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# Authors: Alexandre Gramfort <alexandre.gramfort@telecom-paristech.fr>
# Matti Hamalainen <msh@nmr.mgh.harvard.edu>
#
# License: BSD (3-clause)
import warnings
from copy import deepcopy
from math import sqrt
import numpy as np
from scipy import linalg
from ..io.constants import FIFF
from ..io.open import fiff_open
from ..io.tag import find_tag
from ..io.matrix import (_read_named_matrix, _transpose_named_matrix,
write_named_matrix)
from ..io.proj import _read_proj, make_projector, _write_proj
from ..io.tree import dir_tree_find
from ..io.write import (write_int, write_float_matrix, start_file,
start_block, end_block, end_file, write_float,
write_coord_trans, write_string)
from ..io.pick import channel_type, pick_info, pick_types
from ..cov import prepare_noise_cov, _read_cov, _write_cov
from ..forward import (compute_depth_prior, read_forward_meas_info,
write_forward_meas_info, is_fixed_orient,
compute_orient_prior, _to_fixed_ori)
from ..source_space import (read_source_spaces_from_tree,
find_source_space_hemi, _get_vertno,
_write_source_spaces_to_fid, label_src_vertno_sel)
from ..transforms import invert_transform, transform_surface_to
from ..source_estimate import _make_stc
from ..utils import check_fname, logger, verbose
from functools import reduce
class InverseOperator(dict):
"""InverseOperator class to represent info from inverse operator
"""
def __repr__(self):
"""Summarize inverse info instead of printing all"""
entr = '<InverseOperator'
nchan = len(pick_types(self['info'], meg=True, eeg=False))
entr += ' | ' + 'MEG channels: %d' % nchan
nchan = len(pick_types(self['info'], meg=False, eeg=True))
entr += ' | ' + 'EEG channels: %d' % nchan
# XXX TODO: This and the __repr__ in SourceSpaces should call a
# function _get_name_str() in source_space.py
if self['src'][0]['type'] == 'surf':
entr += (' | Source space: Surface with %d vertices'
% self['nsource'])
elif self['src'][0]['type'] == 'vol':
entr += (' | Source space: Volume with %d grid points'
% self['nsource'])
elif self['src'][0]['type'] == 'discrete':
entr += (' | Source space: Discrete with %d dipoles'
% self['nsource'])
source_ori = {FIFF.FIFFV_MNE_UNKNOWN_ORI: 'Unknown',
FIFF.FIFFV_MNE_FIXED_ORI: 'Fixed',
FIFF.FIFFV_MNE_FREE_ORI: 'Free'}
entr += ' | Source orientation: %s' % source_ori[self['source_ori']]
entr += '>'
return entr
def _pick_channels_inverse_operator(ch_names, inv):
"""Gives the indices of the data channel to be used knowing
an inverse operator
"""
sel = []
for name in inv['noise_cov']['names']:
if name in ch_names:
sel.append(ch_names.index(name))
else:
raise ValueError('The inverse operator was computed with '
'channel %s which is not present in '
'the data. You should compute a new inverse '
'operator restricted to the good data '
'channels.' % name)
return sel
@verbose
def read_inverse_operator(fname, verbose=None):
"""Read the inverse operator decomposition from a FIF file
Parameters
----------
fname : string
The name of the FIF file, which ends with -inv.fif or -inv.fif.gz.
verbose : bool, str, int, or None
If not None, override default verbose level (see mne.verbose).
Returns
-------
inv : instance of InverseOperator
The inverse operator.
"""
check_fname(fname, 'inverse operator', ('-inv.fif', '-inv.fif.gz'))
#
# Open the file, create directory
#
logger.info('Reading inverse operator decomposition from %s...'
% fname)
fid, tree, _ = fiff_open(fname, preload=True)
#
# Find all inverse operators
#
invs = dir_tree_find(tree, FIFF.FIFFB_MNE_INVERSE_SOLUTION)
if invs is None or len(invs) < 1:
fid.close()
raise Exception('No inverse solutions in %s' % fname)
invs = invs[0]
#
# Parent MRI data
#
parent_mri = dir_tree_find(tree, FIFF.FIFFB_MNE_PARENT_MRI_FILE)
if len(parent_mri) == 0:
fid.close()
raise Exception('No parent MRI information in %s' % fname)
parent_mri = parent_mri[0] # take only first one
logger.info(' Reading inverse operator info...')
#
# Methods and source orientations
#
tag = find_tag(fid, invs, FIFF.FIFF_MNE_INCLUDED_METHODS)
if tag is None:
fid.close()
raise Exception('Modalities not found')
inv = dict()
inv['methods'] = int(tag.data)
tag = find_tag(fid, invs, FIFF.FIFF_MNE_SOURCE_ORIENTATION)
if tag is None:
fid.close()
raise Exception('Source orientation constraints not found')
inv['source_ori'] = int(tag.data)
tag = find_tag(fid, invs, FIFF.FIFF_MNE_SOURCE_SPACE_NPOINTS)
if tag is None:
fid.close()
raise Exception('Number of sources not found')
inv['nsource'] = int(tag.data)
inv['nchan'] = 0
#
# Coordinate frame
#
tag = find_tag(fid, invs, FIFF.FIFF_MNE_COORD_FRAME)
if tag is None:
fid.close()
raise Exception('Coordinate frame tag not found')
inv['coord_frame'] = tag.data
#
# Units
#
tag = find_tag(fid, invs, FIFF.FIFF_MNE_INVERSE_SOURCE_UNIT)
if tag is not None:
if tag.data == FIFF.FIFF_UNIT_AM:
inv['units'] = 'Am'
elif tag.data == FIFF.FIFF_UNIT_AM_M2:
inv['units'] = 'Am/m^2'
elif tag.data == FIFF.FIFF_UNIT_AM_M3:
inv['units'] = 'Am/m^3'
else:
inv['units'] = None
else:
inv['units'] = None
#
# The actual source orientation vectors
#
tag = find_tag(fid, invs, FIFF.FIFF_MNE_INVERSE_SOURCE_ORIENTATIONS)
if tag is None:
fid.close()
raise Exception('Source orientation information not found')
inv['source_nn'] = tag.data
logger.info(' [done]')
#
# The SVD decomposition...
#
logger.info(' Reading inverse operator decomposition...')
