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# S.A. Benner, M.A. Cohen, G.H. Gonnet:
# "Amino acid substitution during functionally constrained divergent evolution
# of protein sequences".
# Protein Engineering 7(11): 1323-1332 (1994).
# Figure 3B.
# PMID 7700864
A C D E F G H I K L M N P Q R S T V W Y
A 2.5 -1.2 -0.2 -0.3 -3.1 0.8 -1.6 -0.4 -1.0 -1.7 -0.8 0.0 0.8 -0.9 -1.2 1.3 1.4 0.4 -5.5 -3.5
C -1.2 12.6 -3.7 -4.3 -0.1 -1.7 -1.5 -2.4 -3.3 -2.6 -2.5 -1.9 -3.1 -3.3 -1.6 0.3 -1.1 -1.7 0.5 0.6
D -0.2 -3.7 4.8 3.9 -5.4 0.7 0.3 -4.0 0.2 -4.9 -3.9 2.4 -1.8 0.6 -1.0 0.1 -0.7 -3.0 -6.4 -3.0
E -0.3 -4.3 3.9 4.6 -5.7 0.5 -0.2 -3.6 1.0 -4.4 -3.4 1.2 -1.7 1.7 -0.1 -0.5 -0.9 -2.7 -6.3 -4.0
F -3.1 -0.1 -5.4 -5.7 7.7 -5.8 0.3 0.5 -5.1 2.2 0.7 -3.5 -3.4 -3.6 -4.3 -2.2 -2.6 -0.1 0.5 5.9
G 0.8 -1.7 0.7 0.5 -5.8 6.2 -2.0 -3.8 -1.0 -4.9 -3.8 0.4 -1.8 -1.4 -0.7 0.6 -0.7 -2.5 -4.5 -4.8
H -1.6 -1.5 0.3 -0.2 0.3 -2.0 6.1 -3.2 0.8 -2.1 -2.4 1.4 -0.4 2.4 1.5 -0.5 -1.1 -3.0 -2.7 3.7
I -0.4 -2.4 -4.0 -3.6 0.5 -3.8 -3.2 4.2 -3.0 2.7 3.1 -2.7 -2.3 -2.7 -3.2 -1.4 0.3 3.6 -4.4 -2.2
K -1.0 -3.3 0.2 1.0 -5.1 -1.0 0.8 -3.0 4.4 -3.3 -2.0 1.0 -1.6 2.2 3.9 -0.4 -0.4 -2.7 -3.7 -3.6
L -1.7 -2.6 -4.9 -4.4 2.2 -4.9 -2.1 2.7 -3.3 4.6 3.2 -3.5 -1.3 -2.0 -2.9 -2.1 -1.0 2.0 -1.8 -0.7
M -0.8 -2.5 -3.9 -3.4 0.7 -3.8 -2.4 3.1 -2.0 3.2 4.9 -2.6 -2.0 -1.7 -2.1 -1.5 0.1 2.5 -2.8 -1.8
N 0.0 -1.9 2.4 1.2 -3.5 0.4 1.4 -2.7 1.0 -3.5 -2.6 3.3 -1.1 0.5 0.4 1.1 0.5 -2.3 -5.2 -1.2
P 0.8 -3.1 -1.8 -1.7 -3.4 -1.8 -0.4 -2.3 -1.6 -1.3 -2.0 -1.1 7.0 -0.1 -1.2 1.1 0.4 -1.7 -5.8 -3.5
Q -0.9 -3.3 0.6 1.7 -3.6 -1.4 2.4 -2.7 2.2 -2.0 -1.7 0.5 -0.1 4.2 2.2 -0.6 -0.7 -2.4 -3.3 -1.9
R -1.2 -1.6 -1.0 -0.1 -4.3 -0.7 1.5 -3.2 3.9 -2.9 -2.1 0.4 -1.2 2.2 5.0 -0.5 -0.7 -2.9 -1.1 -2.7
S 1.3 0.3 0.1 -0.5 -2.2 0.6 -0.5 -1.4 -0.4 -2.1 -1.5 1.1 1.1 -0.6 -0.5 2.0 1.5 -0.9 -3.9 -1.9
T 1.4 -1.1 -0.7 -0.9 -2.6 -0.7 -1.1 0.3 -0.4 -1.0 0.1 0.5 0.4 -0.7 -0.7 1.5 2.5 0.4 -4.5 -3.0
V 0.4 -1.7 -3.0 -2.7 -0.1 -2.5 -3.0 3.6 -2.7 2.0 2.5 -2.3 -1.7 -2.4 -2.9 -0.9 0.4 3.7 -4.5 -2.6
W -5.5 0.5 -6.4 -6.3 0.5 -4.5 -2.7 -4.4 -3.7 -1.8 -2.8 -5.2 -5.8 -3.3 -1.1 -3.9 -4.5 -4.5 15.7 1.5
Y -3.5 0.6 -3.0 -4.0 5.9 -4.8 3.7 -2.2 -3.6 -0.7 -1.8 -1.2 -3.5 -1.9 -2.7 -1.9 -3.0 -2.6 1.5 9.0
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