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# STOCKHOLM 1.0
#=GF ID 3Beta_HSD
#=GF AC PF01073.21
#=GF DE 3-beta hydroxysteroid dehydrogenase/isomerase family
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_504 (release 3.0)
#=GF GA 22.00 22.00;
#=GF TC 22.00 22.00;
#=GF NC 21.90 21.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF WK 3β-Hydroxysteroid_dehydrogenase
#=GF CL CL0063
#=GF RN [1]
#=GF RM 1562516
#=GF RT Structure and tissue-specific expression of 3
#=GF RT beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in
#=GF RT human and rat classical and peripheral steroidogenic tissues.
#=GF RA Labrie F, Simard J, Luu-The V, Pelletier G, Belanger A, Lachance
#=GF RA Y, Zhao HF, Labrie C, Breton N, de Launoit Y, et al
#=GF RL J Steroid Biochem Mol Biol 1992;41:421-435.
#=GF DR INTERPRO; IPR002225;
#=GF DR HOMSTRAD; Epimerase;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene
#=GF CC isomerase (3 beta-HSD) catalyses the oxidation and isomerisation
#=GF CC of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene
#=GF CC steroid precursors into the corresponding 4-ene-ketosteroids
#=GF CC necessary for the formation of all classes of steroid hormones.
#=GF SQ 8
#=GS 3BHS_FOWPN/7-287 AC Q67477.2
#=GS Q98318_MCV1/5-278 AC Q98318.1
#=GS 3BHS_VACCW/5-274 AC P26670.1
#=GS 3BHS1_HUMAN/7-288 AC P14060.2
#=GS 3BHS1_MOUSE/7-288 AC P24815.3
#=GS O22813_ARATH/15-299 AC O22813.1
#=GS HSDD3_ARATH/16-287 AC A9X4U2.2
#=GS ERG26_YEAST/8-280 AC P53199.1
3BHS_FOWPN/7-287 VVTGGCGFLGRHIINNLILFESSLKEVRVYD......IRIDQWLLDLVEKCNII.KIVPVIGDVRNKSTLDEALRSADVVIHIASINDVAG.KFTNDSIMDVNINGTKNVVDSCLYNGVRVLVYTSSYSAVGPNFLGDAMIRGNENTYYQSN..HKEAYPLSKQLSEKYILEANG.TMSNIGLRLCTCALRPLGVFGEYCPVLETLYRRSYKSR.KMYKYADDKVFHSRVYAGNVAWMHILAARNMIENGQ....HSPLCNNVYYCYDTSPTEHYHDFNMHFFNQLGMDLRN.T...CLPL
Q98318_MCV1/5-278 AVTGGGGFIGSYIVRALLQCERTLIELRVID......VRWGTKV..SSRNVNVV....YIYCDVCDTARLCAALEGVDVLIHTAGLVDVMG.EYSEDEIYRANVHGTHSALSACVCAGVRFVVYTSSMEVVGPNMRAEPFV.GDEKTEYESC..HQHCYPRSKAEAEELVLSSNGRRVRGGQ.RMLTCALRPPGVYGEGNQLLLRLAKNYVRMGLHVPRTVCENALQSRVYVGNVAWMHVLAARALQEP......DSRLPGNAYFCYDHSPCMDYEAFNVMLLRSFGVELGGP....RLPR
3BHS_VACCW/5-274 AVTGGAGFLGRYIVKLLISADD.VQEIRVID......IVEDPQP..ITSKVKVIN...YIQCDINDFDKVREALDGVNLIIHTAALVDVFG.KYTDNEIMKVNYYGTQTILAACVDLGIKYLIYTSSMEAIGPNKHGDPFI.GHEHTLYDIS..PGHVYAKSKRMAEQLVMKANNSVIMNGA.KLYTCCLRPTGIYGEGDKLTKVFYEQCKQHGNIMYRTVDDDAVHSRVYVGNVAWMHVLAAKYIQYP......GSEIKGNAYFCYDYSPSCSYDMFNLLLMKPLGIEQGSR........
3BHS1_HUMAN/7-288 LVTGAGGFLGQRIIRLLVKEKE.LKEIRVLD......KAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFG.VTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENT..WPAPYPHSKKLAEKAVLAANGWNLKNGG.TLYTCALRPMYIYGEGSRFLSASINEALNNN.GILSSVGKFSTVNPVYVGNVAWAHILALRALQDPKK....APSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRW...SFPL
3BHS1_MOUSE/7-288 LVTGAGGFVGQRIIKMLVQEKE.LQEVRALD......KVFRPETKEEFSKLQTKTKVTVLEGDILDAQCLRRACQGISVVIHTAAVIDVTG.VIPRQTILDVNLKGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLNGHEEQNHEST..WSDPYPYSKKMAEKAVLAANGSMLKNGG.TLNTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKFSI.ANPVYVENVAWAHILAARGLRDPKK....STSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNASW...SLPL
O22813_ARATH/15-299 VVTGGLGFVGAALCLELVRRG..ARQVRSFD......LRHSSPWSDDLKNSGVR....CIQGDVTKKQDVDNALDGADCVLHLASYGMSGKEMLRFGRCDEVNINGTCNVLEAAFKHEITRIVYVSTYNVVFG...GKEILNGNEGLPYFPLDDHVDAYSRTKSIAEQLVLKSNGRPFKNGGKRMYTCAIRPAAIYGPGEDRHLPRIVTLTKLGLALFKIGEPSVKSDWIYVENLVLAIILASMGLLDDIPGREGQPVAAGQPYFVSDGYPVN.TFEFLRPLLKSLDYDLPKCTISVPFAL
HSDD3_ARATH/16-287 VVLGGRGFIGRSLVSRLLRLGN..WTVRVADSGHTLHLDESDSLLEDALSSGRAS...YHCVDVRDKPQIVKVTEGSYVVFYM.GATDLRS.HDYFD.CYKVIVQGTRNVISACRESGVRKLIYNSTADVVFD..GSQPIRDGDESLRRPLK..FQSMLTDFKAQAEALIKLANN...RDG...LLTCALRSSIVFGPGDTEFVPFLVNLAKSGYAKFILGSGENISDFTYSENVSHAHICAVKALDSQ......MEFVAGKEFFITNLKPVR.FWDFVSHIVEGLGYPRPS.I...KLPV
ERG26_YEAST/8-280 LIIGGSGFLGLHLIQQFFDINP.KPDIHIFD......VRDLPEKLSKQFTFNVDDI.KFHKGDLTSPDDMENAINESKANVVVHCASPMHG..QNPDIYDIVNVKGTRNVIDMCKKCGVNILVYTSSAGVIFN...GQDVHNADETWPIPEV..PMDAYNETKAIAEDMVLKAND.....PSSDFYTVALRPAGIFGPGDRQLVPGLRQVAKLGQSKFQIGDNNNLFDWTYAGNVADAHVLAAQKLLDPKT....RTAVSGETFFITNDTPTY.FWALARTVWKADGHIDKHVI...VLKR
#=GC seq_cons lVTGGuGFlGppIlptLlptcp.lpElRVhD......lchssphh-chppsslts...hlpGDlpDpsplccAlcGssVlIHsAulsDVtG.hhsp-pIhcVNlpGTpNlL-AClpsGVphllYTSSh-VlGPN.hucsllsGcEpp.apss..atcsYscSKphAEchVLpANG..h+NGu.cLhTCALRPsuIYGEGsphlhshlppshKpG.thaphucssshpshVYVGNVAWAHILAA+uLp-Ph.....poslsGpsYFloDsoPsppYcsFNhpLhKshGhchsu.h...sLPl
//
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