tag = find_tag(fid, invs, FIFF.FIFF_MNE_INVERSE_SING)
if tag is None:
fid.close()
raise Exception('Singular values not found')
inv['sing'] = tag.data
inv['nchan'] = len(inv['sing'])
#
# The eigenleads and eigenfields
#
inv['eigen_leads_weighted'] = False
eigen_leads = _read_named_matrix(fid, invs, FIFF.FIFF_MNE_INVERSE_LEADS)
if eigen_leads is None:
inv['eigen_leads_weighted'] = True
eigen_leads = _read_named_matrix(fid, invs,
FIFF.FIFF_MNE_INVERSE_LEADS_WEIGHTED)
if eigen_leads is None:
raise ValueError('Eigen leads not found in inverse operator.')
#
# Having the eigenleads as columns is better for the inverse calculations
#
inv['eigen_leads'] = _transpose_named_matrix(eigen_leads, copy=False)
inv['eigen_fields'] = _read_named_matrix(fid, invs,
FIFF.FIFF_MNE_INVERSE_FIELDS)
logger.info(' [done]')
#
# Read the covariance matrices
#
inv['noise_cov'] = _read_cov(fid, invs, FIFF.FIFFV_MNE_NOISE_COV)
logger.info(' Noise covariance matrix read.')
inv['source_cov'] = _read_cov(fid, invs, FIFF.FIFFV_MNE_SOURCE_COV)
logger.info(' Source covariance matrix read.')
#
# Read the various priors
#
inv['orient_prior'] = _read_cov(fid, invs, FIFF.FIFFV_MNE_ORIENT_PRIOR_COV)
if inv['orient_prior'] is not None:
logger.info(' Orientation priors read.')
inv['depth_prior'] = _read_cov(fid, invs, FIFF.FIFFV_MNE_DEPTH_PRIOR_COV)
if inv['depth_prior'] is not None:
logger.info(' Depth priors read.')
inv['fmri_prior'] = _read_cov(fid, invs, FIFF.FIFFV_MNE_FMRI_PRIOR_COV)
if inv['fmri_prior'] is not None:
logger.info(' fMRI priors read.')
#
# Read the source spaces
#
inv['src'] = read_source_spaces_from_tree(fid, tree, add_geom=False)
for s in inv['src']:
s['id'] = find_source_space_hemi(s)
#
# Get the MRI <-> head coordinate transformation
#
tag = find_tag(fid, parent_mri, FIFF.FIFF_COORD_TRANS)
if tag is None:
fid.close()
raise Exception('MRI/head coordinate transformation not found')
else:
mri_head_t = tag.data
if mri_head_t['from'] != FIFF.FIFFV_COORD_MRI or \
mri_head_t['to'] != FIFF.FIFFV_COORD_HEAD:
mri_head_t = invert_transform(mri_head_t)
if mri_head_t['from'] != FIFF.FIFFV_COORD_MRI or \
mri_head_t['to'] != FIFF.FIFFV_COORD_HEAD:
fid.close()
raise Exception('MRI/head coordinate transformation '
'not found')
inv['mri_head_t'] = mri_head_t
#
# get parent MEG info
#
inv['info'] = read_forward_meas_info(tree, fid)
#
# Transform the source spaces to the correct coordinate frame
# if necessary
#
if inv['coord_frame'] != FIFF.FIFFV_COORD_MRI and \
inv['coord_frame'] != FIFF.FIFFV_COORD_HEAD:
fid.close()
raise Exception('Only inverse solutions computed in MRI or '
'head coordinates are acceptable')
#
# Number of averages is initially one
#
inv['nave'] = 1
#
# We also need the SSP operator
#
inv['projs'] = _read_proj(fid, tree)
#
# Some empty fields to be filled in later
#
inv['proj'] = [] # This is the projector to apply to the data
inv['whitener'] = [] # This whitens the data
inv['reginv'] = [] # This the diagonal matrix implementing
# regularization and the inverse
inv['noisenorm'] = [] # These are the noise-normalization factors
#
nuse = 0
for k in range(len(inv['src'])):
try:
inv['src'][k] = transform_surface_to(inv['src'][k],
inv['coord_frame'],
mri_head_t)
except Exception as inst:
fid.close()
raise Exception('Could not transform source space (%s)' % inst)
nuse += inv['src'][k]['nuse']
logger.info(' Source spaces transformed to the inverse solution '
'coordinate frame')
#
# Done!
#
fid.close()
return InverseOperator(inv)
@verbose
def write_inverse_operator(fname, inv, verbose=None):
"""Write an inverse operator to a FIF file
Parameters
----------
fname : string
The name of the FIF file, which ends with -inv.fif or -inv.fif.gz.
inv : dict
The inverse operator.
verbose : bool, str, int, or None
If not None, override default verbose level (see mne.verbose).
"""
check_fname(fname, 'inverse operator', ('-inv.fif', '-inv.fif.gz'))
#
# Open the file, create directory
#
logger.info('Write inverse operator decomposition in %s...' % fname)
# Create the file and save the essentials
fid = start_file(fname)
start_block(fid, FIFF.FIFFB_MNE)
#
# Parent MEG measurement info
#
write_forward_meas_info(fid, inv['info'])
#
# Parent MRI data
#
start_block(fid, FIFF.FIFFB_MNE_PARENT_MRI_FILE)
write_string(fid, FIFF.FIFF_MNE_FILE_NAME, inv['info']['mri_file'])
write_coord_trans(fid, inv['mri_head_t'])
end_block(fid, FIFF.FIFFB_MNE_PARENT_MRI_FILE)
#
# Write SSP operator
#
_write_proj(fid, inv['projs'])
#
# Write the source spaces
#
if 'src' in inv:
_write_source_spaces_to_fid(fid, inv['src'])
start_block(fid, FIFF.FIFFB_MNE_INVERSE_SOLUTION)
logger.info(' Writing inverse operator info...')
