLPLRTRTALVSIGYQKGFKLSRTAPTVWNKVIAKDWNGLVNAFNNIVD
GMSDRRKREGALVQKDIDSGLLK"
variation 5910..5911
/note="compared to AF053945"
/replace=""
variation 5933^5934
/note="compared to AL109969"
/replace="a"
variation 5933^5934
/note="compared to AF053945"
/replace="aa"
variation 5948
/note="compared to AL109969"
/replace="c"
gene 6005..6421
/locus_tag="YP_pPCP07"
/db_xref="GeneID:2767719"
CDS 6005..6421
/locus_tag="YP_pPCP07"
/note="Best Blastp hit = gi|16082685|ref|NP_395232.1|
(NC_003132) hypothetical protein [Yersinia pestis],
gi|5763816|emb|CAB53169.1| (AL109969) hypothetical protein
[Yersinia pestis]"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="NP_995573.1"
/db_xref="GI:45478718"
/db_xref="GeneID:2767719"
/translation="MKFHFCDLNHSYKNQEGKIRSRKTAPGNIRKKQKGDNVSKTKSG
RHRLSKTDKRLLAALVVAGYEERTARDLIQKHVYTLTQADLRHLVSEISNGVGQSQAY
DAIYQARRIRLARKYLSGKKPEGVEPREGQEREDLP"
variation 6525
/note="compared to AF053945 and AL109969"
/replace="c"
gene 6664..7602
/gene="pla"
/locus_tag="YP_pPCP08"
/db_xref="GeneID:2767715"
CDS 6664..7602
/gene="pla"
/locus_tag="YP_pPCP08"
/EC_number="3.4.23.48"
/note="outer membrane protease; involved in virulence in
many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in
Escherichia coli OmpT can degrade antimicrobial peptides;
in Yersinia Pla activates plasminogen during infection; in
Shigella flexneria SopA cleaves the autotransporter IcsA"
/codon_start=1
/transl_table=11
/product="outer membrane protease"
/protein_id="NP_995574.1"
/db_xref="GI:45478719"
/db_xref="GeneID:2767715"
/translation="MKKSSIVATIITILSGSANAASSQLIPNISPDSFTVAASTGMLS
GKSHEMLYDAETGRKISQLDWKIKNVAILKGDISWDPYSFLTLNARGWTSLASGSGNM
DDYDWMNENQSEWTDHSSHPATNVNHANEYDLNVKGWLLQDENYKAGITAGYQETRFS
WTATGGSYSYNNGAYTGNFPKGVRVIGYNQRFSMPYIGLAGQYRINDFELNALFKFSD
WVRAHDNDEHYMRDLTFREKTSGSRYYGTVINAGYYVTPNAKVFAEFTYSKYDEGKGG
TQIIDKNSGDSVSIGGDAAGISNKNYTVTAGLQYRF"
misc_feature 6664..7599
/gene="pla"
/locus_tag="YP_pPCP08"
/note="Omptin family; Region: Omptin; cl01886"
/db_xref="CDD:186487"
gene complement(7789..8088)
/locus_tag="YP_pPCP09"
/db_xref="GeneID:2767713"
CDS complement(7789..8088)
/locus_tag="YP_pPCP09"
/note="Best Blastp hit = gi|16082687|ref|NP_395234.1|
(NC_003132) putative transcriptional regulator [Yersinia
pestis], gi|5763818|emb|CAB53171.1| (AL109969) putative
transcriptional regulator [Yersinia pestis]."
/codon_start=1
/transl_table=11
/product="putative transcriptional regulator"
/protein_id="NP_995575.1"
/db_xref="GI:45478720"
/db_xref="GeneID:2767713"
/translation="MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQK
QVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMGGKLSLDVELPTGRRVAFHV"
misc_feature complement(7837..7995)
/locus_tag="YP_pPCP09"
/note="Helix-turn-helix XRE-family like proteins.
