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# STOCKHOLM 1.0
#=GF ID Alpha_E1_glycop
#=GF AC PF01589.18
#=GF DE Alphavirus E1 glycoprotein
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_587 (release 4.1)
#=GF GA 25.00 25.00;
#=GF TC 34.50 33.30;
#=GF NC 24.10 23.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF WK Alphavirus
#=GF CL CL0543
#=GF RC This paper includes cryoelectron microscopy images.
#=GF RN [1]
#=GF RM 7867069
#=GF RT Nucleocapsid and glycoprotein organization in an enveloped
#=GF RT virus.
#=GF RA Cheng RH, Kuhn RJ, Olson NH, Rossmann MG, Choi HK, Smith TJ,
#=GF RA Baker TS;
#=GF RL Cell 1995;80:621-630.
#=GF RN [2]
#=GF RM 8995682
#=GF RT Role of glycoprotein PE2 in formation and maturation of the
#=GF RT Sindbis virus spike.
#=GF RA Carleton M, Lee H, Mulvey M, Brown DT;
#=GF RL J Virol 1997;71:1558-1566.
#=GF DR INTERPRO; IPR002548;
#=GF DR TC; 1.A.34;
#=GF DR SCOP; 1rer; fa;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC E1 forms a heterodimer with E2 Pfam:PF00943. The virus spikes
#=GF CC are made up of 80 trimers of these heterodimers (sindbis virus)
#=GF CC [2].
#=GF SQ 2
#=GS POLS_SFV/751-1253 AC P03315.1
#=GS POLS_SFV/751-1253 DR PDB; 2V33 A; 292-382;
#=GS POLS_SFV/751-1253 DR PDB; 2ALA A; 1-384;
#=GS POLS_SFV/751-1253 DR PDB; 1RER A; 1-391;
#=GS POLS_SFV/751-1253 DR PDB; 2V33 B; 292-382;
#=GS POLS_SFV/751-1253 DR PDB; 1RER C; 1-391;
#=GS POLS_SFV/751-1253 DR PDB; 1RER B; 1-391;
#=GS POLS_CHIKS/744-1247 AC Q8JUX5.3
#=GS POLS_CHIKS/744-1247 DR PDB; 2RSW A; 1-18;
POLS_SFV/751-1253 PRAHAASVAETMAYLWDQNQALFWLEFAAPVACILIITYCLRNVLCCCKSLSFLVLLSLG.ATARAYEHSTVMPNVVGFPYKAHIERPGYSPLTLQMQVVETSLEPTLNLEYITCEYKTVVPSPYVKCCGASECSTKEKPDYQCKVYTGVYPFMWGGAYCFCDSENTQLSEAYVDRSDVCRHDHASAYKAHTASLKAKVRVMYGNVNQTVDVYVNGDHAVTIGGTQFIFGPLSSAWTPFDNKIVVYKDEVFNQDFPPYGSGQPGRFGDIQSRTVESNDLYANTALKLARPSPGMVHVPYTQTPSGFKYWLKEKGTALNTKAPFGCQIKTNPVRAMNCAVGNIPVSMNLPDSAFTRIVEAPTIIDLTCTVATCTHSSDFGGVLTLTYKTNKNGDCSVHSHSNVATLQEATAKVKTAGKVTLHFSTASASPSFVVSLCSARATCSASCEPPKDHIVPYAASHSNVVFPDMSGTALSWVQKISGGLGAFAIGAILVLVVVTCIGLRR
