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# S.A. Benner, M.A. Cohen, G.H. Gonnet:
# "Amino acid substitution during functionally constrained divergent evolution
# of protein sequences".
# Protein Engineering 7(11): 1323-1332 (1994).
# Figure 3C.
# PMID 7700864
A C D E F G H I K L M N P Q R S T V W Y
A 2.4 0.3 -0.3 -0.1 -2.6 0.6 -1.0 -0.8 -0.4 -1.4 -0.8 -0.2 0.4 -0.3 -0.8 1.1 0.7 0.1 -4.1 -2.6
C 0.3 11.8 -3.2 -3.2 -0.7 -2.0 -1.3 -1.2 -2.9 -1.6 -1.2 -1.8 -3.1 -2.6 -2.2 0.1 -0.6 -0.2 -0.9 -0.4
D -0.3 -3.2 4.8 2.9 -4.7 0.2 0.4 -3.9 0.4 -4.2 -3.2 2.2 -1.0 0.8 -0.5 0.4 -0.2 -2.9 -5.5 -2.8
E -0.1 -3.2 2.9 3.7 -4.3 -0.5 0.2 -2.9 1.2 -3.1 -2.2 1.0 -0.7 1.7 0.3 0.1 -0.2 -2.1 -4.7 -3.0
F -2.6 -0.7 -4.7 -4.3 7.2 -5.4 0.0 0.9 -3.6 2.1 1.3 -3.2 -3.8 -2.8 -3.5 -2.6 -2.2 0.1 3.0 5.3
G 0.6 -2.0 0.2 -0.5 -5.4 6.6 -1.6 -4.3 -1.1 -4.6 -3.5 0.4 -1.7 -1.1 -1.0 0.4 -1.0 -3.1 -4.1 -4.3
H -1.0 -1.3 0.4 0.2 0.0 -1.6 6.1 -2.3 0.6 -1.9 -1.5 1.2 -1.0 1.4 1.0 -0.3 -0.5 -2.1 -1.0 2.5
I -0.8 -1.2 -3.9 -2.9 0.9 -4.3 -2.3 4.0 -2.3 2.8 2.6 -2.8 -2.6 -2.0 -2.6 -1.8 -0.3 3.2 -2.3 -1.0
K -0.4 -2.9 0.4 1.2 -3.6 -1.1 0.6 -2.3 3.4 -2.4 -1.5 0.9 -0.8 1.7 2.9 0.0 0.1 -1.9 -3.6 -2.4
L -1.4 -1.6 -4.2 -3.1 2.1 -4.6 -1.9 2.8 -2.4 4.2 2.9 -3.1 -2.2 -1.7 -2.4 -2.2 -1.1 1.9 -0.9 -0.1
M -0.8 -1.2 -3.2 -2.2 1.3 -3.5 -1.5 2.6 -1.5 2.9 4.5 -2.2 -2.4 -1.0 -1.8 -1.4 -0.4 1.8 -1.3 -0.5
N -0.2 -1.8 2.2 1.0 -3.2 0.4 1.2 -2.8 0.9 -3.1 -2.2 3.6 -1.0 0.7 0.3 0.9 0.4 -2.2 -4.0 -1.4
P 0.4 -3.1 -1.0 -0.7 -3.8 -1.7 -1.0 -2.6 -0.8 -2.2 -2.4 -1.0 7.5 -0.2 -0.1 0.5 0.1 -1.9 -5.2 -3.4
Q -0.3 -2.6 0.8 1.7 -2.8 -1.1 1.4 -2.0 1.7 -1.7 -1.0 0.7 -0.2 3.0 1.6 0.1 -0.1 -1.7 -2.8 -1.8
R -0.8 -2.2 -0.5 0.3 -3.5 -1.0 1.0 -2.6 2.9 -2.4 -1.8 0.3 -0.1 1.6 4.8 -0.2 -0.3 -2.2 -1.6 -2.0
S 1.1 0.1 0.4 0.1 -2.6 0.4 -0.3 -1.8 0.0 -2.2 -1.4 0.9 0.5 0.1 -0.2 2.1 1.4 -1.0 -3.4 -1.9
T 0.7 -0.6 -0.2 -0.2 -2.2 -1.0 -0.5 -0.3 0.1 -1.1 -0.4 0.4 0.1 -0.1 -0.3 1.4 2.5 0.2 -3.7 -2.1
V 0.1 -0.2 -2.9 -2.1 0.1 -3.1 -2.1 3.2 -1.9 1.9 1.8 -2.2 -1.9 -1.7 -2.2 -1.0 0.2 3.4 -2.9 -1.4
W -4.1 -0.9 -5.5 -4.7 3.0 -4.1 -1.0 -2.3 -3.6 -0.9 -1.3 -4.0 -5.2 -2.8 -1.6 -3.4 -3.7 -2.9 14.7 3.6
Y -2.6 -0.4 -2.8 -3.0 5.3 -4.3 2.5 -1.0 -2.4 -0.1 -0.5 -1.4 -3.4 -1.8 -2.0 -1.9 -2.1 -1.4 3.6 8.1
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