1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
|
# STOCKHOLM 1.0
#=GF ID 12TM_1
#=GF AC PF09847.11
#=GF DE Membrane protein of 12 TMs
#=GF PI DUF2074;
#=GF AU COGs;
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE COGs (COG3368)
#=GF GA 33.20 33.20;
#=GF TC 33.60 33.20;
#=GF NC 33.10 32.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF CL CL0181
#=GF DR INTERPRO; IPR018646;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family carries twelve transmembrane regions. It does not
#=GF CC have any characteristic nucleotide-binding-domains of the
#=GF CC GxSGSGKST type. so it may not be an ATP-binding cassette
#=GF CC transporter. However, it may well be a transporter of some
#=GF CC description. ABC transporters always have two nucleotide
#=GF CC binding domains; this has two unusual conserved sequence-motifs:
#=GF CC 'KDhKxhhR' and 'LxxLP'.
#=GF SQ 7
#=GS O29855_ARCFU/39-477 AC O29855.1
#=GS O29125_ARCFU/30-435 AC O29125.1
#=GS Q8U2D3_PYRFU/39-485 AC Q8U2D3.1
#=GS Q5JDA6_THEKO/35-482 AC Q5JDA6.1
#=GS Q97VM1_SACS2/39-451 AC Q97VM1.1
#=GS Q9HM06_THEAC/17-497 AC Q9HM06.1
#=GS Q6L2L5_PICTO/38-510 AC Q6L2L5.1
O29855_ARCFU/39-477 WIRYNALLLKIMFTFAALFSVGPAFFDDKVS....YASSLLSLFFFFLMFGTAYAHGYFQVDL...SYMHTFYSRSDISKVRFYGFFRLFDWPAVIALLS.....LLVLVGMRNPAGLLPALLGFLAVIMGALSIVILLGKRLGSVQTGR.SLRAAFFRIFGLIAWLVSIYGLYLINQLAI......YLMTFKNYEAYDSLFP.......ISYGLWISQPFSAKYAALSLFYF.ALITLLFFYAVRELSKE....EIAKHYGSLK.GWKIKRRGKMTAMVIKDFKQLFRNPQLFVIALLPIYGALM..................QLVFYIKLSEVASVLYLQIFLAITVSSFMSLERSSYITALPLTDLEMKFSKILEGLLIYF.VSMGIVAAVVIYKG.GNLINSLSLFPTGFAVVLVAVQFSRRL.......TSEPVNVE...AVIATLISFFIVLVPAAVGGVAVLILKAPFS...SYAFPVSLAETLAVLAVFALLNRRK
O29125_ARCFU/30-435 SLRVQVAKSFFIMTFLGSFLCWVAFISSGLG.....LSLIFTLSLVFSQIYPAQNIAISASS....RVFEPLRYLPVRFSERMLVVF.FIDSINILAFAT...PTIAVLMVKNLYFGLYSLLWIIAAILLG.YSMVFLYYALFGVKV..RSGFSKSVL..AGILFFAVLVFAL...............RRFQEIPDLTPYLTP......................HLLLLSY..AASSATIKLSTGRVWRSILNPEIVEVKGSSR....LSSGSPLRAMLIKDFRLILRKN.ALFPLIVPLVIVMPNVVSIANMPN........LSIFIITTISTLSTIDLRIIGNLENVDF........LRMLPLSKRGFVMSKACLIFVISFAASLPAGSIAFIVS..QNPFYLFMAFAIPAIVSMLSSLIIFWQ.......KGEEIYFPEV.GFLKWIGLLLVNFGAVYAVLSPRFILSQPVA......DIISSVLTL....LAMTALFEK
Q8U2D3_PYRFU/39-485 NIIWGVFLQSVMYLGLGVMVAVSILYSENEVQKAIFFSSYLIIPFILTLYSTSLATAYLLSS....KAVEPLKPLPLGNLNFIVSLTLLIENLPAFVFLI.....PASLALGNSIASLLGLLWICSTILMG.HSLALFLQIKFSGIHVGKGSVVKTLVKVAGFLI....IAGIYFIVQALMRILEDNIEVIAPIFRKYFIAFP........FAASTIYEPYKS..LVLLALYT.LPFLALYFYDLKRLGEVL...EGIKTYGKVATKYKLTVANPVTAMFRKDYRIIFRKNPYLGTFLSPLLMSIYFIYNLAKEGFPVM.....MTLFSIMGISVLGLVMLDPAFAMDREVF......PFLSSLPIKRREYLLGKMLTVSLSPLTFSAILVLLSCAFNG.TEALLLIPFLASPFLTSSIGILYVKHKM......GNERIELPVL.KFYDGIVMLILSMIPFIIVAIPLFLLSVPKG......YLVSGAIIL....VGALILSKL
