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CLUSTAL W (1.82) multiple sequence alignment
Bks ----TPSCFLKVS-----RLEAQLLLER-YPECGN-----LLLRPS--GDGADGVSVTTR 43
Brdg1 ----MPACFYTVS-----RKEATEMLQK-NPSLGN-----MILRP---GSDSRNYSITIR 42
BC007586 ----QVWYHGAIS-----RTDAENLLRL-CKE-AS-----YLVRNS--ETSKNDFSLSLK 42
Shb ----QIWYHGAIS-----RGDAENLLRL-CKE-CS-----YLVRNS--QTSKHDYPLSLR 42
Shd ----QPWFHGPLN-----RADAESLLSL-CKE-GS-----YLVRLS--ETNPQDCSLSLR 42
Hsh2 ----PEWFHGAIS-----REDAENLLES-QPL-GS-----FLIRVS--HS-HVGYTLSYK 41
Vrap ----PAWFHGFIT-----RREAERLLEP-KPQ-GC-----YLVRFS--ES-AVTFVLTYR 41
Sh2a ----APWFHGILT-----LKKANELLLS-TGMPGS-----FLIRVS--ER-IKGYALSYL 42
Abl ----HSWYHGPVS-----RNAAEYLLSSGIN--GS-----FLVRES-ESS-PSQRSISLR 42
Arg ----HSWYHGPVS-----RSAAEYLLSSLIN--GS-----FLVRES-ESS-PGQLSISLR 42
Hck ----EEWFFKGIS-----RKDAERQLLAPGNMLGS-----FMIRDS-ETT-KGSYSLSVR 44
Lck ----EPWFFKNLS-----RKDAERQLLAPGNTHGS-----FLIRES-EST-AGSFSLSVR 44
Lyn ----EEWFFKDIT-----RKDAERQLLAPGNSAGA-----FLIRES-ETL-KGSFSLSVR 44
Blk ----ERWFFRSQG-----RKEAERQLLAPINKAGS-----FLIRES-ETN-KGAFSLSVK 44
Fgr ----EEWYFGKIG-----RKDAERQLLSPGNPQGA-----FLIRES-ETT-KGAYSLSIR 44
Fyn ----EEWYFGKLG-----RKDAERQLLSFGNPRGT-----FLIRES-ETT-KGAYSLSIR 44
Yes ----EEWYFGKMG-----RKDAERLLLNPGNQRGI-----FLVRES-ETT-KGAYSLSIR 44
Src ----EEWYFGKIT-----RRESERLLLNAENPRGT-----FLVRES-ETT-KGAYCLSVS 44
Frk ----EPWFFGAIG-----RSDAEKQLLYSENKTGS-----FLIRES-ESQ-KGEFSLSV- 43
Slap ----HGWLFEGLG-----RDKAEELLQLPDTKVGS-----FMIRES-ETK-KGFYSLSVR 44
Slap2 ----HGWLYEGLS-----REKAEELLLLPGNPGGA-----FLIRES-QTR-RGSYSLSVR 44
Brk ----EPWFFGCIS-----RSEAVRRLQAEGNATGA-----FLIRVS-EKP-SADYVLSVR 44
Srms ----QPWYFSGVS-----RTQAQQLLLSPPNEPGA-----FLIRPS-ESS-LGGYSLSVR 44
SykC ----MPWFHGKIS-----REESEQIVLIGSKTNGK-----FLIRA--RDN-NGSYALCLL 43
Zap70C ----MPWYHSSLT-----REEAERKLYSGAQTDGK-----FLLRP--RKE-QGTYALSLI 43
SykN ----LPFFFGNIT-----REEAEDYLVQGGMSDGL-----YLLRQS-RNY-LGGFALSVA 44
Zap70N ----LPFFYGSIS-----RAEAEEHLKLAGMADGL-----FLLRQC-LRS-LGGYVLSLV 44
Csk ----MPWFHGKIT-----REQAERLLYPPET--GL-----FLVRES-TNY-PGDYTLCVS 42
Lsk ----MPWFHGKIS-----GQEAVQQLQPPED--GL-----FLVRES-ARH-PGDYVLCVS 42
Cis1 ----SGWYWGSIT-----ASEARQHLQ--KMPEGT-----FLVRDS-THP-SYLFTLSVK 42
Socs2 ----TGWYWGSMT-----VNEAKEKLK--EAPEGT-----FLIRDS-SHS-DYLLTISVK 42
Socs3 ----SGFYWSAVT-----GGEANLLLS--AEPAGT-----FLIRDS-SDQ-RHFFTLSVK 42
Socs1 ----CGFYWGPLS-----VHGAHERLR--AEPVGT-----FLVRDS-RQR-NCFFALSVK 42
Nap4 ----CGWYWGPMN-----WEDAEMKLK--GKPDGS-----FLVRDS-SDP-RYILSLSFR 42
Socs4 ----QGWYWGPIT-----RWEAEGKLA--NVPDGS-----FLVRDS-SDD-RYLLSLSFR 42
Socs5 ----NPCYWGVMD-----RYEAEALLE--GKPEGT-----FLLRDS-AQE-DYLFSVSFR 42
Socs7 ----NPCYWGVMD-----KYAAEALLE--GKPEGT-----FLLRDS-AQE-DYLFSVSFR 42
Crk ----SSWYWGRLS-----RQEAVALLQ--GQRHGV-----FLVRDS-STS-PGDYVLSVS 42
CrkL ----SAWYMGPVS-----RQEAQTRLQ--GQRHGM-----FLVRDS-STC-PGDYVLSVS 42
Pi3kCaplha ----KTWNVGSSN-----RNKAENLLR--GKRDGT-----FLVRES-SK--QGCYACSVV 41