Prokaryotic DNA binding proteins belonging to the
xenobiotic response element family of transcriptional
regulators; Region: HTH_XRE; cl09100"
/db_xref="CDD:195788"
gene complement(8088..8360)
/locus_tag="YP_pPCP10"
/db_xref="GeneID:2767714"
CDS complement(8088..8360)
/locus_tag="YP_pPCP10"
/note="Best Blastp hit = gi|16082688|ref|NP_395235.1|
(NC_003132) hypothetical protein [ Yersinia pestis],
gi|5763819|emb|CAB53172.1| (AL109969) hypothetical protein
[Yersinia pestis]"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="NP_995576.1"
/db_xref="GI:45478721"
/db_xref="GeneID:2767714"
/translation="MADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRA
FYAFDPIRRAIVLCAGDKSNDKRFYEKLVRIAEDEFTAHLNTLESK"
misc_feature complement(8091..>8357)
/locus_tag="YP_pPCP10"
/note="Phage derived protein Gp49-like (DUF891); Region:
Gp49; cl01470"
/db_xref="CDD:194142"
variation 8529^8530
/note="compared to AL109969"
/replace="tt"
ORIGIN
1 tgtaacgaac ggtgcaatag tgatccacac ccaacgcctg aaatcagatc cagggggtaa
61 tctgctctcc tgattcagga gagtttatgg tcacttttga gacagttatg gaaattaaaa
121 tcctgcacaa gcagggaatg agtagccggg cgattgccag agaactgggg atctcccgca
181 ataccgttaa acgttatttg caggcaaaat ctgagccgcc aaaatatacg ccgcgacctg
241 ctgttgcttc actcctggat gaataccggg attatattcg tcaacgcatc gccgatgctc
301 atccttacaa aatcccggca acggtaatcg ctcgcgagat cagagaccag ggatatcgtg
361 gcggaatgac cattctcagg gcattcattc gttctctctc ggttcctcag gagcaggagc
421 ctgccgttcg gttcgaaact gaacccggac gacagatgca ggttgactgg ggcactatgc
481 gtaatggtcg ctcaccgctt cacgtgttcg ttgctgttct cggatacagc cgaatgctgt
541 acatcgaatt cactgacaat atgcgttatg acacgctgga gacctgccat cgtaatgcgt
601 tccgcttctt tggtggtgtg ccgcgcgaag tgttgtatga caatatgaaa actgtggttc
661 tgcaacgtga cgcatatcag accggtcagc accggttcca tccttcgctg tggcagttcg
721 gcaaggagat gggcttctct ccccgactgt gtcgcccctt cagggcacag actaaaggta
781 aggtggaacg gatggtgcag tacacccgta acagttttta catcccacta atgactcgcc
841 tgcgcccgat ggggatcact gtcgatgttg aaacagccaa ccgccacggt ctgcgctggc
901 tgcacgatgt cgctaaccaa cgaaagcatg aaacaatcca ggcccgtccc tgcgatcgct
961 ggctcgaaga gcagcagtcc atgctggcac tgcctccgga gaaaaaagag tatgacgtgc
1021 atcttgatga aaatctggtg aacttcgaca aacaccccct gcatcatcca ctctccatct
1081 acgactcatt ctgcagagga gtggcgtgat gatggaactg caacatcaac gactgatggc
1141 gctcgccggg cagttgcaac tggaaagcct tataagcgca gcgcctgcgc tgtcacaaca
1201 ggcagtagac caggaatgga gttatatgga cttcctggag catctgcttc atgaagaaaa
1261 actggcacgt catcaacgta aacaggcgat gtatacccga atggcagcct tcccggcggt
1321 gaaaacgttc gaagagtatg acttcacatt cgccaccgga gcaccgcaga agcaactcca
1381 gtcgttacgc tcactcagct tcatagaacg taatgaaaat atcgtattac tggggccatc
1441 aggtgtgggg aaaacccatc tggcaatagc gatgggctat gaagcagtcc gtgcaggtat
1501 caaagttcgc ttcacaacag cagcagatct gttacttcag ttatctacgg cacaacgtca
1561 gggccgttat aaaacgacgc ttcagcgtgg agtaatggcc ccccgcctgc tcatcattga
1621 tgaaataggc tatctgccgt tcagtcagga agaagcaaag ctgttcttcc aggtcatcgc
1681 taaacgttac gaaaagagcg caatgatcct gacatccaat ctgccgttcg ggcagtggga
1741 tcaaacgttc gccggtgatg cagcactgac ctcagcgatg ctggaccgta tcttacacca
1801 ctcacatgtc gttcaaatca aaggagaaag ctatcgactc agacagaaac gaaaggccgg