write_int(fid, FIFF.FIFF_MNE_INCLUDED_METHODS, inv['methods'])
write_int(fid, FIFF.FIFF_MNE_COORD_FRAME, inv['coord_frame'])
if 'units' in inv:
if inv['units'] == 'Am':
write_int(fid, FIFF.FIFF_MNE_INVERSE_SOURCE_UNIT,
FIFF.FIFF_UNIT_AM)
elif inv['units'] == 'Am/m^2':
write_int(fid, FIFF.FIFF_MNE_INVERSE_SOURCE_UNIT,
FIFF.FIFF_UNIT_AM_M2)
elif inv['units'] == 'Am/m^3':
write_int(fid, FIFF.FIFF_MNE_INVERSE_SOURCE_UNIT,
FIFF.FIFF_UNIT_AM_M3)
write_int(fid, FIFF.FIFF_MNE_SOURCE_ORIENTATION, inv['source_ori'])
write_int(fid, FIFF.FIFF_MNE_SOURCE_SPACE_NPOINTS, inv['nsource'])
if 'nchan' in inv:
write_int(fid, FIFF.FIFF_NCHAN, inv['nchan'])
elif 'nchan' in inv['info']:
write_int(fid, FIFF.FIFF_NCHAN, inv['info']['nchan'])
write_float_matrix(fid, FIFF.FIFF_MNE_INVERSE_SOURCE_ORIENTATIONS,
inv['source_nn'])
write_float(fid, FIFF.FIFF_MNE_INVERSE_SING, inv['sing'])
#
# write the covariance matrices
#
logger.info(' Writing noise covariance matrix.')
_write_cov(fid, inv['noise_cov'])
logger.info(' Writing source covariance matrix.')
_write_cov(fid, inv['source_cov'])
#
# write the various priors
#
logger.info(' Writing orientation priors.')
if inv['depth_prior'] is not None:
_write_cov(fid, inv['depth_prior'])
if inv['orient_prior'] is not None:
_write_cov(fid, inv['orient_prior'])
if inv['fmri_prior'] is not None:
_write_cov(fid, inv['fmri_prior'])
write_named_matrix(fid, FIFF.FIFF_MNE_INVERSE_FIELDS, inv['eigen_fields'])
#
# The eigenleads and eigenfields
#
if inv['eigen_leads_weighted']:
write_named_matrix(fid, FIFF.FIFF_MNE_INVERSE_LEADS_WEIGHTED,
_transpose_named_matrix(inv['eigen_leads']))
else:
write_named_matrix(fid, FIFF.FIFF_MNE_INVERSE_LEADS,
_transpose_named_matrix(inv['eigen_leads']))
#
# Done!
#
logger.info(' [done]')
end_block(fid, FIFF.FIFFB_MNE_INVERSE_SOLUTION)
end_block(fid, FIFF.FIFFB_MNE)
end_file(fid)
fid.close()
###############################################################################
# Compute inverse solution
def combine_xyz(vec, square=False):
"""Compute the three Cartesian components of a vector or matrix together
Parameters
----------
vec : 2d array of shape [3 n x p]
Input [ x1 y1 z1 ... x_n y_n z_n ] where x1 ... z_n
can be vectors
Returns
-------
comb : array
Output vector [sqrt(x1^2+y1^2+z1^2), ..., sqrt(x_n^2+y_n^2+z_n^2)]
"""
if vec.ndim != 2:
raise ValueError('Input must be 2D')
if (vec.shape[0] % 3) != 0:
raise ValueError('Input must have 3N rows')
n, p = vec.shape
if np.iscomplexobj(vec):
vec = np.abs(vec)
comb = vec[0::3] ** 2
comb += vec[1::3] ** 2
comb += vec[2::3] ** 2
if not square:
comb = np.sqrt(comb)
return comb
def _check_ch_names(inv, info):
"""Check that channels in inverse operator are measurements"""
inv_ch_names = inv['eigen_fields']['col_names']
if inv['noise_cov']['names'] != inv_ch_names:
raise ValueError('Channels in inverse operator eigen fields do not '
'match noise covariance channels.')
data_ch_names = info['ch_names']
missing_ch_names = list()
for ch_name in inv_ch_names:
if ch_name not in data_ch_names:
missing_ch_names.append(ch_name)
n_missing = len(missing_ch_names)
if n_missing > 0:
raise ValueError('%d channels in inverse operator ' % n_missing +
'are not present in the data (%s)' % missing_ch_names)
@verbose
def prepare_inverse_operator(orig, nave, lambda2, method, verbose=None):
"""Prepare an inverse operator for actually computing the inverse
Parameters
----------
orig : dict
The inverse operator structure read from a file.
nave : int
Number of averages (scales the noise covariance).
lambda2 : float
The regularization factor. Recommended to be 1 / SNR**2.
method : "MNE" | "dSPM" | "sLORETA"
Use mininum norm, dSPM or sLORETA.
verbose : bool, str, int, or None
If not None, override default verbose level (see mne.verbose).
Returns
-------
inv : instance of InverseOperator
Prepared inverse operator.
"""
if nave <= 0:
raise ValueError('The number of averages should be positive')
logger.info('Preparing the inverse operator for use...')
inv = deepcopy(orig)
#
# Scale some of the stuff
#
scale = float(inv['nave']) / nave
inv['noise_cov']['data'] = scale * inv['noise_cov']['data']
# deal with diagonal case
if inv['noise_cov']['data'].ndim == 1:
logger.info(' Diagonal noise covariance found')
inv['noise_cov']['eig'] = inv['noise_cov']['data']
inv['noise_cov']['eigvec'] = np.eye(len(inv['noise_cov']['data']))
inv['noise_cov']['eig'] = scale * inv['noise_cov']['eig']
inv['source_cov']['data'] = scale * inv['source_cov']['data']
#
if inv['eigen_leads_weighted']:
inv['eigen_leads']['data'] = sqrt(scale) * inv['eigen_leads']['data']
logger.info(' Scaled noise and source covariance from nave = %d to'
' nave = %d' % (inv['nave'], nave))
inv['nave'] = nave
#
# Create the diagonal matrix for computing the regularized inverse
#
sing = np.array(inv['sing'], dtype=np.float64)
inv['reginv'] = sing / (sing ** 2 + lambda2)
logger.info(' Created the regularized inverter')
#
# Create the projection operator
#
inv['proj'], ncomp, _ = make_projector(inv['projs'],
inv['noise_cov']['names'])
if ncomp > 0:
logger.info(' Created an SSP operator (subspace dimension = %d)'
% ncomp)
else:
logger.info(' The projection vectors do not apply to these '
'channels.')