Pi3kCgamma ----KTWFVEDIN-----RVQAEDLLY--GKPDGA-----FLIRES-SK--KGCYACSVV 41
Pi3kCbeta ----RTWYVGKIN-----RTQAEEMLS--GKRDGT-----FLIRES-SQ--RGCYACSVV 41
Pi3kNalpha ----AEWYWGDIS-----REEVNEKLR--DTADGT-----FLVRDA-STKMHGDYTLTLR 43
Pi3kNgamma ----AEWYWGDIS-----REEVNDKLR--DMPDGT-----FLVRDA-STKMQGDYTLTLR 43
Pi3kNbeta ----AEWYWGDIS-----REEVNEKLR--DTPDGT-----FLVRDA-SSKIQGEYTLTLR 43
Vav1 ----HLWYAGPME-----RAGAESILA--NRSDGT-----FLVRQR-VKD-AAEFAISIK 42
Vav3 ----QPWYAGAME-----RLQAETELI--NRVNST-----YLVRHR-TKE-SGEYAISIK 42
Vav2 ----YPWFAGNME-----RQQTDNLLK--SHASGT-----YLIRER-PAE-AERFAISIK 42
Mist ----NEWYIGEYS-----RQAVE-EAFMKENKDGS-----FLVRDCSTKSKEEPYVLAVF 45
Slp76 ----EEWYVSYIT-----RPEAE-AALRKINQDGT-----FLVRDSSKKTTTNPYVLMVL 45
Blnk ----KPWYAGACD-----RKSAE-EALHRSNKDGS-----FLIRKSSGHDSKQPYTLVVF 45
Plcg1C ----KEWYHASLT-----RAQAE-HMLMRVPRDGA-----FLVRK---RNEPNSYAISFR 42
Plcg2C ----KPWYYDSLS-----RGEAE-DMLMRIPRDGA-----FLIRK---REGSDSYAITFR 42
Btk ----YEWYSKHMT-----RSQAE-QLLKQEGKEGG-----FIVRD---SSKAGKYTVSVF 42
Txk ----YEWYHRNIT-----RNQAE-HLLRQESKEGA-----FIVRD---SRHLGSYTISVF 42
Itk ----YEWYNKSIS-----RDKAE-KLLLDTGKEGA-----FMVRD---SRTAGTYTVSVF 42
Tec ----YEWYCRNMN-----RSKAE-QLLRSEDKEGG-----FMVRD---SSQPGLYTVSLY 42
Bmx ----YDWFAGNIS-----RSQSE-QLLRQKGKEGA-----FMVRN---SSQVGMYTVSLF 42
Eat2 ----LPYYHGRLT-----KQDCE-TLLLKEGVDGN-----FLLRDS--ESIPGVLCLCVS 43
Sap ----VAVYHGKIS-----RETGE-KLLLATGLDGS-----YLLRDS--ESVPGVYCLCVL 43
Ship ----PCWNHGNIT-----RSKAE-ELLSRTGKDGS-----FLVRAS--ESISRAYALCVL 43
Ship2 ----PSWYHRDLS-----RAAAE-ELLARAGRDGS-----FLVRDS--ESVAGAFALCVL 43
Nck ----NPWYYGKVT-----RHQAE-MALNERGHEGD-----FLIRDS--ESSPNDFSVSLK 43
Nck2 ----REWYYGNVT-----RHQAQ-CALNERGVEGD-----FLIRDS--ESSPSDFSVSLK 43
Dapp1 ----LGWYHGNLT-----RHAAE-ALLLSNGCDGS-----YLLRDS--NETTGLYSLSVR 43
Grap ----HPWYSGRIS-----RQLAE-EILMKRNHLGA-----FLIRES--ESSPGEFSVSVN 43
Grb2 ----HPWFFGKIP-----RAKAE-EMLSKQRHDGA-----FLIRES--ESAPGDFSLSVK 43
Grap2 ----PKWFHEGLS-----RHQAE-NLLMG-KEVGF-----FIIRAS--QSSPGDFSISVR 42
Shp1C ----ERWYHGHMS-----GGQAE-TLLQAKGEPWT-----FLVRES--LSQPGDFVLSVL 43
Shp2C ----ERWFHGHLS-----GKEAE-KLLTEKGKHGS-----FLVRES--QSHPGDFVLSVR 43
Shp1N ----VRWFHRDLS-----GLDAE-TLLKGRGVHGS-----FLARPS--RKNQGDFSLSVR 43
Shp2N ----RRWFHPNIT-----GVEAE-NLLLTRGVDGS-----FLARPS--KSNPGDFTLSVR 43
Aps ----YPWFHGTLS-----RVKAAQLVLA----GGPRNHGLFVIRQS--ETRPGEYVLTFN 45
Sh2b ----YPWFHGMLS-----RLKAAQLVLT----GGTGSHGVFLVRQS--ETRRGEYVLTFN 45
Lnk ----YPWFHGPIS-----RVKAAQLVQL----QGPDAHGVFLVRQS--ETRRGEYVLTFN 45
Fer ----QDWYHGAIP-----RIEAQELLKK----QGD-----FLVRES--HGKPGEYVLSVY 40
Fes ----QLWYHGAIP-----RAEVAELLVH----SGD-----FLVRES--QGKQ-EYVLSVL 39
Nsp2 ----HAWYHGRIP-----RQVSENLVQR----DGD-----FLVRDS--LSSPGNFVLTCQ 40
Nsp3 ----HAWYHGRIP-----REVSETLVQR----NGD-----FLIRDS--LTSLGDYVLTCR 40
Nsp1 ----QPWYHGLLS-----RQKAEALLQQ----DGD-----FLVRAS--GSRGGNPVISCR 40
Shca ----EPWFHGKLS-----RREAEALLQL----NGD-----FLVRES--TTTPGQYVLTGL 40
Shcd QLWSEECYHGKLS-----RKAAESLLVK----DGD-----FLVRES--ATSPGQYVLSGL 44
