## File: mic_strength.Rd

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 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100101102103104105 % Generated by roxygen2: do not edit by hand % Please edit documentation in R/mictools.R \name{mic_strength} \alias{mic_strength} \title{Compute the association strengh} \usage{ mic_strength(x, pval, alpha = NULL, C = 5, pthr = 0.05, pval.col = NULL) } \arguments{ \item{x}{a numeric matrix with N samples on the rows and M variables on the columns (NxM).} \item{pval}{a data.frame with pvalues for each pair of association of the \code{x} input matrix. It should contain two colums with the indices of the computed association according to the x input matrix} \item{alpha}{float (0, 1.0] or >=4 if alpha is in (0,1] then B will be max(n^alpha, 4) where n is the number of samples. If alpha is >=4 then alpha defines directly the B parameter. If alpha is higher than the number of samples (n) it will be limited to be n, so B = min(alpha, n) Default value is 0.6 (see Details).} \item{C}{a positive integer number, the \code{C} parameter of the \code{mine} statistic. See \code{\link[minerva]{mine}} function for further details.} \item{pthr}{threshold on pvalue for measure to consider for computing mic_e} \item{pval.col}{an integer or character or vector relative to the columns of \code{pval} dataframe respectively for \code{pvalue}, association between variable 1, variable 2 in the \code{x} input matrix. See Details for further information.} } \value{ A dataframe with the \code{tic_e} Pvalue, the \code{mic} value and the column identifier regarding the input matrix \code{x} of the variables of which the association is computed. } \description{ This function uses the null distribution of the \code{tic_e} computed with the function \code{\link[minerva]{mictools}}. Based on the available pvalue and the permutation null distribution it identifies reliable association between variables. } \details{ The method implemented here is a wrapper for the original method published by Albaese et al. (2018). The python version is available at \url{https://github.com/minepy/mictools}. This function should be called after the estimation of the null distribution of \code{tic_e} scores based on permutations of the input data. The \code{mic} association is computed only for the variables for which the pvalue in the \code{pval} \code{data.frame} is less then the threshold set with the \code{pthr} input parameter. We assume the first column of the \code{pval} \code{data.frame} contains the pvalue, this value can be changed using the \code{pval.col}[1] parameter. The \code{pval.col} parameter, by default takes the first three columns in the \code{pval} \code{data.frame}, in particular the first column containing the \code{pvalues} of the association between variable in column \code{pval.col[2]} and \code{pval.col[3]}. If a character vector is provided names in \code{pval.col} are matched with the names in \code{pval} \code{data.frame}. If \code{NULL} is passed it is assumed the first column contains pvalue, while the 2 and 3 the index or name of the variable in \code{x}. If one value is passed it refers to the \code{pvalue} column and the consecutive two columns are assume to contain variable indexes. } \examples{ data(Spellman) mydata <- as.matrix(Spellman[, 10:20]) ticenull <- mictools(mydata, nperm=1000) ## Use the nominal pvalue: ms <- mic_strength(mydata, pval=ticenull$pval, alpha=NULL, pval.col = c(6, 4,5)) ## Use the adjusted pvalue: ms <- mic_strength(mydata, pval=ticenull$pval, alpha=NULL, pval.col = c(6, 4,5)) ms \dontrun{ ## Use qvalue require(qvalue) qobj <- qvalue(ticenull$pval$pval) ticenull$pval$qvalue <- qobj$qvalue ms <- mic_strength(mydata, pval=ticenull$pval, alpha=NULL, pval.col = c("qvalue", "Var1", "Var2")) ## Get the data from mictools repository lnf <- "https://raw.githubusercontent.com/minepy/mictools/master/examples/datasaurus.txt" datasaurus <- read.table(lnf, header=TRUE, row.names = 1, stringsAsFactors = FALSE) datasaurus <- t(datasaurus) ticenull <- mictools(datasaurus, nperm=200000) micres <- mic_strength(mydata, ticenull$pval, pval.col=c(6, 4, 5)) ## Plot distribution of pvalues hist(ticenull$pval, breaks=50, freq=FALSE) ## Plot distribution of tic_e values hist(ticenull$tic) ## Correct pvalues using qvalue package require(qvalue) require(ggplot2) qobj <- qvalue(ticenull$pval$pval) ticenull$pval$qvalue <- qobj$qvalue micres <- mic_strength(datasaurus, ticenull$pval, pval.col=c("qvalue", "Var1", "Var2")) hist(qobj$qvalue) df <- data.frame(pi0.labmda=qobj$pi0.lambda, lambda=qobj$lambda, pi0.smooth=qobj$pi0.smooth) gp0 <- ggplot(df, aes(lambda, pi0.labmda)) + geom_point() gp0 <- gp0 + geom_line(aes(lambda, pi0.smooth)) gp0 <- gp0 + geom_hline(yintercept = qobj$pi0, linetype="dashed", col="red") } } \seealso{ \code{\link[minerva]{mine}}, \code{\link[minerva]{mictools}}, \code{\link[stats]{p.adjust}} }