#
# Create the whitener
#
if not inv['noise_cov']['diag']:
inv['whitener'] = np.zeros((inv['noise_cov']['dim'],
inv['noise_cov']['dim']))
#
# Omit the zeroes due to projection
#
eig = inv['noise_cov']['eig']
nzero = (eig > 0)
inv['whitener'][nzero, nzero] = 1.0 / np.sqrt(eig[nzero])
#
# Rows of eigvec are the eigenvectors
#
inv['whitener'] = np.dot(inv['whitener'], inv['noise_cov']['eigvec'])
logger.info(' Created the whitener using a full noise '
'covariance matrix (%d small eigenvalues omitted)'
% (inv['noise_cov']['dim'] - np.sum(nzero)))
else:
#
# No need to omit the zeroes due to projection
#
inv['whitener'] = np.diag(1.0 /
np.sqrt(inv['noise_cov']['data'].ravel()))
logger.info(' Created the whitener using a diagonal noise '
'covariance matrix (%d small eigenvalues discarded)'
% ncomp)
#
# Finally, compute the noise-normalization factors
#
if method in ["dSPM", 'sLORETA']:
if method == "dSPM":
logger.info(' Computing noise-normalization factors '
'(dSPM)...')
noise_weight = inv['reginv']
else:
logger.info(' Computing noise-normalization factors '
'(sLORETA)...')
noise_weight = (inv['reginv'] *
np.sqrt((1. + inv['sing'] ** 2 / lambda2)))
noise_norm = np.zeros(inv['eigen_leads']['nrow'])
nrm2, = linalg.get_blas_funcs(('nrm2',), (noise_norm,))
if inv['eigen_leads_weighted']:
for k in range(inv['eigen_leads']['nrow']):
one = inv['eigen_leads']['data'][k, :] * noise_weight
noise_norm[k] = nrm2(one)
else:
for k in range(inv['eigen_leads']['nrow']):
one = (sqrt(inv['source_cov']['data'][k]) *
inv['eigen_leads']['data'][k, :] * noise_weight)
noise_norm[k] = nrm2(one)
#
# Compute the final result
#
if inv['source_ori'] == FIFF.FIFFV_MNE_FREE_ORI:
#
# The three-component case is a little bit more involved
# The variances at three consequtive entries must be squared and
# added together
#
# Even in this case return only one noise-normalization factor
# per source location
#
noise_norm = combine_xyz(noise_norm[:, None]).ravel()
inv['noisenorm'] = 1.0 / np.abs(noise_norm)
logger.info('[done]')
else:
inv['noisenorm'] = []
return InverseOperator(inv)
@verbose
def _assemble_kernel(inv, label, method, pick_ori, verbose=None):
#
# Simple matrix multiplication followed by combination of the
# current components
#
# This does all the data transformations to compute the weights for the
# eigenleads
#
eigen_leads = inv['eigen_leads']['data']
source_cov = inv['source_cov']['data'][:, None]
if method != "MNE":
noise_norm = inv['noisenorm'][:, None]
src = inv['src']
vertno = _get_vertno(src)
if label is not None:
vertno, src_sel = label_src_vertno_sel(label, inv['src'])
if method != "MNE":
noise_norm = noise_norm[src_sel]
if inv['source_ori'] == FIFF.FIFFV_MNE_FREE_ORI:
src_sel = 3 * src_sel
src_sel = np.c_[src_sel, src_sel + 1, src_sel + 2]
src_sel = src_sel.ravel()
eigen_leads = eigen_leads[src_sel]
source_cov = source_cov[src_sel]
if pick_ori == "normal":
if not inv['source_ori'] == FIFF.FIFFV_MNE_FREE_ORI:
raise ValueError('Picking normal orientation can only be done '
'with a free orientation inverse operator.')
is_loose = 0 < inv['orient_prior']['data'][0] < 1
if not is_loose:
raise ValueError('Picking normal orientation can only be done '
'when working with loose orientations.')
# keep only the normal components
eigen_leads = eigen_leads[2::3]
source_cov = source_cov[2::3]
trans = inv['reginv'][:, None] * reduce(np.dot,
[inv['eigen_fields']['data'],
inv['whitener'],
inv['proj']])
#
# Transformation into current distributions by weighting the eigenleads
# with the weights computed above
#
if inv['eigen_leads_weighted']:
#
# R^0.5 has been already factored in
#
logger.info('(eigenleads already weighted)...')
K = np.dot(eigen_leads, trans)
else:
#
# R^0.5 has to be factored in
#
logger.info('(eigenleads need to be weighted)...')
K = np.sqrt(source_cov) * np.dot(eigen_leads, trans)
if method == "MNE":
noise_norm = None
return K, noise_norm, vertno
def _check_method(method):
if method not in ["MNE", "dSPM", "sLORETA"]:
raise ValueError('method parameter should be "MNE" or "dSPM" '
'or "sLORETA".')
return method
def _check_ori(pick_ori, pick_normal):
if pick_normal is not None:
warnings.warn('DEPRECATION: The pick_normal parameter has been '
'changed to pick_ori. Please update your code.')
pick_ori = pick_normal
if pick_ori is True:
warnings.warn('DEPRECATION: The pick_ori parameter should now be None '
'or "normal".')
pick_ori = "normal"
elif pick_ori is False:
warnings.warn('DEPRECATION: The pick_ori parameter should now be None '
'or "normal".')
pick_ori = None
if pick_ori not in [None, "normal"]:
raise ValueError('The pick_ori parameter should now be None or '
'"normal".')
return pick_ori
def _subject_from_inverse(inverse_operator):
"""Get subject id from inverse operator"""
return inverse_operator['src'][0].get('subject_his_id', None)
@verbose
def apply_inverse(evoked, inverse_operator, lambda2, method="dSPM",
pick_ori=None, verbose=None, pick_normal=None):
"""Apply inverse operator to evoked data
Computes a L2-norm inverse solution
Actual code using these principles might be different because
the inverse operator is often reused across data sets.