Shcc ----ETWYQGEMS-----RKEAEGLLEK----DGD-----FLVRKS--TTNPGSFVLTGM 40
Shcb ----EPWYHGRMS-----RRAAERMLRA----DGD-----FLVRDS--VTNPGQYVLTGM 40
Grb10 ----QHWFHGRIS-----REESHRIIKQ----QGLVD-GLFLLRDS--QSNPKAFVLTLC 44
Grb14 ----QPWFHHKIS-----RDEAQRLIIQ----QGLVD-GVFLVRDS--QSNPKTFVLSMS 44
Grb7 ----QLWFHGRIS-----REESQRLIGQ----QGLVD-GLFLVRES--QRNPQGFVLSLC 44
Plcg1N ----EKWFHGKLGAGRDGRHIAERLLTEYCIETGAPD-GSFLVRES--ETFVGDYTLSFW 53
Plcg2N ----EKWFHKKV----EKRTSAEKLLQEYCMETGGKD-GTFLVRES--ETFPNDYTLSFW 49
Chimerin1 ----GREFHGMIS-----REAADQLLIV---AEGS-----YLIRES--QRQPGTYTLALR 41
Chimerin2 ----GREFHGIIS-----REQADELLGG---VEGA-----YILRES--QRQPGCYTLALR 41
Tens1 ----KFWYKADIS-----REQAIAMLKD--KEPGS-----FIVRDS--HSFRGAYGLAMK 42
Tensin ----KYWYKPEIS-----REQAIALLKD--QEPGA-----FIIRDS--HSFRGAYGLAMK 42
Tenc1 ----KFWYKPHLS-----RDQAIALLKD--KDPGA-----FLIRDS--HSFQGAYGLALK 42
Cten ----KYWFKPNIT-----REQAIELLRK--EEPGA-----FVIRDS--SSYRGSFGLALK 42
Rin2 ----PIWLQLSLS-----EEEAAEVLQA--QPPGI-----FLVHKS--TKMQ-KKVLSLR 41
Rin3 ----PVWLQLSLG-----QAEVARILHR--VVAGM-----FLVRRD--SSSK-QLVLCVH 41
Rin1 ----PVWLQLQAN-----AAAALHMLRT--EPPGT-----FLVRKS--NTRQ-CQALCMR 41
Stat1 ----PLWNDGCIMG--FISKERERALLK-DQQPGT-----FLLRFS-ESSREGAITFTWV 47
Stat4 ----PLWIDGYVMG--FVSKEKERLLLK-DKMPGT-----FLLRFS-ES-HLGGITFTWV 46
Stat3 ----ALWNEGYIMG--FISKERERAILS-TKPPGT-----FLLRFS-ESSKEGGVTFTWV 47
Stat2 ----DLWNDGRIMG--FVSRSQERRLLK-KTMSGT-----FLLRFS-ES-SEGGITCSWV 46
Stat5a ----PHWNDGAILG--FVNKQQAHDLLI-NKPDGT-----FLLRFS-DS-EIGGITIAWK 46
Stat5b ----PHWNDGAILG--FVNKQQAHDLLI-NKPDGT-----FLLRFS-DS-EIGGITIAWK 46
Stat6 ----SYWSDRLIIG--FISKQYVTSLLL-NEPDGT-----FLLRFS-DS-EIGGITIAHV 46
Jak2 ----QSNCHGPIS-----MDFAISKLKKAGNQTGL-----YVLRCS--PKDFNKYFLTF- 43
Jak3 ----AEQCHGPIT-----LDFAINKLKTGGSRPGS-----YVLRRS--PQDFDSFLLTV- 43
Jak1 ----QNGCHGPIC-----TEYAINKLRQEGSEEGM-----YVLRWS--CTDFDNILMTVT 44
Cbl ----HPGYMAFLT-----YDEVKARLQKFIHKPGS-----YIFRLS--CTRLGQWAIGYV 44
Cblb ----HPGYMAFLT-----YDEVKARLQKYSTKPGS-----YIFRLS--CTRLGQWAIGYV 44
Cblc ----HPGYMAFLT-----YDEVQERLQACRDKPGS-----YIFRPS--CTRLGQWAIGYV 44
RasGapN ----NQWYHGKLD-----RTIAEERLRQ-AGKSGS-----YLIRES--DRRPGSFVLSFL 43
RasGapC ----KIWFHGKIS-----KQEAYNLLMT-VGQVCS-----FLVRPS--DNTPGDYSLYFR 43
Tyk2 -----DGIHGPLL-----EPFVQAKLRP---EDGL-----YLIHWS--TSHPYRLILTVA 40
Sh3bp2 ----NSVFVNTTE------SCEVERLFKATSPRGEPQDGLYCIRNS--STKSGKVLVVWD 48
Supt6h ----HPSFHNINF------KQAEKMMET--MDQGD-----VIIRPS--SKGENHLTVTWK 41
:
Bks QMHNG--------------THVVRHYKVKREGPKY-------VIDVEQPFS------CTS 76
Brdg1 QEID---------------IPRIKHYKVMSVGQNY-------TIELEKPVT------LPN 74
BC007586 S------------------SQGFMHMKLSRTKEH-------KYVLGQNSPP------FSS 71
Shb S------------------NQGFMHMKLAKTKE--------KYVLGQNSPP------FDS 70
Shd S------------------SQGFLHLKFARTREN-------QVVLGQHSGP------FPS 71
Hsh2 A------------------QSSCCHFMVKLLDDG-------TFMIPGEKVA------HTS 70
Vrap S------------------RTCCRHFLLAQLRDG-------RHVVLGEDSA------HAR 70
