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# Authors: Marijn van Vliet <w.m.vanvliet@gmail.com>
# Britta Westner <britta.wstnr@gmail.com>
#
# License: BSD 3 clause
import copy as cp
import os.path as op
import pytest
from pytest import raises
from numpy.testing import assert_array_equal, assert_allclose
import numpy as np
import mne
from mne.datasets import testing
from mne.beamformer import (make_dics, apply_dics, apply_dics_epochs,
apply_dics_csd, tf_dics, read_beamformer,
Beamformer)
from mne.time_frequency import csd_morlet
from mne.utils import run_tests_if_main, object_diff, requires_h5py
from mne.externals.six import advance_iterator
from mne.proj import compute_proj_evoked, make_projector
data_path = testing.data_path(download=False)
fname_raw = op.join(data_path, 'MEG', 'sample', 'sample_audvis_trunc_raw.fif')
fname_fwd = op.join(data_path, 'MEG', 'sample',
'sample_audvis_trunc-meg-eeg-oct-4-fwd.fif')
fname_fwd_vol = op.join(data_path, 'MEG', 'sample',
'sample_audvis_trunc-meg-vol-7-fwd.fif')
fname_event = op.join(data_path, 'MEG', 'sample',
'sample_audvis_trunc_raw-eve.fif')
subjects_dir = op.join(data_path, 'subjects')
fname_label = op.join(subjects_dir, 'sample', 'label', 'aparc',
'rostralmiddlefrontal-lh.label')
def _load_forward():
"""Load forward models."""
fwd_free = mne.read_forward_solution(fname_fwd)
fwd_free = mne.pick_types_forward(fwd_free, meg=True, eeg=False)
fwd_free = mne.convert_forward_solution(fwd_free, surf_ori=False)
fwd_surf = mne.convert_forward_solution(fwd_free, surf_ori=True,
use_cps=False)
fwd_fixed = mne.convert_forward_solution(fwd_free, force_fixed=True,
use_cps=False)
fwd_vol = mne.read_forward_solution(fname_fwd_vol)
label = mne.read_label(fname_label)
return fwd_free, fwd_surf, fwd_fixed, fwd_vol, label
def _simulate_data(fwd):
"""Simulate an oscillator on the cortex."""
source_vertno = 146374 # Somewhere on the frontal lobe
sfreq = 50. # Hz.
times = np.arange(10 * sfreq) / sfreq # 10 seconds of data
signal = np.sin(20 * 2 * np.pi * times) # 20 Hz oscillator
signal[:len(times) // 2] *= 2 # Make signal louder at the beginning
signal *= 1e-9 # Scale to be in the ballpark of MEG data
# Construct a SourceEstimate object that describes the signal at the
# cortical level.
stc = mne.SourceEstimate(
signal[np.newaxis, :],
vertices=[[source_vertno], []],
tmin=0,
tstep=1 / sfreq,
subject='sample',
)
# Create an info object that holds information about the sensors
info = mne.create_info(fwd['info']['ch_names'], sfreq, ch_types='grad')
info.update(fwd['info']) # Merge in sensor position information
# heavily decimate sensors to make it much faster
info = mne.pick_info(info, np.arange(info['nchan'])[::5])
fwd = mne.pick_channels_forward(fwd, info['ch_names'])
# Run the simulated signal through the forward model, obtaining
# simulated sensor data.
raw = mne.apply_forward_raw(fwd, stc, info)
# Add a little noise
random = np.random.RandomState(42)
noise = random.randn(*raw._data.shape) * 1e-14
raw._data += noise
# Define a single epoch
epochs = mne.Epochs(raw, [[0, 0, 1]], event_id=1, tmin=0,
tmax=raw.times[-1], preload=True)
evoked = epochs.average()
# Compute the cross-spectral density matrix
csd = csd_morlet(epochs, frequencies=[10, 20], n_cycles=[5, 10], decim=10)
return epochs, evoked, csd, source_vertno
def _test_weight_norm(filters, norm=1):
"""Test weight normalization."""
for ws in filters['weights']:
ws = ws.reshape(-1, filters['n_orient'], ws.shape[1])
for w in ws:
assert_allclose(np.trace(w.dot(w.T)), norm)
@pytest.mark.slowtest
@testing.requires_testing_data
@requires_h5py
@pytest.mark.filterwarnings("ignore:The use of several sensor types with the"
":RuntimeWarning")
def test_make_dics(tmpdir):
"""Test making DICS beamformer filters."""