Q5JDA6_THEKO/35-482 DLKKTLLFQTAMYAVFGLML.FPSLKGERDA.VLVMASTYAILPFIIAFYATVTNSSYIASL....DLFKPLLPLPIKLGGRYMSVLLLLESLPVMAFMV..PGAVRIGMVVSATSGLLVLLWSAVGLMLG.HVFGLLVYYSFGKTSSGRFADLKSLAKALGVIL....IFGLFYGFSYFQDYVLQNYTSIKESLGGYEFIYP........LSVLSVDRPSFS..APLAGIYI.AILGVAYYVLISRLWVRI..SEGSYTSGRRRRAGGLGVYPPELALMVKDFKTALRNTPVLTGLLVPIVIPIINVAGIFSNPDIGAFGGRLATITFVAALGWVSAVSVETLTKIEVKSF......ELLLSLPLERGRFLRGKLLTMAAIPSAVGV.LALLGLSLKGFSSPIYLPMAVLVPLATCGIALHVYYH........GTEGLALPQG.GILKSLAVWILNAVVVGIIAG.SWYLSYPIA......LLLTAA.......IDALLLWSL
Q97VM1_SACS2/39-451 NAVTIKISNIIAYTIATIVSASISLINKDAP....FSFIFLDLIILANIFTTGLNVIFFVTNY...DLKTFLLSLPLSERDVNRAVFRGIFEFFYYGFLA..SIVIAPISTYMITSSVLQALMAELEIIFF.FSLSFALVMLLGKRI..RLGITSALFRIGTSLIWIVFIMLPYGL...........TFKYVTIPTYILPIFP........FGFLNIEG......LLISLLYTGLSVFFAYKQSLKFLSFRL........NSQYSTKYSIKLRSPLITYLYKDIRGLLRVPQASFLLTIPVFALIFSFFAPV............YAIFYTIFMITTSSIMLIL...LEASGM......QLLLSLPAGLRSSYISKLLIILIIYL.......IDVLIFSFFNRASLSLIMLPSTITSVELSLFISYNNVI.....KGKGMRLA...DPLSFIIREIEINSIIGIASILTFFANIYYS......LLFSVLSLI....MINIVVYKK
Q9HM06_THEAC/17-497 YVNISYGATSFSFIVFSLILVAPSLMEHRIY....TLSSVVLLLFVYSLFINISNSLLFFVSVNINHILDPLRILPVDFPDHVIAVSWFIYTGSSSLFAVLPAIFLAAFLLGDPYILVIGLIWSIFSVLLG.YIIGSSIFVAFGSRISGKRTRSTNILRNVGRIVFLVFVFAIFEIILYNANIV...NGIIPRLPYPYSYFIPIFNIQSTVFFFHGIYMQATG..FIISMVYT.ALASFAFIYVNRKAFYRLLEP.TARNQSRVKTQMKAEVRSRPFSFFSKDLKISSRKSQNLVLLIMPLFFVFPTIMSEVLYAPTSKADPIILYNAMVAFVIVTSSFYSILFLVIEGNGI......SFIKALPLDGNSIIRWKISAPTFIFAVISISTLAAISVKAL.MGAAFYIIIIVDMMLYFVSSTVYNMNRLYRKIPDTADTVNFYSFGGQIAFITTFAFTGLIVGSADIFSLFLQDLLRLNAYFFFLINTVIGI....IVLLFMVFR
Q6L2L5_PICTO/38-510 TILLYYISNSLSFLFFSIVLNGIYYVKGNTN....DISSFGIILFMYIFVIGIYSSLTYINGISINNLLSPVRSLPIKVNTDVPFLSWFIYTGSSYIFIIIPSLLFYYFLVHNLNTIILGLIYAFAMLLFG.FIITAIAFI.....YSSRKPRAHTSLNNFLRILLIFVFLGFFYLIIYDPNILRAYSIYISSLPVYIKYIAFPLNIDYAVYFHPDIIATFFE..YLSSFIIL.LIFFFIYKKIRSRLFYSL..EYSEEVKSTEVTRTKIKRDSISVSFIKKDIKITARKSQNLTYILMPIIFVLPFLFTIISSRQPFLS....LMFSILSLSILISSFYPIFTLIIENNGI......LIINALPINRKDIAKYKAYFSMIFYSIIITVVSIIIMAYKN.IFNLYYVFIIPDLILIFYTAMIINLNRLIKKIPKGASTINYYSF.GVFPTIVLFIVSGIIFGLLISPGIIISEFLYHSIKMSFIFDIIPDL....IIFLIMIKK
#=GC seq_cons slhhthhhpphhahhhulhlsssuhhscphs....hhSohhhL.Flhshahsshsshhhhss....clhcPLhsLPlp.tschhulhhhI.shsshsFhs....hltshhlhs.hsulLsLLauhhsllhG.aslshhlhhhhGthhsuRhuhspslh+.hGhllhhh.lhulahl..h.........hhh.pl.thh.hlhP........hhh.sI.t...t..hlluhlYh.hhhhhhahhshp+Lhhpl....h.cspuphppthplphtu..huhhhKDh+hhhRps.sLshllhPlhhsl..lhs.h............hhlhhlthh.shSslhl.hhhhlEssuh.......hlpuLPlscpphhhuKhhhhhlI.hhhuh.hshhshhhph.tpshhhlhhlssshhsshluhhhshpp.......su-slph..h.uhlshIshhllshlhhulssh.shhLs..hu......hlloss.hl....lhhLlhhc+
//
|
