--- a/Xlib/display.py
+++ b/Xlib/display.py
@@ -22,9 +22,6 @@
 # Python modules
 import types
 
-# Python 2/3 compatibility.
-from six import create_unbound_method
-
 # Xlib modules
 from . import error
 from . import ext
@@ -283,7 +280,7 @@
                 if hasattr(cls, name):
                     raise AssertionError('attempting to replace %s method: %s' % (class_name, name))
 
-                method = create_unbound_method(function, cls)
+                method = function
 
                 # Maybe should check extension overrides too
                 try:
--- a/Xlib/ext/xinput.py
+++ b/Xlib/ext/xinput.py
@@ -28,9 +28,6 @@
 import array
 import struct
 
-# Python 2/3 compatibility.
-from six import integer_types
-
 from Xlib.protocol import rq
 from Xlib import X
 
@@ -218,7 +215,7 @@
 
         mask_seq = array.array(rq.struct_to_array_codes['L'])
 
-        if isinstance(val, integer_types):
+        if isinstance(val, int):
             # We need to build a "binary mask" that (as far as I can tell) is
             # encoded in native byte order from end to end.  The simple case is
             # with a single unsigned 32-bit value, for which we construct an
--- a/Xlib/protocol/display.py
+++ b/Xlib/protocol/display.py
@@ -29,8 +29,9 @@
 import struct
 import sys
 
-# Python 2/3 compatibility.
-from six import PY3, byte2int, indexbytes
+import operator
+byte2int = operator.itemgetter(0)
+indexbytes = operator.getitem
 
 # Xlib modules
 from .. import error
@@ -42,9 +43,7 @@
 from . import rq
 from . import event
 
-if PY3:
-
-    class bytesview(object):
+class bytesview:
 
         def __init__(self, data, offset=0, size=None):
             if size is None:
@@ -65,15 +64,6 @@
                 return bytes(self.view[key])
             return self.view[key]
 
-else:
-
-    def bytesview(data, offset=0, size=None):
-        if not isinstance(data, (bytes, buffer)):
-            raise TypeError('unsupported type: {}'.format(type(data)))
-        if size is None:
-            size = len(data)-offset
-        return buffer(data, offset, size)
-
 
 class Display(object):
     extension_major_opcodes = {}
--- a/Xlib/protocol/rq.py
+++ b/Xlib/protocol/rq.py
@@ -26,7 +26,9 @@
 from array import array
 
 # Python 2/3 compatibility.
-from six import PY3, binary_type, byte2int, indexbytes, iterbytes
+import operator
+byte2int = operator.itemgetter(0)
+indexbytes = operator.getitem
 
 # Xlib modules
 from .. import X
@@ -36,12 +38,8 @@
 def decode_string(bs):
     return bs.decode('latin1')
 
-if PY3:
-    def encode_array(a):
-        return a.tobytes()
-else:
-    def encode_array(a):
-        return a.tostring()
+def encode_array(a):
+    return a.tobytes()
 
 
 class BadDataError(Exception): pass
@@ -456,7 +454,7 @@
     def pack_value(self, val):
         """Convert 8-byte string into 16-byte list"""
         if isinstance(val, bytes):
-            val = list(iterbytes(val))
+            val = list(iter(val))
 
         slen = len(val)
 
@@ -676,7 +674,7 @@
         if fmt not in (8, 16, 32):
             raise BadDataError('Invalid property data format {0}'.format(fmt))
 
-        if isinstance(val, binary_type):
+        if isinstance(val, bytes):
             size = fmt // 8
             vlen = len(val)
             if vlen % size:
--- a/Xlib/threaded.py
+++ b/Xlib/threaded.py
@@ -19,7 +19,7 @@
 #    Suite 330,
 #    Boston, MA 02111-1307 USA
 
-from six.moves import _thread
+import _thread
 
 # We change the allocate_lock function in Xlib.support.lock to
 # return a basic Python lock, instead of the default dummy lock
--- a/examples/xlsatoms.py
+++ b/examples/xlsatoms.py
@@ -26,15 +26,9 @@
 
 '''
 
-# Python 2/3 compatibility.
-from __future__ import print_function
-
 import sys
 import os
 
-# Python 2/3 compatibility.
-from six import PY2, MAXSIZE
-
 # Change path so we find Xlib
 sys.path.append(os.path.join(os.path.dirname(__file__), '..'))
 