Parameters
----------
evoked : Evoked object
Evoked data.
inverse_operator: dict
Inverse operator read with mne.read_inverse_operator.
lambda2 : float
The regularization parameter.
method : "MNE" | "dSPM" | "sLORETA"
Use mininum norm, dSPM or sLORETA.
pick_ori : None | "normal"
If "normal", rather than pooling the orientations by taking the norm,
only the radial component is kept. This is only implemented
when working with loose orientations.
verbose : bool, str, int, or None
If not None, override default verbose level (see mne.verbose).
Returns
-------
stc : SourceEstimate | VolSourceEstimate
The source estimates
"""
method = _check_method(method)
pick_ori = _check_ori(pick_ori, pick_normal)
#
# Set up the inverse according to the parameters
#
nave = evoked.nave
_check_ch_names(inverse_operator, evoked.info)
inv = prepare_inverse_operator(inverse_operator, nave, lambda2, method)
#
# Pick the correct channels from the data
#
sel = _pick_channels_inverse_operator(evoked.ch_names, inv)
logger.info('Picked %d channels from the data' % len(sel))
logger.info('Computing inverse...')
K, noise_norm, _ = _assemble_kernel(inv, None, method, pick_ori)
sol = np.dot(K, evoked.data[sel]) # apply imaging kernel
is_free_ori = (inverse_operator['source_ori'] == FIFF.FIFFV_MNE_FREE_ORI
and pick_ori is None)
if is_free_ori:
logger.info('combining the current components...')
sol = combine_xyz(sol)
if noise_norm is not None:
logger.info('(dSPM)...')
sol *= noise_norm
tstep = 1.0 / evoked.info['sfreq']
tmin = float(evoked.times[0])
vertno = _get_vertno(inv['src'])
subject = _subject_from_inverse(inverse_operator)
stc = _make_stc(sol, vertices=vertno, tmin=tmin, tstep=tstep,
subject=subject)
logger.info('[done]')
return stc
@verbose
def apply_inverse_raw(raw, inverse_operator, lambda2, method="dSPM",
label=None, start=None, stop=None, nave=1,
time_func=None, pick_ori=None,
buffer_size=None, verbose=None,
pick_normal=None):
"""Apply inverse operator to Raw data
Computes a L2-norm inverse solution
Actual code using these principles might be different because
the inverse operator is often reused across data sets.
Parameters
----------
raw : Raw object
Raw data.
inverse_operator : dict
Inverse operator read with mne.read_inverse_operator.
lambda2 : float
The regularization parameter.
method : "MNE" | "dSPM" | "sLORETA"
Use mininum norm, dSPM or sLORETA.
label : Label | None
Restricts the source estimates to a given label. If None,
source estimates will be computed for the entire source space.
start : int
Index of first time sample (index not time is seconds).
stop : int
Index of first time sample not to include (index not time is seconds).
nave : int
Number of averages used to regularize the solution.
Set to 1 on raw data.
time_func : callable
Linear function applied to sensor space time series.
pick_ori : None | "normal"
If "normal", rather than pooling the orientations by taking the norm,
only the radial component is kept. This is only implemented
when working with loose orientations.
buffer_size : int (or None)
If not None, the computation of the inverse and the combination of the
current components is performed in segments of length buffer_size
samples. While slightly slower, this is useful for long datasets as it
reduces the memory requirements by approx. a factor of 3 (assuming
buffer_size << data length).
Note that this setting has no effect for fixed-orientation inverse
operators.
verbose : bool, str, int, or None
If not None, override default verbose level (see mne.verbose).
Returns
-------
stc : SourceEstimate | VolSourceEstimate
The source estimates.
"""
method = _check_method(method)
pick_ori = _check_ori(pick_ori, pick_normal)
_check_ch_names(inverse_operator, raw.info)
#
# Set up the inverse according to the parameters
#
inv = prepare_inverse_operator(inverse_operator, nave, lambda2, method)
#
# Pick the correct channels from the data
#
sel = _pick_channels_inverse_operator(raw.ch_names, inv)
logger.info('Picked %d channels from the data' % len(sel))
logger.info('Computing inverse...')
data, times = raw[sel, start:stop]
if time_func is not None:
data = time_func(data)
K, noise_norm, vertno = _assemble_kernel(inv, label, method, pick_ori)
is_free_ori = (inverse_operator['source_ori'] == FIFF.FIFFV_MNE_FREE_ORI
and pick_ori is None)
if buffer_size is not None and is_free_ori:
# Process the data in segments to conserve memory
n_seg = int(np.ceil(data.shape[1] / float(buffer_size)))
logger.info('computing inverse and combining the current '
'components (using %d segments)...' % (n_seg))
# Allocate space for inverse solution
n_times = data.shape[1]
sol = np.empty((K.shape[0] // 3, n_times),
dtype=(K[0, 0] * data[0, 0]).dtype)
for pos in range(0, n_times, buffer_size):
sol[:, pos:pos + buffer_size] = \
combine_xyz(np.dot(K, data[:, pos:pos + buffer_size]))
logger.info('segment %d / %d done..'
