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ENTRY map00030 Pathway
NAME Pentose phosphate pathway
DESCRIPTION The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
CLASS Metabolism; Carbohydrate Metabolism
PATHWAY_MAP map00030 Pentose phosphate pathway
MODULE M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:map00030]
M00005 PRPP biosynthesis, ribose 5P -> PRPP [PATH:map00030]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:map00030]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:map00030]
M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:map00030]
M00680 Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glyceraldehyde-3P + pyruvate [PATH:map00030]
M00681 Non-phosphorylative Entner-Doudoroff pathway, gluconate => glyceraldehyde + pyruvate [PATH:map00030]
DISEASE H00196 Phosphoribosylpyrophosphate synthetase I superactivity
DBLINKS GO: 0006098
REFERENCE (map 3)
AUTHORS Nishizuka Y (ed).
TITLE [Metabolic Maps] (In Japanese)
JOURNAL Tokyo Kagaku Dojin (1980)
REFERENCE (map 4)
AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
TITLE [Cellular Functions and Metabolic Maps] (In Japanese)
JOURNAL Tokyo Kagaku Dojin (1997)
REFERENCE
AUTHORS Michal G.
TITLE Biochemical Pathways
JOURNAL Wiley (1999)
REFERENCE PMID:12700258
AUTHORS Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
TITLE Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
JOURNAL J Bacteriol 185:2793-801 (2003)
REL_PATHWAY map00010 Glycolysis / Gluconeogenesis
map00040 Pentose and glucuronate interconversions
map00230 Purine metabolism
map00240 Pyrimidine metabolism
map00340 Histidine metabolism
KO_PATHWAY ko00030
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