# We only test proper handling of parameters here. Testing the results is
# done in test_apply_dics_timeseries and test_apply_dics_csd.
fwd_free, fwd_surf, fwd_fixed, fwd_vol, label = _load_forward()
epochs, _, csd, _ = _simulate_data(fwd_fixed)
raises(ValueError, make_dics, epochs.info, fwd_fixed, csd,
pick_ori="notexistent")
with raises(ValueError, match='rank, if str'):
make_dics(epochs.info, fwd_fixed, csd, rank='foo')
with raises(TypeError, match='rank must be'):
make_dics(epochs.info, fwd_fixed, csd, rank=1.)
# Test if fixed forward operator is detected when picking normal
# orientation
raises(ValueError, make_dics, epochs.info, fwd_fixed, csd,
pick_ori="normal")
# Test if non-surface oriented forward operator is detected when picking
# normal orientation
raises(ValueError, make_dics, epochs.info, fwd_free, csd,
pick_ori="normal")
# Test if volume forward operator is detected when picking normal
# orientation
raises(ValueError, make_dics, epochs.info, fwd_vol, csd, pick_ori="normal")
# Test invalid combinations of parameters
raises(NotImplementedError, make_dics, epochs.info, fwd_free, csd,
reduce_rank=True, pick_ori=None)
raises(NotImplementedError, make_dics, epochs.info, fwd_free, csd,
reduce_rank=True, pick_ori='max-power', inversion='single')
# Sanity checks on the returned filters
n_freq = len(csd.frequencies)
vertices = np.intersect1d(label.vertices, fwd_free['src'][0]['vertno'])
n_verts = len(vertices)
n_orient = 3
n_channels = csd.n_channels
# Test return values
filters = make_dics(epochs.info, fwd_surf, csd, label=label, pick_ori=None,
weight_norm='unit-noise-gain')
assert filters['weights'].shape == (n_freq, n_verts * n_orient, n_channels)
assert np.iscomplexobj(filters['weights'])
assert filters['csd'] == csd
assert filters['ch_names'] == csd.ch_names
assert_array_equal(filters['proj'], np.eye(n_channels))
assert_array_equal(filters['vertices'][0], vertices)
assert_array_equal(filters['vertices'][1], []) # Label was on the LH
assert filters['subject'] == fwd_free['src'][0]['subject_his_id']
assert filters['pick_ori'] is None
assert filters['n_orient'] == n_orient
assert filters['inversion'] == 'single'
assert filters['normalize_fwd']
assert filters['weight_norm'] == 'unit-noise-gain'
assert 'DICS' in repr(filters)
assert 'subject "sample"' in repr(filters)
assert '13' in repr(filters)
assert '62' in repr(filters)
assert 'rank' not in repr(filters)
_test_weight_norm(filters)
# Test picking orientations. Also test weight norming under these different
# conditions.
filters = make_dics(epochs.info, fwd_surf, csd, label=label,
pick_ori='normal', weight_norm='unit-noise-gain')
n_orient = 1
assert filters['weights'].shape == (n_freq, n_verts * n_orient, n_channels)
assert filters['n_orient'] == n_orient
_test_weight_norm(filters)
filters = make_dics(epochs.info, fwd_surf, csd, label=label,
pick_ori='max-power', weight_norm='unit-noise-gain')
n_orient = 1
assert filters['weights'].shape == (n_freq, n_verts * n_orient, n_channels)
assert filters['n_orient'] == n_orient
_test_weight_norm(filters)
# From here on, only work on a single frequency
csd = csd[0]
# Test using a real-valued filter
filters = make_dics(epochs.info, fwd_surf, csd, label=label,
pick_ori='normal', real_filter=True)
assert not np.iscomplexobj(filters['weights'])