% (pos / buffer_size + 1, n_seg))
else:
sol = np.dot(K, data)
if is_free_ori:
logger.info('combining the current components...')
sol = combine_xyz(sol)
if noise_norm is not None:
sol *= noise_norm
tmin = float(times[0])
tstep = 1.0 / raw.info['sfreq']
subject = _subject_from_inverse(inverse_operator)
stc = _make_stc(sol, vertices=vertno, tmin=tmin, tstep=tstep,
subject=subject)
logger.info('[done]')
return stc
def _apply_inverse_epochs_gen(epochs, inverse_operator, lambda2, method='dSPM',
label=None, nave=1, pick_ori=None,
verbose=None, pick_normal=None):
""" see apply_inverse_epochs """
method = _check_method(method)
pick_ori = _check_ori(pick_ori, pick_normal)
_check_ch_names(inverse_operator, epochs.info)
#
# Set up the inverse according to the parameters
#
inv = prepare_inverse_operator(inverse_operator, nave, lambda2, method)
#
# Pick the correct channels from the data
#
sel = _pick_channels_inverse_operator(epochs.ch_names, inv)
logger.info('Picked %d channels from the data' % len(sel))
logger.info('Computing inverse...')
K, noise_norm, vertno = _assemble_kernel(inv, label, method, pick_ori)
tstep = 1.0 / epochs.info['sfreq']
tmin = epochs.times[0]
is_free_ori = (inverse_operator['source_ori'] == FIFF.FIFFV_MNE_FREE_ORI
and pick_ori is None)
if not is_free_ori and noise_norm is not None:
# premultiply kernel with noise normalization
K *= noise_norm
subject = _subject_from_inverse(inverse_operator)
for k, e in enumerate(epochs):
logger.info('Processing epoch : %d' % (k + 1))
if is_free_ori:
# Compute solution and combine current components (non-linear)
sol = np.dot(K, e[sel]) # apply imaging kernel
if is_free_ori:
logger.info('combining the current components...')
sol = combine_xyz(sol)
if noise_norm is not None:
sol *= noise_norm
else:
# Linear inverse: do computation here or delayed
if len(sel) < K.shape[0]:
sol = (K, e[sel])
else:
sol = np.dot(K, e[sel])
stc = _make_stc(sol, vertices=vertno, tmin=tmin, tstep=tstep,
subject=subject)
yield stc
logger.info('[done]')
@verbose
def apply_inverse_epochs(epochs, inverse_operator, lambda2, method="dSPM",
label=None, nave=1, pick_ori=None,
return_generator=False, verbose=None,
pick_normal=None):
"""Apply inverse operator to Epochs
Computes a L2-norm inverse solution on each epochs and returns
single trial source estimates.
Parameters
----------
epochs : Epochs object
Single trial epochs.
inverse_operator : dict
Inverse operator read with mne.read_inverse_operator.
lambda2 : float
The regularization parameter.
method : "MNE" | "dSPM" | "sLORETA"
Use mininum norm, dSPM or sLORETA.
label : Label | None
Restricts the source estimates to a given label. If None,
source estimates will be computed for the entire source space.
nave : int
Number of averages used to regularize the solution.
Set to 1 on single Epoch by default.
pick_ori : None | "normal"
If "normal", rather than pooling the orientations by taking the norm,
only the radial component is kept. This is only implemented
when working with loose orientations.
return_generator : bool
Return a generator object instead of a list. This allows iterating
over the stcs without having to keep them all in memory.
verbose : bool, str, int, or None
If not None, override default verbose level (see mne.verbose).
Returns
-------
stc : list of SourceEstimate or VolSourceEstimate
The source estimates for all epochs.
"""
stcs = _apply_inverse_epochs_gen(epochs, inverse_operator, lambda2,
method=method, label=label, nave=nave,
pick_ori=pick_ori, verbose=verbose,
pick_normal=pick_normal)
if not return_generator:
# return a list
stcs = [stc for stc in stcs]
return stcs
def _xyz2lf(Lf_xyz, normals):
"""Reorient leadfield to one component matching the normal to the cortex
This program takes a leadfield matix computed for dipole components
pointing in the x, y, and z directions, and outputs a new lead field
matrix for dipole components pointing in the normal direction of the
cortical surfaces and in the two tangential directions to the cortex
(that is on the tangent cortical space). These two tangential dipole
components are uniquely determined by the SVD (reduction of variance).
Parameters
----------
Lf_xyz: array of shape [n_sensors, n_positions x 3]
Leadfield
normals : array of shape [n_positions, 3]
Normals to the cortex
Returns
-------
Lf_cortex : array of shape [n_sensors, n_positions x 3]
Lf_cortex is a leadfield matrix for dipoles in rotated orientations, so
that the first column is the gain vector for the cortical normal dipole
and the following two column vectors are the gain vectors for the
tangential orientations (tangent space of cortical surface).