Sh2a S------------------EDGCKHFLIDASADA-------YSFLGVDQLQ------HAT 71
Abl ------------------YEGRVYHYRINTASDGK------LYVSSESR--------FNT 70
Arg ------------------YEGRVYHYRINTTADGK------VYVTAESR--------FST 70
Hck DYDP-----R--------QGDTVKHYKIRTLDNGG------FYISPRST--------FST 77
Lck DFDQ-----N--------QGEVVKHYKIRNLDNGG------FYISPRIT--------FPG 77
Lyn DFDP-----V--------HGDVIKHYKIRSLDNGG------YYISPRIT--------FPC 77
Blk DVT------T--------QGELIKHYKIRCLDEGG------YYISPRIT--------FPS 76
Fgr DWDQ-----T--------RGDHVKHYKIRKLDMGG------YYITTRVQ--------FNS 77
Fyn DWDD-----M--------KGDHVKHYKIRKLDNGG------YYITTRAQ--------FET 77
Yes DWDE-----I--------RGDNVKHYKIRKLDNGG------YYITTRAQ--------FDT 77
Src DFDN-----A--------KGLNVKHYKIRKLDSGG------FYITSRTQ--------FNS 77
Frk ---------L--------DGAVVKHYRIKRLDEGG------FFLTRRRI--------FST 72
Slap HR-------------------QVKHYRIFRLPNNW------YYISPRLT--------FQC 71
Slap2 LSRP-----A--------SWDRIRHYRIHCLDNGW------LYISPRLT--------FPS 77
Brk ------------------DTQAVRHYKIWRRAGGR------LHLNEAVS--------FLS 72
Srms ------------------AQAKVCHYRVSMAADGS------LYLQKGRL--------FPG 72
SykC ------------------HEGKVLHYRIDKDKTGK------LSIPEGKK--------FDT 71
Zap70C ------------------YGKTVYHYLISQDKAGK------YCIPEGTK--------FDT 71
SykN ------------------HGRKAHHYTIERELNGT------YAIAGGRT--------HAS 72
Zap70N ------------------HDVRFHHFPIERQLNGT------YAIAGGKA--------HCG 72
Csk ------------------CDGKVEHYRIMYH-ASK------LSIDEEVY--------FEN 69
Lsk ------------------FGRDVIHYRVLHR-DGH------LTIDEAVF--------FCN 69
Cis1 ------------------TTRGPTNVRIEYA-DSS------FRLDSNCLSRPR-ILAFPD 76
Socs2 ------------------TSAGPTNLRIEYQ-DGK------FRLDSIICVKSK-LKQFDS 76
Socs3 ------------------TQSGTKNLRIQCE-GGS------FSLQSDPRSTQP-VPRFDC 76
Socs1 ------------------MASGPTSIRVHFQ-AGR------FHLDG---SRE----SFDC 70
Nap4 ------------------SQGITHHTRMEHY-RGT------FSLWCHPKFEDR-CQSVVE 76
Socs4 ------------------SHGKTLHTRIEHS-NGR------FSFYEQPDVEG--HTSIVD 75
Socs5 ------------------RYNRSLHARIEQW-NHN------FSFDAHDPCVFH-SSTVTG 76
Socs7 ------------------RYSRSLHARIEQW-NHN------FSFDAHDPCVFH-SPDITG 76
Crk ------------------ENSRVSHYIINSS-GPR------PPVPPSPAQPPP-GVSPSR 76
CrkL ------------------ENSRVSHYIINSL-PNR------------------------R 59
Pi3kCaplha ------------------VDGEVKHCVINKT-ATG------YGFAEPYNL-------YSS 69
Pi3kCgamma ------------------ADGEVKHCVIYST-ARG------YGFAEPYNL-------YSS 69
Pi3kCbeta ------------------VDGDTKHCVIYRT-ATG------FGFAEPYNL-------YGS 69
Pi3kNalpha ------------------KGGNNKLIKIFHR-DGK------YGFSDPLT--------FSS 70
Pi3kNgamma ------------------KGGNNKLIKIYHR-DGK------YGFSDPLT--------FNS 70
Pi3kNbeta ------------------KGGNNKLIKVFHR-DGH------YGFSEPLT--------FCS 70
Vav1 ------------------YNVEVKHIKIMTA-EGL------YRITEKKA--------FRG 69
Vav3 ------------------YNNEAKHIKILTR-DGF------FHIAENRK--------FKS 69
Vav2 ------------------FNDEVKHIKVVEK-DNW------IHITEAKK--------FDS 69