#=GR POLS_SFV/751-1253 SS XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXX-EEEEEEES-SS--EEEEE--TTSS-EEEEEEEEEEEEEEEEEEEEEE--EEEE----EEETSS--------STT-EEEEEES-SSSISCSCS-SSSSS-EEEEEEEEEE-TTGGGS-EEEEEEEEEEEEEEEEEEETTEEEEEEEESSSS-EEEETTEEEEE---S----S--SSEEE-SS-EEE-----GGG--TTSTTSEEBSSTT-S--EE-S--EE----SSSS---EE----HHHHHHHHS-S-GGGT-STT-EEETTTTEEES---SEEEEEESS-TTTS-EETTS--EEEEEEEEEEEBTTSTTEEEEEEEEEESS-EEEEEEESSTTEEESBSEEEE-TT-EEEEEEEESSSS-EEEEEETTEEEEEE---B----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
POLS_CHIKS/744-1247 RTAKAATYQEAAVYLWNEQQPLFWLQALIPLAALIVLCNCLRLLPCCCKTLAFLAVMSIGAHTVSAYEHVTVIPNTVGVPYKTLVNRPGYSPMVLEMELLSVTLEPTLSLDYITCEYKTVIPSPYVKCCGTAECKDKNLPDYSCKVFTGVYPFMWGGAYCFCDAENTQLSEAHVEKSESCKTEFASAYRAHTASASAKLRVLYQGNNITVTAYANGDHAVTVKDAKFIVGPMSSAWTPFDNKIVVYKGDVYNMDYPPFGAGRPGQFGDIQSRTPESKDVYANTQLVLQRPAAGTVHVPYSQAPSGFKYWLKERGASLQHTAPFGCQIATNPVRAMNCAVGNMPISIDIPDAAFTRVVDAPSLTDMSCEVPACTHSSDFGGVAIIKYAVSKKGKCAVHSMTNAVTIREAEIEVEGNSQLQISFSTALASAEFRVQVCSTQVHCAAECHPPKDHIVNYPASHTTLGVQDISATAMSWVQKITGGVGLVVAVAALILIVVLCVSFSR
#=GR POLS_CHIKS/744-1247 SS XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--HHHHH---STTTTS--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC SS_cons XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEEEEESXSSXXEEEEEXXTTSSXEEEEEEEEEEEEEEEEEEEEEEXXEEEEXXXXEEETSSXXXXXXXXSTTXEEEEEES-SCCHCCSCSSTTTTS-EEEEEEEEEEXTTGGGSXEEEEEEEEEEEEEEEEEEETTEEEEEEEESSSSXEEEETTEEEEEXXXSXXXXSXXSSEEEXSSXEEEXXXXXGGGXXTTSTTSEEBSSTTXSXXEEXSXXEEXXXXSSSSXXXEEXXXXHHHHHHHHSXSXGGGTXSTTXEEETTTTEEESXXXSEEEEEESSXTTTSXEETTSXXEEEEEEEEEEEBTTSTTEEEEEEEEEESSXEEEEEEESSTTEEESBSEEEEXTTXEEEEEEEESSSSXEEEEEETTEEEEEEXXXBXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC seq_cons .pA+AAohtEshsYLWsppQsLFWLphhhPlAslllls.CLR.l.CCCKoLuFLslhSlG.tTspAYEHsTVhPNsVGhPYKshlpRPGYSPhsLpMpllpsoLEPTLsL-YITCEYKTVlPSPYVKCCGsuECpsKphPDYpCKVaTGVYPFMWGGAYCFCDuENTQLSEAaV-+S-sC+p-aASAY+AHTAShpAKlRVhYtssN.TVssYsNGDHAVTltsspFIhGPhSSAWTPFDNKIVVYKs-VaN.DaPPaGuGpPGpFGDIQSRTsESpDlYANTtLhLtRPusGhVHVPYoQsPSGFKYWLKE+GsuLpppAPFGCQItTNPVRAMNCAVGNhPlShslPDuAFTRlV-APolhDhoCpVssCTHSSDFGGVhhlpYtssKpGcCuVHShoNssTlpEAphcVcssuplplpFSTA.ASspFhVplCSspspCuApCcPPKDHIVsYsASHoslsh.DhSuTAhSWVQKIoGGlGhhshsAhLlLlVVhCluhpR
//
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