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# S.A. Benner, M.A. Cohen, G.H. Gonnet:
# "Amino acid substitution during functionally constrained divergent evolution
# of protein sequences."
# Figure 5.
# Protein Engineering 7(11): 1323-1332 (1994).
# PMID 7700864
A C D E F G H I K L M N P Q R S T V W Y
A 4.0 -1.9 1.0 1.3 -2.4 1.2 -2.1 -1.8 -1.9 -2.3 -2.0 -1.7 0.8 -2.1 -1.6 0.1 0.9 1.0 -2.2 -2.4
C -1.9 5.5 -1.6 -3.0 1.8 1.0 -1.6 -1.9 -3.2 -1.3 -2.7 -1.5 -1.9 -3.1 0.7 1.5 -1.9 -2.2 4.1 2.6
D 1.0 -1.6 4.8 3.8 -1.7 1.1 1.7 -2.1 0.3 -2.4 -2.5 1.7 -2.2 0.3 -2.3 -2.1 -2.1 1.0 -2.9 2.3
E 1.3 -3.0 3.8 5.7 -2.9 1.4 0.3 -2.3 2.0 -2.5 -1.8 0.3 -2.1 2.0 -2.0 -2.8 -2.1 1.3 -3.2 -0.9
F -2.4 1.8 -1.7 -2.9 4.5 -1.9 -1.1 1.3 -2.8 2.2 0.5 -1.3 -1.8 -2.1 -1.5 0.0 -2.1 1.0 0.0 2.0
G 1.2 1.0 1.1 1.4 -1.9 4.2 -2.2 -2.5 -2.2 -2.2 -2.3 -2.6 -1.8 -2.1 0.8 -0.6 -2.1 1.1 1.4 -1.8
H -2.1 -1.6 1.7 0.3 -1.1 -2.2 4.7 -1.8 0.6 -0.1 -1.8 1.8 0.7 3.6 3.6 -1.6 -1.8 -2.1 -2.1 2.3
I -1.8 -1.9 -2.1 -2.3 1.3 -2.5 -1.8 4.1 0.7 1.2 3.3 0.9 -1.6 -1.9 -1.2 -0.5 0.8 1.0 -2.2 -1.6
K -1.9 -3.2 0.3 2.0 -2.8 -2.2 0.6 0.7 5.6 -2.0 1.6 3.5 -1.5 2.2 -0.2 -1.5 1.0 -2.1 -3.0 -0.8
L -2.3 -1.3 -2.4 -2.5 2.2 -2.2 -0.1 1.2 -2.0 3.4 1.5 -2.2 0.0 0.1 -0.4 -1.2 -1.9 1.1 -0.3 -1.6
M -2.0 -2.7 -2.5 -1.8 0.5 -2.3 -1.8 3.3 1.6 1.5 5.4 0.1 -1.4 -1.2 -0.4 -1.3 0.7 1.0 -2.0 -2.9
N -1.7 -1.5 1.7 0.3 -1.3 -2.6 1.8 0.9 3.5 -2.2 0.1 4.7 -1.6 0.4 -1.5 -0.3 0.9 -2.2 -3.0 2.5
P 0.8 -1.9 -2.2 -2.1 -1.8 -1.8 0.7 -1.6 -1.5 0.0 -1.4 -1.6 3.8 1.0 0.3 0.4 1.1 -2.1 -1.6 -2.3
Q -2.1 -3.1 0.3 2.0 -2.1 -2.1 3.6 -1.9 2.2 0.1 -1.2 0.4 1.0 5.5 0.3 -2.3 -1.7 -2.0 -2.3 -0.8
R -1.6 0.7 -2.3 -2.0 -1.5 0.8 3.6 -1.2 -0.2 -0.4 -0.4 -1.5 0.3 0.3 2.9 0.3 -0.6 -2.1 1.8 -1.9
S 0.1 1.5 -2.1 -2.8 0.0 -0.6 -1.6 -0.5 -1.5 -1.2 -1.3 -0.3 0.4 -2.3 0.3 2.6 1.0 -2.2 0.8 0.3
T 0.9 -1.9 -2.1 -2.1 -2.1 -2.1 -1.8 0.8 1.0 -1.9 0.7 0.9 1.1 -1.7 -0.6 1.0 4.0 -2.2 -2.2 -2.1
V 1.0 -2.2 1.0 1.3 1.0 1.1 -2.1 1.0 -2.1 1.1 1.0 -2.2 -2.1 -2.0 -2.1 -2.2 -2.2 4.1 -2.1 -2.2
W -2.2 4.1 -2.9 -3.2 0.0 1.4 -2.1 -2.2 -3.0 -0.3 -2.0 -3.0 -1.6 -2.3 1.8 0.8 -2.2 -2.1 7.5 -0.5
Y -2.4 2.6 2.3 -0.9 2.0 -1.8 2.3 -1.6 -0.8 -1.6 -2.9 2.5 -2.3 -0.8 -1.9 0.3 -2.1 -2.2 -0.5 6.5
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