# Test forward normalization. When inversion='single', the power of a
# unit-noise CSD should be 1, even without weight normalization.
csd_noise = csd.copy()
inds = np.triu_indices(csd.n_channels)
# Using [:, :] syntax for in-place broadcasting
csd_noise._data[:, :] = np.eye(csd.n_channels)[inds][:, np.newaxis]
filters = make_dics(epochs.info, fwd_surf, csd_noise, label=label,
weight_norm=None, normalize_fwd=True)
w = filters['weights'][0][:3]
assert_allclose(np.diag(w.dot(w.T)), 1.0, rtol=1e-6, atol=0)
# Test turning off both forward and weight normalization
filters = make_dics(epochs.info, fwd_surf, csd, label=label,
weight_norm=None, normalize_fwd=False)
w = filters['weights'][0][:3]
assert not np.allclose(np.diag(w.dot(w.T)), 1.0, rtol=1e-2, atol=0)
# Test neural-activity-index weight normalization. It should be a scaled
# version of the unit-noise-gain beamformer.
filters_nai = make_dics(epochs.info, fwd_surf, csd, label=label,
weight_norm='nai', normalize_fwd=False)
w_nai = filters_nai['weights'][0]
filters_ung = make_dics(epochs.info, fwd_surf, csd, label=label,
weight_norm='unit-noise-gain', normalize_fwd=False)
w_ung = filters_ung['weights'][0]
assert np.allclose(np.corrcoef(np.abs(w_nai).ravel(),
np.abs(w_ung).ravel()), 1)
# Test whether spatial filter contains src_type
assert 'src_type' in filters
fname = op.join(str(tmpdir), 'filters-dics.h5')
filters.save(fname)
filters_read = read_beamformer(fname)
assert isinstance(filters, Beamformer)
assert isinstance(filters_read, Beamformer)
for key in ['tmin', 'tmax']: # deal with strictness of object_diff
setattr(filters['csd'], key, np.float(getattr(filters['csd'], key)))
assert object_diff(filters, filters_read) == ''
@pytest.mark.slowtest
@testing.requires_testing_data
@pytest.mark.filterwarnings("ignore:The use of several sensor types with the"
":RuntimeWarning")
def test_apply_dics_csd():
"""Test applying a DICS beamformer to a CSD matrix."""
fwd_free, fwd_surf, fwd_fixed, fwd_vol, label = _load_forward()
epochs, _, csd, source_vertno = _simulate_data(fwd_fixed)
vertices = np.intersect1d(label.vertices, fwd_free['src'][0]['vertno'])
source_ind = vertices.tolist().index(source_vertno)
reg = 1 # Lots of regularization for our toy dataset
# Construct an identity "noise" CSD, which we will use to test the
# 'unit-noise-gain' setting.
csd_noise = csd.copy()
inds = np.triu_indices(csd.n_channels)
# Using [:, :] syntax for in-place broadcasting
csd_noise._data[:, :] = np.eye(csd.n_channels)[inds][:, np.newaxis]
# Try different types of forward models
for fwd in [fwd_free, fwd_surf, fwd_fixed]:
filters = make_dics(epochs.info, fwd, csd, label=label, reg=reg,
inversion='single')
power, f = apply_dics_csd(csd, filters)
assert f == [10, 20]
# Did we find the true source at 20 Hz?
assert np.argmax(power.data[:, 1]) == source_ind
# Is the signal stronger at 20 Hz than 10?
assert power.data[source_ind, 1] > power.data[source_ind, 0]
# Try picking different orientations and inversion modes
for pick_ori in [None, 'normal', 'max-power']:
for inversion in ['single', 'matrix']:
# Matrix inversion mode needs more regularization for this toy
# dataset.
if inversion == 'matrix':
reg_ = 5
else:
reg_ = reg
filters = make_dics(epochs.info, fwd_surf, csd, label=label,
reg=reg_, pick_ori=pick_ori,
inversion=inversion,
weight_norm='unit-noise-gain')
power, f = apply_dics_csd(csd, filters)
assert f == [10, 20]
assert np.argmax(power.data[:, 1]) == source_ind
assert power.data[source_ind, 1] > power.data[source_ind, 0]
# Test unit-noise-gain weighting
noise_power, f = apply_dics_csd(csd_noise, filters)
assert np.allclose(noise_power.data, 1)
# Test filter with forward normalization instead of weight
# normalization
filters = make_dics(epochs.info, fwd_surf, csd, label=label,
reg=reg_, pick_ori=pick_ori,
inversion=inversion, weight_norm=None,
normalize_fwd=True)
power, f = apply_dics_csd(csd, filters)
assert f == [10, 20]
assert np.argmax(power.data[:, 1]) == source_ind
assert power.data[source_ind, 1] > power.data[source_ind, 0]
# Test using a real-valued filter
filters_real = make_dics(epochs.info, fwd_surf, csd, label=label, reg=reg,
real_filter=True)
# Also test here that no warings are thrown - implemented to check whether
# src should not be None warning occurs:
with pytest.warns(None) as w:
power, f = apply_dics_csd(csd, filters_real)
assert len(w) == 0
assert f == [10, 20]
assert np.argmax(power.data[:, 1]) == source_ind
assert power.data[source_ind, 1] > power.data[source_ind, 0]
# Test rank reduction
filters_real = make_dics(epochs.info, fwd_surf, csd, label=label, reg=5,
pick_ori='max-power', inversion='matrix',
reduce_rank=True)
power, f = apply_dics_csd(csd, filters_real)
assert f == [10, 20]
assert np.argmax(power.data[:, 1]) == source_ind
assert power.data[source_ind, 1] > power.data[source_ind, 0]
# Test computing source power on a volume source space
filters_vol = make_dics(epochs.info, fwd_vol, csd, reg=reg)
power, f = apply_dics_csd(csd, filters_vol)
vol_source_ind = 3851 # FIXME: not make this hardcoded
assert f == [10, 20]
assert np.argmax(power.data[:, 1]) == vol_source_ind
assert power.data[vol_source_ind, 1] > power.data[vol_source_ind, 0]
# check whether a filters object without src_type throws expected warning
del filters_vol['src_type'] # emulate 0.16 behaviour to cause warning
with pytest.warns(RuntimeWarning, match='spatial filter does not contain '
'src_type'):
apply_dics_csd(csd, filters_vol)
@testing.requires_testing_data
@pytest.mark.filterwarnings("ignore:The use of several sensor types with the"
":RuntimeWarning")
def test_apply_dics_timeseries():
"""Test DICS applied to timeseries data."""
fwd_free, fwd_surf, fwd_fixed, fwd_vol, label = _load_forward()
epochs, evoked, csd, source_vertno = _simulate_data(fwd_fixed)
vertices = np.intersect1d(label.vertices, fwd_free['src'][0]['vertno'])
source_ind = vertices.tolist().index(source_vertno)
reg = 5 # Lots of regularization for our toy dataset
multiple_filters = make_dics(evoked.info, fwd_surf, csd, label=label,
reg=reg)
# Sanity checks on the resulting STC after applying DICS on evoked
stcs = apply_dics(evoked, multiple_filters)
assert isinstance(stcs, list)
assert len(stcs) == len(multiple_filters['weights'])
assert_array_equal(stcs[0].vertices[0], multiple_filters['vertices'][0])
assert_array_equal(stcs[0].vertices[1], multiple_filters['vertices'][1])
assert_allclose(stcs[0].times, evoked.times)
# Applying filters for multiple frequencies on epoch data should fail
raises(ValueError, apply_dics_epochs, epochs, multiple_filters)
# From now on, only apply filters with a single frequency (20 Hz).
csd20 = csd.pick_frequency(20)
filters = make_dics(evoked.info, fwd_surf, csd20, label=label, reg=reg)
