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# S.A. Benner, M.A. Cohen, G.H. Gonnet:
# "Amino acid substitution during functionally constrained divergent evolution
# of protein sequences".
# Protein Engineering 7(11): 1323-1332 (1994).
# Figure 3A.
# PMID 7700864
A C D E F G H I K L M N P Q R S T V W Y
A 2.5 -1.7 -0.6 -0.7 -3.2 0.8 -2.1 0.1 -1.9 -1.3 -0.2 0.0 1.1 -1.7 -1.7 1.4 1.7 0.7 -4.3 -4.0
C -1.7 12.1 -3.7 -4.7 -0.1 -1.3 -1.2 -3.6 -2.8 -3.8 -3.7 -1.6 -2.7 -3.2 -0.4 0.9 -1.5 -3.1 1.6 2.6
D -0.6 -3.7 5.2 4.4 -5.7 0.8 0.1 -4.2 -0.2 -5.3 -4.3 2.5 -2.8 0.6 -1.5 -0.4 -1.2 -3.3 -6.3 -2.3
E -0.7 -4.7 4.4 5.2 -6.7 0.5 -0.2 -4.1 0.9 -5.0 -4.1 1.1 -2.6 2.1 -0.4 -1.2 -1.6 -3.0 -5.6 -4.1
F -3.2 -0.1 -5.7 -6.7 8.3 -5.7 0.1 0.0 -6.3 2.4 -0.1 -3.5 -3.2 -4.4 -4.9 -1.8 -2.4 -0.5 -1.6 5.6
G 0.8 -1.3 0.8 0.5 -5.7 5.8 -2.1 -3.4 -1.4 -4.6 -3.7 -0.1 -1.7 -1.6 -0.1 0.8 -0.5 -2.3 -1.7 -4.9
H -2.1 -1.2 0.1 -0.2 0.1 -2.1 6.1 -3.7 0.9 -2.2 -3.4 1.4 -0.4 3.2 1.8 -0.9 -1.7 -3.8 -2.8 4.4
I 0.1 -3.6 -4.2 -4.1 0.0 -3.4 -3.7 4.4 -3.8 2.4 4.0 -2.5 -2.0 -3.8 -3.8 -1.2 0.7 3.9 -5.0 -3.3
K -1.9 -2.8 -0.2 0.9 -6.3 -1.4 0.9 -3.8 5.6 -4.1 -2.9 1.0 -2.3 2.5 4.3 -1.2 -1.1 -3.8 -1.4 -4.0
L -1.3 -3.8 -5.3 -5.0 2.4 -4.6 -2.2 2.4 -4.1 4.8 -2.9 -3.4 -0.2 -2.4 -3.2 -1.5 -0.4 1.9 -3.0 -1.6
M -0.2 -3.7 -4.3 -4.1 -0.1 -3.7 -3.4 4.0 -2.9 -2.9 4.8 -2.5 -1.8 -3.1 -3.0 -1.3 0.6 3.3 -4.4 -3.6
N 0.0 -1.6 2.5 1.1 -3.5 -0.1 1.4 -2.5 1.0 -3.4 -2.5 3.6 -1.1 0.1 -0.1 1.2 0.5 -2.4 -4.4 -0.9
P 1.1 -2.7 -2.8 -2.6 -3.2 -1.7 -0.4 -2.0 -2.3 -0.2 -1.8 -1.1 6.5 0.1 -1.3 1.4 0.6 -1.6 -4.8 -3.8
Q -1.7 -3.2 0.6 2.1 -4.4 -1.6 3.2 -3.8 2.5 -2.4 -3.1 0.1 0.1 5.3 2.5 -1.4 -1.7 -3.5 -2.6 -1.4
R -1.7 -0.4 -1.5 -0.4 -4.9 -0.1 1.8 -3.8 4.3 -3.2 -3.0 -0.1 -1.3 2.5 5.1 -0.9 -1.3 -3.7 2.0 -2.6
S 1.4 0.9 -0.4 -1.2 -1.8 0.8 -0.9 -1.2 -1.2 -1.5 -1.3 1.2 1.4 -1.4 -0.9 2.1 1.5 -0.9 -2.9 -1.8
T 1.7 -1.5 -1.2 -1.6 -2.4 -0.5 -1.7 0.7 -1.1 -0.4 0.6 0.5 0.6 -1.7 -1.3 1.5 2.4 0.6 -2.6 -3.4
V 0.7 -3.1 -3.3 -3.0 -0.5 -2.3 -3.8 3.9 -3.8 1.9 3.3 -2.4 -1.6 -3.5 -3.7 -0.9 0.6 4.0 -4.8 -3.8
W -4.3 1.6 -6.3 -5.6 -1.6 -1.7 -2.8 -5.0 -1.4 -3.0 -4.4 -4.4 -4.8 -2.6 2.0 -2.9 -2.6 -4.8 14.7 -0.3
Y -4.0 2.6 -2.3 -4.1 5.6 -4.9 4.4 -3.3 -4.0 -1.6 -3.6 -0.9 -3.8 -1.4 -2.6 -1.8 -3.4 -3.8 -0.3 9.5
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