1861 ggttatagca gaagctaatc ctgagtaaaa cggtggatca atattgggcc gttggtggag
1921 atataagtgg atcacttttc atccgtcgtt gacaccctga tgaattcacg tgttcacgcc
1981 tgaataacaa gaatgccgga gatacgcagt catatttttt acacaattct ctaatcccga
2041 caaggtcgta ggtcgttata ggaaaattct tagcaccatt ccggaacaat cagaacagca
2101 ggccatgaac gactgacaac attacgaata taaaaaacgc acccgggcca gacattcccc
2161 ctactgatta aaccagccgg acttgtccac ggaacggtct ttttaaaccg acacacagtc
2221 tgagtacaga tacatgtcac gatgatgcag gattagcgga agagtgtgag cacgtttccg
2281 ggaactgtgg tgaaccatag ctcaatattc gagtgagggc ataccggaaa cgcgctcaga
2341 ttcgttgtaa cgcgattttc cgtaccgggc aattttttca gttgtttttt cgtttcatgt
2401 cgtcagaaac gttctgagcg cgtttccggc atctgatgct acgcaaacca tccccatggt
2461 cagttgacag ccggaaacac gcgggtgtcg ttttagcgta tcgacgggac ggcgtcgaga
2521 agcacaaaaa acagatgttg tactcagtca gttgttttac agacagcact gcggcagatt
2581 gaaaaagtac cgtactttca ggaatgtcca gaaaccatgt gtcagacttc gttctccccc
2641 ttccgggtga atttttttgt catccgttca ggaatctctt tataacgatt actccatttc
2701 aggatttttt atgtggcgtt tactacaggc aggatattca aaggcaaaaa aatcccccgg
2761 aacaggcgga acccggacag ggggagaacg aatcgctaaa taattttcgt agttgtattt
2821 cccatcgttg ctactgcaac gggatgaatt tgccgcagtt tatcctgtaa aacaatcctg
2881 atttactcac actccacata tcactgacgg agcacaacgg aatagtgaac aaacaacaac
2941 aaactgcgct gaatatggcg cgatttatca gaagccagag cctgatactg cttgaaaaac
3001 tggatgctct ggatgccgac gagcaggcgg ccatgtgtga acgactgcac gaactcgcgg
3061 aagaactcca gaacagcatc caggctcgct ttgaagccga aagtgaaaca ggaacataac
3121 gaagctcccg gagacggtca cagcttgtct gtgaacggat gccgggagca gacaagcccg
3181 tcagggcgcg tcagcgggtt ttagcgggtg tcggggcgca gccatgaccc agtcacgtag
3241 cgatagcgga gtgtatactg gcttagtcat gcggcatcag tgcggattgt atgaaaagtg
3301 caccatgtac ggtgtgaaat gccgcacaga tgcgtaagga gaacatgcag atgccgatgc
3361 tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggtg
3421 tctgctcact caaaagcggt gatactgtta tccacacaat caggggataa cgccggaaag
3481 aacatgtgag caaaaaacga agaccccaga aaaggccgcg ccggaggcgc tttttccata
3541 ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc
3601 cgacaggact taaagatacc aggcgtttcc ccccggaagc tccctcgtgc gctctcctgt
3661 tccgaccctg ccgcttaccg gatacctctc cgcctttctc ccttcgggaa gcgtggcgct
3721 ttctcatagc tcacgctgtt ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg
3781 ctgtgtgcac gaaccccccg ttcagcccga ccactgcgcc ttatccggta actatcgtct
3841 tgagtccaac ccggtaagac acgactttac gccactggca gcagccattg gtaactgaaa
3901 agtggattta gatacgcaga actcttgaag ttgaagcctt atcgcggcta cactgaaagg
3961 acagcatttg gtatctgtgc tccacttaag ccagctacca caggttagaa agcctgagaa
4021 acttctaacc ttcgaaagaa cccacgcctg agaacgtggg ttttttcgtt tacaggcagc
4081 agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct actgaattgc
4141 gctcccgatc agttcagcag aagattatga tggggttcta tgggtattgc tgcggtaaca
4201 cccatgttac ttgaggttgt atgtagtctg tgtagaatta tacacataag gcttaaactg
4261 ctcttttttt tcaatatgca attggaagtt cattgactac ataaatagat tattccaaat
4321 aatttattta tgtaagaaca ggatgggagg gggaatgatc tcaaagttat tttgcttggc
4381 tctcatattt ttatcatcaa gtggccttgc agaaaaaaac acatatacag caaaagacat