Mist YE-------N--------KVYNVKIRFLERNQQFA------LGTGLRGDEK------FDS 78
Slp76 YK-------D--------KVYNIQIRYQKESQVYL------LGTGLRGKED------FLS 78
Blnk FN-------K--------RVYNIPVRFIEATKQYA------LGRKKNGEEY------FGS 78
Plcg1C AE-------G--------KIKHCRVQ--QEGQTVM------LG----NSE-------FDS 68
Plcg2C AR-------G--------KVKHCRIN--RDGRHFV------LG----TSAY------FES 69
Btk AK----STGD--------PQGVIRHYVVCSTPQS--------QYYLAEKHL------FST 76
Txk MG----ARRS--------TEAAIKHYQIKKNDSG--------QWYVAERHA------FQS 76
Itk TKA---VVSE--------NNPCIKHYHIKETNDNP------KRYYVAEKYV------FDS 79
Tec TK----FGGE--------GSSGFRHYHIKETTTSP------KKYYLAEKHA------FGS 78
Bmx SK----AVND--------KKGTVKHYHVHTNAEN--------KLYLAENYC------FDS 76
Eat2 FK-------N--------IVYTYRIFREKHGYYRI------QTAEGSPKQV------FPS 76
Sap YH-------G--------YIYTYRVSQTETGSWSA------ETAPGVHKRY------FRK 76
Ship YR-------N--------CVYTYRILPNEDDKFTV------QASEGVSMRF------FTK 76
Ship2 YQ-------K--------HVHTYRILPDGEDFLAV------QTSQGVPVRR------FQT 76
Nck AQG------------------KNKHFKVQLKETV---------YCIG-QRK------FST 69
Nck2 ASG------------------KNKHFKVQLVDNV---------YCIG-QRR------FHT 69
Dapp1 AKD------------------SVKHFHVEYTGYS---------FKFG-FNE------FSS 69
Grap YGD------------------QVQHFKVLREASG---------KYFLWEEK------FNS 70
Grb2 FGN------------------DVQHFKVLRDGAG---------KYFLWVVK------FNS 70
Grap2 HED------------------DVQHFKVMRDNKG---------NYFLWTEK------FPS 69
Shp1C SDQPKAGPGS---------PLRVTHIKVMCEGGR---------YTVGGLET------FDS 79
Shp2C TGDDKGESND--------GKSKVTHVMIRCQELK---------YDVGGGER------FDS 80
Shp1N VGD------------------QVTHIRIQNSGDF---------YDLYGGEK------FAT 70
Shp2N RNG------------------AVTHIKIQNTGDY---------YDLYGGEK------FAT 70
Aps F------------------QGKAKHLRLSLNGHG--------QCHVQHL-------WFQS 72
Sh2b F------------------QGKAKHLRLSLNEEG--------QCRVQHL-------WFQS 72
Lnk F------------------QGIAKHLRLSLTERG--------QCRVQHL-------HFPS 72
Fer S------------------DGQRRHFIIQYVDN---------MYRFEGT-------GFSN 66
Fes W------------------DGLPRHFIIQSLDN---------LYRLEGE-------GFPS 65
Nsp2 W------------------KNLAQHFKINRTVLRLSEAYSRVQYQFEME-------SFDS 75
Nsp3 W------------------RNQALHFKINKVVVKAGESYTHIQYLFEQE-------SFDH 75
Nsp1 W------------------RGSALHFEVFRVALRPRPGRPTALFQLEDE-------QFPS 75
Shca Q------------------SGQPKHLLLVDPEG---------VVRTKDH-------RFES 66
Shcd Q------------------GGQAKHLLLVDPEG---------KVRTKDH-------VFDN 70
Shcc H------------------NGQAKHLLLVDPEG---------TIQTKDR-------VFDS 66
Shcb H------------------AGQPKHLLLVDPEG---------VVRTKDV-------LFES 66
Grb10 H------------------HQKIKNFQILPCEDD-----GQTFFSLDDGNT-----KFSD 76
Grb14 H------------------GQKIKHFQIIPVEDD-----GEMFHTLDDGHT-----RFTD 76
Grb7 H------------------LQKVKHYLILPSEEE-----GRLYFSMDDGQT-----RFTD 76
Plcg1N R------------------NGKVQHCRIHSRQDA-----GTPKFFLTDN-L-----VFDS 84
Plcg2N R------------------SGRVQHCRIRSTMEG-----GTLKYYLTDN-L-----RFRR 80
Chimerin1 ------------------FGSQTRNFRLYYDGKH---------FVGEKR--------FES 66
