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% Generated by roxygen2: do not edit by hand
% Please edit documentation in R/differential_expression.R
\name{compare_expression}
\alias{compare_expression}
\title{Compare gene expression between two groups}
\usage{
compare_expression(
x,
umi,
group,
val1,
val2,
method = "LRT",
bin_size = 256,
cell_attr = x$cell_attr,
y = x$y,
min_cells = 5,
weighted = TRUE,
randomize = FALSE,
verbosity = 2,
verbose = NULL,
show_progress = NULL
)
}
\arguments{
\item{x}{A list that provides model parameters and optionally meta data; use output of vst function}
\item{umi}{A matrix of UMI counts with genes as rows and cells as columns}
\item{group}{A vector indicating the groups}
\item{val1}{A vector indicating the values of the group vector to treat as group 1}
\item{val2}{A vector indicating the values of the group vector to treat as group 2}
\item{method}{Either 'LRT' for likelihood ratio test, or 't_test' for t-test}
\item{bin_size}{Number of genes that are processed between updates of progress bar}
\item{cell_attr}{Data frame of cell meta data}
\item{y}{Only used if methtod = 't_test', this is the residual matrix; default is x$y}
\item{min_cells}{A gene has to be detected in at least this many cells in at least one of the groups being compared to be tested}
\item{weighted}{Balance the groups by using the appropriate weights}
\item{randomize}{Boolean indicating whether to shuffle group labels - only set to TRUE when testing methods}
\item{verbosity}{An integer specifying whether to show only messages (1), messages and progress bars (2) or nothing (0) while the function is running; default is 2}
\item{verbose}{Deprecated; use verbosity instead}
\item{show_progress}{Deprecated; use verbosity instead}
}
\value{
Data frame of results
}
\description{
Compare gene expression between two groups
}
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