# Sanity checks on the resulting STC after applying DICS on epochs.
# Also test here that no warnings are thrown - implemented to check whether
# src should not be None warning occurs
with pytest.warns(None) as w:
stcs = apply_dics_epochs(epochs, filters)
assert len(w) == 0
assert isinstance(stcs, list)
assert len(stcs) == 1
assert_array_equal(stcs[0].vertices[0], filters['vertices'][0])
assert_array_equal(stcs[0].vertices[1], filters['vertices'][1])
assert_allclose(stcs[0].times, epochs.times)
# Did we find the source?
stc = (stcs[0] ** 2).mean()
assert np.argmax(stc.data) == source_ind
# Apply filters to evoked
stc = apply_dics(evoked, filters)
stc = (stc ** 2).mean()
assert np.argmax(stc.data) == source_ind
# Test if wrong channel selection is detected in application of filter
evoked_ch = cp.deepcopy(evoked)
evoked_ch.pick_channels(evoked_ch.ch_names[:-1])
raises(ValueError, apply_dics, evoked_ch, filters)
# Test whether projections are applied, by adding a custom projection
filters_noproj = make_dics(evoked.info, fwd_surf, csd20, label=label)
stc_noproj = apply_dics(evoked, filters_noproj)
evoked_proj = evoked.copy()
p = compute_proj_evoked(evoked_proj, n_grad=1, n_mag=0, n_eeg=0)
proj_matrix = make_projector(p, evoked_proj.ch_names)[0]
evoked_proj.info['projs'] += p
filters_proj = make_dics(evoked_proj.info, fwd_surf, csd20, label=label)
assert_array_equal(filters_proj['proj'], proj_matrix)
stc_proj = apply_dics(evoked_proj, filters_proj)
assert np.any(np.not_equal(stc_noproj.data, stc_proj.data))
# Test detecting incompatible projections
filters_proj['proj'] = filters_proj['proj'][:-1, :-1]
raises(ValueError, apply_dics, evoked_proj, filters_proj)
# Test returning a generator
stcs = apply_dics_epochs(epochs, filters, return_generator=False)
stcs_gen = apply_dics_epochs(epochs, filters, return_generator=True)
assert_array_equal(stcs[0].data, advance_iterator(stcs_gen).data)
# Test computing timecourses on a volume source space
filters_vol = make_dics(evoked.info, fwd_vol, csd20, reg=reg)
stc = apply_dics(evoked, filters_vol)
stc = (stc ** 2).mean()
assert np.argmax(stc.data) == 3851 # TODO: don't make this hard coded
# check whether a filters object without src_type throws expected warning
del filters_vol['src_type'] # emulate 0.16 behaviour to cause warning
with pytest.warns(RuntimeWarning, match='spatial filter does not contain '
'src_type'):
apply_dics_epochs(epochs, filters_vol)
@pytest.mark.slowtest
@testing.requires_testing_data
@pytest.mark.filterwarnings("ignore:The use of several sensor types with the"
":RuntimeWarning")
def test_tf_dics():
"""Test 5D time-frequency beamforming based on DICS."""
fwd_free, fwd_surf, fwd_fixed, fwd_vol, label = _load_forward()
epochs, evoked, _, source_vertno = _simulate_data(fwd_fixed)
vertices = np.intersect1d(label.vertices, fwd_free['src'][0]['vertno'])
source_ind = vertices.tolist().index(source_vertno)
reg = 1 # Lots of regularization for our toy dataset
tmin = 0
tmax = 9
tstep = 4
win_lengths = [5, 5]
frequencies = [10, 20]
freq_bins = [(8, 12), (18, 22)]
# Compute DICS for two time windows and two frequencies
for mode in ['fourier', 'multitaper', 'cwt_morlet']:
stcs = tf_dics(epochs, fwd_surf, None, tmin, tmax, tstep, win_lengths,
mode=mode, freq_bins=freq_bins, frequencies=frequencies,
decim=10, reg=reg, label=label)
# Did we find the true source at 20 Hz?
assert np.argmax(stcs[1].data[:, 0]) == source_ind
assert np.argmax(stcs[1].data[:, 1]) == source_ind
# 20 Hz power should decrease over time
assert stcs[1].data[source_ind, 0] > stcs[1].data[source_ind, 1]
# 20 Hz power should be more than 10 Hz power at the true source
assert stcs[1].data[source_ind, 0] > stcs[0].data[source_ind, 0]
