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ENTRY rn00250 Pathway
NAME Alanine, aspartate and glutamate metabolism
CLASS Metabolism; Amino Acid Metabolism
PATHWAY_MAP rn00250 Alanine, aspartate and glutamate metabolism
MODULE M00017 Glutamate biosynthesis, oxoglutarate => glutamate (glutamate dehydrogenase) [PATH:rn00250]
M00018 Glutamine biosynthesis, glutamate => glutamine [PATH:rn00250]
M00019 Glutamate biosynthesis, oxoglutarete => glutamate (glutamate synthase) [PATH:rn00250]
M00021 Aspartate biosynthesis, oxaloacetate => aspartate [PATH:rn00250]
M00022 Asparagine biosynthesis, aspartate => asparagine [PATH:rn00250]
M00026 Alanine biosynthesis, pyruvate => alanine [PATH:rn00250]
M00038 Glutamine degradation, glutamine => glutamate + NH3 [PATH:rn00250]
M00040 GABA (gamma-Aminobutyrate) shunt [PATH:rn00250]
M00044 Aspartate degradation, aspartate => fumarate [PATH:rn00250]
M00045 Aspartate degradation, aspartate => oxaloacetate [PATH:rn00250]
M00046 Asparagine degradation, asparagine => aspartate +NH3 [PATH:rn00250]
DISEASE H00074 Canavan disease (CD)
H00185 Citrullinemia (CTLN)
H00197 Adenylosuccinate lyase deficiency
DBLINKS GO: 0006522 0006531 0006536
REACTION R00093 L-glutamate:NAD+ oxidoreductase (transaminating)
R00114 L-Glutamate:NADP+ oxidoreductase (transaminating)
R00149 Carbon-dioxide:ammonia ligase (ADP-forming,carbamate-phosphorylating)
R00243 L-Glutamate:NAD+ oxidoreductase (deaminating)
R00248 L-Glutamate:NADP+ oxidoreductase (deaminating)
R00253 L-Glutamate:ammonia ligase (ADP-forming)
R00256 L-Glutamine amidohydrolase
R00258 L-Alanine:2-oxoglutarate aminotransferase
R00261 L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
R00269 2-Oxoglutaramate amidohydrolase
R00348 2-Oxosuccinamate amidohydrolase
R00355 L-Aspartate:2-oxoglutarate aminotransferase
R00357 L-Aspartic acid:oxygen oxidoreductase (deaminating)
R00359 D-Aspartate:oxygen oxidoreductase (deaminating)
R00369 L-Alanine:glyoxylate aminotransferase
R00396 L-Alanine:NAD+ oxidoreductase (deaminating)
R00397 L-aspartate 4-carboxy-lyase (L-alanine-forming)
R00400 L-alanine:oxaloacetate aminotransferase
R00483 L-aspartate:ammonia ligase (AMP-forming)
R00484 N-Carbamoyl-L-aspartate amidohydrolase
R00485 L-Asparagine amidohydrolase
R00487 Acetyl-CoA:L-aspartate N-acetyltransferase
R00488 N-Acetyl-L-aspartate amidohydrolase
R00490 L-Aspartate ammonia-lyase
R00491 aspartate racemase
R00575 hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
R00576 L-Glutamine:pyruvate aminotransferase
R00578 L-aspartate:L-glutamine amido-ligase (AMP-forming)
R00707 (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase
R00708 (S)-1-pyrroline-5-carboxylate:NADP+ oxidoreductase
R00713 Succinate-semialdehyde:NAD+ oxidoreductase
R00714 Succinate-semialdehyde:NADP+ oxidoreductase
R00768 L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
R01072 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
R01083 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
R01086 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
R01135 IMP:L-aspartate ligase (GDP-forming)
R01346 L-Asparagine:2-oxo-acid aminotransferase
R01397 carbamoyl-phosphate:L-aspartate carbamoyltransferase
R01648 4-Aminobutanoate:2-oxoglutarate aminotransferase
R01954 L-Citrulline:L-aspartate ligase (AMP-forming)
COMPOUND C00014 NH3
C00022 Pyruvate
C00025 L-Glutamate
C00026 2-Oxoglutarate
C00036 Oxaloacetate
C00041 L-Alanine
C00042 Succinate
C00049 L-Aspartate
C00064 L-Glutamine
C00122 Fumarate
C00152 L-Asparagine
C00169 Carbamoyl phosphate
C00232 Succinate semialdehyde
C00334 4-Aminobutanoate
C00352 D-Glucosamine 6-phosphate
C00402 D-Aspartate
C00438 N-Carbamoyl-L-aspartate
C00940 2-Oxoglutaramate
C01042 N-Acetyl-L-aspartate
C02362 2-Oxosuccinamate
C03090 5-Phosphoribosylamine
C03406 N-(L-Arginino)succinate
C03794 N6-(1,2-Dicarboxyethyl)-AMP
C03912 (S)-1-Pyrroline-5-carboxylate
REFERENCE
AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
TITLE [Cellular Functions and Metabolic Maps] (In Japanese)
JOURNAL Tokyo Kagaku Dojin (1997)
REFERENCE PMID:9687539
AUTHORS Wu G
TITLE Intestinal mucosal amino acid catabolism.
JOURNAL J Nutr 128:1249-52 (1998)
REL_PATHWAY rn00010 Glycolysis / Gluconeogenesis
rn00020 Citrate cycle (TCA cycle)
rn00230 Purine metabolism
rn00240 Pyrimidine metabolism
rn00253 Tetracycline biosynthesis
rn00260 Glycine, serine and threonine metabolism
rn00300 Lysine biosynthesis
rn00330 Arginine and proline metabolism
rn00340 Histidine metabolism
rn00410 beta-Alanine metabolism
rn00460 Cyanoamino acid metabolism
rn00471 D-Glutamine and D-glutamate metabolism
rn00473 D-Alanine metabolism
rn00480 Glutathione metabolism
rn00650 Butanoate metabolism
rn00660 C5-Branched dibasic acid metabolism
rn00760 Nicotinate and nicotinamide metabolism
rn00770 Pantothenate and CoA biosynthesis
rn00860 Porphyrin and chlorophyll metabolism
rn00910 Nitrogen metabolism
KO_PATHWAY ko00250
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