Chimerin2 ------------------FGNQTLNYRLFHDGKH---------FVGEKR--------FES 66
Tens1 VATPPPSVLQLNKKAGDLANELVRHFLIECTPKG---------VRLKGCSN---EPYFGS 90
Tensin VSSPPPTIMQQNKK-GDMTHELVRHFLIETGPRG---------VKLKGCPN---EPNFGS 89
Tenc1 VATPPPSAQP--WK-GDPVEQLVRHFLIETGPKG---------VKIKGCPS---EPYFGS 87
Cten VQEVPASAQN---RPGEDSNDLIRHFLIESSAKG---------VHLKGADE---EPYFGS 87
Rin2 LP--CEFGAP------------LKEFAIKESTYT---------FSLEGS-----GISFAD 73
Rin3 FPSLNESSAE------------VLEYTIKEEKSI---------LYLEGS-----ALVFED 75
Rin1 LP---EASGPS----------FVSSHYILESPGG---------VSLEGS-----ELMFPD 74
Stat1 ERS--------------QNGGEPDFHAVEPYTKKE---LSAVTFPDIIRNYKVMAAENIP 90
Stat4 DHS--------------ESG-EVRFHSVEPYNKGR---LSALPFADILRDYKVIMAENIP 88
Stat3 EKD--------------ISG-KTQIQSVEPYTKQQ---LNNMSFAEIIMGYKIMDATNIL 89
Stat2 EHQ--------------DDD-KVLIYSVQPYTKEV---LQSLPLTEIIRHYQLLTEENIP 88
Stat5a FD---------------SPER--NLWNLKPFTTRD---FSIRSLADRLG----------D 76
Stat5b FD---------------SQER--MFWNLMPFTTRD---FSIRSLADRLG----------D 76
Stat6 IR---------------GQDGSPQIENIQPFSAKD---LSIRSLGDRIR----------D 78
Jak2 AVERE-------------NVIEYKHCLITKNENEE------YNLSGTKKN-------FSS 77
Jak3 CVQNP-------------LGPDYKGCLIRRSPTGT------FLLVGLSRP-------HSS 77
Jak1 CFEKSEQVQG--------AQKQFKNFQIEVQ-KGR------YSLHGSDRS-------FPS 82
Cbl TA----------------DGNILQTIPHNKPLFQALIDGFREGFYLFPDGR-------NQ 81
Cblb TG----------------DGNILQTIPHNKPLFQALIDGSREGFYLYPDGR-------SY 81
Cblc SS----------------DGSILQTIPANKPLSQVLLEGQKDGFYLYPDGK-------TH 81
RasGapN S-----------------QMNVVNHFRIIAMCGDY--------YIGGRR--------FSS 70
RasGapC T------------------NENIQRFKICPTPNNQ--------FMMGGR-------YYNS 70
Tyk2 QRSQ--------------APDGMQSLRLRKFPIEQ----QDGAFVLEGWGR-----SFPS 77
Sh3bp2 ET-----------------SNKVRNYRIFEKDSK---------FYLEGEVL------FVS 76
Supt6h VS-----------------DGIYQHVDVREEGKEN-------AFSLGATLWIN-SEEFED 76
Bks LDAVVNYFVSHTK------KALVP--------FLLDEDYEKVLGYVE- 109
Brdg1 LFSVIDYFVKETR------GNLRP--------FICSTD---------- 98
BC007586 VPEIVHHYASRK----LPIKGA----------EHMSLLYP-------- 97
Shb VPEVIHYYTTRK----LPIKGA----------EHLSLLYPVAVRTL-- 102
Shd VPELVLHYSSRP----LPVQGA----------EHLALLY--------- 96
Hsh2 LDALVTFHQQKP----IEPRR-----------ELLTQPC--------- 94
Vrap LQDLLLHYTAHP----LSPYG-----------ETLTEPLARQ------ 97
Sh2a LADLVEYHKEEP----ITSLGK----------ELLLYPC--------- 96
Abl LAELVHHHSTVAD-------GLI---------TTLHYPA--------- 93
Arg LAELVHHHSTVAD-------GLV---------TTLHYPAP-------- 94
Hck LQELVDHYKKGND-------GLC---------QKLSVPC--------- 100
Lck LHELVRHYTNASD-------GLC---------TRLSRPC--------- 100
Lyn ISDMIKHYQKQAD-------GLC---------RRLEKAC--------- 100
Blk LQALVQHYSKKGD-------GLC---------QRLTLPC--------- 99
Fgr VQELVQHYMEVND-------GLC---------NLLIAPC--------- 100
Fyn LQQLVQHYSERAA-------GLC---------CRLVVPC--------- 100
Yes LQKLVKHYTEHAD-------GLC---------HKLTTVC--------- 100
Src LQQLVAYYSKHAD-------GLC---------HRLTTVC--------- 100