# Manually compute source power and compare with the last tf_dics result.
source_power = []
time_windows = [(0, 5), (4, 9)]
for time_window in time_windows:
csd = csd_morlet(epochs, frequencies=[frequencies[1]],
tmin=time_window[0], tmax=time_window[1], decim=10)
csd = csd.sum()
csd._data /= csd.n_fft
filters = make_dics(epochs.info, fwd_surf, csd, reg=reg, label=label)
stc_source_power, _ = apply_dics_csd(csd, filters)
source_power.append(stc_source_power.data)
# Comparing tf_dics results with dics_source_power results
assert_allclose(stcs[1].data, np.array(source_power).squeeze().T, atol=0)
# Test using noise csds. We're going to use identity matrices. That way,
# since we're using unit-noise-gain weight normalization, there should be
# no effect.
stcs = tf_dics(epochs, fwd_surf, None, tmin, tmax, tstep, win_lengths,
mode='cwt_morlet', frequencies=frequencies, decim=10,
reg=reg, label=label, normalize_fwd=False,
weight_norm='unit-noise-gain')
noise_csd = csd.copy()
inds = np.triu_indices(csd.n_channels)
# Using [:, :] syntax for in-place broadcasting
noise_csd._data[:, :] = 2 * np.eye(csd.n_channels)[inds][:, np.newaxis]
noise_csd.n_fft = 2 # Dividing by n_fft should yield an identity CSD
noise_csds = [noise_csd, noise_csd] # Two frequency bins
stcs_norm = tf_dics(epochs, fwd_surf, noise_csds, tmin, tmax, tstep,
win_lengths, mode='cwt_morlet',
frequencies=frequencies, decim=10, reg=reg,
label=label, normalize_fwd=False,
weight_norm='unit-noise-gain')
assert_allclose(stcs_norm[0].data, stcs[0].data, atol=0)
assert_allclose(stcs_norm[1].data, stcs[1].data, atol=0)
# Test invalid parameter combinations
raises(ValueError, tf_dics, epochs, fwd_surf, None, tmin, tmax, tstep,
win_lengths, mode='fourier', freq_bins=None)
raises(ValueError, tf_dics, epochs, fwd_surf, None, tmin, tmax, tstep,
win_lengths, mode='cwt_morlet', frequencies=None)
# Test if incorrect number of noise CSDs is detected
raises(ValueError, tf_dics, epochs, fwd_surf, [noise_csds[0]], tmin, tmax,
tstep, win_lengths, freq_bins=freq_bins)
# Test if freq_bins and win_lengths incompatibility is detected
raises(ValueError, tf_dics, epochs, fwd_surf, None, tmin, tmax, tstep,
win_lengths=[0, 1, 2], freq_bins=freq_bins)
# Test if time step exceeding window lengths is detected
raises(ValueError, tf_dics, epochs, fwd_surf, None, tmin, tmax, tstep=0.15,
win_lengths=[0.2, 0.1], freq_bins=freq_bins)
# Test if incorrent number of n_ffts is detected
raises(ValueError, tf_dics, epochs, fwd_surf, None, tmin, tmax, tstep,
win_lengths, freq_bins=freq_bins, n_ffts=[1])
# Test if incorrect number of mt_bandwidths is detected
raises(ValueError, tf_dics, epochs, fwd_surf, None, tmin, tmax, tstep,
win_lengths=win_lengths, freq_bins=freq_bins, mode='multitaper',
mt_bandwidths=[20])
# Test if subtracting evoked responses yields NaN's, since we only have one
# epoch. Suppress division warnings.
with pytest.warns(RuntimeWarning, match='[invalid|empty]'):
stcs = tf_dics(epochs, fwd_surf, None, tmin, tmax, tstep, win_lengths,
mode='cwt_morlet', frequencies=frequencies,
subtract_evoked=True, reg=reg, label=label, decim=20)
assert np.all(np.isnan(stcs[0].data))
run_tests_if_main()
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