"""
n_sensors, n_dipoles = Lf_xyz.shape
n_positions = n_dipoles // 3
Lf_xyz = Lf_xyz.reshape(n_sensors, n_positions, 3)
n_sensors, n_positions, _ = Lf_xyz.shape
Lf_cortex = np.zeros_like(Lf_xyz)
for k in range(n_positions):
lf_normal = np.dot(Lf_xyz[:, k, :], normals[k])
lf_normal_n = lf_normal[:, None] / linalg.norm(lf_normal)
P = np.eye(n_sensors, n_sensors) - np.dot(lf_normal_n, lf_normal_n.T)
lf_p = np.dot(P, Lf_xyz[:, k, :])
U, s, Vh = linalg.svd(lf_p)
Lf_cortex[:, k, 0] = lf_normal
Lf_cortex[:, k, 1:] = np.c_[U[:, 0] * s[0], U[:, 1] * s[1]]
Lf_cortex = Lf_cortex.reshape(n_sensors, n_dipoles)
return Lf_cortex
###############################################################################
# Assemble the inverse operator
@verbose
def _prepare_forward(forward, info, noise_cov, pca=False, verbose=None):
"""Util function to prepare forward solution for inverse solvers
"""
fwd_ch_names = [c['ch_name'] for c in forward['info']['chs']]
ch_names = [c['ch_name'] for c in info['chs']
if (c['ch_name'] not in info['bads']
and c['ch_name'] not in noise_cov['bads'])
and (c['ch_name'] in fwd_ch_names
and c['ch_name'] in noise_cov.ch_names)]
if not len(info['bads']) == len(noise_cov['bads']) or \
not all([b in noise_cov['bads'] for b in info['bads']]):
logger.info('info["bads"] and noise_cov["bads"] do not match, '
'excluding bad channels from both')
n_chan = len(ch_names)
logger.info("Computing inverse operator with %d channels." % n_chan)
#
# Handle noise cov
#
noise_cov = prepare_noise_cov(noise_cov, info, ch_names)
# Omit the zeroes due to projection
eig = noise_cov['eig']
nzero = (eig > 0)
n_nzero = sum(nzero)
if pca:
# Rows of eigvec are the eigenvectors
whitener = noise_cov['eigvec'][nzero] / np.sqrt(eig[nzero])[:, None]
logger.info('Reducing data rank to %d' % n_nzero)
else:
whitener = np.zeros((n_chan, n_chan), dtype=np.float)
whitener[nzero, nzero] = 1.0 / np.sqrt(eig[nzero])
# Rows of eigvec are the eigenvectors
whitener = np.dot(whitener, noise_cov['eigvec'])
gain = forward['sol']['data']
fwd_idx = [fwd_ch_names.index(name) for name in ch_names]
gain = gain[fwd_idx]
info_idx = [info['ch_names'].index(name) for name in ch_names]
fwd_info = pick_info(info, info_idx)
logger.info('Total rank is %d' % n_nzero)
return fwd_info, gain, noise_cov, whitener, n_nzero
@verbose
def make_inverse_operator(info, forward, noise_cov, loose=0.2, depth=0.8,
fixed=False, limit_depth_chs=True, verbose=None):
"""Assemble inverse operator
Parameters
----------
info : dict
The measurement info to specify the channels to include.
Bad channels in info['bads'] are not used.
forward : dict
Forward operator.
noise_cov : Covariance
The noise covariance matrix.
loose : None | float in [0, 1]
Value that weights the source variances of the dipole components
defining the tangent space of the cortical surfaces. Requires surface-
based, free orientation forward solutions.
depth : None | float in [0, 1]
Depth weighting coefficients. If None, no depth weighting is performed.
fixed : bool
Use fixed source orientations normal to the cortical mantle. If True,
the loose parameter is ignored.
limit_depth_chs : bool
If True, use only grad channels in depth weighting (equivalent to MNE
C code). If grad chanels aren't present, only mag channels will be
used (if no mag, then eeg). If False, use all channels.
verbose : bool, str, int, or None
If not None, override default verbose level (see mne.verbose).
Returns
-------
inv : instance of InverseOperator
Inverse operator.
Notes
-----
For different sets of options (**loose**, **depth**, **fixed**) to work,
the forward operator must have been loaded using a certain configuration
(i.e., with **force_fixed** and **surf_ori** set appropriately). For
example, given the desired inverse type (with representative choices
of **loose** = 0.2 and **depth** = 0.8 shown in the table in various
places, as these are the defaults for those parameters):
+---------------------+-----------+-----------+-----------+-----------------+--------------+
| Inverse desired | Forward parameters allowed |
+=====================+===========+===========+===========+=================+==============+
| | **loose** | **depth** | **fixed** | **force_fixed** | **surf_ori** |
+---------------------+-----------+-----------+-----------+-----------------+--------------+
| | Loose constraint, | 0.2 | 0.8 | False | False | True |
| | Depth weighted | | | | | |
+---------------------+-----------+-----------+-----------+-----------------+--------------+
| | Loose constraint | 0.2 | None | False | False | True |
+---------------------+-----------+-----------+-----------+-----------------+--------------+
| | Free orientation, | None | 0.8 | False | False | True |
| | Depth weighted | | | | | |
+---------------------+-----------+-----------+-----------+-----------------+--------------+
| | Free orientation | None | None | False | False | True | False |
+---------------------+-----------+-----------+-----------+-----------------+--------------+
| | Fixed constraint, | None | 0.8 | True | False | True |
| | Depth weighted | | | | | |
+---------------------+-----------+-----------+-----------+-----------------+--------------+
| | Fixed constraint | None | None | True | True | True |
+---------------------+-----------+-----------+-----------+-----------------+--------------+
Also note that, if the source space (as stored in the forward solution)
has patch statistics computed, these are used to improve the depth
weighting. Thus slightly different results are to be expected with
and without this information.
"""
is_fixed_ori = is_fixed_orient(forward)
if fixed and loose is not None:
warnings.warn("When invoking make_inverse_operator with fixed=True, "
"the loose parameter is ignored.")
loose = None
if is_fixed_ori and not fixed:
raise ValueError('Forward operator has fixed orientation and can only '
'be used to make a fixed-orientation inverse '
'operator.')
if fixed:
if depth is not None:
if is_fixed_ori or not forward['surf_ori']:
raise ValueError('For a fixed orientation inverse solution '
'with depth weighting, the forward solution '
'must be free-orientation and in surface '
'orientation')
elif forward['surf_ori'] is False:
raise ValueError('For a fixed orientation inverse solution '
'without depth weighting, the forward solution '
'must be in surface orientation')
# depth=None can use fixed fwd, depth=0<x<1 must use free ori
if depth is not None:
if not (0 < depth <= 1):
raise ValueError('depth should be a scalar between 0 and 1')
if is_fixed_ori or not forward['surf_ori']:
raise ValueError('You need a free-orientation, surface-oriented '
'forward solution to do depth weighting even '
'when calculating a fixed-orientation inverse.')
if loose is not None:
if not (0 <= loose <= 1):
raise ValueError('loose value should be smaller than 1 and bigger '
'than 0, or None for not loose orientations.')
if loose < 1 and not forward['surf_ori']:
raise ValueError('Forward operator is not oriented in surface '
'coordinates. A loose inverse operator requires '
'a surface-based, free orientation forward '
'operator.')