Frk LNEFVSHYTKTSD-------GLC---------VKLGKPC--------- 95
Slap LEDLVNHYSEVAD-------GLC---------CVLTTPC--------- 94
Slap2 LQALVDHYSELAD-------DIC---------CLLKEPC--------- 100
Brk LPELVNYHRAQSL-------SHG---------LRLAAPC--------- 95
Srms LEELLTYYKANWK-------LIQ---------NPLLQPC--------- 95
SykC LWQLVEHYSYKAD-------GLL---------RVLTVPCQKIGTQ--- 100
Zap70C LWQLVEYLKLKAD-------GLI---------YCLKEACPNSSASNAS 103
SykN PADLCHYHSQESD-------GLV---------CLLKKPFNRPQ----- 99
Zap70N PAELCEFYSRDPD-------GLP---------CNLRKPC--------- 95
Csk LMQLVEHYTSDAD-------GLC---------TRLIKPK--------- 92
Lsk LMDMVEHYSKDKG-------AIC---------TKLVRPK--------- 92
Cis1 VVSLVQHYVASCTADTRSDSPDP---------AP-TPALPMPK----- 109
Socs2 VVHLIDYYVQMCK-DKRTGPEAP---------RNGTVHLYLTKPL--- 111
Socs3 VLKLVYHYMPPPG-----APSFP---------SPPTEPSS-------- 102
Socs1 LFELLEHYVAAPR--RMLGAPLR---------QRRVRPL--------- 98
Nap4 FIKRAIMHSKNGKFLYFLRSRVP---------GLPPTPVQLLYPV--- 112
Socs4 LIEHSIRDSENGAFCYS-RSRLP---------GSATYPVRLTNPV--- 110
Socs5 LLEH---YKDPSSCMFF----------------EPLLTISL------- 98
Socs7 LLEH---YKDPSACMFF----------------EPLLSTPL------- 98
Crk LRIGDQEFDSLPALLEFYKIHYL---------DTTTLIEPV------- 108
CrkL FKIGDQEFDHLPALLEFYKIHYL---------DTTTLIEPA------- 91
Pi3kCaplha LKELVLHYQHTSLVQHN--DSLN---------VTLAYP---------- 96
Pi3kCgamma LKELVLHYQQTSLVQHN--DSLN---------VRLAYPV--------- 97
Pi3kCbeta LKELVLHYQHASLVQHN--DALT---------VTLAHPVR-------- 98
Pi3kNalpha VVELINHYRNESLAQYN--PKLD---------VKLLYPV--------- 98
Pi3kNgamma VVELINHYHHESLAQYN--PKLD---------VKLMYPV--------- 98
Pi3kNbeta VVDLINHYRHESLAQYN--AKLD---------TRLLYPV--------- 98
Vav1 LTELVEFYQQNSLKDCF--KSLD---------TTLQFPF--------- 97
Vav3 LMELVEYYKHHSLKEGF--RTLD---------TTLQFPY--------- 97
Vav2 LLELVEYYQCHSLKESF--KQLD---------TTLKYPY--------- 97
Mist VEDIIEHYKNFP-------IILIDGKDKTGV-HRKQCHLTQPL----- 113
Slp76 VSDIIDYFRKMP-------LLLIDGKNRG---SRYQCTLTHA------ 110
Blnk VAEIIRNHQHSP-------LVLIDSQNNTKDSTRLKYAVKVS------ 113
Plcg1C LVDLISYYEKHP-------LYRK---------MKLRYPI--------- 91
Plcg2C LVELVSYYEKHS-------LYRK---------MRLRYPV--------- 92
Btk IPELINYHQHNS-------AGLI---------SRLKYPV--------- 99
Txk IPELIWYHQHNA-------AGLM---------TRLRYPV--------- 99
Itk IPLLINYHQHNG-------GGLV---------TRLRYPV--------- 102
Tec IPEIIEYHKHNA-------AGLV---------TRLRYPV--------- 101
Bmx IPKLIHYHQHNS-------AGMI---------TRLRHPV--------- 99
Eat2 LKELISKFEKPN-------QGMV---------VHLLKPI--------- 99
Sap IKNLISAFQKPD-------QGIV---------IPLQYPVEKKSSARST 108
Ship LDQLIEFYKKEN-------MGLV---------THLQYPVPLE------ 102
Ship2 LGELIGLYAQPN-------QGLV---------CALLLPV--------- 99
Nck MEELVEHYKKAP--IFTSEQGEK---------LYLVKHL--------- 97
Nck2 MDELVEHYKKAP--IFTSEHGEK---------LYLVRA---------- 96
Dapp1 LKDFVKHFANQP--LIGSETGTL---------MVLKHPYPRKV----- 101
Grap LNELVDFYRTTT---I-------------------------------- 83
Grb2 LNELVDYHRSTS---VSRNQQIF---------LRDIE----------- 95
Grap2 LNKLVDYYRTNS---ISRQKQIF---------LRDRTREDQ------- 98