@@ -42,12 +36,6 @@
 from Xlib import display, error
 from optparse import OptionParser
 
-
-if PY2:
-    integer_type = long
-else:
-    integer_type = int
-
 parser = OptionParser()
 parser.add_option("-d","--display",dest="display",help="This option specifies the X server to which to connect",metavar="dpy",default=None)
 parser.add_option("-n","--name",dest="name",help="This option specifies the name of an atom to list.  If the atom does  not  exist,  a  message  will  be printed on the standard error.",metavar="string",default=None)
@@ -90,12 +78,12 @@
 
 rangeVals = options.range.split("-")
 if rangeVals[0] != "":
-    low = integer_type(rangeVals[0])
+    low = int(rangeVals[0])
 
 if rangeVals[1] != "":
-    high = integer_type(rangeVals[1])
+    high = int(rangeVals[1])
 else:
-    high = MAXSIZE
+    high = sys.maxint
 
 if options.match_re != None:
     re_obj = re.compile(options.match_re)
--- a/requirements.txt
+++ b/requirements.txt
@@ -1 +0,0 @@
-six>=1.10.0
--- a/setup.py
+++ b/setup.py
@@ -10,7 +10,6 @@
 
 
 setup(
-    install_requires=['six>=1.10.0'],
     setup_requires=['setuptools-scm'],
     packages=[
         'Xlib',
--- a/test/test_bytesview.py
+++ b/test/test_bytesview.py
@@ -1,9 +1,6 @@
 
 import unittest
 
-# Python 2/3 compatibility.
-from six import indexbytes, text_type
-
 from Xlib.protocol.display import bytesview
 
 
@@ -11,17 +8,17 @@
 
     def test(self):
         with self.assertRaises(TypeError):
-            bytesview(text_type('foobar'))
+            bytesview('foobar')
         data = b'0123456789ABCDEF'
         view = bytesview(data)
         self.assertEqual(len(view), 16)
         self.assertEqual(view[:], data)
         self.assertIsInstance(view[:], bytes)
         self.assertEqual(view[5:-6], b'56789')
-        self.assertEqual(indexbytes(view, 7), ord('7'))
+        self.assertEqual(view[7], ord('7'))
         view = bytesview(view, 5)
         self.assertEqual(view[:], b'56789ABCDEF')
-        self.assertEqual(indexbytes(view, 4), ord('9'))
+        self.assertEqual(view[4], ord('9'))
         view = bytesview(view, 0, 5)
         self.assertEqual(view[:], b'56789')
-        self.assertEqual(indexbytes(view, 1), ord('6'))
+        self.assertEqual(view[1], ord('6'))
--- a/test/test_struct.py
+++ b/test/test_struct.py
@@ -5,8 +5,6 @@
 import types
 import re
 
-from six import binary_type, iterbytes
-
 from Xlib.protocol import rq
 from . import DummyDisplay, TestCase
 
@@ -85,7 +83,7 @@
                 values_in[field_name] = field_value_in
             if field_value_out is not None:
                 values_out[field_name] = field_value_out
-        if isinstance(field_binary, binary_type):
+        if isinstance(field_binary, bytes):
             binary += field_binary
         elif isinstance(field_binary, (types.FunctionType, types.LambdaType, partial)):
             binary += field_binary(field_value_in)
@@ -167,7 +165,7 @@
     (None, lambda name: rq.LengthOf('s2', 2)   , None            , pack('H', 3) ),
     ('s1', lambda name: rq.String16(name, pad=0), (0, 1, 2), lambda s: struct.pack('>' + 'H' * len(s), *s)),
     # An 8-bits string is also allowed on input.
-    ('s2', lambda name: rq.String16(name, pad=0), b'\x03\x04\x05', lambda s: struct.pack('>' + 'H' * len(s), *iterbytes(s)), (3, 4, 5)),
+    ('s2', lambda name: rq.String16(name, pad=0), b'\x03\x04\x05', lambda s: struct.pack('>' + 'H' * len(s), *iter(s)), (3, 4, 5)),
 ))
 
 _struct_test('binary', (