4441 cttgcaaaac ctagaattaa atacctttgg caattcattg tctcatggca tctatgggaa
4501 acagacaacc ttcaagcaaa ccgagtttac aaatattaaa agcaacacca aaaaacacat
4561 tgcacttatc aataaagaca actcatggat gatatcatta aaaatactag gaattaagag
4621 agatgagtat actgtctgtt ttgaagattt ctctctaata agaccgccaa catatgtagc
4681 catacatcct ctacttataa aaaaagtaaa atctggaaac tttatagtag tgaaagaaat
4741 aaagaaatct atccctggtt gcactgtata ttatcattaa tagcaagccc ctcattatta
4801 tgaggggctc atggttattt taacaatcca ctatcgatat ctttttgcac cagagcgccc
4861 tctcgtttac gtctgtcaga cattccatca acaatattat taaaagcatt tacaaggcca
4921 ttccagtctt ttgcgataac tttattccat actgtgggag cagttctgga taacttaaac
4981 cctttttgat atccaataga caccagtgct gtacgggttc tcaacggtaa atcgctgaac
5041 cgaagaccga tattagcgtc attgaaaaga ccttcaatct tatgtgagaa tttatcaata
5101 taaatattag ataagagatg agcttcatta tcagaaagcg tcagaggtgc tgttctcact
5161 ttatcataag cctccttccc tcgaagcata taatacccat caagtctatc tgcaatatac
5221 tgagggacac cgtcattcaa taaatcctgt ttgcttcgct gaccaaggtc aaccccggaa
5281 ccgaatgtaa caccggtact gttaaaataa tcgctactag gattagacgg aaaatgactt
5341 gtcggattaa acccttcaaa accattactg gagaaaatat cgtggtcaac aatatttacc
5401 gaacgacgta aaaattcctt cagttgacta atattgtcaa agttaatgac agtgttgtcc
5461 gctaggacga tgcgatttcg gttattattc agaatgtctt cgttctcttt cttatcgaga
5521 tgttcaatag attcggcaat cgttccctca agaaccatga cacggtagac tttcacaccg
5581 tctttttcct gacctgtttc aacagttatt ttctgttcgt aagacacggt cccttcagtt
5641 tttgaaattt tactttcctg gcggatctta tttgaatatt cactgtcttt ctccatctcc
5701 gtatcaatcg gaaaccccat aatgtacatc agtttaaaat tactccggcc aggcagatcc
5761 acataatgtg gtaatgcaat tgtaatcgaa ttagcttcaa aatttggtct gtaactgctt
5821 aatgtacttc cggaaaagag aaaagccgga acaccacctg aaccattcac taccattgta
5881 tctgacataa aaattcctct ttaacacata aaaaaaacaa taagttaaaa aaatactgta
5941 cataaaagca ctgtttttat gtacagtaat aaaattacgc cgctttattt tctctgtcaa
6001 taatatgaaa tttcattttt gtgatctgaa tcactcttat aaaaatcagg aagggaagat
6061 tcgcagcaga aaaacagcac cgggtaacat cagaaaaaaa cagaaaggag ataacgtgag
6121 caaaacaaaa tctggtcgcc accgactgag caaaacagac aaacgcctgc tggctgcact
6181 tgtcgttgcc ggatacgaag aacggacagc ccgtgacctc atccagaaac acgtttacac
6241 actgacacag gccgacctgc gccatctggt cagtgaaatc agtaacggtg tgggacagtc
6301 acaggcctac gatgcgattt accaggcgag acgcattcgt ctcgcccgta aatacctgag
6361 cggaaaaaaa ccggaagggg tggaaccccg ggaagggcag gaacgggaag atttaccata
6421 actcccgtta tcagtaccat cggctcaacg ctcgttgtcg gatctgaaaa attcgctcaa
6481 aagatcatat ttccctggat attttccacc gtttcttatg tgagaaaagt cacataattc
6541 tgtcagacga cgagaaaacg gatatcgatt attgtttaat atttttacat tattaaaaat
6601 gaaattagat aatcagatac aaataatatg ttttcgttca tgcagagaga ttaagggtgt
6661 ctaatgaaga aaagttctat tgtggcaacc attataacta ttctgtccgg gagtgctaat
6721 gcagcatcat ctcagttaat accaaatata tcccctgaca gctttacagt tgcagcctcc
6781 accgggatgc tgagtggaaa gtctcatgaa atgctttatg acgcagaaac aggaagaaag
6841 atcagccagt tagactggaa gatcaaaaat gtcgctatcc tgaaaggtga tatatcctgg
6901 gatccatact catttctgac cctgaatgcc agggggtgga cgtctctggc ttccgggtca
6961 ggtaatatgg atgactacga ctggatgaat gaaaatcaat ctgagtggac agatcactca
7021 tctcatcctg ctacaaatgt taatcatgcc aatgaatatg acctcaatgt gaaaggctgg