Shp1C LTDLVEHFKKTG---IEEASGAF---------VYLRQPY--------- 106
Shp2C LTDLVEHYKKNP---MVETLGTV---------LQLKQPL--------- 107
Shp1N LTELVEYYTQQQG-VLQDRDGTI---------IHLKYPL--------- 99
Shp2N LAELVQYYMEHHG-QLKEKNGDV---------IELKYP---------- 98
Aps VLDMLRHFHTH---PIPLESGGSA-------DITLRSYV--------- 101
Sh2b IFDMLEHFRVH---PIPLESGGSS-------DVVLVSYV--------- 101
Lnk VVDMLHHFQRS---PIPLECGAAC-------DVRLSSYV--------- 101
Fer IPQLIDHHYTT---KQVITKKSG--------VVLLNPI---------- 93
Fes IPLLIDHLLST---QQPLTKKSG--------VVLHRAV---------- 92
Nsp2 IPGLVRCYVGN---RRPISQQSG--------AIIF------------- 99
Nsp3 VPALVRYHVGS---RKAVSEQSG--------AIIYCPVNRTFP----- 107
Nsp1 IPALVHSYMTG---RRPLSQATG--------AVVSRPVT--------- 103
Shca VSHLISYHMDN---HLPIISAGS--------ELCLQQPV--------- 94
Shcd VGHLIRYHMDN---SLPIISSGS--------EVSLKQP---------- 97
Shcc ISHLINHHLES---SLPIVSAGS--------ELCLQQPV--------- 94
Shcb ISHLIDHHLQNG--QPPIVAAES--------ELHLRGVVSREP----- 99
Grb10 LIQLVDFY--------QLNKGV-------------------------- 90
Grb14 LIQLVEFY--------QLNKGVL--------PCKLKHYC--------- 99
Grb7 LLQLVEFH--------QLNRGIL--------PCLLRHCC--------- 99
Plcg1N LYDLITHYQQV-----PLRCNEF--------EMRLSEPV--------- 110
Plcg2N MYALIQHYRET-----HLPCAEF--------ELRLTDPVP-------- 107
Chimerin1 IHDLVTDGLITLY------IETK----------AAEYIAK-------- 90
Chimerin2 IHDLVTDGLITLY------IETK----------AAEYISK-------- 90
Tens1 LTALVCQHSITP-------LALP---------C-LLIPERDPL----- 116
Tensin LSALVYQHSIIP-------LALP---------CKLVIPNR-------- 113
Tenc1 LSALVSQHSISP-------ISLP---------CCLRIPSK-------- 111
Cten LSAFVCQHSIMA-------LALP---------CKLTIPQ--------- 110
Rin2 LFRLIAFYCISR-------DVLP---------FTLKLPY--------- 96
Rin3 IFRLIAFYCVSR-------DLLP---------FTLRLPQ--------- 98
Rin1 LVQLICAYCHTR-------DILL---------LPLQLPR--------- 97
Stat1 ENPLKYLYPNIDK-----DHAFG---------KYYSRPK--------- 115
Stat4 ENPLKYLYPDIPK-----DKAFG---------KHYSS----------- 111
Stat3 VSPLVYLYPDIPK-----EEAFG---------KYCRP----------- 112
Stat2 ENPLRFLYPRIPR-----DEAFG---------CYYQEK---------- 112
Stat5a LSYLIYVFPDRPK-----DEVFS---------KYYTPVL--------- 101
Stat5b LNYLIYVFPDRPK-----DEVYS---------KYYTPVCESAT----- 105
Stat6 LAQLKNLYPKKPK-----DEAFR---------SHYKPEQ--------- 103
Jak2 LKDLLN-CYQ--------METVR------------------------- 91
Jak3 LRELLATCWDGGL----HVDGVA---------VTLTSCC--------- 103
Jak1 LGDLMSHLKKQIL----RTDNIS---------FMLKRCC--------- 108
Cbl NPDLTGLCEPTPQ-------------------DHIK------------ 98
Cblb NPDLTGLCEPTPH-------------------DHIK------------ 98
Cblc NPDLTELGQAEPQ-------------------QRIHVSEEQLQLYW-- 108
RasGapN LSDLIGYYSHVS-------CLLKG--------EKLLYPV--------- 94
RasGapC IGDIIDHYRKEQ-------IVEG---------YYLKEPV--------- 93
Tyk2 VRELGAALQGCLLRAGDDCFSLRR--------CCLPQPGETS------ 111
Sh3bp2 VGSMVEHYHTHVLP-----SHQS---------LLLRHPY--------- 101
Supt6h LDEIVARYVQPMAS---FARDLLN--------HKYYQDCSG------- 106
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