#
# 1. Read the bad channels
# 2. Read the necessary data from the forward solution matrix file
# 3. Load the projection data
# 4. Load the sensor noise covariance matrix and attach it to the forward
#
gain_info, gain, noise_cov, whitener, n_nzero = \
_prepare_forward(forward, info, noise_cov)
#
# 5. Compose the depth-weighting matrix
#
if depth is not None:
patch_areas = forward.get('patch_areas', None)
depth_prior = compute_depth_prior(gain, gain_info, is_fixed_ori,
exp=depth, patch_areas=patch_areas,
limit_depth_chs=limit_depth_chs)
else:
depth_prior = np.ones(gain.shape[1], dtype=gain.dtype)
# Deal with fixed orientation forward / inverse
if fixed:
if depth is not None:
# Convert the depth prior into a fixed-orientation one
logger.info(' Picked elements from a free-orientation '
'depth-weighting prior into the fixed-orientation one')
if not is_fixed_ori:
# Convert to the fixed orientation forward solution now
depth_prior = depth_prior[2::3]
forward = deepcopy(forward)
_to_fixed_ori(forward)
is_fixed_ori = is_fixed_orient(forward)
gain_info, gain, noise_cov, whitener, n_nzero = \
_prepare_forward(forward, info, noise_cov, verbose=False)
logger.info("Computing inverse operator with %d channels."
% len(gain_info['ch_names']))
#
# 6. Compose the source covariance matrix
#
logger.info('Creating the source covariance matrix')
source_cov = depth_prior.copy()
depth_prior = dict(data=depth_prior, kind=FIFF.FIFFV_MNE_DEPTH_PRIOR_COV,
bads=[], diag=True, names=[], eig=None,
eigvec=None, dim=depth_prior.size, nfree=1,
projs=[])
# apply loose orientations
if not is_fixed_ori:
orient_prior = compute_orient_prior(forward, loose=loose)
source_cov *= orient_prior
orient_prior = dict(data=orient_prior,
kind=FIFF.FIFFV_MNE_ORIENT_PRIOR_COV,
bads=[], diag=True, names=[], eig=None,
eigvec=None, dim=orient_prior.size, nfree=1,
projs=[])
else:
orient_prior = None
# 7. Apply fMRI weighting (not done)
#
# 8. Apply the linear projection to the forward solution
# 9. Apply whitening to the forward computation matrix
#
logger.info('Whitening the forward solution.')
gain = np.dot(whitener, gain)
# 10. Exclude the source space points within the labels (not done)
#
# 11. Do appropriate source weighting to the forward computation matrix
#
# Adjusting Source Covariance matrix to make trace of G*R*G' equal
# to number of sensors.
logger.info('Adjusting source covariance matrix.')
source_std = np.sqrt(source_cov)
gain *= source_std[None, :]
trace_GRGT = linalg.norm(gain, ord='fro') ** 2
scaling_source_cov = n_nzero / trace_GRGT
source_cov *= scaling_source_cov
gain *= sqrt(scaling_source_cov)
source_cov = dict(data=source_cov, dim=source_cov.size,
kind=FIFF.FIFFV_MNE_SOURCE_COV, diag=True,
names=[], projs=[], eig=None, eigvec=None,
nfree=1, bads=[])
# now np.trace(np.dot(gain, gain.T)) == n_nzero
# logger.info(np.trace(np.dot(gain, gain.T)), n_nzero)
#
# 12. Decompose the combined matrix
#
logger.info('Computing SVD of whitened and weighted lead field '
'matrix.')
eigen_fields, sing, eigen_leads = linalg.svd(gain, full_matrices=False)
logger.info(' largest singular value = %g' % np.max(sing))
logger.info(' scaling factor to adjust the trace = %g' % trace_GRGT)
eigen_fields = dict(data=eigen_fields.T, col_names=gain_info['ch_names'],
row_names=[], nrow=eigen_fields.shape[1],
ncol=eigen_fields.shape[0])
eigen_leads = dict(data=eigen_leads.T, nrow=eigen_leads.shape[1],
ncol=eigen_leads.shape[0], row_names=[],
col_names=[])
nave = 1.0
# Handle methods
has_meg = False
has_eeg = False
ch_idx = [k for k, c in enumerate(info['chs'])
if c['ch_name'] in gain_info['ch_names']]
for idx in ch_idx:
ch_type = channel_type(info, idx)
if ch_type == 'eeg':
has_eeg = True
if (ch_type == 'mag') or (ch_type == 'grad'):
has_meg = True
if has_eeg and has_meg:
methods = FIFF.FIFFV_MNE_MEG_EEG
elif has_meg:
methods = FIFF.FIFFV_MNE_MEG
else:
methods = FIFF.FIFFV_MNE_EEG
# We set this for consistency with mne C code written inverses
if depth is None:
depth_prior = None
inv_op = dict(eigen_fields=eigen_fields, eigen_leads=eigen_leads,
sing=sing, nave=nave, depth_prior=depth_prior,
source_cov=source_cov, noise_cov=noise_cov,
orient_prior=orient_prior, projs=deepcopy(info['projs']),
eigen_leads_weighted=False, source_ori=forward['source_ori'],
mri_head_t=deepcopy(forward['mri_head_t']),
methods=methods, nsource=forward['nsource'],
coord_frame=forward['coord_frame'],
source_nn=forward['source_nn'].copy(),
src=deepcopy(forward['src']), fmri_prior=None)
inv_info = deepcopy(forward['info'])
inv_info['bads'] = deepcopy(info['bads'])
inv_op['units'] = 'Am'
inv_op['info'] = inv_info
return InverseOperator(inv_op)
def compute_rank_inverse(inv):
"""Compute the rank of a linear inverse operator (MNE, dSPM, etc.)
Parameters
----------
inv : dict
The inverse operator.
Returns
-------
rank : int
The rank of the inverse operator.
"""
# this code shortened from prepare_inverse_operator
eig = inv['noise_cov']['eig']
if not inv['noise_cov']['diag']:
rank = np.sum(eig > 0)
else:
ncomp = make_projector(inv['projs'], inv['noise_cov']['names'])[1]
rank = inv['noise_cov']['dim'] - ncomp
return rank
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