7081 ttactccagg atgagaatta taaagcaggt ataacagcag gatatcagga aacacgtttc
7141 agttggacag ctacaggtgg ttcatatagt tataataatg gagcttatac cggaaacttc
7201 ccgaaaggag tgcgggtaat aggttataac cagcgctttt ctatgccata tattggactt
7261 gcaggccagt atcgcattaa tgattttgag ttaaatgcat tatttaaatt cagcgactgg
7321 gttcgggcac atgataatga tgagcactat atgagagatc ttactttccg tgagaagaca
7381 tccggctcac gttattatgg taccgtaatt aacgctggat attatgtcac acctaatgcc
7441 aaagtctttg cggaatttac atacagtaaa tatgatgagg gcaaaggagg tactcagatc
7501 attgataaga atagtggaga ttctgtctct attggcggag atgctgccgg tatttccaat
7561 aaaaattata ctgtgacggc gggtctgcaa tatcgcttct gaaaaataca gatcatatct
7621 ctcttttcat cctcccctag cggggaggat gtctgtggaa aggaggttgg tgtttgacca
7681 accttcagat gtgtgaaaaa tcaccttttt caccataatg acggggcgct cattctgttg
7741 ttttgccttg acattctcca cgtctttcag ggcatggaga aggtcaaatt agacatggaa
7801 cgctactctc cttcctgtag gaagctcaac atccaagctt aatttgcctc ccattgcttc
7861 aacgtaacgc tttaacgtcg ccagctttaa atcatttccg cgctgctcca gctttgttac
7921 tgctggctgg cttataccca tcgcctcagc aacttgtttt tgtgataact ggagttcttc
7981 acgcatcatc tgcaagccga cctcaagaat catctcatct gccatttctt taattcgtgt
8041 ctggctttca ggtgaacgac tggcaatcac ctcatctaat gttctcatta cttgctctcc
8101 agtgtgttca gatgtgctgt aaattcatcc tcagctatac gcaccagttt ttcataaaac
8161 cgcttatcat tacttttatc tcctgcacaa agaacgatag cccgacgaat cggatcgaac
8221 gcataaaagg ctcttatcgg acggccagaa aactgaacgc gaagctcttt catatttttg
8281 taccgagaac ctttcacggt atcggcatat ggcctgggta actcaggtcc gtaaacctgt
8341 agctttttca aatcagccaa aaccttttcc tgaagagcgt cttcttgctc atttagccag
8401 tcgtcaaatc gctggctaaa aagtaccatc cacatgctca accctataac ctgtagctta
8461 ccccactaac aatataacct acgagttata ttttcaagaa aagctggcta tttaacataa
8521 cggcaatttg tacgcaccac tgaaatgcgt tcagcgcgat cacggcaaca gacaggcaaa
8581 aatagcaaca aacctcccga aaaaccgccg cgatcgcgcc tgataaattt taaccttatg
8641 catatctatg cagccaggcg aatcacgaac gaattgcctg cctgatgtaa ctgaaacggg
8701 tgttttttcc tgatttggtg ggcgtggaag acggaacatg aacgggaaaa cagaattcat
8761 gccagatgag cgcgatctgg caattaaggc aaaacacagc aacaaagaca cgccagaatc
8821 gcgcccggat atgttttaac gcgattttca gactcagaca aattcagcag aatgctactc
8881 cattcaccgg gctgatggtg aatacatgcg tatccaggat gagtacattt ctggctctgc
8941 cacagctctg tctgttggca gctttcgcct gtccggaaac ctgcttaaaa cgctcccgaa
9001 aggcctctga accagaaagc aacaaaacac aggccattaa gtaaatcgcg ttaaaacacg
9061 tctgatggat tgctgcaaaa aaaagtccct aatggagcag ggactgttaa acccagtgaa
9121 tagcgtctaa attaaagtaa gaatacgacc aggtactctt cagaaaagag attaatccac
9181 cgcacagaat aatcaacagt aaaaacaaac aaccctgatt ttttattttt ctttttttcg
9241 ataaaaacaa aattaaagaa ataattaatc agaacattcc ttaacttcag ggcattgcct
9301 gtgttccatt ttgtgattag tctgaaactt ccgaaggtgg ataacacccg gtattttttt
9361 gctcacataa agcccctcct tcaggcagag gggctttttc tttgccacca cataaaaaag
9421 gccctcacag gaggtgttct gtgagggcgt atgataagga ctgaatcgat ggttaatatg
9481 tctagtcctg acttttgcat ctccgaatat aaaaccctgt ttaacggcat gcaaaaccaa
9541 aaaataaaaa tgtgacatcg caatgccaga taatattgac gcatgaggga atgcgtaccc
9601 cgacccctg
//
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